{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:20:52Z","timestamp":1790821252595,"version":"4.1.0"},"reference-count":159,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurodegeneration"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13024-019-0330-8","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T15:02:49Z","timestamp":1562857369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Pineal gland dysfunction in Alzheimer\u2019s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-8507","authenticated-orcid":false,"given":"Juhyun","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"330_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","volume":"9","author":"CR Jack Jr","year":"2010","unstructured":"Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010;9:119\u201328.","journal-title":"Lancet Neurol"},{"key":"330_CR2","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2174\/1568026616666161222121229","volume":"17","author":"SA Bhat","year":"2017","unstructured":"Bhat SA, Kamal MA, Yarla NS, Ashraf GM. Synopsis on Managment strategies for neurodegenerative disorders: challenges from bench to bedside in successful drug discovery and development. Curr Top Med Chem. 2017;17:1371\u20138.","journal-title":"Curr Top Med Chem"},{"key":"330_CR3","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","volume":"390","author":"G Livingston","year":"2017","unstructured":"Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673\u2013734.","journal-title":"Lancet"},{"key":"330_CR4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11064-014-1488-7","volume":"40","author":"AB dos Santos","year":"2015","unstructured":"dos Santos AB, Kohlmeier KA, Barreto GE. Are sleep disturbances preclinical markers of Parkinson's disease? Neurochem Res. 2015;40:421\u20137.","journal-title":"Neurochem Res"},{"key":"330_CR5","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.5665\/sleep.2802","volume":"36","author":"AS Lim","year":"2013","unstructured":"Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA. Sleep fragmentation and the risk of incident Alzheimer's disease and cognitive decline in older persons. Sleep. 2013;36:1027\u201332.","journal-title":"Sleep"},{"key":"330_CR6","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3233\/JAD-150391","volume":"48","author":"G Spalletta","year":"2015","unstructured":"Spalletta G, Long JD, Robinson RG, Trequattrini A, Pizzoli S, Caltagirone C, Orfei MD. Longitudinal neuropsychiatric predictors of death in Alzheimer's disease. J Alzheimer's Dis. 2015;48:627\u201336.","journal-title":"J Alzheimer's Dis"},{"key":"330_CR7","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1098\/rstb.2003.1303","volume":"358","author":"P Ekstrom","year":"2003","unstructured":"Ekstrom P, Meissl H. Evolution of photosensory pineal organs in new light: the fate of neuroendocrine photoreceptors. Philos Trans R Soc Lond Ser B Biol Sci. 2003;358:1679\u2013700.","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"330_CR8","doi-asserted-by":"crossref","first-page":"741974","DOI":"10.4061\/2011\/741974","volume":"2011","author":"V Srinivasan","year":"2010","unstructured":"Srinivasan V, Kaur C, Pandi-Perumal S, Brown GM, Cardinali DP. Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value. Int J Alzheimers Dis. 2010;2011:741974.","journal-title":"Int J Alzheimers Dis"},{"key":"330_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1600-079X.2011.00937.x","volume":"52","author":"SA Rosales-Corral","year":"2012","unstructured":"Rosales-Corral SA, Acuna-Castroviejo D, Coto-Montes A, Boga JA, Manchester LC, Fuentes-Broto L, Korkmaz A, Ma S, Tan DX, Reiter RJ. Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin. J Pineal Res. 2012;52:167\u2013202.","journal-title":"J Pineal Res"},{"key":"330_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2174\/157015910792246137","volume":"8","author":"H He","year":"2010","unstructured":"He H, Dong W, Huang F. Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Curr Neuropharmacol. 2010;8:211\u20137.","journal-title":"Curr Neuropharmacol"},{"key":"330_CR11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0531-5565(02)00198-5","volume":"38","author":"DJ Skene","year":"2003","unstructured":"Skene DJ, Swaab DF. Melatonin rhythmicity: effect of age and Alzheimer's disease. Exp Gerontol. 2003;38:199\u2013206.","journal-title":"Exp Gerontol"},{"key":"330_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.sleep.2006.11.010","volume":"8","author":"YH Wu","year":"2007","unstructured":"Wu YH, Swaab DF. Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med. 2007;8:623\u201336.","journal-title":"Sleep Med"},{"key":"330_CR13","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.sleep.2008.05.003","volume":"10","author":"R Mahlberg","year":"2009","unstructured":"Mahlberg R, Kienast T, Hadel S, Heidenreich JO, Schmitz S, Kunz D. Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med. 2009;10:439\u201345.","journal-title":"Sleep Med"},{"key":"330_CR14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/jmri.21872","volume":"30","author":"I Nolte","year":"2009","unstructured":"Nolte I, Lutkhoff AT, Stuck BA, Lemmer B, Schredl M, Findeisen P, Groden C. Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approach. J Magn Reson Imaging. 2009;30:499\u2013505.","journal-title":"J Magn Reson Imaging"},{"key":"330_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jchemneu.2016.07.008","volume":"78","author":"A Yalcin","year":"2016","unstructured":"Yalcin A, Ceylan M, OF B, Sonkaya AR, Yuce I. Age and gender related prevalence of intracranial calcifications in CT imaging; data from 12,000 healthy subjects. J Chem Neuroanat. 2016;78:20\u20134.","journal-title":"J Chem Neuroanat"},{"key":"330_CR16","first-page":"55","volume":"47","author":"D Admassie","year":"2009","unstructured":"Admassie D, Mekonnen A. Incidence of normal pineal and chroids plexus calcification on brain CT (computerized tomography) at Tikur Anbessa teaching hospital Addis Ababa, Ethiopia. Ethiop Med J. 2009;47:55\u201360.","journal-title":"Ethiop Med J"},{"key":"330_CR17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.4329\/wjr.v5.i4.166","volume":"5","author":"JM Bumb","year":"2013","unstructured":"Bumb JM, Brockmann MA, Groden C, Nolte I. Microstructural analysis of pineal volume using trueFISP imaging. World J Radiol. 2013;5:166\u201372.","journal-title":"World J Radiol"},{"key":"330_CR18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/jsr.12125","volume":"23","author":"JM Bumb","year":"2014","unstructured":"Bumb JM, Schilling C, Enning F, Haddad L, Paul F, Lederbogen F, Deuschle M, Schredl M, Nolte I. Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study. J Sleep Res. 2014;23:274\u201380.","journal-title":"J Sleep Res"},{"key":"330_CR19","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1467-789X.2010.00756.x","volume":"12","author":"DX Tan","year":"2011","unstructured":"Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev. 2011;12:167\u201388.","journal-title":"Obes Rev"},{"key":"330_CR20","first-page":"220","volume":"28","author":"M Grosshans","year":"2016","unstructured":"Grosshans M, Vollmert C, Vollstaedt-Klein S, Nolte I, Schwarz E, Wagner X, Leweke M, Mutschler J, Kiefer F, Bumb JM. The association of pineal gland volume and body mass in obese and normal weight individuals: a pilot study. Psychiatr Danub. 2016;28:220\u20134.","journal-title":"Psychiatr Danub"},{"key":"330_CR21","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1124\/pr.55.2.2","volume":"55","author":"V Simonneaux","year":"2003","unstructured":"Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev. 2003;55:325\u201395.","journal-title":"Pharmacol Rev"},{"key":"330_CR22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1469-185X.2009.00118.x","volume":"85","author":"DX Tan","year":"2010","unstructured":"Tan DX, Hardeland R, Manchester LC, Paredes SD, Korkmaz A, Sainz RM, Mayo JC, Fuentes-Broto L, Reiter RJ. The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness. Biol Rev Camb Philos Soc. 2010;85:607\u201323.","journal-title":"Biol Rev Camb Philos Soc"},{"key":"330_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.cbpa.2008.10.016","volume":"152","author":"J Pawlak","year":"2009","unstructured":"Pawlak J, Golab M, Markowska M, Majewski P, Skwarlo-Sonta K. Photoperiod-related changes in hormonal and immune status of male Siberian hamsters, Phodopus sungorus. Comp Biochem Physiol A Mol Integr Physiol. 2009;152:299\u2013303.","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"330_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0014-2999(00)00416-7","volume":"401","author":"EJ Mortani Barbosa","year":"2000","unstructured":"Mortani Barbosa EJ, Ferreira ZS, Markus RP. Purinergic and noradrenergic cotransmission in the rat pineal gland. Eur J Pharmacol. 2000;401:59\u201362.","journal-title":"Eur J Pharmacol"},{"key":"330_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167063","volume":"11","author":"MP Ibanez Rodriguez","year":"2016","unstructured":"Ibanez Rodriguez MP, Noctor SC, Munoz EM. Cellular basis of pineal gland development: emerging role of microglia as phenotype regulator. PLoS One. 2016;11:e0167063.","journal-title":"PLoS One"},{"key":"330_CR26","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/aja.1001660408","volume":"166","author":"MG Welsh","year":"1983","unstructured":"Welsh MG. CSF-contacting pinealocytes in the pineal recess of the Mongolian gerbil: a correlative scanning and transmission electron microscope study. Am J Anat. 1983;166:483\u201393.","journal-title":"Am J Anat"},{"key":"330_CR27","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1007\/s00429-014-0719-7","volume":"219","author":"RJ Reiter","year":"2014","unstructured":"Reiter RJ, Tan DX, Kim SJ, Cruz MH. Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces. Brain Struct Funct. 2014;219:1873\u201387.","journal-title":"Brain Struct Funct"},{"key":"330_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00238052","volume":"201","author":"RV Krstic","year":"1979","unstructured":"Krstic RV. Scanning electron microscopic study of the freeze-fractured pineal body of the rat. Cell Tissue Res. 1979;201:129\u201335.","journal-title":"Cell Tissue Res"},{"key":"330_CR29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/0006-8993(91)91748-P","volume":"565","author":"AJ McArthur","year":"1991","unstructured":"McArthur AJ, Gillette MU, Prosser RA. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res. 1991;565:158\u201361.","journal-title":"Brain Res"},{"key":"330_CR30","first-page":"33","volume":"54","author":"MU Gillette","year":"1999","unstructured":"Gillette MU, Tischkau SA. Suprachiasmatic nucleus: the brain's circadian clock. Recent Prog Horm Res. 1999;54:33\u201358 discussion 58-39.","journal-title":"Recent Prog Horm Res"},{"key":"330_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5334\/jcr.ab","volume":"13","author":"NE Waly","year":"2015","unstructured":"Waly NE, Hallworth R. Circadian pattern of melatonin MT1 and MT2 receptor localization in the rat suprachiasmatic nucleus. J Circadian Rhythms. 2015;13:1.","journal-title":"J Circadian Rhythms"},{"key":"330_CR32","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.preteyeres.2013.12.001","volume":"39","author":"DG McMahon","year":"2014","unstructured":"McMahon DG, Iuvone PM, Tosini G. Circadian organization of the mammalian retina: from gene regulation to physiology and diseases. Prog Retin Eye Res. 2014;39:58\u201376.","journal-title":"Prog Retin Eye Res"},{"key":"330_CR33","doi-asserted-by":"publisher","first-page":"e0157824","DOI":"10.1371\/journal.pone.0157824","volume":"11","author":"PC Kandalepas","year":"2016","unstructured":"Kandalepas PC, Mitchell JW, Gillette MU. Melatonin signal transduction pathways require E-box-mediated transcription of Per1 and Per2 to reset the SCN clock at dusk. PLoS One. 2016;11:e0157824.","journal-title":"PLoS One"},{"key":"330_CR34","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1159\/000126350","volume":"57","author":"F Gauer","year":"1993","unstructured":"Gauer F, Masson-Pevet M, Skene DJ, Vivien-Roels B, Pevet P. Daily rhythms of melatonin binding sites in the rat pars tuberalis and suprachiasmatic nuclei; evidence for a regulation of melatonin receptors by melatonin itself. Neuroendocrinology. 1993;57:120\u20136.","journal-title":"Neuroendocrinology"},{"key":"330_CR35","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1600-079X.2004.00196.x","volume":"38","author":"YH Wu","year":"2005","unstructured":"Wu YH, Swaab DF. The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res. 2005;38:145\u201352.","journal-title":"J Pineal Res"},{"key":"330_CR36","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/S0531-5565(00)00160-1","volume":"35","author":"E Ferrari","year":"2000","unstructured":"Ferrari E, Arcaini A, Gornati R, Pelanconi L, Cravello L, Fioravanti M, Solerte SB, Magri F. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol. 2000;35:1239\u201350.","journal-title":"Exp Gerontol"},{"key":"330_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1034\/j.1600-079X.2003.00065.x","volume":"35","author":"JN Zhou","year":"2003","unstructured":"Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res. 2003;35:125\u201330.","journal-title":"J Pineal Res"},{"key":"330_CR38","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1210\/jc.2003-030833","volume":"88","author":"YH Wu","year":"2003","unstructured":"Wu YH, Feenstra MG, Zhou JN, Liu RY, Torano JS, Van Kan HJ, Fischer DF, Ravid R, Swaab DF. Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages. J Clin Endocrinol Metab. 2003;88:5898\u2013906.","journal-title":"J Clin Endocrinol Metab"},{"key":"330_CR39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1034\/j.1600-079x.2002.00841.x","volume":"32","author":"E Savaskan","year":"2002","unstructured":"Savaskan E, Olivieri G, Meier F, Brydon L, Jockers R, Ravid R, Wirz-Justice A, Muller-Spahn F. Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. J Pineal Res. 2002;32:59\u201362.","journal-title":"J Pineal Res"},{"key":"330_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1600-079X.2004.00169.x","volume":"38","author":"E Savaskan","year":"2005","unstructured":"Savaskan E, Ayoub MA, Ravid R, Angeloni D, Fraschini F, Meier F, Eckert A, Muller-Spahn F, Jockers R. Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease. J Pineal Res. 2005;38:10\u20136.","journal-title":"J Pineal Res"},{"key":"330_CR41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1745-7254.2005.00102.x","volume":"26","author":"YQ Deng","year":"2005","unstructured":"Deng YQ, Xu GG, Duan P, Zhang Q, Wang JZ. Effects of melatonin on wortmannin-induced tau hyperphosphorylation. Acta Pharmacol Sin. 2005;26:519\u201326.","journal-title":"Acta Pharmacol Sin"},{"key":"330_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1600-079X.1999.tb00575.x","volume":"26","author":"DK Lahiri","year":"1999","unstructured":"Lahiri DK. Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types. J Pineal Res. 1999;26:137\u201346.","journal-title":"J Pineal Res"},{"key":"330_CR43","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1600-079X.2004.00121.x","volume":"36","author":"DK Lahiri","year":"2004","unstructured":"Lahiri DK, Chen D, Ge YW, Bondy SC, Sharman EH. Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. J Pineal Res. 2004;36:224\u201331.","journal-title":"J Pineal Res"},{"key":"330_CR44","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1007\/s11064-007-9563-y","volume":"33","author":"XC Wang","year":"2008","unstructured":"Wang XC, Zhang YC, Chatterjie N, Grundke-Iqbal I, Iqbal K, Wang JZ. Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. Neurochem Res. 2008;33:1138\u201344.","journal-title":"Neurochem Res"},{"key":"330_CR45","first-page":"838","volume":"60","author":"L Guermonprez","year":"2001","unstructured":"Guermonprez L, Ducrocq C, Gaudry-Talarmain YM. Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants. Mol Pharmacol. 2001;60:838\u201346.","journal-title":"Mol Pharmacol"},{"key":"330_CR46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1034\/j.1600-079X.2003.00057.x","volume":"35","author":"S Rosales-Corral","year":"2003","unstructured":"Rosales-Corral S, Tan DX, Reiter RJ, Valdivia-Velazquez M, Martinez-Barboza G, Acosta-Martinez JP, Ortiz GG. Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E. J Pineal Res. 2003;35:80\u20134.","journal-title":"J Pineal Res"},{"key":"330_CR47","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1006\/cbir.1996.0091","volume":"20","author":"JI Chuang","year":"1996","unstructured":"Chuang JI, Mohan N, Meltz ML, Reiter RJ. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int. 1996;20:687\u201392.","journal-title":"Cell Biol Int"},{"key":"330_CR48","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","volume":"71","author":"D Acuna-Castroviejo","year":"2014","unstructured":"Acuna-Castroviejo D, Escames G, Venegas C, Diaz-Casado ME, Lima-Cabello E, Lopez LC, Rosales-Corral S, Tan DX, Reiter RJ. Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci. 2014;71:2997\u20133025.","journal-title":"Cell Mol Life Sci"},{"key":"330_CR49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1196\/annals.1356.025","volume":"1057","author":"DP Cardinali","year":"2005","unstructured":"Cardinali DP, Furio AM, Reyes MP. Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent. Ann N Y Acad Sci. 2005;1057:327\u201336.","journal-title":"Ann N Y Acad Sci"},{"key":"330_CR50","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/00207454.2017.1398156","volume":"128","author":"I Berkiks","year":"2018","unstructured":"Berkiks I, Benmhammed H, Mesfioui A, Ouichou A, El Hasnaoui A, Mouden S, Touil T, Bahbiti Y, Nakache R, El Hessni A. Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress. Int J Neurosci. 2018;128:495\u2013504.","journal-title":"Int J Neurosci"},{"key":"330_CR51","doi-asserted-by":"publisher","unstructured":"Leeboonngam T, Pramong R, Sae-Ung K, Govitrapong P, Phansuwan-Pujito P. Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats. J Pineal Res. 2018;64(3). https:\/\/doi.org\/10.1111\/jpi.12456 .","DOI":"10.1111\/jpi.12456"},{"key":"330_CR52","first-page":"1209","volume":"89","author":"JA Goree","year":"1963","unstructured":"Goree JA, Wallace KK Jr, Bean RL. The pineal tomogram. Visualization of the faintly calcified pineal gland. Am J Roentgenol Radium Ther Nucl Med. 1963;89:1209\u201311.","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"330_CR53","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1365-2265.1990.tb03882.x","volume":"33","author":"CJ Bojkowski","year":"1990","unstructured":"Bojkowski CJ, Arendt J. Factors influencing urinary 6-sulphatoxymelatonin, a major melatonin metabolite, in normal human subjects. Clin Endocrinol. 1990;33:435\u201344.","journal-title":"Clin Endocrinol"},{"key":"330_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.pathophys.2008.02.001","volume":"15","author":"AT Turgut","year":"2008","unstructured":"Turgut AT, Karakas HM, Ozsunar Y, Altin L, Ceken K, Alicioglu B, Sonmez I, Alparslan A, Yurumez B, Celik T, et al. Age-related changes in the incidence of pineal gland calcification in Turkey: a prospective multicenter CT study. Pathophysiology. 2008;15:41\u20138.","journal-title":"Pathophysiology"},{"key":"330_CR55","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0893-133X(99)00069-X","volume":"21","author":"D Kunz","year":"1999","unstructured":"Kunz D, Schmitz S, Mahlberg R, Mohr A, Stoter C, Wolf KJ, Herrmann WM. A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology. 1999;21:765\u201372.","journal-title":"Neuropsychopharmacology"},{"key":"330_CR56","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.neurobiolaging.2006.10.003","volume":"29","author":"R Mahlberg","year":"2008","unstructured":"Mahlberg R, Walther S, Kalus P, Bohner G, Haedel S, Reischies FM, Kuhl KP, Hellweg R, Kunz D. Pineal calcification in Alzheimer's disease: an in vivo study using computed tomography. Neurobiol Aging. 2008;29:203\u20139.","journal-title":"Neurobiol Aging"},{"key":"330_CR57","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF00344824","volume":"18","author":"P Macpherson","year":"1979","unstructured":"Macpherson P, Matheson MS. Comparison of calcification of pineal, habenular commissure and choroid plexus on plain films and computed tomography. Neuroradiology. 1979;18:67\u201372.","journal-title":"Neuroradiology"},{"key":"330_CR58","first-page":"307","volume":"43","author":"T Kodaka","year":"1994","unstructured":"Kodaka T, Mori R, Debari K, Yamada M. Scanning electron microscopy and electron probe microanalysis studies of human pineal concretions. J Electron Microsc. 1994;43:307\u201317.","journal-title":"J Electron Microsc"},{"key":"330_CR59","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0925-4927(98)00013-4","volume":"82","author":"D Kunz","year":"1998","unstructured":"Kunz D, Bes F, Schlattmann P, Herrmann WM. On pineal calcification and its relation to subjective sleep perception: a hypothesis-driven pilot study. Psychiatry Res. 1998;82:187\u201391.","journal-title":"Psychiatry Res"},{"key":"330_CR60","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00062-011-0110-5","volume":"22","author":"JM Bumb","year":"2012","unstructured":"Bumb JM, Brockmann MA, Groden C, Al-Zghloul M, Nolte I. TrueFISP of the pediatric pineal gland: volumetric and microstructural analysis. Clin Neuroradiol. 2012;22:69\u201377.","journal-title":"Clin Neuroradiol"},{"key":"330_CR61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0165-1781(02)00249-4","volume":"113","author":"D Riemann","year":"2002","unstructured":"Riemann D, Klein T, Rodenbeck A, Feige B, Horny A, Hummel R, Weske G, Al-Shajlawi A, Voderholzer U. Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Res. 2002;113:17\u201327.","journal-title":"Psychiatry Res"},{"key":"330_CR62","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1017\/S104161029000028X","volume":"2","author":"RP Friedland","year":"1990","unstructured":"Friedland RP, Luxenberg JS, Koss E. A quantitative study of intracranial calcification in dementia of the Alzheimer type. Int Psychogeriatr. 1990;2:36\u201343.","journal-title":"Int Psychogeriatr"},{"key":"330_CR63","first-page":"323","volume":"84","author":"RY Liu","year":"1999","unstructured":"Liu RY, Zhou JN, van Heerikhuize J, Hofman MA, Swaab DF. Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4\/4 genotype. J Clin Endocrinol Metab. 1999;84:323\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"330_CR64","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/S0006-3223(98)00255-8","volume":"45","author":"Y Ohashi","year":"1999","unstructured":"Ohashi Y, Okamoto N, Uchida K, Iyo M, Mori N, Morita Y. Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type. Biol Psychiatry. 1999;45:1646\u201352.","journal-title":"Biol Psychiatry"},{"key":"330_CR65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1081\/CBI-100103973","volume":"18","author":"R Luboshitzky","year":"2001","unstructured":"Luboshitzky R, Shen-Orr Z, Tzischichinsky O, Maldonado M, Herer P, Lavie P. Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease. Chronobiol Int. 2001;18:513\u201324.","journal-title":"Chronobiol Int"},{"key":"330_CR66","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.brainresrev.2007.06.002","volume":"56","author":"HM Duvernoy","year":"2007","unstructured":"Duvernoy HM, Risold PY. The circumventricular organs: an atlas of comparative anatomy and vascularization. Brain Res Rev. 2007;56:119\u201347.","journal-title":"Brain Res Rev"},{"key":"330_CR67","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000110635","volume":"14","author":"RP Markus","year":"2007","unstructured":"Markus RP, Ferreira ZS, Fernandes PA, Cecon E. The immune-pineal axis: a shuttle between endocrine and paracrine melatonin sources. Neuroimmunomodulation. 2007;14:126\u201333.","journal-title":"Neuroimmunomodulation"},{"key":"330_CR68","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","volume":"42","author":"DX Tan","year":"2007","unstructured":"Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res. 2007;42:28\u201342.","journal-title":"J Pineal Res"},{"key":"330_CR69","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1023\/A:1020107915919","volume":"47","author":"GA Bubenik","year":"2002","unstructured":"Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci. 2002;47:2336\u201348.","journal-title":"Dig Dis Sci"},{"key":"330_CR70","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2174\/1568026023394335","volume":"2","author":"JM Guerrero","year":"2002","unstructured":"Guerrero JM, Reiter RJ. Melatonin-immune system relationships. Curr Top Med Chem. 2002;2:167\u201379.","journal-title":"Curr Top Med Chem"},{"key":"330_CR71","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1096\/fj.03-0694fje","volume":"18","author":"A Carrillo-Vico","year":"2004","unstructured":"Carrillo-Vico A, Calvo JR, Abreu P, Lardone PJ, Garcia-Maurino S, Reiter RJ, Guerrero JM. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and\/or paracrine substance. FASEB J. 2004;18:537\u20139.","journal-title":"FASEB J"},{"key":"330_CR72","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1189\/jlb.1203614","volume":"75","author":"E Martins Jr","year":"2004","unstructured":"Martins E Jr, Ferreira AC, Skorupa AL, Afeche SC, Cipolla-Neto J, Costa Rosa LF. Tryptophan consumption and indoleamines production by peritoneal cavity macrophages. J Leukoc Biol. 2004;75:1116\u201321.","journal-title":"J Leukoc Biol"},{"key":"330_CR73","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-079X.2006.00345.x","volume":"41","author":"GN Pontes","year":"2006","unstructured":"Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP. Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes. J Pineal Res. 2006;41:136\u201341.","journal-title":"J Pineal Res"},{"key":"330_CR74","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1600-079X.2004.00191.x","volume":"38","author":"ZS Ferreira","year":"2005","unstructured":"Ferreira ZS, Fernandes PA, Duma D, Assreuy J, Avellar MC, Markus RP. Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B. J Pineal Res. 2005;38:182\u20138.","journal-title":"J Pineal Res"},{"key":"330_CR75","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1600-079X.2006.00373.x","volume":"41","author":"PA Fernandes","year":"2006","unstructured":"Fernandes PA, Cecon E, Markus RP, Ferreira ZS. Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing. J Pineal Res. 2006;41:344\u201350.","journal-title":"J Pineal Res"},{"key":"330_CR76","first-page":"13","volume":"13","author":"S Bertuglia","year":"1993","unstructured":"Bertuglia S, Colantuoni A, Intaglietta M. Effect of leukocyte adhesion and microvascular permeability on capillary perfusion during ischemia-reperfusion injury in hamster cheek pouch. Int J Microcirc Clin Exp. 1993;13:13\u201326.","journal-title":"Int J Microcirc Clin Exp"},{"key":"330_CR77","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0014-2999(01)01369-3","volume":"430","author":"CM Lotufo","year":"2001","unstructured":"Lotufo CM, Lopes C, Dubocovich ML, Farsky SH, Markus RP. Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. Eur J Pharmacol. 2001;430:351\u20137.","journal-title":"Eur J Pharmacol"},{"key":"330_CR78","doi-asserted-by":"publisher","first-page":"8638","DOI":"10.3390\/ijms14048638","volume":"14","author":"A Carrillo-Vico","year":"2013","unstructured":"Carrillo-Vico A, Lardone PJ, Alvarez-Sanchez N, Rodriguez-Rodriguez A, Guerrero JM. Melatonin: buffering the immune system. Int J Mol Sci. 2013;14:8638\u201383.","journal-title":"Int J Mol Sci"},{"key":"330_CR79","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/j.bcp.2010.07.041","volume":"80","author":"F Radogna","year":"2010","unstructured":"Radogna F, Diederich M, Ghibelli L. Melatonin: a pleiotropic molecule regulating inflammation. Biochem Pharmacol. 2010;80:1844\u201352.","journal-title":"Biochem Pharmacol"},{"key":"330_CR80","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/jpi.12066","volume":"55","author":"MA Pires-Lapa","year":"2013","unstructured":"Pires-Lapa MA, Tamura EK, Salustiano EM, Markus RP. Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells. J Pineal Res. 2013;55:240\u20136.","journal-title":"J Pineal Res"},{"key":"330_CR81","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1600-079X.2008.00657.x","volume":"46","author":"EK Tamura","year":"2009","unstructured":"Tamura EK, Cecon E, Monteiro AW, Silva CL, Markus RP. Melatonin inhibits LPS-induced NO production in rat endothelial cells. J Pineal Res. 2009;46:268\u201374.","journal-title":"J Pineal Res"},{"key":"330_CR82","doi-asserted-by":"publisher","first-page":"8466","DOI":"10.1523\/JNEUROSCI.22-19-08466.2002","volume":"22","author":"AL Bhakar","year":"2002","unstructured":"Bhakar AL, Tannis LL, Zeindler C, Russo MP, Jobin C, Park DS, MacPherson S, Barker PA. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci. 2002;22:8466\u201375.","journal-title":"J Neurosci"},{"key":"330_CR83","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0006-8993(02)03682-X","volume":"958","author":"MS de Freitas","year":"2002","unstructured":"de Freitas MS, Spohr TC, Benedito AB, Caetano MS, Margulis B, Lopes UG, Moura-Neto V. Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappaB activation. Brain Res. 2002;958:359\u201370.","journal-title":"Brain Res"},{"key":"330_CR84","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/stem.1033","volume":"30","author":"P Luningschror","year":"2012","unstructured":"Luningschror P, Stocker B, Kaltschmidt B, Kaltschmidt C. miR-290 cluster modulates pluripotency by repressing canonical NF-kappaB signaling. Stem Cells. 2012;30:655\u201364.","journal-title":"Stem Cells"},{"key":"330_CR85","doi-asserted-by":"publisher","first-page":"e30838","DOI":"10.1371\/journal.pone.0030838","volume":"7","author":"Y Imielski","year":"2012","unstructured":"Imielski Y, Schwamborn JC, Luningschror P, Heimann P, Holzberg M, Werner H, Leske O, Puschel AW, Memet S, Heumann R, et al. Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus. PLoS One. 2012;7:e30838.","journal-title":"PLoS One"},{"key":"330_CR86","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3109\/07420521003661615","volume":"27","author":"E Cecon","year":"2010","unstructured":"Cecon E, Fernandes PA, Pinato L, Ferreira ZS, Markus RP. Daily variation of constitutively activated nuclear factor kappa B (NFKB) in rat pineal gland. Chronobiol Int. 2010;27:52\u201367.","journal-title":"Chronobiol Int"},{"key":"330_CR87","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1096\/fasebj.12.9.685","volume":"12","author":"E Gilad","year":"1998","unstructured":"Gilad E, Wong HR, Zingarelli B, Virag L, O'Connor M, Salzman AL, Szabo C. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation. FASEB J. 1998;12:685\u201393.","journal-title":"FASEB J"},{"key":"330_CR88","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.4049\/jimmunol.0902961","volume":"184","author":"AM Pedrosa","year":"2010","unstructured":"Pedrosa AM, Weinlich R, Mognol GP, Robbs BK, Viola JP, Campa A, Amarante-Mendes GP. Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation. J Immunol. 2010;184:3487\u201394.","journal-title":"J Immunol"},{"key":"330_CR89","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1600-079X.2012.00986.x","volume":"53","author":"CC Chang","year":"2012","unstructured":"Chang CC, Tien CH, Lee EJ, Juan WS, Chen YH, Hung YC, Chen TY, Chen HY, Wu TS. Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis. J Pineal Res. 2012;53:188\u201397.","journal-title":"J Pineal Res"},{"key":"330_CR90","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1600-079X.2008.00560.x","volume":"45","author":"SH Huang","year":"2008","unstructured":"Huang SH, Cao XJ, Wei W. Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-kappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages. J Pineal Res. 2008;45:93\u2013100.","journal-title":"J Pineal Res"},{"key":"330_CR91","doi-asserted-by":"publisher","first-page":"426346","DOI":"10.1155\/2009\/426346","volume":"2009","author":"Q Fang","year":"2009","unstructured":"Fang Q, Chen G, Zhu W, Dong W, Wang Z. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediat Inflamm. 2009;2009:426346.","journal-title":"Mediat Inflamm"},{"key":"330_CR92","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1096\/fj.02-0501fje","volume":"17","author":"A Carrillo-Vico","year":"2003","unstructured":"Carrillo-Vico A, Garcia-Maurino S, Calvo JR, Guerrero JM. Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor. FASEB J. 2003;17:755\u20137.","journal-title":"FASEB J"},{"key":"330_CR93","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.3390\/ijms140610979","volume":"14","author":"RP Markus","year":"2013","unstructured":"Markus RP, Cecon E, Pires-Lapa MA. Immune-pineal axis: nuclear factor kappaB (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells. Int J Mol Sci. 2013;14:10979\u201397.","journal-title":"Int J Mol Sci"},{"key":"330_CR94","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1523\/JNEUROSCI.19-09-03326.1999","volume":"19","author":"E Maronde","year":"1999","unstructured":"Maronde E, Pfeffer M, Olcese J, Molina CA, Schlotter F, Dehghani F, Korf HW, Stehle JH. Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J Neurosci. 1999;19:3326\u201336.","journal-title":"J Neurosci"},{"key":"330_CR95","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.lfs.2013.11.004","volume":"94","author":"D Villela","year":"2014","unstructured":"Villela D, de Sa LL, Peres R. Peliciari-Garcia RA, do Amaral FG, Cipolla-Neto J, Scavone C, Afeche SC: norepinephrine activates NF-kappaB transcription factor in cultured rat pineal gland. Life Sci. 2014;94:122\u20139.","journal-title":"Life Sci"},{"key":"330_CR96","doi-asserted-by":"publisher","first-page":"e52010","DOI":"10.1371\/journal.pone.0052010","volume":"7","author":"SM Muxel","year":"2012","unstructured":"Muxel SM, Pires-Lapa MA, Monteiro AW, Cecon E, Tamura EK, Floeter-Winter LM, Markus RP. NF-kappaB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS One. 2012;7:e52010.","journal-title":"PLoS One"},{"key":"330_CR97","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jneuroim.2008.01.003","volume":"195","author":"H Bajova","year":"2008","unstructured":"Bajova H, Nelson TE, Gruol DL. Chronic CXCL10 alters the level of activated ERK1\/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture. J Neuroimmunol. 2008;195:36\u201346.","journal-title":"J Neuroimmunol"},{"key":"330_CR98","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10571-006-9045-9","volume":"26","author":"J Zou","year":"2006","unstructured":"Zou J, Crews F. CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death. Cell Mol Neurobiol. 2006;26:385\u2013405.","journal-title":"Cell Mol Neurobiol"},{"key":"330_CR99","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ejphar.2006.01.050","volume":"534","author":"CM Lotufo","year":"2006","unstructured":"Lotufo CM, Yamashita CE, Farsky SH, Markus RP. Melatonin effect on endothelial cells reduces vascular permeability increase induced by leukotriene B4. Eur J Pharmacol. 2006;534:258\u201363.","journal-title":"Eur J Pharmacol"},{"key":"330_CR100","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1600-079X.2006.00366.x","volume":"41","author":"EK Tamura","year":"2006","unstructured":"Tamura EK, Silva CL, Markus RP. Melatonin inhibits endothelial nitric oxide production in vitro. J Pineal Res. 2006;41:267\u201374.","journal-title":"J Pineal Res"},{"key":"330_CR101","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1600-079X.2012.01025.x","volume":"54","author":"M Marcola","year":"2013","unstructured":"Marcola M, da Silveira C-MS, Fernandes PA, Monteiro AW, Markus RP, Tamura EK. Endothelial cell adhesiveness is a function of environmental lighting and melatonin level. J Pineal Res. 2013;54:162\u20139.","journal-title":"J Pineal Res"},{"key":"330_CR102","doi-asserted-by":"publisher","first-page":"e67923","DOI":"10.1371\/journal.pone.0067923","volume":"8","author":"JC Karper","year":"2013","unstructured":"Karper JC, Ewing MM, de Vries MR, de Jager SC, Peters EA, de Boer HC, van Zonneveld AJ, Kuiper J, Huizinga EG, Brondijk TH, et al. TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation. PLoS One. 2013;8:e67923.","journal-title":"PLoS One"},{"key":"330_CR103","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/BF03033887","volume":"7","author":"V Srinivasan","year":"2005","unstructured":"Srinivasan V, Pandi-Perumal SR, Maestroni GJ, Esquifino AI, Hardeland R, Cardinali DP. Role of melatonin in neurodegenerative diseases. Neurotox Res. 2005;7:293\u2013318.","journal-title":"Neurotox Res"},{"key":"330_CR104","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2197-425X-2-18","volume":"2","author":"V Papaioannou","year":"2014","unstructured":"Papaioannou V, Mebazaa A, Plaud B, Legrand M. 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Intensive Care Med Exp. 2014;2:18.","journal-title":"Intensive Care Med Exp"},{"key":"330_CR105","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1139\/y03-026","volume":"81","author":"K Skwarlo-Sonta","year":"2003","unstructured":"Skwarlo-Sonta K, Majewski P, Markowska M, Oblap R, Olszanska B. Bidirectional communication between the pineal gland and the immune system. Can J Physiol Pharmacol. 2003;81:342\u20139.","journal-title":"Can J Physiol Pharmacol"},{"key":"330_CR106","doi-asserted-by":"publisher","first-page":"3472032","DOI":"10.1155\/2016\/3472032","volume":"2016","author":"JM Mack","year":"2016","unstructured":"Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD. Melatoninergic system in Parkinson's disease: from neuroprotection to the management of motor and nonmotor symptoms. Oxidative Med Cell Longev. 2016;2016:3472032.","journal-title":"Oxidative Med Cell Longev"},{"key":"330_CR107","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bbr.2014.09.007","volume":"275","author":"AC Noseda","year":"2014","unstructured":"Noseda AC, Rodrigues LS, Targa AD, Aurich MF, Vital MA, Da Cunha C, Lima MM. Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade. Behav Brain Res. 2014;275:136\u201345.","journal-title":"Behav Brain Res"},{"key":"330_CR108","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1096\/fj.14-265678","volume":"29","author":"E Cecon","year":"2015","unstructured":"Cecon E, Chen M, Marcola M, Fernandes PA, Jockers R, Markus RP. Amyloid beta peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J. 2015;29:2566\u201382.","journal-title":"FASEB J"},{"key":"330_CR109","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jamaneurol.2015.3135","volume":"73","author":"B Lehallier","year":"2016","unstructured":"Lehallier B, Essioux L, Gayan J, Alexandridis R, Nikolcheva T, Wyss-Coray T, Britschgi M. Alzheimer's disease neuroimaging I: combined plasma and cerebrospinal fluid signature for the prediction of midterm progression from mild cognitive impairment to Alzheimer disease. JAMA neurol. 2016;73:203\u201312.","journal-title":"JAMA neurol"},{"key":"330_CR110","first-page":"276","volume":"48","author":"D Maslinska","year":"2010","unstructured":"Maslinska D, Laure-Kamionowska M, Deregowski K, Maslinski S. Association of mast cells with calcification in the human pineal gland. Folia Neuropathol. 2010;48:276\u201382.","journal-title":"Folia Neuropathol"},{"key":"330_CR111","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1749-6632.2012.06616.x","volume":"1261","author":"B Gomez-Gonzalez","year":"2012","unstructured":"Gomez-Gonzalez B, Dominguez-Salazar E, Hurtado-Alvarado G, Esqueda-Leon E, Santana-Miranda R, Rojas-Zamorano JA, Velazquez-Moctezuma J. Role of sleep in the regulation of the immune system and the pituitary hormones. Ann N Y Acad Sci. 2012;1261:97\u2013106.","journal-title":"Ann N Y Acad Sci"},{"key":"330_CR112","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.tins.2015.07.007","volume":"38","author":"J Westermann","year":"2015","unstructured":"Westermann J, Lange T, Textor J, Born J. System consolidation during sleep - a common principle underlying psychological and immunological memory formation. Trends Neurosci. 2015;38:585\u201397.","journal-title":"Trends Neurosci"},{"key":"330_CR113","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/sleep\/12.1.13","volume":"12","author":"CA Everson","year":"1989","unstructured":"Everson CA, Gilliland MA, Kushida CA, Pilcher JJ, Fang VS, Refetoff S, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: IX. Sleep. 1989;12:60\u20137.","journal-title":"Sleep"},{"key":"330_CR114","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/15672026113109990002","volume":"10","author":"B Gomez-Gonzalez","year":"2013","unstructured":"Gomez-Gonzalez B, Hurtado-Alvarado G, Esqueda-Leon E, Santana-Miranda R, Rojas-Zamorano JA, Velazquez-Moctezuma J. REM sleep loss and recovery regulates blood-brain barrier function. Curr Neurovasc Res. 2013;10:197\u2013207.","journal-title":"Curr Neurovasc Res"},{"key":"330_CR115","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/sj.npp.1300923","volume":"31","author":"DA Schmid","year":"2006","unstructured":"Schmid DA, Wichniak A, Uhr M, Ising M, Brunner H, Held K, Weikel JC, Sonntag A, Steiger A. Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology. 2006;31:832\u201344.","journal-title":"Neuropsychopharmacology"},{"key":"330_CR116","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000335363","volume":"33","author":"B Guarnieri","year":"2012","unstructured":"Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P, Caltagirone C, Cerroni G, Concari L, Cosentino FI, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord. 2012;33:50\u20138.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"330_CR117","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neuron.2017.02.004","volume":"94","author":"BA Mander","year":"2017","unstructured":"Mander BA, Winer JR, Walker MP. Sleep and Human Aging. Neuron. 2017;94:19\u201336.","journal-title":"Neuron"},{"key":"330_CR118","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nrn.2017.55","volume":"18","author":"AJ Krause","year":"2017","unstructured":"Krause AJ, Simon EB, Mander BA, Greer SM, Saletin JM, Goldstein-Piekarski AN, Walker MP. The sleep-deprived human brain. Nat Rev Neurosci. 2017;18:404\u201318.","journal-title":"Nat Rev Neurosci"},{"key":"330_CR119","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.tins.2016.05.002","volume":"39","author":"BA Mander","year":"2016","unstructured":"Mander BA, Winer JR, Jagust WJ, Walker MP. Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease? Trends Neurosci. 2016;39:552\u201366.","journal-title":"Trends Neurosci"},{"key":"330_CR120","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.smrv.2017.07.005","volume":"40","author":"J Van Erum","year":"2018","unstructured":"Van Erum J, Van Dam D, De Deyn PP. Sleep and Alzheimer's disease: a pivotal role for the suprachiasmatic nucleus. Sleep Med Rev. 2018;40:17\u201327.","journal-title":"Sleep Med Rev"},{"key":"330_CR121","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","volume":"80","author":"MR Irwin","year":"2016","unstructured":"Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80:40\u201352.","journal-title":"Biol Psychiatry"},{"key":"330_CR122","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/npp.2016.148","volume":"42","author":"MR Irwin","year":"2017","unstructured":"Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017;42:129\u201355.","journal-title":"Neuropsychopharmacology"},{"key":"330_CR123","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.sleep.2015.08.021","volume":"17","author":"JC Lo","year":"2016","unstructured":"Lo JC, Groeger JA, Cheng GH, Dijk DJ, Chee MW. Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis. Sleep Med. 2016;17:87\u201398.","journal-title":"Sleep Med"},{"key":"330_CR124","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1017\/S1041610216002131","volume":"29","author":"AP Spira","year":"2017","unstructured":"Spira AP, Gottesman RF. Sleep disturbance: an emerging opportunity for Alzheimer's disease prevention? Int Psychogeriatr. 2017;29:529\u201331.","journal-title":"Int Psychogeriatr"},{"key":"330_CR125","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1001\/jamaneurol.2014.2510","volume":"71","author":"C Liguori","year":"2014","unstructured":"Liguori C, Romigi A, Nuccetelli M, Zannino S, Sancesario G, Martorana A, Albanese M, Mercuri NB, Izzi F, Bernardini S, et al. Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease. JAMA neurol. 2014;71:1498\u2013505.","journal-title":"JAMA neurol"},{"key":"330_CR126","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuroscience.2015.01.035","volume":"290","author":"M Sethi","year":"2015","unstructured":"Sethi M, Joshi SS, Webb RL, Beckett TL, Donohue KD, Murphy MP, O'Hara BF, Duncan MJ. Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's disease. Neuroscience. 2015;290:80\u20139.","journal-title":"Neuroscience"},{"key":"330_CR127","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbi.2017.04.007","volume":"64","author":"GC Kincheski","year":"2017","unstructured":"Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek V, Donato J Jr, De Felice FG, Ferreira ST. Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-beta oligomers in mice. Brain Behav Immun. 2017;64:140\u201351.","journal-title":"Brain Behav Immun"},{"key":"330_CR128","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1073\/pnas.1721694115","volume":"115","author":"E Shokri-Kojori","year":"2018","unstructured":"Shokri-Kojori E, Wang GJ, Wiers CE, Demiral SB, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A. Freeman C, et al: beta-amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A. 2018;115:4483\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"330_CR129","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.neurobiolaging.2016.02.009","volume":"41","author":"P Branger","year":"2016","unstructured":"Branger P, Arenaza-Urquijo EM, Tomadesso C, Mezenge F, Andre C, de Flores R, Mutlu J, de La Sayette V, Eustache F, Chetelat G, Rauchs G. Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood. Neurobiol Aging. 2016;41:107\u201314.","journal-title":"Neurobiol Aging"},{"key":"330_CR130","first-page":"1537","volume":"70","author":"AP Spira","year":"2013","unstructured":"Spira AP, Gamaldo AA, An Y, Wu MN, Simonsick EM, Bilgel M, Zhou Y, Wong DF, Ferrucci L, Resnick SM. Self-reported sleep and beta-amyloid deposition in community-dwelling older adults. JAMA neurol. 2013;70:1537\u201343.","journal-title":"JAMA neurol"},{"key":"330_CR131","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1212\/WNL.0000000000003732","volume":"88","author":"AJ Westwood","year":"2017","unstructured":"Westwood AJ, Beiser A, Jain N, Himali JJ, DeCarli C, Auerbach SH, Pase MP, Seshadri S. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017;88:1172\u20139.","journal-title":"Neurology"},{"key":"330_CR132","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1007\/s00415-017-8613-x","volume":"264","author":"C Liguori","year":"2017","unstructured":"Liguori C, Chiaravalloti A, Nuccetelli M, Izzi F, Sancesario G, Cimini A, Bernardini S, Schillaci O, Mercuri NB, Fabio P. Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer's disease. J Neurol. 2017;264:2215\u201323.","journal-title":"J Neurol"},{"key":"330_CR133","first-page":"263","volume":"2018","author":"H Zheng","year":"1864","unstructured":"Zheng H, Zhou Q, Du Y, Li C, Xu P, Lin L, Xiao J, Gao H. The hypothalamus as the primary brain region of metabolic abnormalities in APP\/PS1 transgenic mouse model of Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 1864;2018:263\u201373.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"330_CR134","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1148\/radiol.2017170188","volume":"286","author":"T Matsuoka","year":"2018","unstructured":"Matsuoka T, Imai A, Fujimoto H, Kato Y, Shibata K, Nakamura K, Yokota H, Yamada K, Narumoto J. Reduced pineal volume in Alzheimer disease: a retrospective cross-sectional MR imaging study. Radiology. 2018;286:239\u201348.","journal-title":"Radiology"},{"key":"330_CR135","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10072-015-2357-0","volume":"37","author":"W Zhang","year":"2016","unstructured":"Zhang W, Chen XY, Su SW, Jia QZ, Ding T, Zhu ZN, Zhang T. Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials. Neurol Sci. 2016;37:57\u201365.","journal-title":"Neurol Sci"},{"key":"330_CR136","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1111\/j.1460-9568.2010.07521.x","volume":"32","author":"M Migaud","year":"2010","unstructured":"Migaud M, Batailler M, Segura S, Duittoz A, Franceschini I, Pillon D. Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones. Eur J Neurosci. 2010;32:2042\u201352.","journal-title":"Eur J Neurosci"},{"key":"330_CR137","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s10571-014-0058-5","volume":"34","author":"E Rojczyk-Golebiewska","year":"2014","unstructured":"Rojczyk-Golebiewska E, Palasz A, Wiaderkiewicz R. Hypothalamic subependymal niche: a novel site of the adult neurogenesis. Cell Mol Neurobiol. 2014;34:631\u201342.","journal-title":"Cell Mol Neurobiol"},{"key":"330_CR138","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnagi.2013.00043","volume":"5","author":"O Lazarov","year":"2013","unstructured":"Lazarov O, Marr RA. Of mice and men: neurogenesis, cognition and Alzheimer's disease. Front Aging Neurosci. 2013;5:43.","journal-title":"Front Aging Neurosci"},{"key":"330_CR139","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.12.006","volume":"138-140","author":"O Lazarov","year":"2016","unstructured":"Lazarov O, Hollands C. Hippocampal neurogenesis: learning to remember. Prog Neurobiol. 2016;138-140:1\u201318.","journal-title":"Prog Neurobiol"},{"key":"330_CR140","doi-asserted-by":"publisher","unstructured":"Ramirez-Rodriguez GB, Olvera-Hernandez S, Vega-Rivera NM, Ortiz-Lopez L. Melatonin influences structural plasticity in the axons of granule cells in the dentate gyrus of Balb\/C mice. Int J Mol Sci. 2018;20(1). https:\/\/doi.org\/10.3390\/ijms20010073 .","DOI":"10.3390\/ijms20010073"},{"key":"330_CR141","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuroscience.2014.06.026","volume":"275","author":"C Tocharus","year":"2014","unstructured":"Tocharus C, Puriboriboon Y, Junmanee T, Tocharus J, Ekthuwapranee K, Govitrapong P. Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor. Neuroscience. 2014;275:314\u201321.","journal-title":"Neuroscience"},{"key":"330_CR142","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s10571-007-9212-7","volume":"28","author":"X Kong","year":"2008","unstructured":"Kong X, Li X, Cai Z, Yang N, Liu Y, Shu J, Pan L, Zuo P. Melatonin regulates the viability and differentiation of rat midbrain neural stem cells. Cell Mol Neurobiol. 2008;28:569\u201379.","journal-title":"Cell Mol Neurobiol"},{"key":"330_CR143","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1038\/npp.2009.46","volume":"34","author":"G Ramirez-Rodriguez","year":"2009","unstructured":"Ramirez-Rodriguez G, Klempin F, Babu H, Benitez-King G, Kempermann G. Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology. 2009;34:2180\u201391.","journal-title":"Neuropsychopharmacology"},{"key":"330_CR144","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-079X.2010.00802.x","volume":"50","author":"G Ramirez-Rodriguez","year":"2011","unstructured":"Ramirez-Rodriguez G, Ortiz-Lopez L, Dominguez-Alonso A, Benitez-King GA, Kempermann G. Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice. J Pineal Res. 2011;50:29\u201337.","journal-title":"J Pineal Res"},{"key":"330_CR145","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-2202-5-41","volume":"5","author":"LP Niles","year":"2004","unstructured":"Niles LP, Armstrong KJ, Rincon Castro LM, Dao CV, Sharma R, McMillan CR, Doering LC, Kirkham DL. Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers. BMC Neurosci. 2004;5:41.","journal-title":"BMC Neurosci"},{"key":"330_CR146","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yfrne.2014.11.004","volume":"37","author":"M Migaud","year":"2015","unstructured":"Migaud M, Butrille L, Batailler M. Seasonal regulation of structural plasticity and neurogenesis in the adult mammalian brain: focus on the sheep hypothalamus. Front Neuroendocrinol. 2015;37:146\u201357.","journal-title":"Front Neuroendocrinol"},{"key":"330_CR147","doi-asserted-by":"publisher","first-page":"6188","DOI":"10.1038\/s41598-018-24381-4","volume":"8","author":"M Batailler","year":"2018","unstructured":"Batailler M, Chesneau D, Derouet L, Butruille L, Segura S, Cognie J, Dupont J, Pillon D, Migaud M. Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep. Sci Rep. 2018;8:6188.","journal-title":"Sci Rep"},{"key":"330_CR148","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/cne.21492","volume":"505","author":"MV Kokoeva","year":"2007","unstructured":"Kokoeva MV, Yin H, Flier JS. Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol. 2007;505:209\u201320.","journal-title":"J Comp Neurol"},{"key":"330_CR149","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1172\/JCI43134","volume":"122","author":"DE McNay","year":"2012","unstructured":"McNay DE, Briancon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012;122:142\u201352.","journal-title":"J Clin Invest"},{"key":"330_CR150","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/cne.23514","volume":"522","author":"M Batailler","year":"2014","unstructured":"Batailler M, Droguerre M, Baroncini M, Fontaine C, Prevot V, Migaud M. DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: a comparative study between mouse, sheep, and human tissues. J Comp Neurol. 2014;522:1966\u201385.","journal-title":"J Comp Neurol"},{"key":"330_CR151","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1007\/s00429-015-1101-0","volume":"221","author":"M Batailler","year":"2016","unstructured":"Batailler M, Derouet L, Butruille L, Migaud M. Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus. Brain Struct Funct. 2016;221:3301\u201314.","journal-title":"Brain Struct Funct"},{"key":"330_CR152","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1177\/0748730411420062","volume":"26","author":"M Migaud","year":"2011","unstructured":"Migaud M, Batailler M, Pillon D, Franceschini I, Malpaux B. Seasonal changes in cell proliferation in the adult sheep brain and pars tuberalis. J Biol Rhythm. 2011;26:486\u201396.","journal-title":"J Biol Rhythm"},{"key":"330_CR153","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1073\/pnas.2634794100","volume":"101","author":"K Jin","year":"2004","unstructured":"Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA. Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004;101:343\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"330_CR154","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/jnr.22387","volume":"88","author":"M Demars","year":"2010","unstructured":"Demars M, Hu YS, Gadadhar A, Lazarov O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res. 2010;88:2103\u201317.","journal-title":"J Neurosci Res"},{"key":"330_CR155","doi-asserted-by":"publisher","first-page":"6498","DOI":"10.1073\/pnas.1001422107","volume":"107","author":"JM Wang","year":"2010","unstructured":"Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2010;107:6498\u2013503.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"330_CR156","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neurobiolaging.2008.12.011","volume":"32","author":"K Aizawa","year":"2011","unstructured":"Aizawa K, Ageyama N, Terao K, Hisatsune T. Primate-specific alterations in neural stem\/progenitor cells in the aged hippocampus. Neurobiol Aging. 2011;32:140\u201350.","journal-title":"Neurobiol Aging"},{"key":"330_CR157","doi-asserted-by":"publisher","first-page":"e2935","DOI":"10.1371\/journal.pone.0002935","volume":"3","author":"JJ Rodriguez","year":"2008","unstructured":"Rodriguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One. 2008;3:e2935.","journal-title":"PLoS One"},{"key":"330_CR158","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1111\/bph.14058","volume":"175","author":"SG Bahna","year":"2018","unstructured":"Bahna SG, Niles LP. Epigenetic regulation of melatonin receptors in neuropsychiatric disorders. Br J Pharmacol. 2018;175:3209\u201319.","journal-title":"Br J Pharmacol"},{"key":"330_CR159","first-page":"28","volume":"2017","author":"Y Yang","year":"1668","unstructured":"Yang Y, Sun B, Huang J, Xu L, Pan J, Fang C, Li M, Li G, Tao Y, Yang X, et al. Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats. Brain Res. 1668;2017:28\u201335.","journal-title":"Brain Res"}],"container-title":["Molecular Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-019-0330-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13024-019-0330-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-019-0330-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T21:52:51Z","timestamp":1721512371000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularneurodegeneration.biomedcentral.com\/articles\/10.1186\/s13024-019-0330-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":159,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["330"],"URL":"https:\/\/doi.org\/10.1186\/s13024-019-0330-8","relation":{},"ISSN":["1750-1326"],"issn-type":[{"value":"1750-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]},"assertion":[{"value":"8 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author has no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28"}}