{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:19:19Z","timestamp":1772241559725,"version":"3.50.1"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1ZIAAG000936-03"],"award-info":[{"award-number":["1ZIAAG000936-03"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1ZIAAG000936-03"],"award-info":[{"award-number":["1ZIAAG000936-03"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1ZIAAG000936-03"],"award-info":[{"award-number":["1ZIAAG000936-03"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurodegeneration"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Although \u0251-synuclein (\u0251-syn) spreading in age-related neurodegenerative diseases such as Parkinson\u2019s disease (PD) and Dementia with Lewy bodies (DLB) has been extensively investigated, the role of aging in the manifestation of disease remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We explored the role of aging and inflammation in the pathogenesis of synucleinopathies in a mouse model of DLB\/PD initiated by intrastriatal injection of \u0251-syn preformed fibrils (pff).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found that aged mice showed more extensive accumulation of \u0251-syn in selected brain regions and behavioral deficits that were associated with greater infiltration of T cells and microgliosis. Microglial inflammatory gene expression induced by \u0251-syn-pff injection in young mice had hallmarks of aged microglia, indicating that enhanced age-associated pathologies may result from inflammatory synergy between aging and the effects of \u0251-syn aggregation. Based on the transcriptomics analysis projected from Ingenuity Pathway Analysis, we found a network that included colony stimulating factor 2 (CSF2), LPS related genes, TNF\u0251 and poly rl:rC-RNA as common regulators.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We propose that aging related inflammation (eg: CSF2) influences outcomes of pathological spreading of \u0251-syn and suggest that targeting neuro-immune responses might be important in developing treatments for DLB\/PD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13024-022-00564-6","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T18:02:34Z","timestamp":1662400954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to \u03b1-synuclein pathology and functional deficits in\u00a0a mouse model of DLB\/PD"],"prefix":"10.1186","volume":"17","author":[{"given":"Michiyo","family":"Iba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross A.","family":"McDevitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyoun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshni","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Sarantopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Tommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Siegars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Sallin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somin","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti Misra","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5569","authenticated-orcid":false,"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"564_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","volume":"15","author":"Y Hou","year":"2019","unstructured":"Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 2019;15:565\u201381.","journal-title":"Nat Rev Neurol"},{"key":"564_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/35081564","volume":"2","author":"M Goedert","year":"2001","unstructured":"Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci. 2001;2:492\u2013501.","journal-title":"Nat Rev Neurosci"},{"key":"564_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1385\/JMN:17:2:225","volume":"17","author":"PT Kotzbauer","year":"2001","unstructured":"Kotzbauer PT, Trojanowsk JQ, Lee VM. Lewy body pathology in Alzheimer\u2019s disease. J Mol Neurosci. 2001;17:225\u201332.","journal-title":"J Mol Neurosci"},{"key":"564_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13024-019-0320-x","volume":"14","author":"D Twohig","year":"2019","unstructured":"Twohig D, Nielsen HM. \u03b1-synuclein in the pathophysiology of Alzheimer\u2019s disease. Mol Neurodegener. 2019;14:23.","journal-title":"Mol Neurodegener"},{"key":"564_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/B978-0-12-802395-2.00024-9","volume":"145","author":"I Alafuzoff","year":"2017","unstructured":"Alafuzoff I, Hartikainen P. Alpha-synucleinopathies. Handb Clin Neurol. 2017;145:339\u201353.","journal-title":"Handb Clin Neurol"},{"key":"564_CR6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1001\/jamaneurol.2017.4243","volume":"75","author":"R Savica","year":"2018","unstructured":"Savica R, Boeve BF, Mielke MM. When do \u03b1-synucleinopathies start? An epidemiological timeline: a review. JAMA Neurol. 2018;75:503\u20139.","journal-title":"JAMA Neurol"},{"key":"564_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00401-015-1406-3","volume":"129","author":"L Walker","year":"2015","unstructured":"Walker L, McAleese KE, Thomas AJ, Johnson M, Martin-Ruiz C, Parker C, Colloby SJ, Jellinger K, Attems J. Neuropathologically mixed Alzheimer\u2019s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes. Acta Neuropathol. 2015;129:729\u201348.","journal-title":"Acta Neuropathol"},{"key":"564_CR8","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/nan.12659","volume":"46","author":"DG Coughlin","year":"2020","unstructured":"Coughlin DG, Ittyerah R, Peterson C, Phillips JS, Miller S, Rascovsky K, Weintraub D, Siderowf AD, Duda JE, Hurtig HI, et al. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer\u2019s disease. Neuropathol Appl Neurobiol. 2020;46:707\u201321.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"564_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jalz.2017.09.014","volume":"14","author":"TJ Ferman","year":"2018","unstructured":"Ferman TJ, Aoki N, Crook JE, Murray ME, Graff-Radford NR, van Gerpen JA, Uitti RJ, Wszolek ZK, Graff-Radford J, Pedraza O, et al. The limbic and neocortical contribution of alpha-synuclein, tau, and amyloid beta to disease duration in dementia with Lewy bodies. Alzheimers Dement. 2018;14:330\u20139.","journal-title":"Alzheimers Dement"},{"key":"564_CR10","doi-asserted-by":"publisher","first-page":"e13080","DOI":"10.1111\/acel.13080","volume":"19","author":"L Ferrucci","year":"2020","unstructured":"Ferrucci L, Gonzalez-Freire M, Fabbri E, Simonsick E, Tanaka T, Moore Z, Salimi S, Sierra F, de Cabo R. Measuring biological aging in humans: a quest. Aging Cell. 2020;19:e13080.","journal-title":"Aging Cell"},{"key":"564_CR11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s11357-019-00131-w","volume":"41","author":"GH Royce","year":"2019","unstructured":"Royce GH, Brown-Borg HM, Deepa SS. The potential role of necroptosis in inflammaging and aging. Geroscience. 2019;41:795\u2013811.","journal-title":"Geroscience"},{"key":"564_CR12","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194\u2013217.","journal-title":"Cell"},{"key":"564_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","volume":"21","author":"S Saez-Atienzar","year":"2020","unstructured":"Saez-Atienzar S, Masliah E. Cellular senescence and Alzheimer disease: the egg and the chicken scenario. Nat Rev Neurosci. 2020;21:433\u201344.","journal-title":"Nat Rev Neurosci"},{"key":"564_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","volume":"20","author":"MS Hipp","year":"2019","unstructured":"Hipp MS, Kasturi P, Hartl FU. The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol. 2019;20:421\u201335.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"564_CR15","doi-asserted-by":"publisher","first-page":"8083","DOI":"10.1523\/JNEUROSCI.1091-10.2010","volume":"30","author":"DA Scott","year":"2010","unstructured":"Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci. 2010;30:8083\u201395.","journal-title":"J Neurosci"},{"key":"564_CR16","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nrneurol.2010.145","volume":"6","author":"SJ Lee","year":"2010","unstructured":"Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010;6:702\u20136.","journal-title":"Nat Rev Neurol"},{"key":"564_CR17","doi-asserted-by":"publisher","first-page":"13010","DOI":"10.1073\/pnas.0903691106","volume":"106","author":"P Desplats","year":"2009","unstructured":"Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009;106:13010\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"564_CR18","doi-asserted-by":"publisher","first-page":"E8284","DOI":"10.1073\/pnas.1710442114","volume":"114","author":"P Thakur","year":"2017","unstructured":"Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Bj\u00f6rklund A. Modeling Parkinson\u2019s disease pathology by combination of fibril seeds and \u03b1-synuclein overexpression in the rat brain. Proc Natl Acad Sci U S A. 2017;114:E8284-e8293.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"564_CR19","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.1227157","volume":"338","author":"KC Luk","year":"2012","unstructured":"Luk KC, Kehm V, Carroll J, Zhang B, O\u2019Brien P, Trojanowski JQ, Lee VM. Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science. 2012;338:949\u201353.","journal-title":"Science"},{"key":"564_CR20","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nrneurol.2013.275","volume":"10","author":"HJ Lee","year":"2014","unstructured":"Lee HJ, Bae EJ, Lee SJ. Extracellular \u03b1\u2013synuclein-a novel and crucial factor in Lewy body diseases. Nat Rev Neurol. 2014;10:92\u20138.","journal-title":"Nat Rev Neurol"},{"key":"564_CR21","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00401-020-02157-3","volume":"139","author":"A Van der Perren","year":"2020","unstructured":"Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, Van den Haute C, Gentleman S, Melki R, Baekelandt V. The structural differences between patient-derived alpha-synuclein strains dictate characteristics of Parkinson\u2019s disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol. 2020;139:977\u20131000.","journal-title":"Acta Neuropathol"},{"key":"564_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fimmu.2019.00080","volume":"10","author":"JM Peralta Ramos","year":"2019","unstructured":"Peralta Ramos JM, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A. Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic \u03b1-synuclein administration. Front Immunol. 2019;10:80.","journal-title":"Front Immunol"},{"key":"564_CR23","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.parkreldis.2015.10.009","volume":"21","author":"A Surendranathan","year":"2015","unstructured":"Surendranathan A, Rowe JB, O\u2019Brien JT. Neuroinflammation in Lewy body dementia. Parkinsonism Relat Disord. 2015;21:1398\u2013406.","journal-title":"Parkinsonism Relat Disord"},{"key":"564_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JPD-140491","volume":"5","author":"HE Allen Reish","year":"2015","unstructured":"Allen Reish HE, Standaert DG. Role of \u03b1-synuclein in inducing innate and adaptive immunity in Parkinson disease. J Parkinsons Dis. 2015;5:1\u201319.","journal-title":"J Parkinsons Dis"},{"key":"564_CR25","doi-asserted-by":"publisher","first-page":"4784268","DOI":"10.1155\/2018\/4784268","volume":"2018","author":"G Gelders","year":"2018","unstructured":"Gelders G, Baekelandt V, Van der Perren A. Linking neuroinflammation and neurodegeneration in Parkinson\u2019s disease. J Immunol Res. 2018;2018:4784268.","journal-title":"J Immunol Res"},{"key":"564_CR26","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1038\/ncomms2534","volume":"4","author":"C Kim","year":"2013","unstructured":"Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Joong Lee S, Masliah E, Hwang D, Lee HJ, Lee SJ. Neuron-released oligomeric \u03b1-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun. 2013;4:1562.","journal-title":"Nat Commun"},{"key":"564_CR27","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1074\/jbc.M109.081125","volume":"285","author":"HJ Lee","year":"2010","unstructured":"Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem. 2010;285:9262\u201372.","journal-title":"J Biol Chem"},{"key":"564_CR28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/ana.25557","volume":"86","author":"V Grozdanov","year":"2019","unstructured":"Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, et al. Increased immune activation by pathologic \u03b1-synuclein in Parkinson\u2019s disease. Ann Neurol. 2019;86:593\u2013606.","journal-title":"Ann Neurol"},{"key":"564_CR29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00401-018-1907-y","volume":"137","author":"CD Hughes","year":"2019","unstructured":"Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Bot\u00eda JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, et al. Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson\u2019s disease pathogenesis. Acta Neuropathol. 2019;137:103\u201320.","journal-title":"Acta Neuropathol"},{"key":"564_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13024-018-0276-2","volume":"13","author":"C Kim","year":"2018","unstructured":"Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, et al. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating \u03b1-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018;13:43.","journal-title":"Mol Neurodegener"},{"key":"564_CR31","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3389\/fphar.2018.00417","volume":"9","author":"IF Caplan","year":"2018","unstructured":"Caplan IF, Maguire-Zeiss KA. Toll-Like receptor 2 signaling and current approaches for therapeutic modulation in synucleinopathies. Front Pharmacol. 2018;9:417.","journal-title":"Front Pharmacol"},{"key":"564_CR32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.bbi.2018.02.012","volume":"69","author":"P La Vitola","year":"2018","unstructured":"La Vitola P, Balducci C, Cerovic M, Santamaria G, Brandi E, Grandi F, Caldinelli L, Colombo L, Morgese MG, Trabace L, et al. Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2. Brain Behav Immun. 2018;69:591\u2013602.","journal-title":"Brain Behav Immun"},{"key":"564_CR33","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00401-016-1648-8","volume":"133","author":"N Dzamko","year":"2017","unstructured":"Dzamko N, Gysbers A, Perera G, Bahar A, Shankar A, Gao J, Fu Y, Halliday GM. Toll-like receptor 2 is increased in neurons in Parkinson\u2019s disease brain and may contribute to alpha-synuclein pathology. Acta Neuropathol. 2017;133:303\u201319.","journal-title":"Acta Neuropathol"},{"key":"564_CR34","doi-asserted-by":"crossref","unstructured":"Galiano-Landeira J, Torra A, Vila M, Bove J. CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease. Brain. 2020;143:3717-33.","DOI":"10.1093\/brain\/awaa269"},{"key":"564_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.coi.2019.07.004","volume":"59","author":"CS Lindestam Arlehamn","year":"2019","unstructured":"Lindestam Arlehamn CS, Garretti F, Sulzer D, Sette A. Roles for the adaptive immune system in Parkinson\u2019s and Alzheimer\u2019s diseases. Curr Opin Immunol. 2019;59:115\u201320.","journal-title":"Curr Opin Immunol"},{"key":"564_CR36","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12974-020-01888-0","volume":"17","author":"M Iba","year":"2020","unstructured":"Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and alpha-synuclein transgenic models. J Neuroinflammation. 2020;17:214.","journal-title":"J Neuroinflammation"},{"key":"564_CR37","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12974-020-01911-4","volume":"17","author":"MS Subbarayan","year":"2020","unstructured":"Subbarayan MS, Hudson C, Moss LD, Nash KR, Bickford PC. T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an alpha-synuclein rat model of Parkinson\u2019s disease. J Neuroinflammation. 2020;17:242.","journal-title":"J Neuroinflammation"},{"key":"564_CR38","doi-asserted-by":"crossref","unstructured":"Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, et al. CD4(+) T cells contribute to neurodegeneration in Lewy body dementia. Science. 2021;374:868-74.","DOI":"10.1126\/science.abf7266"},{"key":"564_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-4939-9124-2_5","volume":"1948","author":"B Zhang","year":"2019","unstructured":"Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Stereotaxic targeting of alpha-synuclein pathology in mouse brain using preformed fibrils. Methods Mol Biol. 2019;1948:45\u201357.","journal-title":"Methods Mol Biol"},{"key":"564_CR40","doi-asserted-by":"publisher","unstructured":"Lecca D, Jung YJ, Scerba MT, Hwang I, Kim YK, Kim S, Modrow S, Tweedie D, Hsueh SC, Liu D, et al. Role of chronic neuroinflammation in neuroplasticity and cognitive function: a hypothesis. Alzheimers Dement. 2022. https:\/\/doi.org\/10.1002\/alz.12610.","DOI":"10.1002\/alz.12610"},{"key":"564_CR41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jneumeth.2011.01.019","volume":"197","author":"JP Guilloux","year":"2011","unstructured":"Guilloux JP, Seney M, Edgar N, Sibille E. Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex. J Neurosci Methods. 2011;197:21\u201331.","journal-title":"J Neurosci Methods"},{"key":"564_CR42","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s12974-019-1636-8","volume":"16","author":"RH Earls","year":"2019","unstructured":"Earls RH, Menees KB, Chung J, Barber J, Gutekunst CA, Hazim MG, Lee JK. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. J Neuroinflammation. 2019;16:250.","journal-title":"J Neuroinflammation"},{"key":"564_CR43","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2642-12.2013","volume":"33","author":"M Iba","year":"2013","unstructured":"Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer\u2019s-like tauopathy. J Neurosci. 2013;33:1024\u201337.","journal-title":"J Neurosci"},{"key":"564_CR44","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1750-1326-9-18","volume":"9","author":"CR Overk","year":"2014","unstructured":"Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Hippocampal neuronal cells that accumulate alpha-synuclein fragments are more vulnerable to Abeta oligomer toxicity via mGluR5\u2013implications for dementia with Lewy bodies. Mol Neurodegener. 2014;9:18.","journal-title":"Mol Neurodegener"},{"key":"564_CR45","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1093\/brain\/aww238","volume":"139","author":"W Wrasidlo","year":"2016","unstructured":"Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, et al. A de novo compound targeting alpha-synuclein improves deficits in models of Parkinson\u2019s disease. Brain. 2016;139:3217\u201336.","journal-title":"Brain"},{"key":"564_CR46","unstructured":"Paxinos G, Franklin KJ. The mouse brain in stereotaxic coordinates. 3rd edn. Cambridge: Academic Press; 2007."},{"key":"564_CR47","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.nbd.2017.05.002","volume":"104","author":"O El-Agnaf","year":"2017","unstructured":"El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, et al. Differential effects of immunotherapy with antibodies targeting alpha-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017;104:85\u201396.","journal-title":"Neurobiol Dis"},{"key":"564_CR48","doi-asserted-by":"crossref","unstructured":"Young K, Morrison H. Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using imageJ. J Vis Exp. 2018;136:57648.","DOI":"10.3791\/57648"},{"key":"564_CR49","first-page":"255","volume-title":"Advances in the study of behavior","author":"HM Schellinck","year":"2010","unstructured":"Schellinck HM, Cyr DP, Brown RE. How many ways can mouse behavioral experiments go wrong? Confounding variables in mouse models of neurodegenerative diseases and how to control them. In: Brockmann HJ, Roper TJ, Naguib M, Wynne-Edwards KE, editors. Advances in the study of behavior, vol. 41. Mitani JC: Simmons LW; 2010. p. 255\u2013366."},{"key":"564_CR50","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.expneurol.2012.06.025","volume":"237","author":"MB Watson","year":"2012","unstructured":"Watson MB, Richter F, Lee SK, Gabby L, Wu J, Masliah E, Effros RB, Chesselet MF. Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein. Exp Neurol. 2012;237:318\u201334.","journal-title":"Exp Neurol"},{"key":"564_CR51","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.neurobiolaging.2007.04.006","volume":"29","author":"X Su","year":"2008","unstructured":"Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. Synuclein activates microglia in a model of Parkinson\u2019s disease. Neurobiol Aging. 2008;29:1690\u2013701.","journal-title":"Neurobiol Aging"},{"key":"564_CR52","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41467-018-02926-5","volume":"9","author":"M Olah","year":"2018","unstructured":"Olah M, Patrick E, Villani AC, Xu J, White CC, Ryan KJ, Piehowski P, Kapasi A, Nejad P, Cimpean M, et al. A transcriptomic atlas of aged human microglia. Nat Commun. 2018;9:539.","journal-title":"Nat Commun"},{"key":"564_CR53","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41586-020-2499-y","volume":"583","author":"N Schaum","year":"2020","unstructured":"Schaum N, Lehallier B, Hahn O, Palovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, et al. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020;583:596\u2013602.","journal-title":"Nature"},{"key":"564_CR54","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","volume":"22","author":"M Ximerakis","year":"2019","unstructured":"Ximerakis M, Lipnick SL, Innes BT, Simmons SK, Adiconis X, Dionne D, Mayweather BA, Nguyen L, Niziolek Z, Ozek C, et al. Single-cell transcriptomic profiling of the aging mouse brain. Nat Neurosci. 2019;22:1696\u2013708.","journal-title":"Nat Neurosci"},{"key":"564_CR55","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1186\/1471-2105-8-392","volume":"8","author":"J Chen","year":"2007","unstructured":"Chen J, Xu H, Aronow BJ, Jegga AG. Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics. 2007;8:392.","journal-title":"BMC Bioinformatics"},{"key":"564_CR56","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00335-015-9573-z","volume":"26","author":"H Motenko","year":"2015","unstructured":"Motenko H, Neuhauser SB, O\u2019Keefe M, Richardson JE. MouseMine: a new data warehouse for MGI. Mamm Genome. 2015;26:325\u201330.","journal-title":"Mamm Genome"},{"key":"564_CR57","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fimmu.2019.00239","volume":"10","author":"J Campos-Acu\u00f1a","year":"2019","unstructured":"Campos-Acu\u00f1a J, Elgueta D, Pacheco R. T-cell-driven inflammation as a mediator of the gut-brain axis involved in Parkinson\u2019s disease. Front Immunol. 2019;10:239.","journal-title":"Front Immunol"},{"key":"564_CR58","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/s41591-018-0051-5","volume":"24","author":"SP Yun","year":"2018","unstructured":"Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, et al. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson\u2019s disease. Nat Med. 2018;24:931\u20138.","journal-title":"Nat Med"},{"key":"564_CR59","doi-asserted-by":"crossref","unstructured":"Sun F, Salinas AG, Filser S, Blumenstock S, Medina-Luque J, Herms J, Sgobio C. Impact of alpha-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology. Brain Pathol. 2022;32(2):e13036.","DOI":"10.1111\/bpa.13036"},{"key":"564_CR60","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40478-017-0494-9","volume":"5","author":"AS Harms","year":"2017","unstructured":"Harms AS, Delic V, Thome AD, Bryant N, Liu Z, Chandra S, Jurkuvenaite A, West AB. \u03b1-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. Acta Neuropathol Commun. 2017;5:85.","journal-title":"Acta Neuropathol Commun"},{"key":"564_CR61","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","volume":"23","author":"C Challis","year":"2020","unstructured":"Challis C, Hori A, Sampson TR, Yoo BB, Challis RC, Hamilton AM, Mazmanian SK, Volpicelli-Daley LA, Gradinaru V. Gut-seeded alpha-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nat Neurosci. 2020;23:327\u201336.","journal-title":"Nat Neurosci"},{"key":"564_CR62","doi-asserted-by":"publisher","first-page":"104708","DOI":"10.1016\/j.nbd.2019.104708","volume":"134","author":"LE Stoyka","year":"2020","unstructured":"Stoyka LE, Arrant AE, Thrasher DR, Russell DL, Freire J, Mahoney CL, Narayanan A, Dib AG, Standaert DG, Volpicelli-Daley LA. Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded alpha-synuclein inclusions. Neurobiol Dis. 2020;134:104708.","journal-title":"Neurobiol Dis"},{"key":"564_CR63","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.nbd.2015.06.003","volume":"82","author":"KL Paumier","year":"2015","unstructured":"Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, et al. Intrastriatal injection of pre-formed mouse alpha-synuclein fibrils into rats triggers alpha-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol Dis. 2015;82:185\u201399.","journal-title":"Neurobiol Dis"},{"key":"564_CR64","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1002\/mds.23356","volume":"25","author":"V Sossi","year":"2010","unstructured":"Sossi V, de la Fuente-Fernandez R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, Stoessl JA. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov Disord. 2010;25:2717\u201323.","journal-title":"Mov Disord"},{"key":"564_CR65","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/jnr.22611","volume":"89","author":"HA Lam","year":"2011","unstructured":"Lam HA, Wu N, Cely I, Kelly RL, Hean S, Richter F, Magen I, Cepeda C, Ackerson LC, Walwyn W, et al. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human alpha-synuclein. J Neurosci Res. 2011;89:1091\u2013102.","journal-title":"J Neurosci Res"},{"key":"564_CR66","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.nbd.2005.08.005","volume":"21","author":"EL Unger","year":"2006","unstructured":"Unger EL, Eve DJ, Perez XA, Reichenbach DK, Xu Y, Lee MK, Andrews AM. Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiol Dis. 2006;21:431\u201343.","journal-title":"Neurobiol Dis"},{"key":"564_CR67","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3233\/JPD-120130","volume":"3","author":"SM Rothman","year":"2013","unstructured":"Rothman SM, Griffioen KJ, Vranis N, Ladenheim B, Cong WN, Cadet JL, Haran J, Martin B, Mattson MP. Neuronal expression of familial Parkinson\u2019s disease A53T alpha-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice. J Parkinsons Dis. 2013;3:215\u201329.","journal-title":"J Parkinsons Dis"},{"key":"564_CR68","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.expneurol.2017.10.002","volume":"298","author":"J Blesa","year":"2017","unstructured":"Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA. Compensatory mechanisms in Parkinson\u2019s disease: circuits adaptations and role in disease modification. Exp Neurol. 2017;298:148\u201361.","journal-title":"Exp Neurol"},{"key":"564_CR69","doi-asserted-by":"publisher","first-page":"639646","DOI":"10.3389\/fnins.2021.639646","volume":"15","author":"F Piancone","year":"2021","unstructured":"Piancone F, Saresella M, La Rosa F, Marventano I, Meloni M, Navarro J, Clerici M. Inflammatory responses to monomeric and aggregated alpha-synuclein in peripheral blood of Parkinson disease patients. Front Neurosci. 2021;15:639646.","journal-title":"Front Neurosci"},{"issue":"75\u201390","key":"564_CR70","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/j.neuron.2018.09.014","volume":"100","author":"S Nuber","year":"2018","unstructured":"Nuber S, Rajsombath M, Minakaki G, Winkler J, Muller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating native alpha-synuclein tetramers in mice causes a L-DOPA-responsive motor syndrome closely resembling Parkinson\u2019s disease. Neuron. 2018;100(75\u201390):e75.","journal-title":"Neuron"},{"key":"564_CR71","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41593-019-0423-2","volume":"22","author":"SH Shahmoradian","year":"2019","unstructured":"Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castano-Diez D, Schweighauser G, Graff-Meyer A, Goldie KN, et al. Lewy pathology in Parkinson\u2019s disease consists of crowded organelles and lipid membranes. Nat Neurosci. 2019;22:1099\u2013109.","journal-title":"Nat Neurosci"},{"key":"564_CR72","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/jnc.14871","volume":"152","author":"D Trudler","year":"2020","unstructured":"Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha synuclein deficiency increases CD4(+) T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem. 2020;152:61\u201371.","journal-title":"J Neurochem"},{"key":"564_CR73","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.imbio.2015.10.002","volume":"221","author":"A Shameli","year":"2016","unstructured":"Shameli A, Xiao W, Zheng Y, Shyu S, Sumodi J, Meyerson HJ, Harding CV, Maitta RW. A critical role for alpha-synuclein in development and function of T lymphocytes. Immunobiology. 2016;221:333\u201340.","journal-title":"Immunobiology"},{"key":"564_CR74","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.imbio.2014.07.014","volume":"219","author":"W Xiao","year":"2014","unstructured":"Xiao W, Shameli A, Harding CV, Meyerson HJ, Maitta RW. Late stages of hematopoiesis and B cell lymphopoiesis are regulated by alpha-synuclein, a key player in Parkinson\u2019s disease. Immunobiology. 2014;219:836\u201344.","journal-title":"Immunobiology"},{"key":"564_CR75","doi-asserted-by":"publisher","first-page":"110887","DOI":"10.1016\/j.exger.2020.110887","volume":"134","author":"L Pangrazzi","year":"2020","unstructured":"Pangrazzi L, Weinberger B. T cells, aging and senescence. Exp Gerontol. 2020;134:110887.","journal-title":"Exp Gerontol"},{"key":"564_CR76","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/jnc.14860","volume":"151","author":"DM Angelova","year":"2019","unstructured":"Angelova DM, Brown DR. Microglia and the aging brain: are senescent microglia the key to neurodegeneration? J Neurochem. 2019;151:676\u201388.","journal-title":"J Neurochem"},{"key":"564_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.08.002","volume":"169","author":"Z Chen","year":"2018","unstructured":"Chen Z, Chen S, Liu J. The role of T cells in the pathogenesis of Parkinson\u2019s disease. Prog Neurobiol. 2018;169:1\u201323.","journal-title":"Prog Neurobiol"},{"key":"564_CR78","first-page":"11","volume":"2020","author":"CS Lindestam Arlehamn","year":"1875","unstructured":"Lindestam Arlehamn CS, Dhanwani R, Pham J, Kuan R, Frazier A, Rezende Dutra J, Phillips E, Mallal S, Roederer M, Marder KS, et al. \u03b1-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson\u2019s disease. Nat Commun. 1875;2020:11.","journal-title":"Nat Commun"},{"key":"564_CR79","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00401-020-02126-w","volume":"139","author":"GP Williams","year":"2020","unstructured":"Williams GP, Marmion DJ, Schonhoff AM, Jurkuvenaite A, Won WJ, Standaert DG, Kordower JH, Harms AS. T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease. Acta Neuropathol. 2020;139:855\u201374.","journal-title":"Acta Neuropathol"},{"key":"564_CR80","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.4049\/jimmunol.1700149","volume":"198","author":"G Chandra","year":"2017","unstructured":"Chandra G, Roy A, Rangasamy SB, Pahan K. Induction of adaptive immunity leads to nigrostriatal disease progression in MPTP Mouse Model of Parkinson\u2019s disease. J Immunol. 2017;198:4312\u201326.","journal-title":"J Immunol"},{"key":"564_CR81","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuroscience.2020.01.043","volume":"431","author":"J Seo","year":"2020","unstructured":"Seo J, Park J, Kim K, Won J, Yeo HG, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, et al. Chronic Infiltration of T Lymphocytes into the brain in a non-human primate model of Parkinson\u2019s disease. Neuroscience. 2020;431:73\u201385.","journal-title":"Neuroscience"},{"key":"564_CR82","doi-asserted-by":"publisher","first-page":"110358","DOI":"10.1016\/j.celrep.2022.110358","volume":"38","author":"JK Sterling","year":"2022","unstructured":"Sterling JK, Kam TI, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, et al. Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein. Cell Rep. 2022;38:110358.","journal-title":"Cell Rep"},{"key":"564_CR83","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12974-020-01903-4","volume":"17","author":"HO Dikmen","year":"2020","unstructured":"Dikmen HO, Hemmerich M, Lewen A, Hollnagel JO, Chausse B, Kann O. GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ. J Neuroinflammation. 2020;17:235.","journal-title":"J Neuroinflammation"},{"key":"564_CR84","first-page":"225","volume":"265","author":"EV Gruntenko","year":"1982","unstructured":"Gruntenko EV, Nikolin VP, Matienko NA, Kaledin VI, Vakhrusheva TA. Liposomes as the carriers of antitumor chemical preparations in neoplastic liver lesions. Dokl Akad Nauk SSSR. 1982;265:225\u20138.","journal-title":"Dokl Akad Nauk SSSR"},{"key":"564_CR85","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1038\/s12276-020-00505-7","volume":"52","author":"RH Earls","year":"2020","unstructured":"Earls RH, Lee JK. The role of natural killer cells in Parkinson\u2019s disease. Exp Mol Med. 2020;52:1517\u201325.","journal-title":"Exp Mol Med"},{"key":"564_CR86","first-page":"194","volume":"7","author":"DG Walker","year":"2020","unstructured":"Walker DG. Defining activation states of microglia in human brain tissue: an unresolved issue for Alzheimer\u2019s disease. Neuroimmunol Nueoinflamm. 2020;7:194\u2013214.","journal-title":"Neuroimmunol Nueoinflamm"},{"key":"564_CR87","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/08977194.2011.649919","volume":"30","author":"TR Hercus","year":"2012","unstructured":"Hercus TR, Broughton SE, Ekert PG, Ramshaw HS, Perugini M, Grimbaldeston M, Woodcock JM, Thomas D, Pitson S, Hughes T, et al. The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors. 2012;30:63\u201375.","journal-title":"Growth Factors"},{"key":"564_CR88","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.nbd.2014.12.001","volume":"74","author":"V Chitu","year":"2015","unstructured":"Chitu V, Gokhan S, Gulinello M, Branch CA, Patil M, Basu R, Stoddart C, Mehler MF, Stanley ER. Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP). Neurobiol Dis. 2015;74:219\u201328.","journal-title":"Neurobiol Dis"},{"issue":"3004\u20133019","key":"564_CR89","first-page":"e3005","volume":"30","author":"V Chitu","year":"2020","unstructured":"Chitu V, Biundo F, Shlager GGL, Park ES, Wang P, Gulinello ME, Gokhan S, Ketchum HC, Saha K, DeTure MA, et al. Microglial homeostasis requires balanced CSF-1\/CSF-2 receptor signaling. Cell Rep. 2020;30(3004\u20133019):e3005.","journal-title":"Cell Rep"},{"key":"564_CR90","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fnagi.2017.00244","volume":"9","author":"DG Walker","year":"2017","unstructured":"Walker DG, Tang TM, Lue LF. Studies on colony stimulating factor receptor-1 and ligands colony stimulating factor-1 and interleukin-34 in Alzheimer\u2019s disease brains and human microglia. Front Aging Neurosci. 2017;9:244.","journal-title":"Front Aging Neurosci"},{"issue":"Suppl 1","key":"564_CR91","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/S1353-8020(11)70008-6","volume":"18","author":"D Beraud","year":"2012","unstructured":"Beraud D, Maguire-Zeiss KA. Misfolded alpha-synuclein and Toll-like receptors: therapeutic targets for Parkinson\u2019s disease. Parkinsonism Relat Disord. 2012;18(Suppl 1):S17-20.","journal-title":"Parkinsonism Relat Disord"}],"updated-by":[{"DOI":"10.1186\/s13024-024-00762-4","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"record-id":"62935"},{"DOI":"10.1186\/s13024-024-00762-4","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000}}],"container-title":["Molecular Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-022-00564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13024-022-00564-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-022-00564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:03:44Z","timestamp":1729080224000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularneurodegeneration.biomedcentral.com\/articles\/10.1186\/s13024-022-00564-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":91,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s13024-022-00564-6","relation":{},"ISSN":["1750-1326"],"issn-type":[{"value":"1750-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"1 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13024-024-00762-4","URL":"https:\/\/doi.org\/10.1186\/s13024-024-00762-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were performed in accordance with the ALAC-and ACUC approved protocols of NIA\/NIH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have approved of the consents of this manuscript and provided consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}