{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:47:07Z","timestamp":1771627627224,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066514"],"award-info":[{"award-number":["P30AG066514"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG058469"],"award-info":[{"award-number":["RF1AG058469"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG059319"],"award-info":[{"award-number":["RF1AG059319"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG046170"],"award-info":[{"award-number":["U01AG046170"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG061894"],"award-info":[{"award-number":["R01AG061894"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NIGMS","award":["R35GM130331"],"award-info":[{"award-number":["R35GM130331"]}]},{"name":"Fast Forward Protein Folding Disease Initiative","award":["Fast Forward Protein Folding Disease Initiative"],"award-info":[{"award-number":["Fast Forward Protein Folding Disease Initiative"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurodegeneration"],"DOI":"10.1186\/s13024-022-00568-2","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T13:02:38Z","timestamp":1666357358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Golgi apparatus: Site for convergence of COVID-19 brain fog and Alzheimer\u2019s disease?"],"prefix":"10.1186","volume":"17","author":[{"given":"Yanzhuang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-4721","authenticated-orcid":false,"given":"Sam","family":"Gandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"568_CR1","doi-asserted-by":"crossref","unstructured":"Shen WB, Logue J, Yang P, Baracco L, Elahi M, Reece EA, Wang B, Li L, Blanchard TG, Han Z, et al: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer\u2019s-like neuropathology. bioRxiv: the preprint server for biology 2022.","DOI":"10.1101\/2022.01.31.478476"},{"key":"568_CR2","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.cell.2022.01.024","volume":"185","author":"M Zazhytska","year":"2022","unstructured":"Zazhytska M, Kodra A, Hoagland DA, Frere J, Fullard JF, Shayya H, McArthur NG, Moeller R, Uhl S, Omer AD, et al. Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell. 2022;185:1052\u201364 e1012.","journal-title":"Cell"},{"key":"568_CR3","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1016\/j.cell.2022.06.008","volume":"185","author":"A Fernandez-Castaneda","year":"2022","unstructured":"Fernandez-Castaneda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O\u2019Dea MR, Dutton S, Shamardani K, Nwangwu K, et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022;185:2452\u201368 e2416.","journal-title":"Cell"},{"key":"568_CR4","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.tibs.2020.08.001","volume":"45","author":"X Zhang","year":"2020","unstructured":"Zhang X, Wang Y. Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond. Trends Biochem Sci. 2020;45:1065\u201379.","journal-title":"Trends Biochem Sci"},{"key":"568_CR5","doi-asserted-by":"crossref","unstructured":"Zhang J, Kennedy AA, Xing L, Bui S, Reid W, Joppich J, Ahat E, Rose M, Tang Q, Tai AW, Wang Y: SARS-CoV-2 triggers Golgi fragmentation via downregulation of GRASP55 to facilitate viral trafficking. bioRxiv: the preprint server for biology 2022, https:\/\/doi.org\/10.1101\/2022.03.04.483074.","DOI":"10.1101\/2022.03.04.483074"},{"key":"568_CR6","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.cell.2020.09.033","volume":"183","author":"TM Clausen","year":"2020","unstructured":"Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020;183:1043\u201357 e1015.","journal-title":"Cell"},{"key":"568_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00018-022-04223-3","volume":"79","author":"E Ahat","year":"2022","unstructured":"Ahat E, Song Y, Xia K, Reid W, Li J, Bui S, Zhang F, Linhardt RJ, Wang Y. GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion. Cell Mol Life Sci. 2022;79:199.","journal-title":"Cell Mol Life Sci"},{"key":"568_CR8","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1073\/pnas.1220978110","volume":"110","author":"DA Thayer","year":"2013","unstructured":"Thayer DA, Jan YN, Jan LY. Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013;110:1482\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"568_CR9","doi-asserted-by":"publisher","first-page":"E1230","DOI":"10.1073\/pnas.1320192111","volume":"111","author":"G Joshi","year":"2014","unstructured":"Joshi G, Chi Y, Huang Z, Wang Y. Abeta-induced Golgi fragmentation in Alzheimer\u2019s disease enhances Abeta production. Proc Natl Acad Sci U S A. 2014;111:E1230\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"568_CR10","doi-asserted-by":"crossref","unstructured":"Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, Nesvizhskii AI, Paulson HL, Wang Y. GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. J Biol Chem 2022:102219.","DOI":"10.1101\/2021.10.05.463252"}],"container-title":["Molecular Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-022-00568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13024-022-00568-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-022-00568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T13:11:18Z","timestamp":1666357878000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularneurodegeneration.biomedcentral.com\/articles\/10.1186\/s13024-022-00568-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["568"],"URL":"https:\/\/doi.org\/10.1186\/s13024-022-00568-2","relation":{},"ISSN":["1750-1326"],"issn-type":[{"value":"1750-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"7 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Y.W. is a founder of Camillo, Inc., a biotechnology company focusing on the potential use of GRASPs and other Golgi structural proteins as treatments for neurodegenerative diseases.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"67"}}