{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:17:46Z","timestamp":1792721866473,"version":"4.5.0"},"reference-count":377,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurodegeneration"],"DOI":"10.1186\/s13024-025-00922-0","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:24:43Z","timestamp":1767421483000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases"],"prefix":"10.1186","volume":"21","author":[{"given":"Huachao","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"issue":"26","key":"922_CR1","doi-asserted-by":"publisher","first-page":"10480","DOI":"10.1073\/pnas.1201836109","volume":"109","author":"M Inoue","year":"2012","unstructured":"Inoue M, Williams KL, Gunn MD, et al. NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012;109(26):10480\u201385.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"922_CR2","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","volume":"19","author":"A Akbal","year":"2022","unstructured":"Akbal A, Dernst A, Lovotti M, et al. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol. 2022;19(11):1201\u201314.","journal-title":"Cell Mol Immunol"},{"issue":"8","key":"922_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477\u201389.","journal-title":"Nat Rev Immunol"},{"key":"922_CR4","doi-asserted-by":"publisher","first-page":"133719","DOI":"10.1016\/j.jhazmat.2024.133719","volume":"467","author":"M Liu","year":"2024","unstructured":"Liu M, Lu J, Hu J, et al. Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells. J Hazard Mater. 2024;467:133719.","journal-title":"J Hazard Mater"},{"issue":"1","key":"922_CR5","doi-asserted-by":"publisher","first-page":"e70180","DOI":"10.1002\/ctm2.70180","volume":"15","author":"Y Zheng","year":"2025","unstructured":"Zheng Y, Xie Y, Li J, et al. CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis. Clin Transl Med. 2025;15(1):e70180.","journal-title":"Clin Transl Med"},{"issue":"2","key":"922_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrm.2017.66","volume":"19","author":"A Suomalainen","year":"2018","unstructured":"Suomalainen A, Battersby BJ. Mitochondrial diseases: the contribution of organelle stress responses to pathology. Nat Rev Mol Cell Biol. 2018;19(2):77\u201392.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"922_CR7","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s11064-022-03781-z","volume":"48","author":"R Chen","year":"2023","unstructured":"Chen R, Xu W, Sun Y, et al. 2-BFI provides neuroprotection against fluorosis by stabilizing endoplasmic reticulum-mitochondria contact sites and inhibiting activation of the NLRP3 inflammasome. Neurochem Res. 2023;48(2):591\u2013603.","journal-title":"Neurochem Res"},{"issue":"5","key":"922_CR8","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1007\/s10753-024-02013-6","volume":"47","author":"A Sharma","year":"2024","unstructured":"Sharma A, Dhavale DD, Kotzbauer PT, et al. VCP inhibition augments NLRP3 inflammasome activation. Inflammation. 2024;47(5):1868\u201383.","journal-title":"Inflammation"},{"issue":"9","key":"922_CR9","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1084\/jem.20162040","volume":"214","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Meszaros G, He WT, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214(9):2671\u201393.","journal-title":"J Exp Med"},{"issue":"Pt 2","key":"922_CR10","doi-asserted-by":"publisher","first-page":"118856","DOI":"10.1016\/j.jep.2024.118856","volume":"337","author":"S Huang","year":"2025","unstructured":"Huang S, Zeng Z, Chu Y, et al. Mitigation of lipopolysaccharide-induced intestinal injury in rats by Chimonanthus nitens Oliv. essential oil via suppression of mitochondrial fusion protein mitofusin 2 (MFN2)-mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) formation. J Ethnopharmacol. 2025;337(Pt 2):118856 .","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"922_CR11","first-page":"486","volume":"22","author":"Y Yang","year":"2024","unstructured":"Yang Y, Che Y, Fang M, et al. Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase. Chin J Nat Med. 2024;22(6):486\u2013500.","journal-title":"Chin J Nat Med"},{"issue":"2","key":"922_CR12","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.immuni.2025.01.007","volume":"58","author":"RM McManus","year":"2025","unstructured":"McManus RM, Komes MP, Griep A, et al. NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer\u2019s disease progression. Immunity. 2025;58(2):326\u201343.e11.","journal-title":"Immunity"},{"key":"922_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","volume":"3","author":"S Sarkar","year":"2017","unstructured":"Sarkar S, Malovic E, Harishchandra DS, et al. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson\u2019s disease. NPJ Parkinsons Dis. 2017;3:30.","journal-title":"NPJ Parkinsons Dis"},{"issue":"4","key":"922_CR14","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s12035-020-02198-5","volume":"58","author":"Z Ou","year":"2021","unstructured":"Ou Z, Zhou Y, Wang L, et al. NLRP3 inflammasome inhibition prevents \u03b1-synuclein pathology by relieving autophagy dysfunction in chronic MPTP-Treated NLRP3 knockout mice. Mol Neurobiol. 2021;58(4):1303\u201311.","journal-title":"Mol Neurobiol"},{"key":"922_CR15","doi-asserted-by":"publisher","first-page":"154801","DOI":"10.1016\/j.phymed.2023.154801","volume":"115","author":"P Liu","year":"2023","unstructured":"Liu P, Zhou Y, Shi J, et al. Myricetin improves pathological changes in 3\u00d7Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway. Phytomedicine. 2023;115:154801.","journal-title":"Phytomedicine"},{"issue":"5","key":"922_CR16","doi-asserted-by":"publisher","first-page":"e13623","DOI":"10.1111\/acel.13623","volume":"21","author":"ES Jung","year":"2022","unstructured":"Jung ES, Suh K, Han J, et al. Amyloid-\u03b2 activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21(5):e13623.","journal-title":"Aging Cell"},{"key":"922_CR17","doi-asserted-by":"crossref","unstructured":"Teixeira M, Sheta R, Idi W, et al. Alpha-synuclein and the endolysosomal system in Parkinson\u2019s disease: guilty by association. Biomolecules. 2021;11(9).","DOI":"10.3390\/biom11091333"},{"key":"922_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.expneurol.2013.11.001","volume":"251","author":"L Wang","year":"2014","unstructured":"Wang L, Zhai YQ, Xu LL, et al. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp Neurol. 2014;251:22\u201329.","journal-title":"Exp Neurol"},{"issue":"1","key":"922_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12974-025-03501-8","volume":"22","author":"V Brezani","year":"2025","unstructured":"Brezani V, Joshi RS, Ortega-Ribera M, et al. Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer\u2019s disease associated with inflammasome activation and asc speck propagation. J Neuroinflammation. 2025;22(1):183.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"922_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12974-023-02759-0","volume":"20","author":"A Grotemeyer","year":"2023","unstructured":"Grotemeyer A, Fischer JF, Koprich JB, et al. Inflammasome inhibition protects dopaminergic neurons from \u03b1-synuclein pathology in a model of progressive Parkinson\u2019s disease. J Neuroinflammation. 2023;20(1):79.","journal-title":"J Neuroinflammation"},{"issue":"7434","key":"922_CR21","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature. 2013;493(7434):674\u201378.","journal-title":"Nature"},{"issue":"15","key":"922_CR22","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.neuron.2022.05.009","volume":"110","author":"N Panicker","year":"2022","unstructured":"Panicker N, Kam TI, Wang H, et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson\u2019s disease. Neuron. 2022;110(15):2422\u201337.e9.","journal-title":"Neuron"},{"issue":"3","key":"922_CR23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00401-022-02466-9","volume":"144","author":"E Van Schoor","year":"2022","unstructured":"Van Schoor E, Ospitalieri S, Moonen S, et al. Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex. Acta Neuropathol. 2022;144(3):393\u2013411.","journal-title":"Acta Neuropathol"},{"issue":"26","key":"922_CR24","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1016\/j.cell.2021.11.011","volume":"184","author":"L Andreeva","year":"2021","unstructured":"Andreeva L, David L, Rawson S, et al. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell. 2021;184(26):6299\u2013312.e22.","journal-title":"Cell"},{"issue":"8045","key":"922_CR25","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41586-024-08136-y","volume":"637","author":"A Bhardwaj","year":"2025","unstructured":"Bhardwaj A, Panepinto MC, Ueberheide B, et al. A mechanism for hypoxia-induced inflammatory cell death in cancer. Nature. 2025;637(8045):470\u201377.","journal-title":"Nature"},{"issue":"5633","key":"922_CR26","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1126\/science.1087262","volume":"301","author":"M Yamamoto","year":"2003","unstructured":"Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301(5633):640\u201343.","journal-title":"Science"},{"key":"922_CR27","doi-asserted-by":"crossref","unstructured":"Xia J, Jiang S, Dong S, et al. The role of post-translational modifications in regulation of NLRP3 inflammasome activation. Int J Mol Sci. 2023;24(7).","DOI":"10.3390\/ijms24076126"},{"issue":"12","key":"922_CR28","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"Y He","year":"2016","unstructured":"He Y, Hara H, N\u00fa\u00f1ez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41(12):1012\u201321.","journal-title":"Trends Biochem Sci"},{"issue":"4","key":"922_CR29","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.7150\/ijbs.85851","volume":"20","author":"X Jiang","year":"2024","unstructured":"Jiang X, Ding X, Wei J, et al. Dioscin alleviates periodontitis by inhibiting NLRP3 inflammasome activation via regulation of K(+) homeostasis and mitochondrial function. Int J Biol Sci. 2024;20(4):1375\u201388.","journal-title":"Int J Biol Sci"},{"issue":"4","key":"922_CR30","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.7150\/thno.50905","volume":"11","author":"M Zhao","year":"2021","unstructured":"Zhao M, Wang Y, Li L, et al. Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance. Theranostics. 2021;11(4):1845\u201363.","journal-title":"Theranostics"},{"issue":"1","key":"922_CR31","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41467-017-00227-x","volume":"8","author":"T Tang","year":"2017","unstructured":"Tang T, Lang X, Xu C, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8(1):202.","journal-title":"Nat Commun"},{"issue":"40","key":"922_CR32","doi-asserted-by":"publisher","first-page":"E9371","DOI":"10.1073\/pnas.1812744115","volume":"115","author":"JP Green","year":"2018","unstructured":"Green JP, Yu S, Mart\u00edn-S\u00e1nchez F, et al. Chloride regulates dynamic NLRP3-dependent asc oligomerization and inflammasome priming. Proc Natl Acad Sci U S A. 2018;115(40):E9371\u2013e80.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"922_CR33","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1073\/pnas.1117765109","volume":"109","author":"T Murakami","year":"2012","unstructured":"Murakami T, Ockinger J, Yu J, et al. Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2012;109(28):11282\u201387.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7427","key":"922_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nature11588","volume":"492","author":"GS Lee","year":"2012","unstructured":"Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492(7427):123\u201327 .","journal-title":"Nature"},{"issue":"3","key":"922_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.immuni.2024.01.018","volume":"57","author":"S Huang","year":"2024","unstructured":"Huang S, Dong W, Lin X, et al. Disruption of the Na(+)\/K(+)-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity. 2024;57(3):495\u2013512.e11.","journal-title":"Immunity"},{"issue":"1","key":"922_CR36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12974-017-0865-y","volume":"14","author":"N Yue","year":"2017","unstructured":"Yue N, Huang H, Zhu X, et al. Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation. 2017;14(1):102.","journal-title":"J Neuroinflammation"},{"issue":"6","key":"922_CR37","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","volume":"38","author":"R Mu\u00f1oz-Planillo","year":"2013","unstructured":"Mu\u00f1oz-Planillo R, Kuffa P, Mart\u00ednez-Col\u00f3n G, et al. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38(6):1142\u201353 .","journal-title":"Immunity"},{"issue":"6","key":"922_CR38","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/icb.2014.21","volume":"92","author":"S Neumann","year":"2014","unstructured":"Neumann S, Burkert K, Kemp R, et al. Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunol Cell Biol. 2014;92(6):535\u201342.","journal-title":"Immunol Cell Biol"},{"issue":"7293","key":"922_CR39","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell P, Kono H, Rayner KJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464(7293):1357\u201361.","journal-title":"Nature"},{"key":"922_CR40","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.2147\/JIR.S371536","volume":"15","author":"L Ma","year":"2022","unstructured":"Ma L, Han Z, Yin H, et al. Characterization of cathepsin B in mediating silica nanoparticle-induced macrophage pyroptosis via an NLRP3-dependent manner. J Inflamm Res. 2022;15:4537\u201345.","journal-title":"J Inflamm Res"},{"issue":"45","key":"922_CR41","doi-asserted-by":"publisher","first-page":"39033","DOI":"10.1074\/jbc.M111.244079","volume":"286","author":"MK Atianand","year":"2011","unstructured":"Atianand MK, Duffy EB, Shah A, et al. Francisella tularensis reveals a disparity between human and mouse NLRP3 inflammasome activation. J Biol Chem. 2011;286(45):39033\u201342.","journal-title":"J Biol Chem"},{"issue":"1","key":"922_CR42","doi-asserted-by":"publisher","first-page":"C83","DOI":"10.1152\/ajpcell.00298.2015","volume":"311","author":"MA Katsnelson","year":"2016","unstructured":"Katsnelson MA, Lozada-Soto KM, Russo HM, et al. NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx. Am J Physiol Cell Physiol. 2016;311(1):C83\u2013C100 .","journal-title":"Am J Physiol Cell Physiol"},{"key":"922_CR43","doi-asserted-by":"crossref","unstructured":"Hochheiser IV, Pilsl M, Hagelueken G, et al. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature. 2022;604(7904):184\u201389.","DOI":"10.1038\/s41586-022-04467-w"},{"issue":"5","key":"922_CR44","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell. 2014;157(5):1013\u201322.","journal-title":"Cell"},{"key":"922_CR45","doi-asserted-by":"publisher","first-page":"113968","DOI":"10.1016\/j.biopha.2022.113968","volume":"156","author":"Y Liu","year":"2022","unstructured":"Liu Y, Guo ZW, Li J, et al. Insight into the regulation of NLRP3 inflammasome activation by mitochondria in liver injury and the protective role of natural products. Biomed Pharmacother. 2022;156:113968.","journal-title":"Biomed Pharmacother"},{"issue":"14","key":"922_CR46","doi-asserted-by":"publisher","first-page":"e2409362","DOI":"10.1002\/smll.202409362","volume":"21","author":"Y Shi","year":"2025","unstructured":"Shi Y, Hu Y, Li J, et al. Inhibition of caspase-1 suppresses GSDMD-mediated peritoneal mesothelial cell pyroptosis and inflammation in peritoneal fibrosis. Small. 2025;21(14):e2409362 .","journal-title":"Small"},{"issue":"11","key":"922_CR47","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1084\/jem.20160027","volume":"213","author":"BA Napier","year":"2016","unstructured":"Napier BA, Brubaker SW, Sweeney TE, et al. Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med. 2016;213(11):2365\u201382.","journal-title":"J Exp Med"},{"issue":"7371","key":"922_CR48","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature10558","volume":"479","author":"N Kayagaki","year":"2011","unstructured":"Kayagaki N, Warming S, Lamkanfi M, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479(7371):117\u201321.","journal-title":"Nature"},{"issue":"6151","key":"922_CR49","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1126\/science.1240988","volume":"341","author":"JA Hagar","year":"2013","unstructured":"Hagar JA, Powell DA, Aachoui Y, et al. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science. 2013;341(6151):1250\u201353.","journal-title":"Science"},{"issue":"12","key":"922_CR50","doi-asserted-by":"publisher","first-page":"e1007519","DOI":"10.1371\/journal.ppat.1007519","volume":"14","author":"DM Cerqueira","year":"2018","unstructured":"Cerqueira DM, Gomes MTR, Silva ALN, et al. Guanylate-binding protein 5 licenses caspase-11 for gasdermin-D mediated host resistance to Brucella abortus infection. PLoS Pathog. 2018;14(12):e1007519.","journal-title":"PLoS Pathog"},{"issue":"2","key":"922_CR51","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.cell.2016.09.012","volume":"167","author":"SM Man","year":"2016","unstructured":"Man SM, Karki R, Sasai M, et al. IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes. Cell. 2016;167(2):382\u201396.e17.","journal-title":"Cell"},{"issue":"7521","key":"922_CR52","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature13683","volume":"514","author":"J Shi","year":"2014","unstructured":"Shi J, Zhao Y, Wang Y, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514(7521):187\u201392.","journal-title":"Nature"},{"key":"922_CR53","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.coi.2015.01.007","volume":"32","author":"J Yang","year":"2015","unstructured":"Yang J, Zhao Y, Shao F. Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity. Curr Opin Immunol. 2015;32:78\u201383.","journal-title":"Curr Opin Immunol"},{"issue":"7575","key":"922_CR54","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki N, Stowe IB, Lee BL, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526(7575):666\u201371.","journal-title":"Nature"},{"issue":"7575","key":"922_CR55","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660\u201365.","journal-title":"Nature"},{"issue":"10","key":"922_CR56","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1002\/eji.201545772","volume":"45","author":"S R\u00fchl","year":"2015","unstructured":"R\u00fchl S, Broz P. Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux. Eur J Immunol. 2015;45(10):2927\u201336 .","journal-title":"Eur J Immunol"},{"issue":"4","key":"922_CR57","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.immuni.2023.03.003","volume":"56","author":"F Zhu","year":"2023","unstructured":"Zhu F, Ma J, Li W, et al. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023;56(4):753\u201367.e8.","journal-title":"Immunity"},{"issue":"7991","key":"922_CR58","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41586-023-06751-9","volume":"624","author":"P Devant","year":"2023","unstructured":"Devant P, Dong Y, Mintseris J, et al. Structural insights into cytokine cleavage by inflammatory caspase-4. Nature. 2023;624(7991):451\u201359.","journal-title":"Nature"},{"issue":"7991","key":"922_CR59","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41586-023-06742-w","volume":"624","author":"X Shi","year":"2023","unstructured":"Shi X, Sun Q, Hou Y, et al. Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome. Nature. 2023;624(7991):442\u201350.","journal-title":"Nature"},{"issue":"10","key":"922_CR60","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1002\/eji.201545655","volume":"45","author":"PJ Baker","year":"2015","unstructured":"Baker PJ, Boucher D, Bierschenk D, et al. NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. Eur J Immunol. 2015;45(10):2918\u201326.","journal-title":"Eur J Immunol"},{"key":"922_CR61","first-page":"17","volume":"35","author":"S He","year":"2024","unstructured":"He S, Li Z, Wang L, et al. A nanoenzyme-modified hydrogel targets macrophage reprogramming-angiogenesis crosstalk to boost diabetic wound repair. Bioact Mater. 2024;35:17\u201330.","journal-title":"Bioact Mater"},{"issue":"3","key":"922_CR62","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/brv.12291","volume":"92","author":"RE Koch","year":"2017","unstructured":"Koch RE, Josefson CC, Hill GE. Mitochondrial function, ornamentation, and immunocompetence. Biol Rev Camb Philos Soc. 2017;92(3):1459\u201374.","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"8","key":"922_CR63","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","volume":"55","author":"H Xian","year":"2022","unstructured":"Xian H, Watari K, Sanchez-Lopez E, et al. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022;55(8):1370\u201385.e8.","journal-title":"Immunity"},{"key":"922_CR64","doi-asserted-by":"publisher","first-page":"155241","DOI":"10.1016\/j.metabol.2022.155241","volume":"134","author":"JY Zhu","year":"2022","unstructured":"Zhu JY, Chen M, Mu WJ, et al. Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. Metabolism. 2022;134:155241.","journal-title":"Metabolism"},{"issue":"6","key":"922_CR65","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/j.celrep.2018.09.071","volume":"25","author":"JM Platnich","year":"2018","unstructured":"Platnich JM, Chung H, Lau A, et al. Shiga Toxin\/Lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome. Cell Rep. 2018;25(6):1525\u201336.e7.","journal-title":"Cell Rep"},{"issue":"5","key":"922_CR66","doi-asserted-by":"publisher","first-page":"101522","DOI":"10.1016\/j.xcrm.2024.101522","volume":"5","author":"X Guan","year":"2024","unstructured":"Guan X, Zhu S, Song J, et al. Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke. Cell Rep Med. 2024;5(5):101522.","journal-title":"Cell Rep Med"},{"issue":"1","key":"922_CR67","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s13046-023-02834-7","volume":"42","author":"P Su","year":"2023","unstructured":"Su P, Mao X, Ma J, et al. ERR\u03b1 promotes glycolytic metabolism and targets the NLRP3\/caspase-1\/GSDMD pathway to regulate pyroptosis in endometrial cancer. J Exp Clin Cancer Res. 2023;42(1):274.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"922_CR68","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.immuni.2024.10.012","volume":"58","author":"BS Saller","year":"2025","unstructured":"Saller BS, W\u00f6hrle S, Fischer L, et al. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2025;58(1):90\u2013107.e11.","journal-title":"Immunity"},{"issue":"1","key":"922_CR69","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41420-022-01046-w","volume":"8","author":"M Yan","year":"2022","unstructured":"Yan M, Li Y, Luo Q, et al. Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice. Cell Death Discov. 2022;8(1):258.","journal-title":"Cell Death Discov"},{"key":"922_CR70","doi-asserted-by":"publisher","first-page":"166478","DOI":"10.1016\/j.scitotenv.2023.166478","volume":"903","author":"D Wang","year":"2023","unstructured":"Wang D, Wu Y, Sun S, et al. NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis. Sci Total Environ. 2023;903:166478.","journal-title":"Sci Total Environ"},{"key":"922_CR71","doi-asserted-by":"publisher","first-page":"116003","DOI":"10.1016\/j.biopha.2023.116003","volume":"170","author":"J Chen","year":"2024","unstructured":"Chen J, Zhou Z, Wu N, et al. Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2\/HO-1 and inhibiting MAPK\/NF-\u03baB\/NLRP3 pathways. Biomed Pharmacother. 2024;170:116003.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"922_CR72","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","volume":"45","author":"CJ Gro\u00df","year":"2016","unstructured":"Gro\u00df CJ, Mishra R, Schneider KS, et al. K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity. 2016;45(4):761\u201373 .","journal-title":"Immunity"},{"issue":"5","key":"922_CR73","doi-asserted-by":"publisher","first-page":"114237","DOI":"10.1016\/j.celrep.2024.114237","volume":"43","author":"Y Tang","year":"2024","unstructured":"Tang Y, Wu J, Sun X, et al. Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia. Cell Rep. 2024;43(5):114237 .","journal-title":"Cell Rep"},{"issue":"7","key":"922_CR74","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.immuni.2021.05.004","volume":"54","author":"H Xian","year":"2021","unstructured":"Xian H, Liu Y, Rundberg Nilsson A, et al. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021;54(7):1463\u201377.e11.","journal-title":"Immunity"},{"issue":"7285","key":"922_CR75","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104\u201307.","journal-title":"Nature"},{"issue":"3","key":"922_CR76","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","volume":"36","author":"K Shimada","year":"2012","unstructured":"Shimada K, Crother TR, Karlin J, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012;36(3):401\u201314.","journal-title":"Immunity"},{"issue":"1","key":"922_CR77","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s42003-023-04817-y","volume":"6","author":"A Cabral","year":"2023","unstructured":"Cabral A, Cabral JE, Wang A, et al. Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 inflammasome activation. Commun Biol. 2023;6(1):578.","journal-title":"Commun Biol"},{"issue":"1","key":"922_CR78","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-023-02982-9","volume":"20","author":"Z Yang","year":"2023","unstructured":"Yang Z, Liu Y, Chen X, et al. Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury. J Neuroinflammation. 2023;20(1):296.","journal-title":"J Neuroinflammation"},{"key":"922_CR79","doi-asserted-by":"publisher","first-page":"103225","DOI":"10.1016\/j.redox.2024.103225","volume":"74","author":"X Li","year":"2024","unstructured":"Li X, Yuan F, Xiong Y, et al. FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. Redox Biol. 2024;74:103225.","journal-title":"Redox Biol"},{"issue":"6","key":"922_CR80","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1161\/ATVBAHA.115.306964","volume":"36","author":"X Li","year":"2016","unstructured":"Li X, Fang P, Li Y, et al. Mitochondrial reactive oxygen species mediate lysophosphatidylcholine-induced endothelial cell activation. Arterioscler Thromb Vasc Biol. 2016;36(6):1090\u2013100 .","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"922_CR81","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","volume":"32","author":"AC Codo","year":"2020","unstructured":"Codo AC, Davanzo GG, Monteiro LB, et al. Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1\u03b1\/Glycolysis-dependent axis. Cell Metab. 2020;32(3):437\u201346.e5.","journal-title":"Cell Metab"},{"issue":"1","key":"922_CR82","doi-asserted-by":"publisher","first-page":"242","DOI":"10.7150\/ijbs.77304","volume":"19","author":"WJ Zhong","year":"2023","unstructured":"Zhong WJ, Liu T, Yang HH, et al. TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury. Int J Biol Sci. 2023;19(1):242\u201357.","journal-title":"Int J Biol Sci"},{"issue":"11","key":"922_CR83","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1136\/annrheumdis-2020-217342","volume":"79","author":"F Renaudin","year":"2020","unstructured":"Renaudin F, Orliaguet L, Castelli F, et al. Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1\u03b2 activation on macrophages. Ann Rheum Dis. 2020;79(11):1506\u201314.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"922_CR84","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41423-022-00962-2","volume":"20","author":"CG Hsu","year":"2023","unstructured":"Hsu CG, Li W, Sowden M, et al. Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages. Cell Mol Immunol. 2023;20(2):131\u201342.","journal-title":"Cell Mol Immunol"},{"issue":"10","key":"922_CR85","doi-asserted-by":"publisher","first-page":"111770","DOI":"10.1016\/j.celrep.2022.111770","volume":"41","author":"J Fu","year":"2022","unstructured":"Fu J, Han Z, Wu Z, et al. GABA regulates IL-1\u03b2 production in macrophages. Cell Rep. 2022;41(10):111770.","journal-title":"Cell Rep"},{"issue":"1","key":"922_CR86","doi-asserted-by":"publisher","first-page":"e0169372","DOI":"10.1371\/journal.pone.0169372","volume":"12","author":"K Sumegi","year":"2017","unstructured":"Sumegi K, Fekete K, Antus C, et al. BGP-15 protects against oxidative stress- or lipopolysaccharide-induced mitochondrial destabilization and reduces mitochondrial production of reactive oxygen species. PLoS One. 2017;12(1):e0169372.","journal-title":"PLoS One"},{"key":"922_CR87","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ceb.2020.04.002","volume":"65","author":"BP Phillips","year":"2020","unstructured":"Phillips BP, Gomez-Navarro N, Miller EA. Protein quality control in the endoplasmic reticulum. Curr Opin Cell Biol. 2020;65:96\u2013102.","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"922_CR88","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","volume":"13","author":"I Tabas","year":"2011","unstructured":"Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 2011;13(3):184\u201390.","journal-title":"Nat Cell Biol"},{"issue":"8","key":"922_CR89","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nri.2016.62","volume":"16","author":"J Grootjans","year":"2016","unstructured":"Grootjans J, Kaser A, Kaufman RJ, et al. The unfolded protein response in immunity and inflammation. Nat Rev Immunol. 2016;16(8):469\u201384.","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"922_CR90","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10695-023-01242-0","volume":"49","author":"Y Shen","year":"2023","unstructured":"Shen Y, Zhao W, Bao Y, et al. Molecular cloning and characterization of endoplasmic reticulum stress related genes grp78 and atf6\u03b1 from black seabream (acanthopagrus schlegelii) and their expressions in response to nutritional regulation. Fish Physiol Biochem. 2023;49(6):1115\u201328.","journal-title":"Fish Physiol Biochem"},{"issue":"2","key":"922_CR91","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","volume":"13","author":"C Hetz","year":"2012","unstructured":"Hetz C. The unfolded protein response: controlling cell fate decisions under er stress and beyond. Nat Rev Mol Cell Biol. 2012;13(2):89\u2013102.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"922_CR92","doi-asserted-by":"publisher","first-page":"e25937","DOI":"10.1016\/j.heliyon.2024.e25937","volume":"10","author":"Y Lei","year":"2024","unstructured":"Lei Y, Yu H, Ding S, et al. Molecular mechanism of ATF6 in unfolded protein response and its role in disease. Heliyon. 2024;10(5):e25937.","journal-title":"Heliyon"},{"key":"922_CR93","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fmed.2020.00351","volume":"7","author":"G Lu","year":"2020","unstructured":"Lu G, Luo H, Zhu X. Targeting the GRP78 pathway for cancer therapy. Front Med (Lausanne). 2020;7:351.","journal-title":"Front Med (Lausanne)"},{"key":"922_CR94","doi-asserted-by":"publisher","first-page":"112815","DOI":"10.1016\/j.intimp.2024.112815","volume":"140","author":"J He","year":"2024","unstructured":"He J, Xu M, Chen Y, et al. Grp78 regulates NLRP3 inflammasome and participates in Sjogren\u2019s syndrome. Int Immunopharmacol. 2024;140:112815.","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"922_CR95","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"EH Choi","year":"2023","unstructured":"Choi EH, Park SJ. TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target. Exp Mol Med. 2023;55(7):1348\u201356.","journal-title":"Exp Mol Med"},{"issue":"14","key":"922_CR96","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.65.14.34","volume":"65","author":"Z Zha","year":"2024","unstructured":"Zha Z, Xiao D, Liu Z, et al. Endoplasmic reticulum stress induces ROS production and activates NLRP3 inflammasome via the PERK-CHOP signaling pathway in dry eye disease. Invest Ophthalmol Vis Sci. 2024;65(14):34.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"922_CR97","doi-asserted-by":"publisher","first-page":"125997","DOI":"10.1016\/j.jhazmat.2021.125997","volume":"417","author":"X Liu","year":"2021","unstructured":"Liu X, Chen Y, Wang H, et al. Microglia-derived IL-1\u03b2 promoted neuronal apoptosis through er stress-mediated signaling pathway PERK\/eIF2\u03b1\/ATF4\/CHOP upon arsenic exposure. J Hazard Mater. 2021;417:125997.","journal-title":"J Hazard Mater"},{"issue":"5","key":"922_CR98","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/jnr.22280","volume":"88","author":"N Fradejas","year":"2010","unstructured":"Fradejas N, Pastor MD, Burgos M, et al. Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C\/EBP homologous protein. J Neurosci Res. 2010;88(5):1094\u2013105.","journal-title":"J Neurosci Res"},{"issue":"3","key":"922_CR99","first-page":"1684","volume":"42","author":"A Chen","year":"2018","unstructured":"Chen A, Liu J, Zhu J, et al. FGF21 attenuates hypoxia\u2011induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress. Int J Mol Med. 2018;42(3):1684\u201394.","journal-title":"Int J Mol Med"},{"issue":"1","key":"922_CR100","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","volume":"3","author":"J Shen","year":"2002","unstructured":"Shen J, Chen X, Hendershot L, et al. Er stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of Golgi localization signals. Dev Cell. 2002;3(1):99\u2013111.","journal-title":"Dev Cell"},{"issue":"42","key":"922_CR101","doi-asserted-by":"publisher","first-page":"17775","DOI":"10.1073\/pnas.0910342106","volume":"106","author":"AJ Schindler","year":"2009","unstructured":"Schindler AJ, Schekman R. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc Natl Acad Sci U S A. 2009;106(42):17775\u201380.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2\u20133","key":"922_CR102","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10863-025-10055-0","volume":"57","author":"P Wang","year":"2025","unstructured":"Wang P, Li H, Wu W. Anti-inflammatory effects of esomeprazole in septic lung injury by mediating endoplasmic reticulum stress. J Bioenerg Biomembr. 2025;57(2\u20133):173\u201382.","journal-title":"J Bioenerg Biomembr"},{"key":"922_CR103","doi-asserted-by":"publisher","first-page":"156638","DOI":"10.1016\/j.phymed.2025.156638","volume":"140","author":"JJ Zhang","year":"2025","unstructured":"Zhang JJ, Zhong JT, Wang WL, et al. Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway. Phytomedicine. 2025;140:156638.","journal-title":"Phytomedicine"},{"issue":"1","key":"922_CR104","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13048-023-01242-x","volume":"16","author":"Y Weng","year":"2023","unstructured":"Weng Y, Zhang Y, Wang D, et al. Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1\u03b1-TXNIP\/ROS-NLRP3 pathway in PCOS. J Ovarian Res. 2023;16(1):151.","journal-title":"J Ovarian Res"},{"key":"922_CR105","doi-asserted-by":"publisher","first-page":"170129","DOI":"10.1016\/j.scitotenv.2024.170129","volume":"915","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Dong B, Jiao X, et al. Nano\u2011selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway. Sci Total Environ. 2024;915:170129.","journal-title":"Sci Total Environ"},{"issue":"46","key":"922_CR106","doi-asserted-by":"publisher","first-page":"17968","DOI":"10.1021\/acs.jafc.3c06587","volume":"71","author":"Z Wang","year":"2023","unstructured":"Wang Z, Li L, Yan H, et al. Salidroside ameliorates furan-induced testicular inflammation in relation to the Gut-testis axis and intestinal apoptosis. J Agric Food Chem. 2023;71(46):17968\u201387.","journal-title":"J Agric Food Chem"},{"issue":"8","key":"922_CR107","doi-asserted-by":"publisher","first-page":"10835","DOI":"10.1096\/fj.202000734R","volume":"34","author":"M Jiang","year":"2020","unstructured":"Jiang M, Wang H, Liu Z, et al. Endoplasmic reticulum stress-dependent activation of iNOS\/NO-NF-\u03baB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. Faseb J. 2020;34(8):10835\u201349.","journal-title":"Faseb J"},{"key":"922_CR108","doi-asserted-by":"crossref","unstructured":"Dong H, Song H, Liu Y, et al. Zinc-mediated endoplasmic reticulum stress and metallothionein alleviate arsenic-induced cardiotoxicity in Cyprinus Carpio. Biol Trace Elem Res. 2023.","DOI":"10.1007\/s12011-023-03975-8"},{"issue":"3","key":"922_CR109","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.apsb.2023.08.013","volume":"14","author":"X Zhuo","year":"2024","unstructured":"Zhuo X, Wu Y, Fu X, et al. Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK\/NLRP3\/IL-1\u03b2 and NO\/iNOS signalling. Acta Pharm Sin B. 2024;14(3):1441\u201356.","journal-title":"Acta Pharm Sin B"},{"key":"922_CR110","doi-asserted-by":"publisher","first-page":"729094","DOI":"10.3389\/fimmu.2021.729094","volume":"12","author":"L Ye","year":"2021","unstructured":"Ye L, Zeng Q, Ling M, et al. Inhibition of IP3R\/Ca2+ dysregulation protects mice from Ventilator-induced lung injury via endoplasmic reticulum and mitochondrial pathways. Front Immunol. 2021;12:729094.","journal-title":"Front Immunol"},{"issue":"1","key":"922_CR111","doi-asserted-by":"publisher","first-page":"159061","DOI":"10.1016\/j.bbalip.2021.159061","volume":"1867","author":"H Liu","year":"2022","unstructured":"Liu H, Nan B, Yang C, et al. Elaidic acid induced NLRP3 inflammasome activation via ERS-MAPK signaling pathways in Kupffer cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867(1):159061.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"1","key":"922_CR112","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12974-022-02598-5","volume":"19","author":"G Jing","year":"2022","unstructured":"Jing G, Zuo J, Fang Q, et al. Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1\u03b1\/Xbp1s-Ca(2+) axis. J Neuroinflammation. 2022;19(1):237.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"922_CR113","doi-asserted-by":"publisher","first-page":"e1011791","DOI":"10.1371\/journal.ppat.1011791","volume":"19","author":"AK Sharma","year":"2023","unstructured":"Sharma AK, El Andaloussi A, Ismail N. Evasion of host antioxidative response via disruption of NRF2 signaling in fatal Ehrlichia-induced liver injury. PLoS Pathog. 2023;19(11):e1011791.","journal-title":"PLoS Pathog"},{"issue":"4","key":"922_CR114","doi-asserted-by":"publisher","first-page":"104050","DOI":"10.1016\/j.isci.2022.104050","volume":"25","author":"H Tsutsuki","year":"2022","unstructured":"Tsutsuki H, Zhang T, Yahiro K, et al. Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection. iScience. 2022;25(4):104050.","journal-title":"iScience"},{"issue":"12","key":"922_CR115","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1136\/gutjnl-2021-325013","volume":"71","author":"MU Latif","year":"2022","unstructured":"Latif MU, Schmidt GE, Mercan S, et al. NFATc1 signaling drives chronic er stress responses to promote NAFLD progression. Gut. 2022;71(12):2561\u201373.","journal-title":"Gut"},{"key":"922_CR116","doi-asserted-by":"publisher","first-page":"120915","DOI":"10.1016\/j.lfs.2022.120915","volume":"308","author":"NS Youssef","year":"2022","unstructured":"Youssef NS, Elzaitony AS, Abdel Baky NA. Diacerein attenuate LPS-induced acute lung injury via inhibiting er stress and apoptosis: impact on the crosstalk between SphK1\/S1P, TLR4\/NF\u03baB\/STAT3, and NLRP3\/IL-1\u03b2 signaling pathways. Life Sci. 2022;308:120915.","journal-title":"Life Sci"},{"issue":"10","key":"922_CR117","doi-asserted-by":"publisher","first-page":"a005330","DOI":"10.1101\/cshperspect.a005330","volume":"3","author":"Y Wang","year":"2011","unstructured":"Wang Y, Seemann J. Golgi biogenesis. Cold Spring Harb Perspect Biol. 2011;3(10):a005330.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"922_CR118","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1084\/jem.20160933","volume":"214","author":"A Stutz","year":"2017","unstructured":"Stutz A, Kolbe CC, Stahl R, et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017;214(6):1725\u201336.","journal-title":"J Exp Med"},{"issue":"7734","key":"922_CR119","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","volume":"564","author":"J Chen","year":"2018","unstructured":"Chen J, Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018;564(7734):71\u201376.","journal-title":"Nature"},{"key":"922_CR120","doi-asserted-by":"publisher","first-page":"118556","DOI":"10.1016\/j.atherosclerosis.2024.118556","volume":"397","author":"WX Liu","year":"2024","unstructured":"Liu WX, Hu YF, Tai GJ, et al. Macrophages regulate plaque progression in diabetic Apoe-\/- mice dependent on Pi4p\/NLRP3 signaling pathway. Atherosclerosis. 2024;397:118556 .","journal-title":"Atherosclerosis"},{"issue":"2","key":"922_CR121","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1194\/jlr.R088328","volume":"60","author":"RS Kuna","year":"2019","unstructured":"Kuna RS, Field SJ. GOLPH3: a Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer. J Lipid Res. 2019;60(2):269\u201375.","journal-title":"J Lipid Res"},{"key":"922_CR122","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbi.2024.03.051","volume":"119","author":"W Zhu","year":"2024","unstructured":"Zhu W, Zhang H, Niu T, et al. Microglial scap deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation. Brain Behav Immun. 2024;119:154\u201370.","journal-title":"Brain Behav Immun"},{"issue":"10","key":"922_CR123","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1038\/s41418-022-00997-y","volume":"29","author":"S Arumugam","year":"2022","unstructured":"Arumugam S, Qin Y, Liang Z, et al. GSK3\u03b2 mediates the spatiotemporal dynamics of NLRP3 inflammasome activation. Cell Death Differ. 2022;29(10):2060\u201369.","journal-title":"Cell Death Differ"},{"issue":"1","key":"922_CR124","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/thoraxjnl-2012-202182","volume":"68","author":"K Triantafilou","year":"2013","unstructured":"Triantafilou K, Kar S, Vakakis E, et al. Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. Thorax. 2013;68(1):66\u201375 .","journal-title":"Thorax"},{"issue":"3","key":"922_CR125","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1096\/fj.201801585R","volume":"33","author":"S Hong","year":"2019","unstructured":"Hong S, Hwang I, Gim E, et al. Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation. Faseb J. 2019;33(3):4547\u201358.","journal-title":"Faseb J"},{"issue":"10","key":"922_CR126","doi-asserted-by":"publisher","first-page":"108826","DOI":"10.1016\/j.celrep.2021.108826","volume":"34","author":"K Phulphagar","year":"2021","unstructured":"Phulphagar K, K\u00fchn LI, Ebner S, et al. Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis. Cell Rep. 2021;34(10):108826.","journal-title":"Cell Rep"},{"issue":"14","key":"922_CR127","doi-asserted-by":"publisher","first-page":"e0212721","DOI":"10.1128\/jvi.02127-21","volume":"96","author":"S He","year":"2022","unstructured":"He S, Li L, Chen H, et al. PRRSV infection induces gasdermin D-Driven pyroptosis of porcine alveolar macrophages through NLRP3 inflammasome activation. J Virol. 2022;96(14):e0212721.","journal-title":"J Virol"},{"issue":"1\u20132","key":"922_CR128","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00335-010-9293-3","volume":"22","author":"JP Hunn","year":"2011","unstructured":"Hunn JP, Feng CG, Sher A, et al. The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm Genome. 2011;22(1\u20132):43\u201354.","journal-title":"Mamm Genome"},{"key":"922_CR129","doi-asserted-by":"crossref","unstructured":"Daussy CF, Monard SC, Guy C, et al. The inflammasome components NLRP3 and asc act in concert with IRGM to rearrange the Golgi apparatus during hepatitis C virus infection. J Virol. 2021;95(3).","DOI":"10.1128\/JVI.00826-20"},{"issue":"3","key":"922_CR130","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.molcel.2018.11.018","volume":"73","author":"S Mehto","year":"2019","unstructured":"Mehto S, Jena KK, Nath P, et al. The Crohn\u2019s disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy. Mol Cell. 2019;73(3):429\u201345.e7.","journal-title":"Mol Cell"},{"key":"922_CR131","doi-asserted-by":"publisher","first-page":"111324","DOI":"10.1016\/j.intimp.2023.111324","volume":"127","author":"T Gao","year":"2024","unstructured":"Gao T, Wang T, Wu L, et al. Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation. Int Immunopharmacol. 2024;127:111324.","journal-title":"Int Immunopharmacol"},{"key":"922_CR132","doi-asserted-by":"publisher","first-page":"111092","DOI":"10.1016\/j.cellsig.2024.111092","volume":"117","author":"J Chen","year":"2024","unstructured":"Chen J, Sun X, Liu Y, et al. SENP3 attenuates foam cell formation by deSumoylating NLRP3 in macrophages stimulated with ox-LDL. Cell Signal. 2024;117:111092.","journal-title":"Cell Signal"},{"issue":"4","key":"922_CR133","doi-asserted-by":"publisher","first-page":"114070","DOI":"10.1016\/j.celrep.2024.114070","volume":"43","author":"T Yu","year":"2024","unstructured":"Yu T, Hou D, Zhao J, et al. NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. 2024;43(4):114070.","journal-title":"Cell Rep"},{"issue":"2","key":"922_CR134","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.molcel.2022.12.002","volume":"83","author":"L Wang","year":"2023","unstructured":"Wang L, Cai J, Zhao X, et al. Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy. Mol Cell. 2023;83(2):281\u201397.e10.","journal-title":"Mol Cell"},{"issue":"8","key":"922_CR135","doi-asserted-by":"publisher","first-page":"114516","DOI":"10.1016\/j.celrep.2024.114516","volume":"43","author":"S Leishman","year":"2024","unstructured":"Leishman S, Aljadeed NM, Qian L, et al. Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation. Cell Rep. 2024;43(8):114516.","journal-title":"Cell Rep"},{"issue":"1","key":"922_CR136","doi-asserted-by":"publisher","first-page":"8396","DOI":"10.1038\/s41467-023-44203-0","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Luo L, Xu X, et al. Acetylation is required for full activation of the NLRP3 inflammasome. Nat Commun. 2023;14(1):8396.","journal-title":"Nat Commun"},{"key":"922_CR137","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2014.03.034","volume":"31","author":"CC Scott","year":"2014","unstructured":"Scott CC, Vacca F, Gruenberg J. Endosome maturation, transport and functions. Semin Cell Dev Biol. 2014;31:2\u201310.","journal-title":"Semin Cell Dev Biol"},{"key":"922_CR138","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.semcdb.2014.04.024","volume":"31","author":"L Lu","year":"2014","unstructured":"Lu L, Hong W. From endosomes to the trans-Golgi network. Semin Cell Dev Biol. 2014;31:30\u201339.","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"922_CR139","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41577-021-00577-0","volume":"22","author":"NA Lind","year":"2022","unstructured":"Lind NA, Rael VE, Pestal K, et al. Regulation of the nucleic acid-sensing toll-like receptors. Nat Rev Immunol. 2022;22(4):224\u201335.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"922_CR140","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","volume":"18","author":"S Paik","year":"2021","unstructured":"Paik S, Kim JK, Silwal P, et al. An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. 2021;18(5):1141\u201360.","journal-title":"Cell Mol Immunol"},{"issue":"7183","key":"922_CR141","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature06664","volume":"452","author":"DA Muruve","year":"2008","unstructured":"Muruve DA, P\u00e9trilli V, Zaiss AK, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature. 2008;452(7183):103\u201307.","journal-title":"Nature"},{"key":"922_CR142","doi-asserted-by":"crossref","unstructured":"Nicholas SA, Bubnov VV, Yasinska IM, et al. Involvement of xanthine oxidase and hypoxia-inducible factor 1 in toll-like receptor 7\/8-mediated activation of caspase 1 and interleukin-1\u03b2. Cell Mol Life Sci. 2011;68(1):151\u201358.","DOI":"10.1007\/s00018-010-0450-3"},{"issue":"1","key":"922_CR143","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1038\/s41467-022-31132-7","volume":"13","author":"C Yang","year":"2022","unstructured":"Yang C, Bachu M, Du Y, et al. CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes. Nat Commun. 2022;13(1):3426.","journal-title":"Nat Commun"},{"issue":"8","key":"922_CR144","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/s41589-025-01919-y","volume":"21","author":"Q Liu","year":"2025","unstructured":"Liu Q, Tang Z, Qian Y, et al. Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome. Nat Chem Biol. 2025;21(8):1283\u201391.","journal-title":"Nat Chem Biol"},{"issue":"1","key":"922_CR145","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00395-023-01014-0","volume":"118","author":"D Xie","year":"2023","unstructured":"Xie D, Guo H, Li M, et al. Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia\/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion. Basic Res Cardiol. 2023;118(1):44.","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"922_CR146","doi-asserted-by":"publisher","first-page":"e0348822","DOI":"10.1128\/spectrum.03488-22","volume":"10","author":"M Pudla","year":"2022","unstructured":"Pudla M, Sanongkiet S, Ekchariyawat P, et al. TLR9 negatively regulates intracellular bacterial killing by pyroptosis in Burkholderia pseudomallei-infected mouse macrophage Cell line (Raw264.7). Microbiol Spectr. 2022;10(5):e0348822.","journal-title":"Microbiol Spectr"},{"issue":"1","key":"922_CR147","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12974-018-1162-0","volume":"15","author":"K Yamashita","year":"2018","unstructured":"Yamashita K, Kinoshita M, Miyamoto K, et al. Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder. J Neuroinflammation. 2018;15(1):125.","journal-title":"J Neuroinflammation"},{"issue":"16","key":"922_CR148","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1111\/bph.70053","volume":"182","author":"L Chen","year":"2025","unstructured":"Chen L, Bai D, Du J, et al. GL-V9 inhibits caspase-11 activation-induced pyroptosis by suppressing ALOX12-mediated lipid peroxidation to alleviate sepsis. Br J Pharmacol. 2025;182(16):3767\u201385.","journal-title":"Br J Pharmacol"},{"issue":"24","key":"922_CR149","doi-asserted-by":"publisher","first-page":"e108080","DOI":"10.15252\/embj.2021108080","volume":"40","author":"X Wang","year":"2021","unstructured":"Wang X, Ni J, You Y, et al. SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. Embo J. 2021;40(24):e108080.","journal-title":"Embo J"},{"issue":"1","key":"922_CR150","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1038\/s41467-019-10041-2","volume":"10","author":"C Fang","year":"2019","unstructured":"Fang C, Manes TD, Liu L, et al. ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-\u03baB via phosphoinosotide remodeling of endosomes. Nat Commun. 2019;10(1):2247.","journal-title":"Nat Commun"},{"issue":"7","key":"922_CR151","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1172\/JCI135060","volume":"130","author":"CB Xie","year":"2020","unstructured":"Xie CB, Jiang B, Qin L, et al. Complement-activated interferon-\u03b3-primed human endothelium transpresents interleukin-15 to CD8+ T cells. J Clin Invest. 2020;130(7):3437\u201352 .","journal-title":"J Clin Invest"},{"issue":"1","key":"922_CR152","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1038\/s41467-023-38684-2","volume":"14","author":"X Li","year":"2023","unstructured":"Li X, Jiang Q, Song G, et al. A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nat Commun. 2023;14(1):3002.","journal-title":"Nat Commun"},{"issue":"32","key":"922_CR153","doi-asserted-by":"publisher","first-page":"e2305089","DOI":"10.1002\/advs.202305089","volume":"10","author":"H Ma","year":"2023","unstructured":"Ma H, Fang W, Li Q, et al. Arf1 ablation in colorectal cancer cells activates a super signal complex in DC to enhance anti-tumor immunity. Adv Sci (Weinh). 2023;10(32):e2305089 .","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"922_CR154","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41423-022-00968-w","volume":"20","author":"F Zhu","year":"2023","unstructured":"Zhu F, Yu D, Qin X, et al. The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection. Cell Mol Immunol. 2023;20(3):264\u201376.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"922_CR155","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","volume":"14","author":"L Edvinsson","year":"2018","unstructured":"Edvinsson L, Haanes KA, Warfvinge K, et al. CGRP as the target of new migraine therapies - successful translation from bench to clinic. Nat Rev Neurol. 2018;14(6):338\u201350.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"922_CR156","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/s41467-022-28204-z","volume":"13","author":"F De Logu","year":"2022","unstructured":"De Logu F, Nassini R, Hegron A, et al. Schwann cell endosome CGRP signals elicit periorbital Mechanical allodynia in mice. Nat Commun. 2022;13(1):646.","journal-title":"Nat Commun"},{"issue":"26","key":"922_CR157","doi-asserted-by":"publisher","first-page":"6833","DOI":"10.1016\/j.biomaterials.2010.05.036","volume":"31","author":"T Morishige","year":"2010","unstructured":"Morishige T, Yoshioka Y, Inakura H, et al. The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture. Biomaterials. 2010;31(26):6833\u201342.","journal-title":"Biomaterials"},{"key":"922_CR158","doi-asserted-by":"crossref","unstructured":"Scharf B, Clement CC, Wu XX, et al. Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nat Commun. 2012;3:755.","DOI":"10.1038\/ncomms1754"},{"issue":"10","key":"922_CR159","doi-asserted-by":"publisher","first-page":"e29954","DOI":"10.1002\/jmv.29954","volume":"96","author":"C Shang","year":"2024","unstructured":"Shang C, Yu J, Zou S, et al. Functional evaluation of TMEM176B and its predictive role for severe respiratory viral infection through integrated analysis of single-cell and bulk RNA-sequencing. J Med Virol. 2024;96(10):e29954.","journal-title":"J Med Virol"},{"issue":"5","key":"922_CR160","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/ajt.12708","volume":"14","author":"M Segovia","year":"2014","unstructured":"Segovia M, Louvet C, Charnet P, et al. Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Am J Transpl. 2014;14(5):1021\u201331.","journal-title":"Am J Transpl"},{"issue":"7302","key":"922_CR161","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature09204","volume":"466","author":"C Behrends","year":"2010","unstructured":"Behrends C, Sowa ME, Gygi SP, et al. Network organization of the human autophagy system. Nature. 2010;466(7302):68\u201376.","journal-title":"Nature"},{"key":"922_CR162","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","volume":"43","author":"C He","year":"2009","unstructured":"He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009;43:67\u201393.","journal-title":"Annu Rev Genet"},{"key":"922_CR163","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev-cellbio-092910-154005","volume":"27","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 2011;27:107\u201332.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"5","key":"922_CR164","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1007\/s12035-018-1325-0","volume":"56","author":"S Sil","year":"2019","unstructured":"Sil S, Niu F, Tom E, et al. Cocaine mediated neuroinflammation: role of dysregulated autophagy in Pericytes. Mol Neurobiol. 2019;56(5):3576\u201390.","journal-title":"Mol Neurobiol"},{"issue":"12","key":"922_CR165","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.7150\/thno.72713","volume":"12","author":"Y Li","year":"2022","unstructured":"Li Y, Lei Z, Ritzel RM, et al. Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice. Theranostics. 2022;12(12):5364\u201388.","journal-title":"Theranostics"},{"issue":"1","key":"922_CR166","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s12951-021-01137-3","volume":"19","author":"R Zuo","year":"2021","unstructured":"Zuo R, Ye LF, Huang Y, et al. Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7. J Nanobiotechnol. 2021;19(1):396.","journal-title":"J Nanobiotechnol"},{"key":"922_CR167","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnmol.2019.00014","volume":"12","author":"S Chen","year":"2019","unstructured":"Chen S, Zhou C, Yu H, et al. 27-hydroxycholesterol contributes to lysosomal membrane permeabilization-mediated pyroptosis in Co-cultured SH-SY5Y cells and C6 cells. Front Mol Neurosci. 2019;12:14.","journal-title":"Front Mol Neurosci"},{"issue":"12","key":"922_CR168","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1161\/CIRCRESAHA.121.318908","volume":"129","author":"L Qiao","year":"2021","unstructured":"Qiao L, Ma J, Zhang Z, et al. Deficient chaperone-mediated autophagy promotes inflammation and atherosclerosis. Circ Res. 2021;129(12):1141\u201357.","journal-title":"Circ Res"},{"issue":"6","key":"922_CR169","doi-asserted-by":"publisher","first-page":"C1481","DOI":"10.1152\/ajpcell.00322.2024","volume":"327","author":"Y Lin","year":"2024","unstructured":"Lin Y, Cheng L, Chen Y, et al. TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy. Am J Physiol Cell Physiol. 2024;327(6):C1481\u2013c96.","journal-title":"Am J Physiol Cell Physiol"},{"key":"922_CR170","doi-asserted-by":"publisher","first-page":"114630","DOI":"10.1016\/j.ecoenv.2023.114630","volume":"252","author":"H Zhang","year":"2023","unstructured":"Zhang H, Xie Z, Peng Y, et al. PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration. Ecotoxicol Environ Saf. 2023;252:114630.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"12","key":"922_CR171","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1038\/s41418-019-0346-1","volume":"26","author":"SM Hill","year":"2019","unstructured":"Hill SM, Wrobel L, Rubinsztein DC. Correction to: post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation. Cell Death Differ. 2019;26(12):2810.","journal-title":"Cell Death Differ"},{"issue":"6","key":"922_CR172","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.cell.2012.11.001","volume":"151","author":"E Itakura","year":"2012","unstructured":"Itakura E, Kishi-Itakura C, Mizushima N. The hairpin-type tail-anchored snare syntaxin 17 targets to autophagosomes for fusion with endosomes\/lysosomes. Cell. 2012;151(6):1256\u201369.","journal-title":"Cell"},{"issue":"6","key":"922_CR173","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1080\/15548627.2019.1569916","volume":"15","author":"Y Xia","year":"2019","unstructured":"Xia Y, Liu N, Xie X, et al. The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy. 2019;15(6):960\u201375.","journal-title":"Autophagy"},{"issue":"8","key":"922_CR174","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/ni.1631","volume":"9","author":"V Hornung","year":"2008","unstructured":"Hornung V, Bauernfeind F, Halle A, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008;9(8):847\u201356.","journal-title":"Nat Immunol"},{"issue":"26","key":"922_CR175","doi-asserted-by":"publisher","first-page":"9035","DOI":"10.1073\/pnas.0803933105","volume":"105","author":"SL Cassel","year":"2008","unstructured":"Cassel SL, Eisenbarth SC, Iyer SS, et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008;105(26):9035\u201340.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"922_CR176","doi-asserted-by":"publisher","first-page":"170893","DOI":"10.1016\/j.scitotenv.2024.170893","volume":"919","author":"B Nie","year":"2024","unstructured":"Nie B, Liu X, Lei C, et al. The role of lysosomes in airborne particulate matter-induced pulmonary toxicity. Sci Total Environ. 2024;919:170893.","journal-title":"Sci Total Environ"},{"key":"922_CR177","doi-asserted-by":"publisher","first-page":"114941","DOI":"10.1016\/j.taap.2020.114941","volume":"393","author":"HW Chen","year":"2020","unstructured":"Chen HW, Yen CC, Kuo LL, et al. Benzyl isothiocyanate ameliorates high-fat\/cholesterol\/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells. Toxicol Appl Pharmacol. 2020;393:114941.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7","key":"922_CR178","doi-asserted-by":"publisher","first-page":"e11765","DOI":"10.1371\/journal.pone.0011765","volume":"5","author":"K Rajam\u00e4ki","year":"2010","unstructured":"Rajam\u00e4ki K, Lappalainen J, O\u00f6rni K, et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010;5(7):e11765.","journal-title":"PLoS One"},{"issue":"8","key":"922_CR179","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle A, Hornung V, Petzold GC, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008;9(8):857\u201365.","journal-title":"Nat Immunol"},{"key":"922_CR180","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.omtn.2022.09.019","volume":"30","author":"C Liu","year":"2022","unstructured":"Liu C, Yao Q, Hu T, et al. Cathepsin B deteriorates diabetic cardiomyopathy induced by streptozotocin via promoting NLRP3-mediated pyroptosis. Mol Ther Nucleic Acids. 2022;30:198\u2013207.","journal-title":"Mol Ther Nucleic Acids"},{"key":"922_CR181","doi-asserted-by":"publisher","first-page":"18479","DOI":"10.1038\/srep18479","volume":"5","author":"K Caution","year":"2015","unstructured":"Caution K, Gavrilin MA, Tazi M, et al. Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance. Sci Rep. 2015;5:18479.","journal-title":"Sci Rep"},{"issue":"1","key":"922_CR182","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.immuni.2012.05.001","volume":"37","author":"A Akhter","year":"2012","unstructured":"Akhter A, Caution K, Abu Khweek A, et al. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity. 2012;37(1):35\u201347.","journal-title":"Immunity"},{"issue":"47","key":"922_CR183","doi-asserted-by":"publisher","first-page":"32926","DOI":"10.1074\/jbc.M114.579961","volume":"289","author":"M Okada","year":"2014","unstructured":"Okada M, Matsuzawa A, Yoshimura A, et al. The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem. 2014;289(47):32926\u201336.","journal-title":"J Biol Chem"},{"issue":"5","key":"922_CR184","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.cell.2017.09.039","volume":"171","author":"MM Gaidt","year":"2017","unstructured":"Gaidt MM, Ebert TS, Chauhan D, et al. The DNA inflammasome in human myeloid cells is initiated by a STING-Cell death program upstream of NLRP3. Cell. 2017;171(5):1110\u201324.e18.","journal-title":"Cell"},{"issue":"1","key":"922_CR185","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12974-021-02226-8","volume":"18","author":"P Xu","year":"2021","unstructured":"Xu P, Tao C, Zhu Y, et al. TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage. J Neuroinflammation. 2021;18(1):188.","journal-title":"J Neuroinflammation"},{"key":"922_CR186","first-page":"37","volume":"34","author":"T Ye","year":"2024","unstructured":"Ye T, Wang C, Yan J, et al. Lysosomal destabilization: a missing link between pathological calcification and osteoarthritis. Bioact Mater. 2024;34:37\u201350.","journal-title":"Bioact Mater"},{"key":"922_CR187","doi-asserted-by":"publisher","first-page":"1128700","DOI":"10.3389\/fimmu.2023.1128700","volume":"14","author":"Y Hou","year":"2023","unstructured":"Hou Y, He H, Ma M, et al. Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage. Front Immunol. 2023;14:1128700.","journal-title":"Front Immunol"},{"issue":"8","key":"922_CR188","doi-asserted-by":"publisher","first-page":"116002","DOI":"10.1016\/j.celrep.2025.116002","volume":"44","author":"S Shivcharan","year":"2025","unstructured":"Shivcharan S, Younis DA, Wright SS, et al. Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens. Cell Rep. 2025;44(8):116002.","journal-title":"Cell Rep"},{"issue":"1","key":"922_CR189","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s10753-023-01928-w","volume":"47","author":"F Wang","year":"2024","unstructured":"Wang F, Ye J, Zhu W, et al. Galectin-3 mediates endotoxin Internalization and caspase-4\/11 activation in tubular epithelials and macrophages during sepsis and sepsis-associated acute kidney injury. Inflammation. 2024;47(1):454\u201368.","journal-title":"Inflammation"},{"key":"922_CR190","doi-asserted-by":"crossref","unstructured":"Baldrighi M, Doreth C, Li Y, et al. PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models. J Clin Invest. 2023;133(21).","DOI":"10.1172\/JCI162129"},{"issue":"18","key":"922_CR191","doi-asserted-by":"publisher","first-page":"e70054","DOI":"10.1096\/fj.202401185R","volume":"38","author":"J Niu","year":"2024","unstructured":"Niu J, Wen Y, Zhang F, et al. Pericentriolar material 1 promotes intestinal inflammation in ulcerative colitis by activating NLRP3\/gasdermin D-mediated macrophage pyroptosis. Faseb J. 2024;38(18):e70054.","journal-title":"Faseb J"},{"issue":"7944","key":"922_CR192","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41586-022-05570-8","volume":"613","author":"L Xiao","year":"2023","unstructured":"Xiao L, Magupalli VG, Wu H. Cryo-EM structures of the active NLRP3 inflammasome disc. Nature. 2023;613(7944):595\u2013600.","journal-title":"Nature"},{"issue":"1","key":"922_CR193","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/s41467-024-45396-8","volume":"15","author":"X Yu","year":"2024","unstructured":"Yu X, Matico RE, Miller R, et al. Structural basis for the oligomerization-facilitated NLRP3 activation. Nat Commun. 2024;15(1):1164.","journal-title":"Nat Commun"},{"issue":"12","key":"922_CR194","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/j.immuni.2022.10.021","volume":"55","author":"NA Schmacke","year":"2022","unstructured":"Schmacke NA, O\u2019Duill F, Gaidt MM, et al. IKK\u03b2 primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity. 2022;55(12):2271\u201384.e7.","journal-title":"Immunity"},{"issue":"2","key":"922_CR195","doi-asserted-by":"publisher","first-page":"e102201","DOI":"10.15252\/embj.2019102201","volume":"39","author":"XD Yang","year":"2020","unstructured":"Yang XD, Li W, Zhang S, et al. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. Embo J. 2020;39(2):e102201.","journal-title":"Embo J"},{"key":"922_CR196","doi-asserted-by":"publisher","first-page":"15986","DOI":"10.1038\/ncomms15986","volume":"8","author":"X Li","year":"2017","unstructured":"Li X, Thome S, Ma X, et al. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017;8:15986.","journal-title":"Nat Commun"},{"issue":"5","key":"922_CR197","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.immuni.2015.04.016","volume":"42","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Li Q, Rao E, et al. Epidermal fatty acid binding protein promotes skin inflammation induced by high-fat diet. Immunity. 2015;42(5):953\u201364.","journal-title":"Immunity"},{"issue":"1","key":"922_CR198","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13046-020-01688-7","volume":"39","author":"M Liang","year":"2020","unstructured":"Liang M, Chen X, Wang L, et al. Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression. J Exp Clin Cancer Res. 2020;39(1):176.","journal-title":"J Exp Clin Cancer Res"},{"key":"922_CR199","doi-asserted-by":"publisher","first-page":"109099","DOI":"10.1016\/j.intimp.2022.109099","volume":"111","author":"LC Meng","year":"2022","unstructured":"Meng LC, Zheng JY, Qiu YH, et al. Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob\/ob mice. Int Immunopharmacol. 2022;111:109099.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"922_CR200","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1194\/jlr.M053785","volume":"56","author":"GN Ioannou","year":"2015","unstructured":"Ioannou GN, Van Rooyen DM, Savard C, et al. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of nash. J Lipid Res. 2015;56(2):277\u201385.","journal-title":"J Lipid Res"},{"issue":"2","key":"922_CR201","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10522-025-10192-4","volume":"26","author":"D Guo","year":"2025","unstructured":"Guo D, Wu J, Shen C, et al. Upregulation of LXR\u03b2\/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL\/6 J mice via reducing lipid droplet accumulation. Biogerontology. 2025;26(2):49.","journal-title":"Biogerontology"},{"key":"922_CR202","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ceb.2018.06.003","volume":"53","author":"S Cohen","year":"2018","unstructured":"Cohen S, Valm AM, Lippincott-Schwartz J. Interacting organelles. Curr Opin Cell Biol. 2018;53:84\u201391.","journal-title":"Curr Opin Cell Biol"},{"issue":"19","key":"922_CR203","doi-asserted-by":"publisher","first-page":"5566","DOI":"10.1039\/D2BM00883A","volume":"10","author":"J Forster Iii","year":"2022","unstructured":"Forster Iii J, Nandi D, Kulkarni A. mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency. Biomater Sci. 2022;10(19):5566\u201382.","journal-title":"Biomater Sci"},{"issue":"1","key":"922_CR204","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1096\/fj.201500093r","volume":"31","author":"R Alvarado","year":"2017","unstructured":"Alvarado R, To J, Lund ME, et al. The immune modulatory peptide FhHDM-1 secreted by the helminth fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages. Faseb J. 2017;31(1):85\u201395.","journal-title":"Faseb J"},{"issue":"1","key":"922_CR205","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12974-021-02270-4","volume":"18","author":"H Zeng","year":"2021","unstructured":"Zeng H, Chen H, Li M, et al. Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after sah. J Neuroinflammation. 2021;18(1):210.","journal-title":"J Neuroinflammation"},{"issue":"9","key":"922_CR206","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","volume":"17","author":"K Sun","year":"2021","unstructured":"Sun K, Jing X, Guo J, et al. Mitophagy in degenerative joint diseases. Autophagy. 2021;17(9):2082\u201392.","journal-title":"Autophagy"},{"key":"922_CR207","doi-asserted-by":"publisher","first-page":"973108","DOI":"10.3389\/fimmu.2022.973108","volume":"13","author":"W Sang","year":"2022","unstructured":"Sang W, Chen S, Lin L, et al. Antioxidant mitoquinone ameliorates EtOH-LPS induced lung injury by inhibiting mitophagy and NLRP3 inflammasome activation. Front Immunol. 2022;13:973108.","journal-title":"Front Immunol"},{"key":"922_CR208","doi-asserted-by":"publisher","first-page":"113369","DOI":"10.1016\/j.fct.2022.113369","volume":"168","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, Zhang Y, Lu L, et al. Copper induces microglia-mediated neuroinflammation through ROS\/NF-\u03baB pathway and mitophagy disorder. Food Chem Toxicol. 2022;168:113369.","journal-title":"Food Chem Toxicol"},{"key":"922_CR209","doi-asserted-by":"publisher","first-page":"116137","DOI":"10.1016\/j.ecoenv.2024.116137","volume":"273","author":"J Li","year":"2024","unstructured":"Li J, Li M, Wang R, et al. Mitophagy protects against silver nanoparticle-induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome. Ecotoxicol Environ Saf. 2024;273:116137.","journal-title":"Ecotoxicol Environ Saf"},{"key":"922_CR210","doi-asserted-by":"publisher","first-page":"155629","DOI":"10.1016\/j.phymed.2024.155629","volume":"129","author":"R Zhang","year":"2024","unstructured":"Zhang R, Zhu Z, Ma Y, et al. Rhizoma alismatis decoction improved mitochondrial dysfunction to alleviate SASP by enhancing autophagy flux and apoptosis in hyperlipidemia acute pancreatitis. Phytomedicine. 2024;129:155629.","journal-title":"Phytomedicine"},{"key":"922_CR211","doi-asserted-by":"publisher","first-page":"109200","DOI":"10.1016\/j.intimp.2022.109200","volume":"112","author":"K Liu","year":"2022","unstructured":"Liu K, Zhou X, Fang L, et al. PINK1\/parkin-mediated mitophagy alleviates Staphylococcus aureus-induced NLRP3 inflammasome and NF-\u03baB pathway activation in bovine mammary epithelial cells. Int Immunopharmacol. 2022;112:109200.","journal-title":"Int Immunopharmacol"},{"key":"922_CR212","doi-asserted-by":"publisher","first-page":"628168","DOI":"10.3389\/fimmu.2021.628168","volume":"12","author":"X Wu","year":"2021","unstructured":"Wu X, Gong L, Xie L, et al. NLRP3 deficiency protects against intermittent hypoxia-induced neuroinflammation and mitochondrial ROS by promoting the PINK1-Parkin pathway of mitophagy in a murine model of sleep apnea. Front Immunol. 2021;12:628168.","journal-title":"Front Immunol"},{"issue":"2","key":"922_CR213","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/jbmr.4756","volume":"38","author":"L Zhu","year":"2023","unstructured":"Zhu L, Wang Z, Sun X, et al. STAT3\/Mitophagy axis coordinates macrophage NLRP3 inflammasome activation and inflammatory Bone loss. J Bone Min Res. 2023;38(2):335\u201353.","journal-title":"J Bone Min Res"},{"issue":"7","key":"922_CR214","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1080\/15548627.2021.1997051","volume":"18","author":"D Bai","year":"2022","unstructured":"Bai D, Du J, Bu X, et al. ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation. Autophagy. 2022;18(7):1673\u201393.","journal-title":"Autophagy"},{"key":"922_CR215","doi-asserted-by":"publisher","first-page":"102305","DOI":"10.1016\/j.redox.2022.102305","volume":"52","author":"Z Liu","year":"2022","unstructured":"Liu Z, Wang M, Wang X, et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 2022;52:102305.","journal-title":"Redox Biol"},{"key":"922_CR216","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neuro.2022.04.005","volume":"90","author":"W Jiang","year":"2022","unstructured":"Jiang W, Liu F, Li H, et al. TREM2 ameliorates anesthesia and surgery-induced cognitive impairment by regulating mitophagy and NLRP3 inflammasome in aged C57\/BL6 mice. Neurotoxicology. 2022;90:216\u201327.","journal-title":"Neurotoxicology"},{"key":"922_CR217","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2024.04.236","volume":"220","author":"X Lin","year":"2024","unstructured":"Lin X, Wang H, Zou L, et al. The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation. Free Radic Biol Med. 2024;220:15\u201327.","journal-title":"Free Radic Biol Med"},{"key":"922_CR218","doi-asserted-by":"publisher","first-page":"112801","DOI":"10.1016\/j.intimp.2024.112801","volume":"140","author":"J Wang","year":"2024","unstructured":"Wang J, Jing X, Liu X, et al. Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy. Int Immunopharmacol. 2024;140:112801.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"922_CR219","doi-asserted-by":"publisher","first-page":"159428","DOI":"10.1016\/j.bbalip.2023.159428","volume":"1869","author":"X Li","year":"2024","unstructured":"Li X, Mai K, Ai Q. Palmitic acid activates NLRP3 inflammasome through NF-\u03baB and AMPK-mitophagy-ROS pathways to induce IL-1\u03b2 production in large yellow croaker (Larimichthys crocea). Biochim Biophys Acta Mol Cell Biol Lipids. 2024;1869(2):159428 .","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"1","key":"922_CR220","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13073-021-00863-5","volume":"13","author":"B Han","year":"2021","unstructured":"Han B, Jiang W, Cui P, et al. Microglial PGC-1\u03b1 protects against ischemic brain injury by suppressing neuroinflammation. Genome Med. 2021;13(1):47.","journal-title":"Genome Med"},{"key":"922_CR221","doi-asserted-by":"publisher","first-page":"156052","DOI":"10.1016\/j.phymed.2024.156052","volume":"135","author":"W Li","year":"2024","unstructured":"Li W, Zhong Y, Lin Z, et al. Forsythoside a mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway. Phytomedicine. 2024;135:156052.","journal-title":"Phytomedicine"},{"issue":"5","key":"922_CR222","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1097\/JS9.0000000000001215","volume":"110","author":"T Jiang","year":"2024","unstructured":"Jiang T, Liu E, Li Z, et al. SIRT1-Rab7 axis attenuates NLRP3 and sting activation through late endosomal-dependent mitophagy during sepsis-induced acute lung injury. Int J Surg. 2024;110(5):2649\u201368.","journal-title":"Int J Surg"},{"key":"922_CR223","doi-asserted-by":"publisher","first-page":"925835","DOI":"10.3389\/fcell.2022.925835","volume":"10","author":"Y Yang","year":"2022","unstructured":"Yang Y, Wu J, Lu W, et al. Olaparib, a PARP-1 inhibitor, protects retinal cells from ocular hypertension-associated oxidative damage. Front Cell Dev Biol. 2022;10:925835.","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"922_CR224","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/ars.2014.6223","volume":"22","author":"C Giorgi","year":"2015","unstructured":"Giorgi C, Missiroli S, Patergnani S, et al. Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications. Antioxid Redox Signal. 2015;22(12):995\u20131019.","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"922_CR225","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1038\/s41467-024-49597-z","volume":"15","author":"JR Zhang","year":"2024","unstructured":"Zhang JR, Shen SY, Zhai MY, et al. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nat Commun. 2024;15(1):5199.","journal-title":"Nat Commun"},{"key":"922_CR226","doi-asserted-by":"publisher","first-page":"164620","DOI":"10.1016\/j.scitotenv.2023.164620","volume":"892","author":"B Li","year":"2023","unstructured":"Li B, Huo S, Du J, et al. Dibutyl phthalate causes heart damage by disrupting Ca(2+) transfer from endoplasmic reticulum to mitochondria and triggering subsequent pyroptosis. Sci Total Environ. 2023;892:164620.","journal-title":"Sci Total Environ"},{"key":"922_CR227","doi-asserted-by":"crossref","unstructured":"Li F, Guan Z, Gao Y, et al. Er stress promotes mitochondrial calcium overload and activates the ROS\/NLRP3 axis to mediate fatty liver ischemic injury. Hepatol Commun. 2024;8(4).","DOI":"10.1097\/HC9.0000000000000399"},{"issue":"1","key":"922_CR228","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s10020-023-00656-z","volume":"29","author":"S Zhang","year":"2023","unstructured":"Zhang S, Lv Y, Luo X, et al. Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder. Mol Med. 2023;29(1):73.","journal-title":"Mol Med"},{"issue":"6","key":"922_CR229","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1083\/jcb.201401126","volume":"205","author":"WA Prinz","year":"2014","unstructured":"Prinz WA. Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J Cell Biol. 2014;205(6):759\u201369.","journal-title":"J Cell Biol"},{"issue":"19","key":"922_CR230","doi-asserted-by":"publisher","first-page":"eaax 9093","DOI":"10.1126\/sciadv.aax9093","volume":"6","author":"A Rimessi","year":"2020","unstructured":"Rimessi A, Pozzato C, Carparelli L, et al. Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis. Sci Adv. 2020;6(19):eaax 9093.","journal-title":"Sci Adv"},{"key":"922_CR231","doi-asserted-by":"crossref","unstructured":"Li J, Zhang D, Brundel B, et al. Imbalance of ER and Mitochondria interactions: prelude to cardiac ageing and disease? Cells. 2019;8(12).","DOI":"10.3390\/cells8121617"},{"key":"922_CR232","doi-asserted-by":"crossref","unstructured":"Missiroli S, Perrone M, Gaf\u00e0 R, et al. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022;1\u201313.","DOI":"10.1038\/s41418-022-01095-9"},{"issue":"35","key":"922_CR233","doi-asserted-by":"publisher","first-page":"e2116505119","DOI":"10.1073\/pnas.2116505119","volume":"119","author":"SJ Park","year":"2022","unstructured":"Park SJ, Kim Y, Li C, et al. Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome. Proc Natl Acad Sci U S A. 2022;119(35):e2116505119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"922_CR234","doi-asserted-by":"publisher","first-page":"110617","DOI":"10.1016\/j.cbi.2023.110617","volume":"382","author":"H Chang","year":"2023","unstructured":"Chang H, Yang F, Bai H, et al. Molybdenum and\/or cadmium induce NLRP3 inflammasome production by causing mitochondria-associated endoplasmic reticulum membrane dysfunction in sheep hepatocytes. Chem Biol Interact. 2023;382:110617.","journal-title":"Chem Biol Interact"},{"key":"922_CR235","doi-asserted-by":"publisher","first-page":"117887","DOI":"10.1016\/j.jep.2024.117887","volume":"325","author":"L Jia","year":"2024","unstructured":"Jia L, Gong Y, Jiang X, et al. Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis. J Ethnopharmacol. 2024;325:117887.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"922_CR236","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1093\/bjd\/ljad305","volume":"189","author":"A Petrasca","year":"2023","unstructured":"Petrasca A, Hambly R, Kearney N, et al. Metformin has anti-inflammatory effects and induces immunometabolic reprogramming via multiple mechanisms in hidradenitis suppurativa. Br J Dermatol. 2023;189(6):730\u201340.","journal-title":"Br J Dermatol"},{"issue":"3","key":"922_CR237","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41419-024-06600-1","volume":"15","author":"Y Cao","year":"2024","unstructured":"Cao Y, Chen X, Zhu Z, et al. Sting contributes to lipopolysaccharide-induced tubular cell inflammation and pyroptosis by activating endoplasmic reticulum stress in acute kidney injury. Cell Death Dis. 2024;15(3):217.","journal-title":"Cell Death Dis"},{"issue":"1","key":"922_CR238","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12974-022-02511-0","volume":"19","author":"R Ding","year":"2022","unstructured":"Ding R, Li H, Liu Y, et al. Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis. J Neuroinflammation. 2022;19(1):137.","journal-title":"J Neuroinflammation"},{"key":"922_CR239","doi-asserted-by":"publisher","first-page":"101215","DOI":"10.1016\/j.redox.2019.101215","volume":"24","author":"N Li","year":"2019","unstructured":"Li N, Zhou H, Wu H, et al. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol. 2019;24:101215.","journal-title":"Redox Biol"},{"issue":"4","key":"922_CR240","doi-asserted-by":"publisher","first-page":"100534","DOI":"10.1016\/j.jlr.2024.100534","volume":"65","author":"M Yalcinkaya","year":"2024","unstructured":"Yalcinkaya M, Liu W, Xiao T, et al. Cholesterol trafficking to the er leads to the activation of CaMKII\/JNK\/NLRP3 and promotes atherosclerosis. J Lipid Res. 2024;65(4):100534.","journal-title":"J Lipid Res"},{"issue":"20","key":"922_CR241","doi-asserted-by":"publisher","first-page":"11235","DOI":"10.1073\/pnas.96.20.11235","volume":"96","author":"A Nohturfft","year":"1999","unstructured":"Nohturfft A, DeBose-Boyd RA, Scheek S, et al. Sterols regulate cycling of SREBP cleavage-activating protein (scap) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci U S A. 1999;96(20):11235\u201340.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"922_CR242","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.immuni.2018.08.021","volume":"49","author":"C Guo","year":"2018","unstructured":"Guo C, Chi Z, Jiang D, et al. Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. Immunity. 2018;49(5):842\u201356.e7.","journal-title":"Immunity"},{"issue":"1","key":"922_CR243","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41590-022-01355-3","volume":"24","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Venditti R, Ran L, et al. Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Nat Immunol. 2023;24(1):30\u201341.","journal-title":"Nat Immunol"},{"issue":"11","key":"922_CR244","doi-asserted-by":"publisher","first-page":"e2121353119","DOI":"10.1073\/pnas.2121353119","volume":"119","author":"U Ohto","year":"2022","unstructured":"Ohto U, Kamitsukasa Y, Ishida H, et al. Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2022;119(11):e2121353119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"922_CR245","doi-asserted-by":"publisher","first-page":"720655","DOI":"10.3389\/fimmu.2021.720655","volume":"12","author":"I Diaz-Del-Olmo","year":"2021","unstructured":"Diaz-Del-Olmo I, Worboys J, Martin-Sanchez F, et al. Internalization of the membrane attack complex triggers NLRP3 inflammasome activation and IL-1\u03b2 secretion in human macrophages. Front Immunol. 2021;12:720655.","journal-title":"Front Immunol"},{"key":"922_CR246","doi-asserted-by":"publisher","first-page":"123180","DOI":"10.1016\/j.lfs.2024.123180","volume":"360","author":"MS Khan","year":"2025","unstructured":"Khan MS, Tak J, Kim YS, et al. Chronic hyperglycemia induces hepatocyte pyroptosis via G\u03b1(12)\/G\u03b1(13)-associated endoplasmic reticulum stress: effect of pharmacological intervention. Life Sci. 2025;360:123180.","journal-title":"Life Sci"},{"key":"922_CR247","doi-asserted-by":"publisher","first-page":"106997","DOI":"10.1016\/j.prostaglandins.2025.106997","volume":"178","author":"L Wang","year":"2025","unstructured":"Wang L, Yang Y, Sun H, et al. Magnoflorine alleviates nonalcoholic fatty liver disease by modulating lipid metabolism, mitophagy and inflammation. Prostaglandins Other Lipid Mediat. 2025;178:106997.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"922_CR248","doi-asserted-by":"publisher","first-page":"154235","DOI":"10.1016\/j.phymed.2022.154235","volume":"103","author":"W Zhou","year":"2022","unstructured":"Zhou W, Yan X, Zhai Y, et al. Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy. Phytomedicine. 2022;103:154235.","journal-title":"Phytomedicine"},{"issue":"1","key":"922_CR249","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","volume":"63","author":"W Liu","year":"2014","unstructured":"Liu W, Yin Y, Zhou Z, et al. OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation. Inflamm Res. 2014;63(1):33\u201343.","journal-title":"Inflamm Res"},{"issue":"4","key":"922_CR250","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"DM Wilson 3rd","year":"2023","unstructured":"Wilson DM 3rd, Cookson MR, Van Den Bosch L, et al. Hallmarks of neurodegenerative diseases. Cell. 2023;186(4):693\u2013714.","journal-title":"Cell"},{"issue":"2","key":"922_CR251","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.apsb.2021.06.014","volume":"12","author":"SN Austad","year":"2022","unstructured":"Austad SN, Ballinger S, Buford TW, et al. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer\u2019s disease. Acta Pharm Sin B. 2022;12(2):511\u201331.","journal-title":"Acta Pharm Sin B"},{"issue":"4","key":"922_CR252","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","volume":"18","author":"YH Youm","year":"2013","unstructured":"Youm YH, Grant RW, McCabe LR, et al. Canonical NLRP3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18(4):519\u201332 .","journal-title":"Cell Metab"},{"issue":"10284","key":"922_CR253","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, et al. Alzheimer\u2019s disease. Lancet. 2021;397(10284):1577\u201390.","journal-title":"Lancet"},{"key":"922_CR254","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s41232-018-0085-6","volume":"38","author":"A Nakanishi","year":"2018","unstructured":"Nakanishi A, Kaneko N, Takeda H, et al. Amyloid \u03b2 directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system. Inflamm Regen. 2018;38:27.","journal-title":"Inflamm Regen"},{"issue":"1","key":"922_CR255","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","volume":"19","author":"D Singh","year":"2022","unstructured":"Singh D. Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease. J Neuroinflammation. 2022;19(1):206.","journal-title":"J Neuroinflammation"},{"key":"922_CR256","doi-asserted-by":"crossref","unstructured":"Vontell RT, de Rivero Vaccari JP, Sun X, et al. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer\u2019s disease. Brain Pathol. 2022;e13142.","DOI":"10.1111\/bpa.13142"},{"issue":"10","key":"922_CR257","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/cns.13427","volume":"26","author":"QS Wang","year":"2020","unstructured":"Wang QS, Ding HG, Chen SL, et al. Hypertonic saline mediates the NLRP3\/IL-1\u03b2 signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats. CNS Neurosci Ther. 2020;26(10):1045\u201357.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"922_CR258","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1515\/revneuro-2024-0081","volume":"36","author":"ZB Mohammad","year":"2025","unstructured":"Mohammad ZB, Yudin SCY, Goldberg BJ, et al. Exploring neuroglial signaling: diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication. Rev Neurosci. 2025;36(1):91\u2013117.","journal-title":"Rev Neurosci"},{"issue":"11","key":"922_CR259","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1111\/cns.14290","volume":"29","author":"G Wang","year":"2023","unstructured":"Wang G, Shen J, Zhai L, et al. TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes. CNS Neurosci Ther. 2023;29(11):3588\u201397.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"922_CR260","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12974-023-02791-0","volume":"20","author":"JM Li","year":"2023","unstructured":"Li JM, Hu T, Zhou XN, et al. The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice. J Neuroinflammation. 2023;20(1):112.","journal-title":"J Neuroinflammation"},{"key":"922_CR261","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2022.02.092","volume":"602","author":"T Xiao","year":"2022","unstructured":"Xiao T, Ji H, Shangguan X, et al. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochem Biophys Res Commun. 2022;602:1\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"922_CR262","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/alz.13020","volume":"19","author":"CM Kloske","year":"2023","unstructured":"Kloske CM, Barnum CJ, Batista AF, et al. APOE and immunity: research highlights. Alzheimers Dement. 2023;19(6):2677\u201396.","journal-title":"Alzheimers Dement"},{"key":"922_CR263","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-pathmechdis-030421-112756","volume":"17","author":"N Koutsodendris","year":"2022","unstructured":"Koutsodendris N, Nelson MR, Rao A, et al. Apolipoprotein E and Alzheimer\u2019s disease: findings, hypotheses, and potential mechanisms. Annu Rev Pathol. 2022;17:73\u201399.","journal-title":"Annu Rev Pathol"},{"issue":"6","key":"922_CR264","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","volume":"160","author":"Y Wang","year":"2015","unstructured":"Wang Y, Cella M, Mallinson K, et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model. Cell. 2015;160(6):1061\u201371.","journal-title":"Cell"},{"issue":"3","key":"922_CR265","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","volume":"62","author":"RH Swerdlow","year":"2018","unstructured":"Swerdlow RH. Mitochondria and mitochondrial cascades in Alzheimer\u2019s disease. J Alzheimers Dis. 2018;62(3):1403\u201316.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"922_CR266","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12974-020-02004-y","volume":"17","author":"DF Silva","year":"2020","unstructured":"Silva DF, Candeias E, Esteves AR, et al. Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer\u2019s disease features in cortical neurons. J Neuroinflammation. 2020;17(1):332.","journal-title":"J Neuroinflammation"},{"key":"922_CR267","doi-asserted-by":"publisher","first-page":"154227","DOI":"10.1016\/j.metabol.2020.154227","volume":"107","author":"WY Chen","year":"2020","unstructured":"Chen WY, Chen YF, Chan HC, et al. Role of apolipoprotein E in electronegative low-density lipoprotein-induced mitochondrial dysfunction in cardiomyocytes. Metabolism. 2020;107:154227.","journal-title":"Metabolism"},{"issue":"1","key":"922_CR268","doi-asserted-by":"publisher","first-page":"17604","DOI":"10.1038\/s41598-021-97117-6","volume":"11","author":"HY Sohn","year":"2021","unstructured":"Sohn HY, Kim SI, Park JY, et al. ApoE4 attenuates autophagy via FoxO3a repression in the brain. Sci Rep. 2021;11(1):17604.","journal-title":"Sci Rep"},{"key":"922_CR269","doi-asserted-by":"publisher","first-page":"155298","DOI":"10.1016\/j.phymed.2023.155298","volume":"124","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Zhao Q, Zhang Y, et al. A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice. Phytomedicine. 2024;124:155298.","journal-title":"Phytomedicine"},{"issue":"9","key":"922_CR270","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1038\/s12276-024-01295-y","volume":"56","author":"S Chung","year":"2024","unstructured":"Chung S, Jeong JH, Park JC, et al. Blockade of sting activation alleviates microglial dysfunction and a broad spectrum of Alzheimer\u2019s disease pathologies. Exp Mol Med. 2024;56(9):1936\u201351.","journal-title":"Exp Mol Med"},{"issue":"9","key":"922_CR271","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/pcn.13704","volume":"78","author":"XT Liu","year":"2024","unstructured":"Liu XT, Chen X, Zhao N, et al. Synergism of ApoE4 and systemic infectious burden is mediated by the APOE-NLRP3 axis in Alzheimer\u2019s disease. Psychiatry Clin Neurosci. 2024;78(9):517\u201326.","journal-title":"Psychiatry Clin Neurosci"},{"issue":"1","key":"922_CR272","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s11658-024-00600-x","volume":"29","author":"Z Ning","year":"2024","unstructured":"Ning Z, Liu Y, Wan M, et al. APOE2 protects against A\u03b2 pathology by improving neuronal mitochondrial function through ERR\u03b1 signaling. Cell Mol Biol Lett. 2024;29(1):87.","journal-title":"Cell Mol Biol Lett"},{"issue":"18","key":"922_CR273","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1016\/j.neuron.2024.06.029","volume":"112","author":"H Scheiblich","year":"2024","unstructured":"Scheiblich H, Eikens F, Wischhof L, et al. Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron. 2024;112(18):3106\u201325.e8.","journal-title":"Neuron"},{"key":"922_CR274","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.molimm.2024.04.002","volume":"170","author":"GS Ramakrishnan","year":"2024","unstructured":"Ramakrishnan GS, Berry WL, Pacherille A, et al. Ship inhibition mediates select TREM2-induced microglial functions. Mol Immunol. 2024;170:35\u201345.","journal-title":"Mol Immunol"},{"key":"922_CR275","doi-asserted-by":"crossref","unstructured":"Hu L, Liu J, Peng J, et al. TREM2 alleviates neuroinflammation by maintaining cellular metabolic homeostasis and mitophagy activity during early inflammation. Diseases. 2025;13(2).","DOI":"10.3390\/diseases13020060"},{"issue":"1","key":"922_CR276","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12640-021-00459-2","volume":"40","author":"H Li","year":"2022","unstructured":"Li H, Liu F, Jiang W, et al. TREM2 ameliorates lipopolysaccharide-induced oxidative stress response and neuroinflammation by promoting Sirtuin3 in BV2 cells. Neurotox Res. 2022;40(1):56\u201365.","journal-title":"Neurotox Res"},{"key":"922_CR277","doi-asserted-by":"crossref","unstructured":"Chen YC, Chang SC, Lee YS, et al. TOMM40 genetic variants cause neuroinflammation in Alzheimer\u2019s disease. Int J Mol Sci. 2023;24(4).","DOI":"10.3390\/ijms24044085"},{"issue":"6593","key":"922_CR278","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/382685a0","volume":"382","author":"SD Yan","year":"1996","unstructured":"Yan SD, Chen X, Fu J, et al. Rage and amyloid-beta peptide neurotoxicity in Alzheimer\u2019s disease. Nature. 1996;382(6593):685\u201391.","journal-title":"Nature"},{"issue":"4","key":"922_CR279","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/jnc.13079","volume":"133","author":"B Hassel","year":"2015","unstructured":"Hassel B, Elsais A, Fr\u00f8land AS, et al. Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro. J Neurochem. 2015;133(4):572\u201381.","journal-title":"J Neurochem"},{"issue":"4","key":"922_CR280","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41419-022-04840-7","volume":"13","author":"O Sbai","year":"2022","unstructured":"Sbai O, Djelloul M, Auletta A, et al. Correction to: RAGE-TXNIP axis drives inflammation in Alzheimer\u2019s by targeting A\u03b2 to mitochondria in microglia. Cell Death Dis. 2022;13(4):368.","journal-title":"Cell Death Dis"},{"key":"922_CR281","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.intimp.2017.10.024","volume":"54","author":"M Aminzadeh","year":"2018","unstructured":"Aminzadeh M, Roghani M, Sarfallah A, et al. TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer\u2019s disease. Int Immunopharmacol. 2018;54:78\u201385.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"922_CR282","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41419-022-04758-0","volume":"13","author":"O Sbai","year":"2022","unstructured":"Sbai O, Djelloul M, Auletta A, et al. AGE-TXNIP axis drives inflammation in Alzheimer\u2019s by targeting A\u03b2 to mitochondria in microglia. Cell Death Dis. 2022;13(4):302.","journal-title":"Cell Death Dis"},{"key":"922_CR283","doi-asserted-by":"crossref","unstructured":"Zhang X, Wang R, Hu D, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer\u2019s disease. Sci Adv. 2020;6(49).","DOI":"10.1126\/sciadv.abb8680"},{"key":"922_CR284","doi-asserted-by":"crossref","unstructured":"Han S, He Z, Jacob C, et al. Effect of increased IL-1\u03b2 on expression of HK in Alzheimer\u2019s disease. Int J Mol Sci. 2021;22(3).","DOI":"10.3390\/ijms22031306"},{"issue":"1","key":"922_CR285","doi-asserted-by":"publisher","first-page":"e13529","DOI":"10.1111\/cpr.13529","volume":"57","author":"X Xia","year":"2024","unstructured":"Xia X, He X, Zhao T, et al. Inhibiting mtDNA-STING-NLRP3\/IL-1\u03b2 axis-mediated neutrophil infiltration protects neurons in Alzheimer\u2019s disease. Cell Prolif. 2024;57(1):e13529.","journal-title":"Cell Prolif"},{"key":"922_CR286","doi-asserted-by":"publisher","first-page":"113997","DOI":"10.1016\/j.bcp.2020.113997","volume":"177","author":"Y Gao","year":"2020","unstructured":"Gao Y, Li J, Li J, et al. Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1\/Parkin signaling pathway. Biochem Pharmacol. 2020;177:113997.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"922_CR287","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13195-025-01695-w","volume":"17","author":"F Zhou","year":"2025","unstructured":"Zhou F, Lian W, Yuan X, et al. Cornuside alleviates cognitive impairments induced by A\u03b2(1-42) through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy. Alzheimers Res Ther. 2025;17(1):47.","journal-title":"Alzheimers Res Ther"},{"key":"922_CR288","doi-asserted-by":"publisher","first-page":"118145","DOI":"10.1016\/j.jep.2024.118145","volume":"329","author":"X Shan","year":"2024","unstructured":"Shan X, Tao W, Li J, et al. Kai-Xin-San ameliorates Alzheimer\u2019s disease-related neuropathology and cognitive impairment in APP\/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway. J Ethnopharmacol. 2024;329:118145.","journal-title":"J Ethnopharmacol"},{"key":"922_CR289","doi-asserted-by":"publisher","first-page":"156928","DOI":"10.1016\/j.phymed.2025.156928","volume":"145","author":"M Guo","year":"2025","unstructured":"Guo M, Wang Z, Zhou X, et al. Ciliatoside a attenuates neuroinflammation in Alzheimer\u2019s disease by activating mitophagy and inhibiting NLRP3 inflammasome activation. Phytomedicine. 2025;145:156928.","journal-title":"Phytomedicine"},{"key":"922_CR290","doi-asserted-by":"crossref","unstructured":"Elariny HA, Kabel AM, Selim H, et al. Repositioning canagliflozin for Mitigation of aluminium chloride-induced Alzheimer\u2019s disease: involvement of TXNIP\/NLRP3 inflammasome axis, mitochondrial dysfunction, and SIRT1\/HMGB1 signalling. Medicina (Kaunas). 2024;60(11).","DOI":"10.3390\/medicina60111805"},{"key":"922_CR291","doi-asserted-by":"crossref","unstructured":"Ismael S, Wajidunnisa S, K, et al. Er stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer\u2019s disease. Neurochem Int. 2021;148:105104.","DOI":"10.1016\/j.neuint.2021.105104"},{"issue":"1","key":"922_CR292","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12011-015-0553-7","volume":"172","author":"SHM Rizvi","year":"2016","unstructured":"Rizvi SHM, Parveen A, Ahmad I, et al. Aluminum activates PERK-EIF2\u03b1 signaling and inflammatory proteins in human neuroblastoma SH-SY5Y cells. Biol Trace Elem Res. 2016;172(1):108\u201319.","journal-title":"Biol Trace Elem Res"},{"issue":"34","key":"922_CR293","doi-asserted-by":"publisher","first-page":"e2401731","DOI":"10.1002\/advs.202401731","volume":"11","author":"X He","year":"2024","unstructured":"He X, Peng Y, Huang S, et al. Blood brain barrier-crossing delivery of Felodipine nanodrug ameliorates anxiety-like behavior and cognitive impairment in Alzheimer\u2019s disease. Adv Sci (Weinh). 2024;11(34):e2401731.","journal-title":"Adv Sci (Weinh)"},{"key":"922_CR294","doi-asserted-by":"crossref","unstructured":"Song X, Cui Z, He J, et al. \u03ba\u2011opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+\/CaMKII\/CREB signaling pathway and improves synaptic plasticity in APP\/PS1 mice. Mol Med Rep. 2021;24(1) .","DOI":"10.3892\/mmr.2021.12168"},{"issue":"23","key":"922_CR295","doi-asserted-by":"publisher","first-page":"10923","DOI":"10.18632\/aging.102495","volume":"11","author":"XY Zheng","year":"2019","unstructured":"Zheng XY, Lv YD, Jin FY, et al. Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice. Aging (albany NY). 2019;11(23):10923\u201338.","journal-title":"Aging (albany NY)"},{"issue":"1","key":"922_CR296","doi-asserted-by":"publisher","first-page":"27","DOI":"10.15252\/embr.201540614","volume":"17","author":"MD Tambini","year":"2016","unstructured":"Tambini MD, Pera M, Kanter E, et al. ApoE4 upregulates the activity of mitochondria-associated er membranes. EMBO Rep. 2016;17(1):27\u201336.","journal-title":"EMBO Rep"},{"issue":"2","key":"922_CR297","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3233\/JAD-190419","volume":"71","author":"T Liang","year":"2019","unstructured":"Liang T, Xue F, Hang W, et al. Neuron-specific Apolipoprotein E4 (1-272) fragment induces tau Hyperphosphorylation and axonopathy via triggering endoplasmic reticulum stress. J Alzheimers Dis. 2019;71(2):597\u2013611.","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"922_CR298","doi-asserted-by":"publisher","first-page":"6654","DOI":"10.1021\/acsomega.0c04810","volume":"6","author":"J Kou","year":"2021","unstructured":"Kou J, Wang M, Shi J, et al. Curcumin reduces cognitive deficits by inhibiting neuroinflammation through the endoplasmic reticulum stress pathway in Apolipoprotein E4 transgenic mice. ACS Omega. 2021;6(10):6654\u201362.","journal-title":"ACS Omega"},{"issue":"20","key":"922_CR299","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1091\/mbc.e17-06-0423","volume":"28","author":"DW Sirkis","year":"2017","unstructured":"Sirkis DW, Aparicio RE, Schekman R. Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Mol Biol Cell. 2017;28(20):2723\u201333.","journal-title":"Mol Biol Cell"},{"issue":"4","key":"922_CR300","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","volume":"170","author":"TK Ulland","year":"2017","unstructured":"Ulland TK, Song WM, Huang SC, et al. TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease. Cell. 2017;170(4):649\u201363.e13.","journal-title":"Cell"},{"issue":"8","key":"922_CR301","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1021\/acschemneuro.9b00260","volume":"10","author":"M Aftabizadeh","year":"2019","unstructured":"Aftabizadeh M, Tatarek-Nossol M, Andreetto E, et al. Blocking inflammasome activation caused by \u03b2-amyloid peptide (A\u03b2) and islet amyloid polypeptide (IAPP) through an IAPP mimic. ACS Chem Neurosci. 2019;10(8):3703\u201317.","journal-title":"ACS Chem Neurosci"},{"key":"922_CR302","doi-asserted-by":"publisher","first-page":"105669","DOI":"10.1016\/j.intimp.2019.05.054","volume":"74","author":"Y Hong","year":"2019","unstructured":"Hong Y, Liu Y, Yu D, et al. The neuroprotection of progesterone against A\u03b2-induced NLRP3-caspase-1 inflammasome activation via enhancing autophagy in astrocytes. Int Immunopharmacol. 2019;74:105669.","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"922_CR303","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1080\/15548627.2017.1293766","volume":"13","author":"D Wang","year":"2017","unstructured":"Wang D, Zhang J, Jiang W, et al. The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability. Autophagy. 2017;13(5):914\u201327.","journal-title":"Autophagy"},{"issue":"1","key":"922_CR304","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12974-023-02698-w","volume":"20","author":"W Lin","year":"2023","unstructured":"Lin W, Li Z, Liang G, et al. TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer\u2019s disease via TFEB\/TFE3 activation. J Neuroinflammation. 2023;20(1):21.","journal-title":"J Neuroinflammation"},{"issue":"3","key":"922_CR305","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3233\/JAD-170634","volume":"60","author":"ME Ahmed","year":"2017","unstructured":"Ahmed ME, Iyer S, Thangavel R, et al. Co-localization of glia maturation factor with NLRP3 inflammasome and autophagosome markers in human Alzheimer\u2019s disease brain. J Alzheimers Dis. 2017;60(3):1143\u201360.","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"922_CR306","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1007\/s10787-025-01754-6","volume":"33","author":"RA Mohamed","year":"2025","unstructured":"Mohamed RA, Abdallah DM, El-Abhar HS. Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel targets of beta-hydroxybutyrate in HFFD\/LPS-induced sporadic Alzheimer\u2019s disease model. Inflammopharmacology. 2025;33(6):3461\u201377.","journal-title":"Inflammopharmacology"},{"issue":"4","key":"922_CR307","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","volume":"137","author":"IC Stancu","year":"2019","unstructured":"Stancu IC, Cremers N, Vanrusselt H, et al. Aggregated tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded tau pathology in vivo. Acta Neuropathol. 2019;137(4):599\u2013617.","journal-title":"Acta Neuropathol"},{"key":"922_CR308","doi-asserted-by":"publisher","first-page":"653334","DOI":"10.3389\/fnagi.2021.653334","volume":"13","author":"S Bandyopadhyay","year":"2021","unstructured":"Bandyopadhyay S. Role of neuron and glia in Alzheimer\u2019s disease and associated Vascular dysfunction. Front Aging Neurosci. 2021;13:653334.","journal-title":"Front Aging Neurosci"},{"key":"922_CR309","doi-asserted-by":"crossref","unstructured":"Zhang D, Zhang Y, Pan J, et al. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer\u2019s disease by maintaining the phagocytic function of microglia. CNS Neurosci Ther. 2023.","DOI":"10.1111\/cns.14219"},{"key":"922_CR310","doi-asserted-by":"publisher","first-page":"629891","DOI":"10.3389\/fnagi.2021.629891","volume":"13","author":"W Zhou","year":"2021","unstructured":"Zhou W, Xiao D, Zhao Y, et al. Enhanced autolysosomal function ameliorates the inflammatory response mediated by the NLRP3 inflammasome in Alzheimer\u2019s disease. Front Aging Neurosci. 2021;13:629891.","journal-title":"Front Aging Neurosci"},{"issue":"10","key":"922_CR311","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.4161\/auto.29647","volume":"10","author":"MH Cho","year":"2014","unstructured":"Cho MH, Cho K, Kang HJ, et al. Autophagy in microglia degrades extracellular \u03b2-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy. 2014;10(10):1761\u201375.","journal-title":"Autophagy"},{"key":"922_CR312","doi-asserted-by":"publisher","first-page":"102032","DOI":"10.1016\/j.pneurobio.2021.102032","volume":"202","author":"ZH Wang","year":"2021","unstructured":"Wang ZH, Xia Y, Liu P, et al. ApoE4 activates C\/EBP\u03b2\/\u03b4-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer\u2019s disease. Prog Neurobiol. 2021;202:102032.","journal-title":"Prog Neurobiol"},{"issue":"1","key":"922_CR313","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13024-025-00802-7","volume":"20","author":"S Wang","year":"2025","unstructured":"Wang S, Li B, Li J, et al. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and ad. Mol Neurodegener. 2025;20(1):15.","journal-title":"Mol Neurodegener"},{"issue":"1","key":"922_CR314","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13024-020-00382-8","volume":"15","author":"R Larramona-Arcas","year":"2020","unstructured":"Larramona-Arcas R, Gonz\u00e1lez-Arias C, Perea G, et al. Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice. Mol Neurodegener. 2020;15(1):35.","journal-title":"Mol Neurodegener"},{"issue":"2","key":"922_CR315","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3233\/JAD-150738","volume":"56","author":"T Persson","year":"2017","unstructured":"Persson T, Lattanzio F, Calvo-Garrido J, et al. Apolipoprotein E4 elicits lysosomal cathepsin D release, Decreased thioredoxin-1 levels, and apoptosis. J Alzheimers Dis. 2017;56(2):601\u201317.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"922_CR316","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cell.2024.10.027","volume":"188","author":"JL Guo","year":"2025","unstructured":"Guo JL, Braun D, Fitzgerald GA, et al. Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes. Cell. 2025;188(1):187\u2013206.e26.","journal-title":"Cell"},{"issue":"27","key":"922_CR317","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1523\/JNEUROSCI.2427-21.2022","volume":"42","author":"Q Shi","year":"2022","unstructured":"Shi Q, Chang C, Saliba A, et al. Microglial mTOR activation upregulates Trem2 and enhances \u03b2-amyloid plaque clearance in the 5XFAD Alzheimer\u2019s disease model. J Neurosci. 2022;42(27):5294\u2013313.","journal-title":"J Neurosci"},{"issue":"6","key":"922_CR318","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00401-023-02568-y","volume":"145","author":"F Filipello","year":"2023","unstructured":"Filipello F, You SF, Mirfakhar FS, et al. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathol. 2023;145(6):749\u201372.","journal-title":"Acta Neuropathol"},{"issue":"5","key":"922_CR319","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/15548627.2017.1390636","volume":"14","author":"J Liu","year":"2018","unstructured":"Liu J, Liu W, Lu Y, et al. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. 2018;14(5):845\u201361.","journal-title":"Autophagy"},{"issue":"4","key":"922_CR320","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/mds.27616","volume":"34","author":"A Schrag","year":"2019","unstructured":"Schrag A, Anastasiou Z, Ambler G, et al. Predicting diagnosis of Parkinson\u2019s disease: a risk algorithm based on primary care presentations. Mov Disord. 2019;34(4):480\u201386.","journal-title":"Mov Disord"},{"issue":"6","key":"922_CR321","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1084\/jem.20182191","volume":"216","author":"N Panicker","year":"2019","unstructured":"Panicker N, Sarkar S, Harischandra DS, et al. Fyn kinase regulates misfolded \u03b1-synuclein uptake and NLRP3 inflammasome activation in microglia. J Exp Med. 2019;216(6):1411\u201330.","journal-title":"J Exp Med"},{"key":"922_CR322","doi-asserted-by":"publisher","first-page":"548283","DOI":"10.3389\/fcell.2020.548283","volume":"8","author":"YM Jeon","year":"2020","unstructured":"Jeon YM, Kwon Y, Jo M, et al. The role of glial mitochondria in \u03b1-synuclein toxicity. Front Cell Dev Biol. 2020;8:548283.","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"922_CR323","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41419-024-07258-5","volume":"15","author":"V Vasquez","year":"2024","unstructured":"Vasquez V, Kodavati M, Mitra J, et al. Mitochondria-targeted oligomeric \u03b1-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson\u2019s disease and parkinsonism-dementia of Guam. Cell Death Dis. 2024;15(12):914.","journal-title":"Cell Death Dis"},{"issue":"2\u20133","key":"922_CR324","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0022-510X(90)90225-C","volume":"97","author":"BR Bloem","year":"1990","unstructured":"Bloem BR, Irwin I, Buruma OJ, et al. The MPTP model: versatile contributions to the treatment of idiopathic Parkinson\u2019s disease. J Neurol Sci. 1990;97(2\u20133):273\u201393.","journal-title":"J Neurol Sci"},{"key":"922_CR325","doi-asserted-by":"publisher","first-page":"794770","DOI":"10.3389\/fimmu.2021.794770","volume":"12","author":"R Que","year":"2021","unstructured":"Que R, Zheng J, Chang Z, et al. Dl-3-n-butylphthalide rescues dopaminergic neurons in Parkinson\u2019s disease models by inhibiting the NLRP3 inflammasome and ameliorating mitochondrial impairment. Front Immunol. 2021;12:794770.","journal-title":"Front Immunol"},{"key":"922_CR326","doi-asserted-by":"publisher","first-page":"106441","DOI":"10.1016\/j.intimp.2020.106441","volume":"83","author":"H Javed","year":"2020","unstructured":"Javed H, Thangavel R, Selvakumar GP, et al. NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson\u2019s disease. Int Immunopharmacol. 2020;83:106441.","journal-title":"Int Immunopharmacol"},{"key":"922_CR327","doi-asserted-by":"publisher","first-page":"116280","DOI":"10.1016\/j.ecoenv.2024.116280","volume":"276","author":"M Song","year":"2024","unstructured":"Song M, Qiang Y, Wang S, et al. High-fat diet exacerbates 1-bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway. Ecotoxicol Environ Saf. 2024;276:116280.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"922_CR328","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s11481-019-09843-4","volume":"14","author":"S Yao","year":"2019","unstructured":"Yao S, Li L, Sun X, et al. FTY720 inhibits MPP+-induced microglial activation by affecting NLRP3 inflammasome activation. J Neuroimmune Pharmacol. 2019;14(3):478\u201392 .","journal-title":"J Neuroimmune Pharmacol"},{"key":"922_CR329","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bbi.2020.09.017","volume":"91","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Kwatra M, Ranjan Panda S, et al. Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain Behav Immun. 2021;91:142\u201358.","journal-title":"Brain Behav Immun"},{"key":"922_CR330","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbi.2019.07.009","volume":"81","author":"ZL Hu","year":"2019","unstructured":"Hu ZL, Sun T, Lu M, et al. Kir6.1\/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson\u2019s disease via promoting mitophagy. Brain Behav Immun. 2019;81:509\u201322.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"922_CR331","doi-asserted-by":"publisher","first-page":"8446","DOI":"10.1038\/s41598-018-26603-1","volume":"8","author":"IG Rodrigue-Gervais","year":"2018","unstructured":"Rodrigue-Gervais IG, Doiron K, Champagne C, et al. The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. Sci Rep. 2018;8(1):8446.","journal-title":"Sci Rep"},{"issue":"12","key":"922_CR332","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nrn2935","volume":"11","author":"MR Cookson","year":"2010","unstructured":"Cookson MR. The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson\u2019s disease. Nat Rev Neurosci. 2010;11(12):791\u201397.","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"922_CR333","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1093\/hmg\/dds003","volume":"21","author":"X Wang","year":"2012","unstructured":"Wang X, Yan MH, Fujioka H, et al. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet. 2012;21(9):1931\u201344.","journal-title":"Hum Mol Genet"},{"key":"922_CR334","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mito.2023.09.002","volume":"73","author":"J Xue","year":"2023","unstructured":"Xue J, Zhang J, Zhang J, et al. The Parkinson\u2019s disease-associated mutation LRRK2 G2385R alters mitochondrial biogenesis via the PGC-1\u03b1-TFAM pathway. Mitochondrion. 2023;73:10\u201318.","journal-title":"Mitochondrion"},{"issue":"2","key":"922_CR335","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41582-019-0301-2","volume":"16","author":"E Tolosa","year":"2020","unstructured":"Tolosa E, Vila M, Klein C, et al. LRRK2 in Parkinson disease: challenges of clinical trials. Nat Rev Neurol. 2020;16(2):97\u2013107.","journal-title":"Nat Rev Neurol"},{"issue":"22","key":"922_CR336","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1212\/WNL.0b013e3181ff9685","volume":"75","author":"H Mortiboys","year":"2010","unstructured":"Mortiboys H, Johansen KK, Aasly JO, et al. Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2. Neurology. 2010;75(22):2017\u201320.","journal-title":"Neurology"},{"issue":"11","key":"922_CR337","doi-asserted-by":"publisher","first-page":"108130","DOI":"10.1016\/j.isci.2023.108130","volume":"26","author":"KJ He","year":"2023","unstructured":"He KJ, Zhang JB, Liu JY, et al. LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric \u03b1-synuclein through NF-\u03baB pathway. iScience. 2023;26(11):108130.","journal-title":"iScience"},{"issue":"17","key":"922_CR338","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1016\/j.cell.2022.06.038","volume":"185","author":"CG Weindel","year":"2022","unstructured":"Weindel CG, Martinez EL, Zhao X, et al. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell. 2022;185(17):3214\u201331.e23.","journal-title":"Cell"},{"issue":"1","key":"922_CR339","doi-asserted-by":"publisher","first-page":"17293","DOI":"10.1038\/s41598-020-74195-6","volume":"10","author":"CP Gonzalez-Hunt","year":"2020","unstructured":"Gonzalez-Hunt CP, Thacker EA, Toste CM, et al. Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson\u2019s disease. Sci Rep. 2020;10(1):17293.","journal-title":"Sci Rep"},{"issue":"2","key":"922_CR340","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ajpath.2012.10.027","volume":"182","author":"SJ Cherra 3rd","year":"2013","unstructured":"Cherra SJ 3rd, Steer E, Gusdon AM, et al. Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol. 2013;182(2):474\u201384.","journal-title":"Am J Pathol"},{"issue":"1","key":"922_CR341","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40478-019-0716-4","volume":"7","author":"JH Lee","year":"2019","unstructured":"Lee JH, Han JH, Kim H, et al. Parkinson\u2019s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control er stress in astrocytes. Acta Neuropathol Commun. 2019;7(1):68.","journal-title":"Acta Neuropathol Commun"},{"issue":"22","key":"922_CR342","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1093\/hmg\/ddt301","volume":"22","author":"YC Su","year":"2013","unstructured":"Su YC, Qi X. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013;22(22):4545\u201361.","journal-title":"Hum Mol Genet"},{"issue":"19","key":"922_CR343","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1093\/hmg\/ddz126","volume":"28","author":"JA Korecka","year":"2019","unstructured":"Korecka JA, Thomas R, Christensen DP, et al. Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson\u2019s disease patient fibroblasts. Hum Mol Genet. 2019;28(19):3232\u201343.","journal-title":"Hum Mol Genet"},{"key":"922_CR344","doi-asserted-by":"crossref","unstructured":"Salem HA, Abu-Elfotuh K, Alzahrani S, et al. Punicalagin\u2019s protective effects on Parkinson\u2019s progression in socially isolated and socialized rats: insights into multifaceted pathway. Pharmaceutics. 2023;15(10).","DOI":"10.3390\/pharmaceutics15102420"},{"key":"922_CR345","doi-asserted-by":"publisher","first-page":"661505","DOI":"10.3389\/fnagi.2021.661505","volume":"13","author":"M Samidurai","year":"2021","unstructured":"Samidurai M, Palanisamy BN, Bargues-Carot A, et al. PKC delta activation promotes endoplasmic reticulum stress (ERS) and NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation subsequent to asynuclein-induced microglial activation: involvement of thioredoxin-interacting protein (Txnip)\/thioredoxin (Trx) redoxisome pathway. Front Aging Neurosci. 2021;13:661505.","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"922_CR346","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.neurobiolaging.2013.08.015","volume":"35","author":"M Lu","year":"2014","unstructured":"Lu M, Sun XL, Qiao C, et al. Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation. Neurobiol Aging. 2014;35(2):421\u201330.","journal-title":"Neurobiol Aging"},{"issue":"8","key":"922_CR347","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00011-020-01355-9","volume":"69","author":"J Wang","year":"2020","unstructured":"Wang J, Zheng B, Yang S, et al. The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes. Inflamm Res. 2020;69(8):779\u201387.","journal-title":"Inflamm Res"},{"issue":"7","key":"922_CR348","doi-asserted-by":"publisher","first-page":"e3001287","DOI":"10.1371\/journal.pbio.3001287","volume":"19","author":"A Dilsizoglu Senol","year":"2021","unstructured":"Dilsizoglu Senol A, Samarani M, Syan S, et al. \u03b1-synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes. PLoS Biol. 2021;19(7):e3001287.","journal-title":"PLoS Biol"},{"key":"922_CR349","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-016-0094-3","volume":"11","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Lu M, Du RH, et al. MicroRNA-7 targets nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson\u2019s disease. Mol Neurodegener. 2016;11:28.","journal-title":"Mol Neurodegener"},{"key":"922_CR350","doi-asserted-by":"crossref","unstructured":"Ren Z, Ding H, Zhou M, et al. Ganoderma lucidum modulates inflammatory responses following 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration in mice. Nutrients. 2022;14(18).","DOI":"10.3390\/nu14183872"},{"issue":"7","key":"922_CR351","doi-asserted-by":"publisher","first-page":"104879","DOI":"10.1016\/j.jbc.2023.104879","volume":"299","author":"E Pajarillo","year":"2023","unstructured":"Pajarillo E, Kim S, Digman A, et al. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023;299(7):104879.","journal-title":"J Biol Chem"},{"issue":"21","key":"922_CR352","doi-asserted-by":"publisher","first-page":"9879","DOI":"10.1073\/pnas.1004676107","volume":"107","author":"Y Tong","year":"2010","unstructured":"Tong Y, Yamaguchi H, Giaime E, et al. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A. 2010;107(21):9879\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"922_CR353","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/cns.12514","volume":"22","author":"C Qiao","year":"2016","unstructured":"Qiao C, Yin N, Gu HY, et al. Atp13a2 deficiency aggravates astrocyte-mediated neuroinflammation via NLRP3 inflammasome activation. CNS Neurosci Ther. 2016;22(6):451\u201360.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"922_CR354","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12974-023-02989-2","volume":"20","author":"H Zhu","year":"2023","unstructured":"Zhu H, Xiao F, Xiao Y, et al. Targeting CB2R in astrocytes for Parkinson\u2019s disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation. J Neuroinflammation. 2023;20(1):304.","journal-title":"J Neuroinflammation"},{"key":"922_CR355","doi-asserted-by":"publisher","first-page":"116673","DOI":"10.1016\/j.biopha.2024.116673","volume":"175","author":"A Shadab","year":"2024","unstructured":"Shadab A, Abbasi-Kolli M, Saharkhiz M, et al. The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: therapeutic implications and animal model studies. Biomed Pharmacother. 2024;175:116673.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"922_CR356","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12974-025-03453-z","volume":"22","author":"L Yang","year":"2025","unstructured":"Yang L, Hu C, Chen X, et al. Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation. J Neuroinflammation. 2025;22(1):126.","journal-title":"J Neuroinflammation"},{"issue":"3","key":"922_CR357","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41593-025-01875-9","volume":"28","author":"A Kadowaki","year":"2025","unstructured":"Kadowaki A, Wheeler MA, Li Z, et al. CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model. Nat Neurosci. 2025;28(3):470\u201386.","journal-title":"Nat Neurosci"},{"key":"922_CR358","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fimmu.2020.00161","volume":"11","author":"G Gao","year":"2020","unstructured":"Gao G, Li C, Zhu J, et al. Glutaminase 1 regulates neuroinflammation after Cerebral ischemia through enhancing microglial activation and pro-inflammatory exosome release. Front Immunol. 2020;11:161.","journal-title":"Front Immunol"},{"key":"922_CR359","doi-asserted-by":"publisher","first-page":"109133","DOI":"10.1016\/j.intimp.2022.109133","volume":"112","author":"X Zhang","year":"2022","unstructured":"Zhang X, Wang G, Bi Y, et al. Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR\/P70S6K\/4EBP1 and NLRP3\/caspase-1\/IL-1\u03b2 pathways in MRL\/lpr mice. Int Immunopharmacol. 2022;112:109133.","journal-title":"Int Immunopharmacol"},{"issue":"7745","key":"922_CR360","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41586-019-0903-2","volume":"566","author":"S J\u00e4kel","year":"2019","unstructured":"J\u00e4kel S, Agirre E, Mendanha Falc\u00e3o A, et al. Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature. 2019;566(7745):543\u201347.","journal-title":"Nature"},{"issue":"1","key":"922_CR361","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12964-023-01447-z","volume":"22","author":"DJ Byun","year":"2024","unstructured":"Byun DJ, Lee J, Ko K, et al. NLRP3 exacerbates EAE severity through ROS-dependent net formation in the mouse brain. Cell Commun Signal. 2024;22(1):96.","journal-title":"Cell Commun Signal"},{"key":"922_CR362","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3389\/fphys.2013.00169","volume":"4","author":"K Su","year":"2013","unstructured":"Su K, Bourdette D, Forte M. Mitochondrial dysfunction and neurodegeneration in multiple sclerosis. Front Physiol. 2013;4:169.","journal-title":"Front Physiol"},{"key":"922_CR363","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.freeradbiomed.2025.06.055","volume":"238","author":"N Zhang","year":"2025","unstructured":"Zhang N, Zhang S, Liu X, et al. Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice. Free Radic Biol Med. 2025;238:370\u201386.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"922_CR364","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00011-024-01856-x","volume":"73","author":"SR Zack","year":"2024","unstructured":"Zack SR, Venkatesan M, Nikolaienko R, et al. Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction. Inflamm Res. 2024;73(4):563\u201380.","journal-title":"Inflamm Res"},{"issue":"5","key":"922_CR365","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s11910-009-0060-3","volume":"9","author":"KG Su","year":"2009","unstructured":"Su KG, Banker G, Bourdette D, et al. Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep. 2009;9(5):411\u201317.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"922_CR366","doi-asserted-by":"crossref","unstructured":"Pukoli D, V\u00e9csei L. Kynurenines and mitochondrial disturbances in multiple sclerosis. Int J Mol Sci. 2025;26(11).","DOI":"10.3390\/ijms26115098"},{"key":"922_CR367","doi-asserted-by":"publisher","first-page":"102002","DOI":"10.1016\/j.mito.2024.102002","volume":"81","author":"R Rahimi Darehbagh","year":"2025","unstructured":"Rahimi Darehbagh R, Khanmohammadi S, Rezaei N. The role of mitochondrial DNA variants and dysfunction in the pathogenesis and progression of multiple sclerosis. Mitochondrion. 2025;81:102002.","journal-title":"Mitochondrion"},{"key":"922_CR368","doi-asserted-by":"publisher","first-page":"102550","DOI":"10.1016\/j.redox.2022.102550","volume":"59","author":"S Bhaskaran","year":"2023","unstructured":"Bhaskaran S, Kumar G, Thadathil N, et al. Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Redox Biol. 2023;59:102550.","journal-title":"Redox Biol"},{"issue":"19","key":"922_CR369","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.2174\/0929867324666170316114452","volume":"24","author":"E Fetisova","year":"2017","unstructured":"Fetisova E, Chernyak B, Korshunova G, et al. Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosis. Curr Med Chem. 2017;24(19):2086\u2013114.","journal-title":"Curr Med Chem"},{"issue":"3","key":"922_CR370","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s10787-023-01186-0","volume":"31","author":"S Stra\u00df","year":"2023","unstructured":"Stra\u00df S, Geiger J, Cloos N, et al. Immune cell targeted fumaric esters support a role of GPR109A as a primary target of monomethyl fumarate in vivo. Inflammopharmacology. 2023;31(3):1223\u201339.","journal-title":"Inflammopharmacology"},{"issue":"13","key":"922_CR371","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/j.molcel.2023.05.018","volume":"83","author":"SPT Yiu","year":"2023","unstructured":"Yiu SPT, Zerbe C, Vanderwall D, et al. An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation. Mol Cell. 2023;83(13):2367\u201386.e15.","journal-title":"Mol Cell"},{"issue":"10360","key":"922_CR372","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","volume":"400","author":"EL Feldman","year":"2022","unstructured":"Feldman EL, Goutman SA, Petri S, et al. Amyotrophic lateral sclerosis. Lancet. 2022;400(10360):1363\u201380.","journal-title":"Lancet"},{"key":"922_CR373","doi-asserted-by":"crossref","unstructured":"Fu RH, Chen HJ, Hong SY. Glycine-alanine dipeptide repeat protein from C9-ALS interacts with sulfide quinone oxidoreductase (SQOR) to induce the activity of the NLRP3 inflammasome in HMC3 microglia: irisflorentin reverses this interaction. Antioxid (basel). 2023;12(10).","DOI":"10.3390\/antiox12101896"},{"issue":"1","key":"922_CR374","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1038\/s41467-019-11441-0","volume":"10","author":"JJ Siew","year":"2019","unstructured":"Siew JJ, Chen HM, Chen HY, et al. Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington\u2019s disease. Nat Commun. 2019;10(1):3473.","journal-title":"Nat Commun"},{"issue":"11","key":"922_CR375","doi-asserted-by":"publisher","first-page":"e2208571","DOI":"10.1002\/adma.202208571","volume":"35","author":"J Zhang","year":"2023","unstructured":"Zhang J, Gao B, Ye B, et al. Mitochondrial-targeted delivery of polyphenol-mediated Antioxidases complexes against pyroptosis and inflammatory diseases. Adv Mater. 2023;35(11):e2208571.","journal-title":"Adv Mater"},{"key":"922_CR376","doi-asserted-by":"publisher","first-page":"102816","DOI":"10.1016\/j.redox.2023.102816","volume":"65","author":"BR Jin","year":"2023","unstructured":"Jin BR, Lim CY, Kim HJ, et al. Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR-NLRP3 pathway. Redox Biol. 2023;65:102816.","journal-title":"Redox Biol"},{"issue":"5","key":"922_CR377","first-page":"3800","volume":"17","author":"H Zhou","year":"2019","unstructured":"Zhou H, Ye M, Xu W, et al. DL-3-n-butylphthalide therapy for Parkinson\u2019s disease: a randomized controlled trial. Exp Ther Med. 2019;17(5):3800\u201306.","journal-title":"Exp Ther Med"}],"container-title":["Molecular Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13024-025-00922-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-025-00922-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13024-025-00922-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:02:47Z","timestamp":1781625767000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13024-025-00922-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":377,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["922"],"URL":"https:\/\/doi.org\/10.1186\/s13024-025-00922-0","relation":{},"ISSN":["1750-1326"],"issn-type":[{"value":"1750-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,3]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors are consent to the publication of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}