{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:17:02Z","timestamp":1782789422521,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Agents Cancer"],"DOI":"10.1186\/s13027-025-00638-2","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:45:51Z","timestamp":1739997951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Epstein-Barr virus and CD lymphocytes on the prognosis of patients with advanced nasopharyngeal carcinoma"],"prefix":"10.1186","volume":"20","author":[{"given":"Fangchu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"638_CR1","doi-asserted-by":"publisher","unstructured":"Chen YP, Chan ATC, Le QT et al. Nasopharyngeal carcinoma[J]. The Lancet, 2019;394(10192):64\u201380.https:\/\/doi.org\/10.1016\/S0140-6736(19)30956-0","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"638_CR2","unstructured":"Wei KR, Zheng RS, Zhang SW. Analysis of the incidence and mortality of nasopharyngeal carcinoma in China in 2013 [J]. Cancer, 2018(4):9. CNKI: SUN: AIZH. 0.2018-04-005."},{"issue":"3","key":"638_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","journal-title":"CA Cancer J Clin"},{"issue":"34","key":"638_CR4","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.12114\/j.issn.1007-9572.2023.0247","volume":"26","author":"WP Zhu","year":"2023","unstructured":"Zhu WP, Han MQ, Wang YX, et al. Study on the Trend and Prediction of Nasopharyngeal Cancer incidence and death in China from 1990 to 2019 [J]. Chin J Gen Pract. 2023;26(34):4269\u201376. https:\/\/doi.org\/10.12114\/j.issn.1007-9572.2023.0247.","journal-title":"Chin J Gen Pract"},{"issue":"11","key":"638_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3760\/cmA.j.cn113030-20200220-00065","volume":"30","author":"ML He","year":"2021","unstructured":"He ML, Yi JL. Current status of treatment for recurrent nasopharyngeal carcinoma [J]. Chin J Radiation Oncol. 2021;30(11):7. https:\/\/doi.org\/10.3760\/cmA.j.cn113030-20200220-00065.","journal-title":"Chin J Radiation Oncol"},{"issue":"1","key":"638_CR6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41579-022-00770-5","volume":"21","author":"SS Soldan","year":"2023","unstructured":"Soldan SS, Lieberman PM. Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol. 2023;21(1):51\u201364. https:\/\/doi.org\/10.1038\/s41579-022-00770-5.","journal-title":"Nat Rev Microbiol"},{"key":"638_CR7","doi-asserted-by":"publisher","unstructured":"Yang J, Liu Z, Zeng B, et al. Epstein-Barr virus-associated gastric cancer: a distinct subtype[J]. Cancer Lett. 2020;495. https:\/\/doi.org\/10.1016\/j.canlet.2020.09.019.","DOI":"10.1016\/j.canlet.2020.09.019"},{"issue":"20","key":"638_CR8","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1016\/j.cell.2022.08.026","volume":"185","author":"B Damania","year":"2022","unstructured":"Damania B, Kenney SC, Raab-Traub N. Epstein-Barr virus: Biology and clinical disease. Cell. 2022;185(20):3652\u201370. https:\/\/doi.org\/10.1016\/j.cell.2022.08.026.","journal-title":"Cell"},{"issue":"3","key":"638_CR9","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3390\/v15030714","volume":"15","author":"H Yu","year":"2023","unstructured":"Yu H, Robertson ES. Epstein-Barr Virus History and Pathogenesis. Viruses. 2023;15(3):714. https:\/\/doi.org\/10.3390\/v15030714.","journal-title":"Viruses"},{"issue":"12","key":"638_CR10","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1002\/hed.22008","volume":"34","author":"JR He","year":"2012","unstructured":"He JR, Shen GP, Ren ZF, Qin H, Cui C, Zhang Y, Zeng YX, Jia WH. Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck. 2012;34(12):1769\u201376. https:\/\/doi.org\/10.1002\/hed.22008.","journal-title":"Head Neck"},{"issue":"11","key":"638_CR11","doi-asserted-by":"publisher","first-page":"9992","DOI":"10.18632\/oncotarget.24173","volume":"9","author":"Y Jiang","year":"2018","unstructured":"Jiang Y, Qu S, Pan X, Huang S, Zhu X. Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma. Oncotarget. 2018;9(11):9992\u201310004. https:\/\/doi.org\/10.18632\/oncotarget.24173.","journal-title":"Oncotarget"},{"key":"638_CR12","unstructured":"Medical Immunology\/Gong Feili (Ed.-4). Beijing, China. Science Press. 2014.8. ISBN 978-07-03-041594-3."},{"issue":"1","key":"638_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12105-022-01449-2","volume":"16","author":"C Badoual","year":"2022","unstructured":"Badoual C. Update from the 5th Edition of the World Health Organization Classification of Head and Neck tumors: Oropharynx and Nasopharynx. Head Neck Pathol. 2022;16(1):19\u201330. https:\/\/doi.org\/10.1007\/s12105-022-01449-2.","journal-title":"Head Neck Pathol"},{"issue":"4","key":"638_CR14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/cncr.29795","volume":"122","author":"JJ Pan","year":"2016","unstructured":"Pan JJ, Ng WT, Zong JF, et al. Proposal for the 8th edition of the AJCC\/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy. Cancer. 2016;122(4):546\u201358. https:\/\/doi.org\/10.1002\/cncr.29795.","journal-title":"Cancer"},{"key":"638_CR15","unstructured":"Chinese Medical Association Radiation Oncology Therapy Physician Branch, Chinese Medical Association Radiation Oncology Therapy Branch. Chinese nasopharyngeal Cancer Radiotherapy Guidelines (2022 Edition) [J]. Chin J Cancer Prev Treat, 2022(009):029."},{"key":"638_CR16","doi-asserted-by":"publisher","first-page":"860700","DOI":"10.3389\/fonc.2022.860700","volume":"12","author":"GY Liu","year":"2022","unstructured":"Liu GY, Xia WX, Bi ZF, Lu N, Li WZ, Bei WX, Liang H, Xie JZ, Liu YM, Yao HR, Xiang YQ. Plasma circulating Tumor Epstein-Barr Virus for the Surveillance of Cancer Progression in bone-only metastatic nasopharyngeal carcinoma. Front Oncol. 2022;12:860700. https:\/\/doi.org\/10.3389\/fonc.2022.860700.","journal-title":"Front Oncol"},{"issue":"6","key":"638_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3971\/j.issn.1000-8578.2021.20.1402","volume":"48","author":"XL Wei","year":"2021","unstructured":"Wei XL, Lan M, Peng XH, et al. The correlation between immune function status and EBV DNA in nasopharyngeal carcinoma patients and its impact on prognosis [J]. Cancer Prev Treat Res. 2021;48(6):7. https:\/\/doi.org\/10.3971\/j.issn.1000-8578.2021.20.1402.","journal-title":"Cancer Prev Treat Res"},{"key":"638_CR18","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41418-022-00939-8","volume":"29","author":"L Yuan","year":"2022","unstructured":"Yuan L, Li S, Chen QY, et al. EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma[J]. Cell Death Differ. 2022;29:1513\u201327. https:\/\/doi.org\/10.1038\/s41418-022-00939-8.","journal-title":"Cell Death Differ"},{"key":"638_CR19","doi-asserted-by":"publisher","unstructured":"Hu J, Li Y, Li H, Shi F, Xie L, Zhao L, Tang M, Luo X, Jia W, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Liao W, Bode AM, Cao Y. Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy. Theranostics. 2020;10(26):11921\u201311937. doi: 10.7150\/thno.46006. Erratum in: Theranostics. 2022;12(8):3609. https:\/\/doi.org\/10.7150\/thno.73630","DOI":"10.7150\/thno.73630"},{"issue":"5","key":"638_CR20","doi-asserted-by":"publisher","first-page":"e0178423","DOI":"10.1128\/mbio.01784-23","volume":"14","author":"F Baccianti","year":"2023","unstructured":"Baccianti F, Masson C, Delecluse S, Li Z, Poirey R, Delecluse H-J. Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response. mBio. 2023;14(5):e0178423. https:\/\/doi.org\/10.1128\/mbio.01784-23.","journal-title":"mBio"},{"issue":"17","key":"638_CR21","doi-asserted-by":"publisher","first-page":"e01215","DOI":"10.1128\/JVI.01215-20","volume":"94","author":"KD Yetming","year":"2020","unstructured":"Yetming KD, Lupey-Green LN, Biryukov S, Hughes DJ, Marendy EM, Miranda JL, Sample JT. The BHLF1 locus of Epstein-Barr Virus contributes to viral latency and B-Cell immortalization. J Virol. 2020;94(17):e01215\u201320. https:\/\/doi.org\/10.1128\/JVI.01215-20.","journal-title":"J Virol"},{"issue":"13","key":"638_CR22","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1158\/1078-0432.CCR-19-3211","volume":"26","author":"SS Kim","year":"2020","unstructured":"Kim SS, Shen S, Miyauchi S, Sanders PD, Franiak-Pietryga I, Mell L, Gutkind JS, Cohen EEW, Califano JA, Sharabi AB. B cells improve overall survival in HPV-Associated squamous cell carcinomas and are activated by Radiation and PD-1 blockade. Clin Cancer Res. 2020;26(13):3345\u201359. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-3211.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"638_CR23","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.7314\/apjcp.2012.13.5.2219","volume":"13","author":"QM Yu","year":"2012","unstructured":"Yu QM, Yu CD, Ling ZQ. Elevated circulating CD19\u2009+\u2009lymphocytes predict survival advantage in patients with gastric cancer. Asian Pac J Cancer Prev. 2012;13(5):2219\u201324. https:\/\/doi.org\/10.7314\/apjcp.2012.13.5.2219.","journal-title":"Asian Pac J Cancer Prev"},{"key":"638_CR24","doi-asserted-by":"publisher","first-page":"935749","DOI":"10.3389\/fgene.2022.935749","volume":"13","author":"YM Huang","year":"2022","unstructured":"Huang YM, Wang LQ, Liu Y, Tang FQ, Zhang WL. Integrated analysis of bulk and single-cell RNA sequencing reveals the interaction of PKP1 and tumor-infiltrating B cells and their therapeutic potential for nasopharyngeal carcinoma. Front Genet. 2022;13:935749. https:\/\/doi.org\/10.3389\/fgene.2022.935749.","journal-title":"Front Genet"}],"container-title":["Infectious Agents and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13027-025-00638-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13027-025-00638-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13027-025-00638-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:46:00Z","timestamp":1739997960000},"score":1,"resource":{"primary":{"URL":"https:\/\/infectagentscancer.biomedcentral.com\/articles\/10.1186\/s13027-025-00638-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["638"],"URL":"https:\/\/doi.org\/10.1186\/s13027-025-00638-2","relation":{},"ISSN":["1750-9378"],"issn-type":[{"value":"1750-9378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"5 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was reviewed and approved by the Ethics Committee of Ganzhou People\u2019s Hospital. (TY-ZKY2024-069-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient to publish this report in accordance with the journal\u2019s patient consent policy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}