{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:07:30Z","timestamp":1760080050869,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Norwegian Reindeer Development Fund"},{"name":"Nordic Council of Ministers NORDREGIO"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Vet Scand"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13028-017-0291-2","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T13:31:43Z","timestamp":1493040703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer"],"prefix":"10.1186","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-5196","authenticated-orcid":false,"given":"Morten","family":"Tryland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier S\u00e1nchez","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Marcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingebj\u00f8rg Helena","family":"Nymo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terje Domaas","family":"Josefsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Kristine","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torill","family":"M\u00f8rk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"291_CR1","first-page":"145","volume":"2","author":"A Bergman","year":"1912","unstructured":"Bergman A. Contagious keratitis in reindeer. Scand Vet J. 1912;2:145\u201377.","journal-title":"Scand Vet J."},{"key":"291_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7557\/2.15.1.1151","volume":"15","author":"C Rehbinder","year":"1995","unstructured":"Rehbinder C, Nilsson A. An outbreak of kerato-conjunctivitis among corralled, supplementary fed, semi-domesticated reindeer calves. Rangifer. 1995;15:9\u201314.","journal-title":"Rangifer"},{"key":"291_CR3","unstructured":"Oksanen A. Keratoconjunctivitis in a corralled reindeer. Proceedings of the seventh Nordic Workshop on Reindeer Research. Rangifer Report. 1993;1:50."},{"key":"291_CR4","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1128\/JCM.01198-09","volume":"47","author":"M Tryland","year":"2009","unstructured":"Tryland M, das Neves CG, Sunde M, M\u00f8rk T. Cervid herpesvirus 2 the primary agent in an outbreak of infectious keratoconjunctivitis in semidomesticated reindeer. J Clin Microbiol. 2009;47:3707\u201313. doi: 10.1128\/JCM.01198-09 .","journal-title":"J Clin Microbiol."},{"key":"291_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cvfa.2014.11.006","volume":"31","author":"JA Angelos","year":"2015","unstructured":"Angelos JA. Infectious bovine keratoconjunctivitis (pinkeye). Vet Clin North Am Food Anim Pract. 2015;31:61\u201379.","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"291_CR6","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1099\/ijs.0.64333-0","volume":"57","author":"JA Angelos","year":"2007","unstructured":"Angelos JA, Spinks PQ, Ball LM, George LW. Moraxella bovoculi sp. nov., isolated from calves with infectious bovine keratoconjunctivitis. Int J Syst Evol Microbiol. 2007;57:789\u201395.","journal-title":"Int J Syst Evol Microbiol"},{"key":"291_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cvfa.2009.10.002","volume":"26","author":"JA Angelos","year":"2010","unstructured":"Angelos JA. Moraxella bovoculi and infectious bovine keratoconjunctivitis: cause or coincidence? Vet Clin North Am Food Anim Pract. 2010;26:73\u20138. doi: 10.1016\/j.cvfa.2009.10.002 .","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"291_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1751-0147-45-19","volume":"45","author":"J \u00c5kerstedt","year":"2004","unstructured":"\u00c5kerstedt J, Hofshagen M. Bacteriological investigation of infectious keratoconjunctivitis in Norwegian sheep. Acta Vet Scand. 2004;45:19\u201326.","journal-title":"Acta Vet Scand"},{"key":"291_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/lam.12362","volume":"60","author":"S Gupta","year":"2015","unstructured":"Gupta S, Chahota R, Bhardwaj B, Malik P, Verma S, Sharma M. Identification of Chlamydia and Mycoplasma species in ruminants with ocular infections. Lett Appl Microbiol. 2015;60:135\u20139. doi: 10.1111\/lam.12362 .","journal-title":"Lett Appl Microbiol"},{"key":"291_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.7589\/0090-3558-36.2.241","volume":"36","author":"SA Dubay","year":"2000","unstructured":"Dubay SA, Williams ES, Mills K, Boerger-Fields AM. Association of Moraxella ovis with keratoconjunctivitis in mule deer and moose in Wyoming. J Wildl Dis. 2000;36:241\u20137.","journal-title":"J Wildl Dis"},{"key":"291_CR11","doi-asserted-by":"publisher","first-page":"335","DOI":"10.20506\/rst.21.2.1338","volume":"21","author":"M Giacometti","year":"2002","unstructured":"Giacometti M, Janovsky M, Belloy L, Frey J. Infectious keratoconjunctivitis of ibex, chamois and other caprinae. Rev Sci Tech. 2002;21:335\u201345.","journal-title":"Rev Sci Tech"},{"key":"291_CR12","first-page":"257","volume":"44","author":"C Gort\u00e1zar","year":"1998","unstructured":"Gort\u00e1zar C, Fern\u00e1ndez-de-Luco D, Fr\u00f6lich K. Keratoconjunctivitis in a free-ranging red deer (Cervus elaphus) population in Spain. Z Jagdwiss. 1998;44:257\u201361.","journal-title":"Z Jagdwiss."},{"key":"291_CR13","doi-asserted-by":"publisher","first-page":"619","DOI":"10.7589\/0090-3558-48.3.619","volume":"48","author":"F Mavrot","year":"2012","unstructured":"Mavrot F, Vilei EM, Marreros N, Signer C, Frey J, Ryser-Degiorgis MP. Occurrence, quantification and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis. J Wildl Dis. 2012;48:619\u201331.","journal-title":"J Wildl Dis"},{"key":"291_CR14","first-page":"854","volume":"67","author":"J Grymer","year":"1984","unstructured":"Grymer J. Infekti\u00f8s bovin keratokonjunktivitis hos kv\u00e6g og r\u00e5dyr. Dansk Vet Tidsskr. 1984;67:854\u20136.","journal-title":"Dansk Vet Tidsskr"},{"key":"291_CR15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/BF03547947","volume":"17","author":"K Kummeneje","year":"1976","unstructured":"Kummeneje K. Isolation of Neisseria ovis and a Colesiota conjunctivae-like organism from cases of kerato-conjunctivitis in reindeer in northern Norway. Acta Vet Scand. 1976;17:107\u20138.","journal-title":"Acta Vet Scand"},{"key":"291_CR16","first-page":"295","volume":"110","author":"A Aschfalk","year":"2003","unstructured":"Aschfalk A, Josefsen TD, Steingass H, M\u00fcller W, Goethe R. Crowding and winter emergency feeding as predisposing factors for kerato-conjunctivitis in semi-domesticated reindeer in Norway. Dtsch Tierarztl Wochenschr. 2003;110:295\u20138.","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"291_CR17","unstructured":"Sanchez Romano J, Marcin N, Josefsen TD, Nymo IH, S\u00f8rensen KK, Tryland M. Severe transmissible eye infection in reindeer: bacterium or virus? 64th Annual International Conference of the Wildlife Disease Association, Queensland; 2015. p. 26\u201330 (abstract 45, page 13)."},{"key":"291_CR18","volume-title":"Reindriften og dens naturgrunnlag","author":"S Skjenneberg","year":"1968","unstructured":"Skjenneberg S, Slagsvold L. Reindriften og dens naturgrunnlag. Oslo: Universitetsforlaget; 1968."},{"key":"291_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13028-016-0203-x","volume":"58","author":"M Tryland","year":"2016","unstructured":"Tryland M, Stubsj\u00f8en SM, \u00c5gren E, Johansen B, Kielland C. Herding conditions related to infectious keratoconjunctivitis (IKC) in semi-domesticated reindeer (Rangifer t. tarandus) in Norway and Sweden\u2014a questionnaire-based survey among reindeer herders. Acta Vet Scand. 2016;58:22. doi: 10.1186\/s13028-016-0203-x .","journal-title":"Acta Vet Scand"},{"key":"291_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2460\/ajvr.2001.62.119","volume":"62","author":"KA Ryeng","year":"2001","unstructured":"Ryeng KA, Arnemo JM, Larsen S. Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer. Am J Vet Res. 2001;62:119\u201326.","journal-title":"Am J Vet Res"},{"key":"291_CR21","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/JCM.37.5.1247-1253.1999","volume":"37","author":"C Ros","year":"1999","unstructured":"Ros C, Belak S. Studies of genetic relationships between bovine, caprine, cervine, and rangiferine alphaherpesviruses and improved molecular methods for virus detection and identification. J Clin Microbiol. 1999;37:1247\u201353.","journal-title":"J Clin Microbiol"},{"key":"291_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1023\/A:1014504730475","volume":"24","author":"C Ros","year":"2002","unstructured":"Ros C, Belak S. Characterization of the glycoprotein B gene from ruminant alphaherpesviruses. Virus Genes. 2002;24:99\u2013105.","journal-title":"Virus Genes"},{"key":"291_CR23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/BF03548174","volume":"27","author":"C Ek-Kommonen","year":"1986","unstructured":"Ek-Kommonen C, Pelkonen S, Nettleton PF. Isolation of a herpesvirus serologically related to bovine herpesvirus 1 from a reindeer (Rangifer tarandus). Acta Vet Scand. 1986;27:299\u2013301.","journal-title":"Acta Vet Scand"},{"key":"291_CR24","first-page":"790","volume":"45","author":"JM Miller","year":"1984","unstructured":"Miller JM, van der Maaten MJ. Reproductive tract lesions in heifers after intrauterine inoculation with infectious bovine rhinotracheitis virus. Am J Vet Res. 1984;45:790\u20134.","journal-title":"Am J Vet Res"},{"key":"291_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jviromet.2007.04.002","volume":"144","author":"J Wang","year":"2007","unstructured":"Wang J, O\u2019Keefe J, Orr D, Loth L, Banks M, Wakeley P, West D, Card R, Ibata G, Van Maanen K, Thoren P, Isaksson M, Kerkhofs P. Validation of a real-time PCR assay for the detection of bovine herpesvirus 1 in bovine semen. J Virol Meth. 2007;144:103\u20138.","journal-title":"J Virol Meth"},{"key":"291_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1751-0147-51-9","volume":"51","author":"CG Das Neves","year":"2009","unstructured":"Das Neves CG, Roger M, Yoccoz NG, Rimstad E, Tryland M. Evaluation of three commercial bovine ELISA kits for detection of antibodies against alphaherpesviruses in reindeer (Rangifer tarandus tarandus). Acta Vet Scand. 2009;51:9. doi: 10.1186\/1751-0147-51-9 .","journal-title":"Acta Vet Scand"},{"key":"291_CR27","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.vetmic.2009\/06.013","volume":"139","author":"CG Das Neves","year":"2009","unstructured":"Das Neves CG, Thiry J, Skjerve E, Yoccoz N, Rimstad E, Thiry E, Tryland M. Alphaherpesvirus infections in semidomesticated reindeer: a cross-sectional serological study. Vet Microbiol. 2009;139:262\u20139. doi: 10.1016\/j.vetmic.2009\/06.013 .","journal-title":"Vet Microbiol"},{"key":"291_CR28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.tvjl.2015.10.034","volume":"209","author":"MS Marin","year":"2016","unstructured":"Marin MS, Leunda MR, Verna AE, Mor\u00e1n PE, Ode\u00f3n AC, P\u00e9rez SE. Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves. Vet J. 2016;209:82\u20136. doi: 10.1016\/j.tvjl.2015.10.034 .","journal-title":"Vet J."},{"issue":"1\u20132","key":"291_CR29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.vetmic.2013.01.038","volume":"164","author":"S Gould","year":"2013","unstructured":"Gould S, Dewell R, Tofflemire K, Whitley RD, Millman ST, Opriessnig T, Rosenbusch R, Trujillo J, O`Connor AM. Randomized blinded challenge study to assess association between Moraxella bovoculi and Infectious Bovine Keratoconjunctivitis in dairy calves. Vet Microbiol. 2013;164(1\u20132):108\u201315. doi: 10.1016\/j.vetmic.2013.01.038 .","journal-title":"Vet Microbiol"},{"key":"291_CR30","first-page":"2217","volume":"47","author":"HG Jayappa","year":"1986","unstructured":"Jayappa HG, Lehr C. Pathogenicity and immunogenicity of piliated and nonpili-ated phases of Moraxella bovis in calves. Am J Vet Res. 1986;47:2217\u201321.","journal-title":"Am J Vet Res"},{"key":"291_CR31","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1177\/030098588702400401","volume":"24","author":"DG Rogers","year":"1987","unstructured":"Rogers DG, Cheville NF, Pugh GW Jr. Pathogenesis of corneal lesions caused by Moraxella bovis in gnotobiotic calves. Vet Pathol. 1987;24:287\u201395.","journal-title":"Vet Pathol"},{"issue":"26","key":"291_CR32","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/1040638714551403","volume":"2014","author":"JD Loy","year":"2010","unstructured":"Loy JD, Brodersen BW. Moraxella spp. isolated from field outbreaks of infectious keratoconjunctivitis: a retrospective study of case submissions from to 2013. J Vet Diagn Invest. 2010;2014(26):761\u20138. doi: 10.1177\/1040638714551403 .","journal-title":"J Vet Diagn Invest"},{"key":"291_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.vetmic.2007.05.009","volume":"125","author":"JA Angelos","year":"2007","unstructured":"Angelos JA, Ball LM, Hess JF. Identification and characterization of complete RTX operons in Moraxella bovoculi and Moraxella ovis. Vet Microbiol. 2007;125:73\u20139.","journal-title":"Vet Microbiol"},{"key":"291_CR34","doi-asserted-by":"publisher","first-page":"e00612","DOI":"10.1128\/genomeA.00612-14","volume":"2","author":"MJ Calcutt","year":"2014","unstructured":"Calcutt MJ, Foecking MF, Martin NT, Mhlanga-Mutangadura T, Reilly TJ. Draft genome sequence of Moraxella bovoculi strain 237T (ATCC BAA-1259T) isolated from a calf with infectious bovine keratoconjunctivitis. Genome Announc. 2014;2:e00612\u20134. doi: 10.1128\/genomeA.00612-14 .","journal-title":"Genome Announc"},{"key":"291_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13567-016-0316-2","volume":"47","author":"AM Dickey","year":"2016","unstructured":"Dickey AM, Loy JD, Bono JL, Smith TPL, Apley MD, Lubbers BV, DeDonder KD, Capik SF, Larson RL, White BJ, Blom J, Chitko-McKown CG, Clawson ML. Large genomic differences between Moraxella bovoculi isolates acquired from the eyes of cattle with infectious bovine keratoconjunctivitis versus the deep nasopharynx of asymptomatic cattle. Vet Res. 2016;47:31. doi: 10.1186\/s13567-016-0316-2 .","journal-title":"Vet Res"},{"key":"291_CR36","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1128\/CVI.00218-09","volume":"16","author":"CG Das Neves","year":"2009","unstructured":"Das Neves CG, M\u00f8rk T, Godfroid J, S\u00f8rensen KK, Breines E, Hareide E, Thiry J, Rimstad E, Thiry E, Tryland M. Experimental infection of reindeer with cervid herpesvirus 2. Clin Vaccine Immunol. 2009;16:1758\u201365. doi: 10.1128\/CVI.00218-09 .","journal-title":"Clin Vaccine Immunol"},{"key":"291_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.virusres.2009.08.002","volume":"145","author":"CG Das Neves","year":"2009","unstructured":"Das Neves CG, M\u00f8rk T, Thiry J, Godfroid J, Rimstad E, Thiry E, Tryland M. Cervid herpesvirus 2 experimentally reactivated in reindeer can produce generalized viremia and abortion. Virus Res. 2009;145:321\u20138. doi: 10.1016\/j.virusres.2009.08.002 .","journal-title":"Virus Res"},{"key":"291_CR38","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.vetmic.2011.09.011","volume":"155","author":"AM O\u2019Connor","year":"2012","unstructured":"O\u2019Connor AM, Shen HG, Wang C, Opriesnig T. Descriptive epidemiology of Moraxella bovis, Moraxella bovoculi and Moraxella ovis in beef calves with naturally occuring infectious bovine keratoconjunctivitis (pinkeye). Vet Microbiol. 2012;155:374\u201380.","journal-title":"Vet Microbiol"}],"container-title":["Acta Veterinaria Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13028-017-0291-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T20:55:24Z","timestamp":1658955324000},"score":1,"resource":{"primary":{"URL":"http:\/\/actavetscand.biomedcentral.com\/articles\/10.1186\/s13028-017-0291-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,24]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["291"],"URL":"https:\/\/doi.org\/10.1186\/s13028-017-0291-2","relation":{},"ISSN":["1751-0147"],"issn-type":[{"type":"electronic","value":"1751-0147"}],"subject":[],"published":{"date-parts":[[2017,4,24]]},"article-number":"23"}}