{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:28:47Z","timestamp":1791772127211,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WKP DS1"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Vet Scand"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13028-018-0424-2","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T10:23:46Z","timestamp":1541240626000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Epidemiological assessment of the risk of canine mast cell tumours based on the Kiupel two-grade malignancy classification"],"prefix":"10.1186","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-4521","authenticated-orcid":false,"given":"Anna","family":"\u015amiech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brygida","family":"\u015alaska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"\u0141opuszy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Jasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Bochy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"D\u0105browski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,3]]},"reference":[{"key":"424_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/j.1476-5829.2012.00341.x","volume":"10","author":"L Blackwood","year":"2012","unstructured":"Blackwood L, Murphy S, Buracco P, De Vos JP, De Fornel-Thibaud P, Hirschberger J, et al. European consensus document on mast cell tumours in dogs and cats. Vet Comp Oncol. 2012;10:e1\u201329.","journal-title":"Vet Comp Oncol"},{"key":"424_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/01652176.2004.9695178","volume":"26","author":"W Misdorp","year":"2004","unstructured":"Misdorp W. Mast cells and canine mast cell tumours. A review. Vet Q. 2004;26:156\u201369.","journal-title":"Vet Q"},{"key":"424_CR3","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/vr.154.24.743","volume":"154","author":"S Murphy","year":"2004","unstructured":"Murphy S, Sparkes AH, Smith KC, Blunden AS, Brearley M. Relationships between the histological grade of cutaneous mast cell tumours in dogs, their survival and the efficacy of surgical resection. Vet Rec. 2004;154:743\u20136.","journal-title":"Vet Rec"},{"key":"424_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1365-3164.2008.00694.x","volume":"19","author":"MM Welle","year":"2008","unstructured":"Welle MM, Bley CR, Howard J, R\u00fcfenacht S. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol. 2008;19:321\u201339.","journal-title":"Vet Dermatol"},{"key":"424_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1476-5829.2011.00287.x","volume":"10","author":"D Berlato","year":"2012","unstructured":"Berlato D, Stewart J, Newton R, Maglennon GA, Monti P, Flindall A, et al. Evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours. Vet Comp Oncol. 2012;10:135\u201342.","journal-title":"Vet Comp Oncol"},{"key":"424_CR6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jcpa.2008.08.002","volume":"141","author":"GK Froberg","year":"2009","unstructured":"Froberg GK, Lindberg R, Ritter M, Nordlind K. Expression of serotonin and its 5-HT1A receptor in canine cutaneous mast cell tumours. J Comp Pathol. 2009;141:89\u201397.","journal-title":"J Comp Pathol"},{"key":"424_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4236\/ojvm.2012.24041","volume":"2","author":"SSC Poggiani","year":"2012","unstructured":"Poggiani SSC, Terra EM, Neto RT, Costa MT, Amorim RL. Canine cutaneous mast cell tumor: biologic behavior and its correlation with prognostic indicators. Open J Vet Med. 2012;2:255\u201361.","journal-title":"Open J Vet Med"},{"key":"424_CR8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1354\/vp.44-3-335","volume":"44","author":"EM Romansik","year":"2007","unstructured":"Romansik EM, Reilly CM, Kass PH, Moore PF, London CA. Mitotic index is predictive for survival for canine cutaneous mast cell tumors. Vet Pathol. 2007;44:335\u201341.","journal-title":"Vet Pathol"},{"key":"424_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1439-0442.2006.00795.x","volume":"53","author":"H Wu","year":"2006","unstructured":"Wu H, Hayashi T, Inoue M. Immunohistochemical expression of Mdm2 and p53 in canine cutaneous mast cell tumours. J Vet Med A Physiol Pathol Clin Med. 2006;53:65\u20138.","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"424_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1354\/vp.39-5-529","volume":"39","author":"D Zemke","year":"2002","unstructured":"Zemke D, Yamini B, Yuzbasiyan-Gurkan V. Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs. Vet Pathol. 2002;39:529\u201335.","journal-title":"Vet Pathol"},{"key":"424_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1751-0147-52-6","volume":"52","author":"LB Br\u00f8nden","year":"2010","unstructured":"Br\u00f8nden LB, Eriksen T, Kristensen AT. Mast cell tumours and other skin neoplasia in Danish dogs\u2014data from the Danish veterinary cancer registry. Acta Vet Scand. 2010;52:6.","journal-title":"Acta Vet Scand"},{"key":"424_CR12","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1748-5827.2007.00366.x","volume":"48","author":"JM Dobson","year":"2007","unstructured":"Dobson JM, Scase TJ. Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J Small Anim Pract. 2007;48:424\u201331.","journal-title":"J Small Anim Pract"},{"key":"424_CR13","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1177\/030098588402100503","volume":"21","author":"AK Patnaik","year":"1984","unstructured":"Patnaik AK, Ehler WJ, MacEwen EG. Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol. 1984;21:469\u201374.","journal-title":"Vet Pathol"},{"key":"424_CR14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0300985810386469","volume":"48","author":"M Kiupel","year":"2011","unstructured":"Kiupel M, Webster JD, Bailey KL, Best S, DeLay J, Detrisac CJ, et al. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol. 2011;48:147\u201355.","journal-title":"Vet Pathol"},{"key":"424_CR15","first-page":"601","volume":"84","author":"B Artukovi\u0107","year":"2014","unstructured":"Artukovi\u0107 B, Medven L, Hoh\u0161teter M, \u0160o\u0161tari\u0107-Zuckermann I-C, Kurilj AG, Beck A, et al. Prevalence of cutaneous mast cell sarcoma in dogs in Croatia. Vet Arhiv. 2014;84:601\u201314.","journal-title":"Vet Arhiv"},{"key":"424_CR16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jcpa.2015.02.005","volume":"152","author":"K Gr\u00fcntzig","year":"2015","unstructured":"Gr\u00fcntzig K, Graf R, Hassig M, Welle M, Meier D, Lott G, et al. The Swiss Canine Cancer Registry: a retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol. 2015;152:161\u201371.","journal-title":"J Comp Pathol"},{"key":"424_CR17","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jcpa.2016.05.011","volume":"155","author":"K Gr\u00fcntzig","year":"2016","unstructured":"Gr\u00fcntzig K, Graf R, Boo G, Guscetti F, H\u00e4ssig M, Axhausen KW, et al. Swiss Canine Cancer Registry 1955\u20132008: occurrence of the most common tumour diagnoses and influence of age, breed, body size, sex and neutering status on tumour development. J Comp Pathol. 2016;155:156\u201370.","journal-title":"J Comp Pathol"},{"key":"424_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1748-5827.2002.tb00066.x","volume":"43","author":"JM Dobson","year":"2002","unstructured":"Dobson JM, Samuel S, Milstein H, Rogers K, Wood JL. Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs. J Small Anim Pract. 2002;43:240\u20136.","journal-title":"J Small Anim Pract"},{"key":"424_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.15654\/TPK-140165","volume":"42","author":"EF Leidinger","year":"2014","unstructured":"Leidinger EF, Freeman K, Kirtz G, Hooijberg EH, Sick K. Breed related odds ratio and anatomic distribution of canine mast cell tumours in Austria. Retrospective study of cases in the years 2000\u20132010. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2014;42:367\u201373.","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"424_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2052-6687-2-1","volume":"2","author":"SJW Shoop","year":"2015","unstructured":"Shoop SJW, Marlow S, Church DB, English K, McGreevy PD, Stell AJ, et al. Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genet Epidemiol. 2015;2:1.","journal-title":"Canine Genet Epidemiol"},{"key":"424_CR21","doi-asserted-by":"publisher","first-page":"960","DOI":"10.2460\/javma.239.7.960","volume":"239","author":"JA Villamil","year":"2011","unstructured":"Villamil JA, Henry CJ, Bryan JN, Ellersieck M, Schultz L, Tyler JW, et al. Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J Am Vet Med Assoc. 2011;239:960\u20135.","journal-title":"J Am Vet Med Assoc"},{"key":"424_CR22","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.tvjl.2013.02.017","volume":"197","author":"J Warland","year":"2013","unstructured":"Warland J, Dobson J. Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom. Vet J. 2013;197:496\u20138.","journal-title":"Vet J"},{"key":"424_CR23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.5326\/JAAHA-MS-5621","volume":"47","author":"CR White","year":"2011","unstructured":"White CR, Hohenhaus AE, Kelsey J, Procter-Gray E. Cutaneous MCTs: associations with spay\/neuter status, breed, body size, and phylogenetic cluster. J Am Anim Hosp Assoc. 2011;47:210\u20136.","journal-title":"J Am Anim Hosp Assoc"},{"key":"424_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.2460\/javma.244.3.309","volume":"244","author":"MC Zink","year":"2014","unstructured":"Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomised Vizslas. J Am Vet Med Assoc. 2014;244:309\u201319.","journal-title":"J Am Vet Med Assoc"},{"key":"424_CR25","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/vco.12225","volume":"15","author":"H Mochizuki","year":"2017","unstructured":"Mochizuki H, Motsinger-Reif A, Bettini C, Moroff S, Breen M. Association of breed and histopathological grade in canine mast cell tumours. Vet Comp Oncol. 2017;15:829\u201339.","journal-title":"Vet Comp Oncol"},{"key":"424_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1053\/svms.2003.36624","volume":"18","author":"SM Govier","year":"2003","unstructured":"Govier SM. Principles of treatment for mast cell tumors. Clin Tech Small Anim Pract. 2003;18:103\u20136.","journal-title":"Clin Tech Small Anim Pract"},{"key":"424_CR27","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.2460\/javma.2005.226.1368","volume":"226","author":"G Sfiligoi","year":"2005","unstructured":"Sfiligoi G, Rassnick KM, Scarlett JM, Northrup NC, Gieger TL. Outcome of dogs with mast cell tumors in the inguinal or perineal region versus other cutaneous locations: 124 cases (1990\u20132001). J Am Vet Med Assoc. 2005;226:1368\u201374.","journal-title":"J Am Vet Med Assoc"},{"key":"424_CR28","volume-title":"Histological classification of mesenchymal tumors of skin and soft tissues of domestic animals","author":"MJ Hendrick","year":"1998","unstructured":"Hendrick MJ. Histological classification of mesenchymal tumors of skin and soft tissues of domestic animals. 2nd ed. Washington, D.C: Armed Forces Institute of Pathology; 1998.","edition":"2"},{"key":"424_CR29","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1016\/j.jas.2011.02.028","volume":"38","author":"M Pionnier-Capitan","year":"2011","unstructured":"Pionnier-Capitan M, Bemilli C, Bodu P, C\u00e9l\u00e9rier G, Ferri\u00e9 J-G, Fosse P, et al. New evidence for Upper Palaeolithic small domestic dogs in South-Western Europe. J Archaeol Sci. 2011;38:2123\u201340.","journal-title":"J Archaeol Sci"},{"key":"424_CR30","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1751-0813.1979.tb07068.x","volume":"55","author":"JW Finnie","year":"1979","unstructured":"Finnie JW, Bostock DE. Skin neoplasia in dogs. Aust Vet J. 1979;55:602\u20134.","journal-title":"Aust Vet J"},{"key":"424_CR31","first-page":"435","volume":"42","author":"JA Peters","year":"1969","unstructured":"Peters JA. Canine mastocytoma: excess risk as related to ancestry. J Natl Cancer Inst. 1969;42:435\u201343.","journal-title":"J Natl Cancer Inst"},{"key":"424_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/941275","author":"JM Dobson","year":"2013","unstructured":"Dobson JM. Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci. 2013. \n                    https:\/\/doi.org\/10.1155\/2013\/941275\n                    \n                  .","journal-title":"ISRN Vet Sci"},{"key":"424_CR33","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/104063879500700311","volume":"7","author":"DM Miller","year":"1995","unstructured":"Miller DM. The occurrence of mast cell tumors in young Shar-Peis. J Vet Diagn Invest. 1995;7:360\u20133.","journal-title":"J Vet Diagn Invest"},{"key":"424_CR34","first-page":"261","volume-title":"Small animal clinical oncology","author":"DH Thamm","year":"2001","unstructured":"Thamm DH, Vail DM. Mast cell tumors. In: Withrow SJ, Mac Ewen EG, editors. Small animal clinical oncology. Philadelphia: W. B. Saunders; 2001. p. 261\u201382."},{"issue":"Suppl 1","key":"424_CR35","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1017\/S000711451100211X","volume":"106","author":"JJ Wakshlag","year":"2011","unstructured":"Wakshlag JJ, Rassnick KM, Malone EK, Struble AM, Vachhani P, Trump DL, et al. Cross-sectional study to investigate the association between vitamin D status and cutaneous mast cell tumours in Labrador retrievers. Br J Nutr. 2011;106(Suppl 1):S60\u20133.","journal-title":"Br J Nutr"},{"key":"424_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0007-1935(86)90002-3","volume":"142","author":"DE Bostock","year":"1986","unstructured":"Bostock DE. Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br Vet J. 1986;142:1\u201319.","journal-title":"Br Vet J"},{"key":"424_CR37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1476-5810.2006.00085.x","volume":"4","author":"EA McNiel","year":"2006","unstructured":"McNiel EA, Prink AL, O\u2019Brien TD. Evaluation of risk and clinical outcome of mast cell tumours in pug dogs. Vet Comp Oncol. 2006;4:2\u20138.","journal-title":"Vet Comp Oncol"},{"key":"424_CR38","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13028-016-0210-y","volume":"58","author":"A \u015amiech","year":"2016","unstructured":"\u015amiech A, \u015alaska B, Surdyka M, Grzybowska-Szatkowska L, \u0141opuszy\u0144ski W, R\u00f3\u017ca\u0144ska D. Identification of additional mitochondrial DNA mutations in canine mast cell tumours. Acta Vet Scand. 2016;58:28.","journal-title":"Acta Vet Scand"},{"key":"424_CR39","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1439-0442.2005.00726.x","volume":"52","author":"M Kiupel","year":"2005","unstructured":"Kiupel M, Webster JD, Miller RA, Kaneene JB. Impact of tumour depth, tumour location and multiple synchronous masses on the prognosis of canine cutaneous mast cell tumours. J Vet Med A Physiol Pathol Clin Med. 2005;52:280\u20136.","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"424_CR40","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1476-5829.2011.00301.x","volume":"11","author":"K O\u2019Connell","year":"2013","unstructured":"O\u2019Connell K, Thomson M. Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases. Vet Comp Oncol. 2013;11:51\u201362.","journal-title":"Vet Comp Oncol"}],"container-title":["Acta Veterinaria Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13028-018-0424-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13028-018-0424-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13028-018-0424-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T20:11:24Z","timestamp":1572725484000},"score":1,"resource":{"primary":{"URL":"https:\/\/actavetscand.biomedcentral.com\/articles\/10.1186\/s13028-018-0424-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["424"],"URL":"https:\/\/doi.org\/10.1186\/s13028-018-0424-2","relation":{},"ISSN":["1751-0147"],"issn-type":[{"value":"1751-0147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,3]]},"assertion":[{"value":"8 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"70"}}