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Antimicrobial flock treatment has been routinely applied as preventive\/therapeutic protocol on Danish mink farms with increased mortality associated with MUTD. The therapeutic effect of this treatment strategy has not previously been investigated. In this study, we applied controlled parallel group treatment trials to assess the effect of sulfadiazine\/trimethoprim and amoxicillin treatment on mortality associated with MUTD in mink kits. On farm A, eight mink kits were diagnosed with MUTD post mortem in the treatment group (n\u2009=\u20091920, sulfadiazine\/trimethoprim treatment: 30\u00a0mg\/kg, q 24\u00a0h, P.O for 5\u00a0days) compared to 16 in the untreated control group (n\u2009=\u20091920). No significant difference in mortality associated with MUTD were found between \u00a0the\u00a0treatment and\u00a0the control group using the Fisher\u2019s exact test (P\u2009=\u20090.15). Treatment group 2 (n\u2009=\u20091920, amoxicillin treatment: 14\u00a0mg\/kg q 24\u00a0h, P.O for 5\u00a0days) and treatment group 3 (n\u2009=\u20092088, amoxicillin treatment: 7.5\u00a0mg\/kg q 24\u00a0h, P.O for 5\u00a0days) were investigated on farm B. Eight and four mink kits were diagnosed with MUTD post mortem in group 2 and 3, respectively. No difference between occurrence of MUTD were found between the control group and treatment group 2 (P\u2009=\u20090.42) or treatment group 3 (P\u2009=\u20090.75). No significant difference between final body weights or weight gain were found between treatment and control weighing groups on farm A or B. In conclusion, antimicrobial treatment administered in the feed showed no significant effect on weight gain or mortality associated with MUTD on the farms included in this study.<\/jats:p>","DOI":"10.1186\/s13028-021-00581-3","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T22:02:45Z","timestamp":1617314565000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of antimicrobial treatment on mortality associated with urinary tract disease in mink kits (Neovison vison)"],"prefix":"10.1186","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-3197","authenticated-orcid":false,"given":"Karin","family":"Mundbjerg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder Elbek","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sofie","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"581_CR1","doi-asserted-by":"publisher","first-page":"108706","DOI":"10.1016\/j.vetmic.2020.108706","volume":"245","author":"K Mundbjerg","year":"2020","unstructured":"Mundbjerg K, Pedersen PE, Sebbelov I, Honor\u00e9 OL, Aalb\u00e6k B, Larsen C, et al. Urolithiasis and cystitis associated with Staphylococcus delphini group A and mortality in post-weaning mink kits (Neovison vison). Vet Microbiol. 2020;245:108706. https:\/\/doi.org\/10.1016\/j.vetmic.2020.108706.","journal-title":"Vet Microbiol"},{"key":"581_CR2","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/S0022-5347(17)66854-X","volume":"75","author":"IM Nielsen","year":"1956","unstructured":"Nielsen IM. Urolithiasis in mink: pathology, bacteriology and experimental production. J Urol. 1956;75:602\u201314.","journal-title":"J Urol"},{"key":"581_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cvsm.2008.09.005","volume":"39","author":"CA Osborne","year":"2009","unstructured":"Osborne CA, Albasan H, Lulich JP, Nwaokorie E, Koehler LA, Ulrich LK. Quantitative analysis of 4468 uroliths retrieved from farm animals, exotic species, and wildlife submitted to the Minnesota Urolith Center: 1981 to 2007. 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The animals were handled according to national legislation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}