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Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible. The aim of this study was to test if iron dextran, which can be used in flexible volumes, is statistically non-inferior to a combinatory product, containing gleptoferron and toltrazuril. In addition, different administration schemes for iron dextran with respect to time point and dosage were compared on a conventional farm. Within each out of 17 litters eight healthy piglets were allocated to one of the four treatment groups on the second day of life: (1) 200\u00a0mg iron dextran, (2) 200\u00a0mg gleptoferron and 45\u00a0mg toltrazuril in combination, (3) 300\u00a0mg iron dextran, (4) 200\u00a0mg iron dextran and additional intramuscular administration of 200\u00a0mg iron dextran on day 11 of life. Pigs of groups 1, 3 and 4 received toltrazuril orally. Red blood cell measures were determined prior to treatment on day 2 of life and at weaning. Body weights were measured on day 2, 24, 74 and 160 of life.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Iron dextran was non-inferior compared to gleptoferron within a tolerance range of <jats:italic>\u00b1<\/jats:italic>\u20095\u00a0g haemoglobin\/L. In total, treatment groups did not differ with respect to red blood cell parameters and average daily weight gain. The 50% pigs with intermediate birth weights profited from an additional iron dextran administration with respect to higher haemoglobin concentrations at weaning.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this investigation gleptoferron and iron dextran appear equally appropriate for prevention of iron deficiency anaemia. Piglets of different birth weights might profit differently from an additional iron administration, so that usage of a product containing iron as a single substance is of advantage to allow a flexible adjustment of dosage during the suckling period.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13028-024-00790-6","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T04:58:55Z","timestamp":1735966735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron"],"prefix":"10.1186","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-5979","authenticated-orcid":false,"given":"Isabel","family":"Hennig-Pauka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ganter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bornhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Almond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Kreienbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Steen","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"790_CR1","unstructured":"Antonczyk C. 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Accessed 28 Dec 2023."}],"container-title":["Acta Veterinaria Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13028-024-00790-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13028-024-00790-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13028-024-00790-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T17:01:46Z","timestamp":1736010106000},"score":1,"resource":{"primary":{"URL":"https:\/\/actavetscand.biomedcentral.com\/articles\/10.1186\/s13028-024-00790-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,4]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["790"],"URL":"https:\/\/doi.org\/10.1186\/s13028-024-00790-6","relation":{},"ISSN":["1751-0147"],"issn-type":[{"value":"1751-0147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,4]]},"assertion":[{"value":"2 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This study was financially supported by Pharmacosmos A\/S (Holbaek, Denmark). Author Wesley Lyons was employed by the company Pharmacosmos A\/S. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Pharmacosmos A\/S was neither involved in performance of study, data evaluation or data interpretation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Pigs were housed in accordance with the German regulations on pig husbandry and the national animal welfare law. Husbandry conditions and the animal trial procedure follow regulations of the European Convention concerning the protection of vertebrate animals and followed the Directive of the European Convention for the Protection of Vertebrae Animals used for Experimental and Other Scientific Purposes (European Treaty Series, nos. 123). The study was approved from the local permitting authorities in the Lower Saxony State Office for Consumer Protection and Food Safety and in accordance with the requirements of the national animal welfare law (approval number: 33.19-42502-04-22-00132) following the guidelines of FELASA and ARRIVE. The animals were handled according to high ethical standards and national legislation. Unnecessary suffering was avoided by precautions taken at all stages of the experiment, as e.g. blood sampling was performed by an experienced and skilled veterinarian. Pigs were continuously observed during the whole experiment. Humane intervention points were defined for circulatory failure during life-threatened emergency and drug intolerance situations. Decisions for euthanasia due to diseases were based on medical and ethical considerations []. Euthanasia was conducted by injection of 60\u00a0mg pentobarbital\/kg bw intravenously. All animal procedures were approved by the Lower Saxony State Office for Consumer Protection and Food Safety.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Data have not been published previously.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Prior publication"}}],"article-number":"1"}}