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Written informed consent was obtained from all participants prior to their participation.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants for results to be published.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Jennifer Brunet (corresponding author) reports financial support was provided by Canadian CAM Research Fund. While declared for transparency, the provision of financial support did not influence the research results, methodology, or interpretation. Andrew Seely from the Ottawa Hospital Research Institute (OHRI) is a patent holder, Founder\/CEO, and shareholder of Therapeutic Monitoring Systems (TMS) Inc.\u2014a company focused on commercialization of variability-derived clinical decisions support tools developed in OHRI\u2019s Dynamical Analysis Laboratory. Christophe Herry is one of the inventors related to this patent. Neither A. Seely nor C. Herry report any conflict of interest directly related to the subject matter of this manuscript. Remaining co-authors declare no financial interests\/personal relationships that may be considered as potential competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"13"}}