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Natural therapeutic agents, particularly plant extracts, have been widely used in wound management due to their antimicrobial and regenerative properties. Here, we report a novel multifunctional wound dressing by integrating\n                      <jats:italic>Petroselinum crispum<\/jats:italic>\n                      (parsley, PS) extract and zinc ascorbate-based metal-organic frameworks (MOFs) into a polyvinyl alcohol (PVA) nanofibrous matrix. The resulting MOF\/PS-loaded PVA nanofibers (NFs) combine biodegradability, biocompatibility, and enhanced bioactivity for wound healing. The optimized formulation (PVA\/MOF5\/PS30-NFs) exhibited strong antibacterial activity, with inhibition zones of ~\u2009250\u00a0mm\u00b2, total phenolic content of 1.41\u00a0mg GAE\/g, and antioxidant IC\u2085\u2080 values of 15.17 and 11.11\u00a0mg\/3mL at 2 and 24\u00a0h, respectively. Cytocompatibility tests confirmed excellent cell viability (&gt;\u2009100%). In-vitro assays demonstrated enhanced fibroblast migration and edge contraction, with substantial wound closure after 48\u00a0h. In-vivo studies showed complete (&gt;\u2009100%) wound closure by day 15, surpassing controls (~\u200980%), with the fastest healing trajectory and early acceleration phase observed. To our knowledge, this is the first report of this composition and application. These findings highlight MOF\/PS-loaded PVA nanofibrous mats as a promising platform for advanced wound-healing therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13036-026-00736-8","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:04:41Z","timestamp":1786953881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combined bioactive PVA nanofibrous scaffolds loaded with Zn ascorbate MOFs and Petroselinum crispum (Parsley) extract for enhanced in-vitro and in-vivo wound healing applications"],"prefix":"10.1186","volume":"20","author":[{"given":"Shimaa","family":"Husien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana R.","family":"Haikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha El.","family":"Salakawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdellatif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Mamdouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"736_CR1","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","volume":"91","author":"ACO Gonzalez","year":"2016","unstructured":"Gonzalez ACO, Costa TF, Andrade ZA, Medrado ARAP. 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