{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:44:58Z","timestamp":1785800698692,"version":"3.56.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BioData Mining"],"DOI":"10.1186\/s13040-026-00564-y","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:26:22Z","timestamp":1781177182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics analysis of genetic drivers linking aortic stenosis and left ventricular diastolic dysfunction in heart failure"],"prefix":"10.1186","volume":"19","author":[{"given":"Zeeshan","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi","family":"Govindareddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayden","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveena","family":"Yanamala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partho P.","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"564_CR1","doi-asserted-by":"publisher","unstructured":"Martin SS, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, et al. 2024 Heart Disease and Stroke Statistics: a report of US and global data from the American Heart Association. Circulation. 2024;149(8):e347\u2013913. https:\/\/doi.org\/10.1161\/CIR.0000000000001209.","DOI":"10.1161\/CIR.0000000000001209"},{"issue":"4","key":"564_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/ehjqcco\/qcae110","volume":"11","author":"QF Chen","year":"2025","unstructured":"Chen QF, Chen L, Katsouras CS, Liu C, Shi J, Liang D, et al. Global burden of heart failure and its underlying causes in 204 countries and territories, 1990\u20132021. Eur Heart J Qual Care Clin Outcomes. 2025;11(4):493\u2013509. https:\/\/doi.org\/10.1093\/ehjqcco\/qcae110.","journal-title":"Eur Heart J - Qual Care Clin Outcomes"},{"issue":"6","key":"564_CR3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","volume":"13","author":"B Ziaeian","year":"2016","unstructured":"Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13(6):368\u201378. https:\/\/doi.org\/10.1038\/nrcardio.2016.25.","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"564_CR4","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/ejhf.2908","volume":"25","author":"B Shahim","year":"2023","unstructured":"Shahim B, Shahim A, Adamo M, Chioncel O, Benson L, Crespo-Leiro MG, et al. Prevalence, characteristics and prognostic impact of aortic valve disease in patients with heart failure and reduced, mildly reduced, and preserved ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2023;25(7):1049\u201360. https:\/\/doi.org\/10.1002\/ejhf.2908.","journal-title":"Eur J Heart Fail"},{"key":"564_CR5","doi-asserted-by":"publisher","unstructured":"Verbrugge FH, Reddy YNV, Eleid MF, Lin G, Burkhoff D, Borlaug BA. Mild aortic valve disease and the diastolic pressure\u2013volume relationship in heart failure with preserved ejection fraction. Open Heart. 2021;8(2):e001701. https:\/\/doi.org\/10.1136\/openhrt-2021-001701.","DOI":"10.1136\/openhrt-2021-001701"},{"key":"564_CR6","doi-asserted-by":"publisher","unstructured":"Venema CS, van Bergeijk KH, Krikken JA, van der Werf HW, van den Heuvel AFM, Douglas YL, et al. Heart failure with preserved ejection fraction phenotype is associated with early symptom onset in aortic stenosis and residual symptoms after transcatheter aortic valve implantation. J Am Heart Assoc. 2025;14(9):e038786. https:\/\/doi.org\/10.1161\/JAHA.124.038786.","DOI":"10.1161\/JAHA.124.038786"},{"issue":"2","key":"564_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcmg.2024.07.017","volume":"18","author":"M Tokodi","year":"2025","unstructured":"Tokodi M, Shah R, Jamthikar A, Craig N, Hamirani Y, Casaclang-Verzosa G, et al. Deep Learning model of diastolic dysfunction risk stratifies the progression of early-stage aortic stenosis. JACC Cardiovasc Imag. 2025;18(2):150\u201365. https:\/\/doi.org\/10.1016\/j.jcmg.2024.07.017.","journal-title":"JACC Cardiovasc Imag"},{"issue":"6","key":"564_CR8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1001\/jamacardio.2024.0595","volume":"9","author":"EK Oikonomou","year":"2024","unstructured":"Oikonomou EK, Holste G, Yuan N, Coppi A, McNamara RL, Haynes NA, et al. A multimodal video-based AI biomarker for aortic stenosis development and progression. JAMA Cardiol. 2024;9(6):534\u201344. https:\/\/doi.org\/10.1001\/jamacardio.2024.0595.","journal-title":"JAMA Cardiol"},{"issue":"30","key":"564_CR9","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1093\/eurheartj\/ehab153","volume":"42","author":"M Cohen-Shelly","year":"2021","unstructured":"Cohen-Shelly M, Attia ZI, Friedman PA, Ito S, Essayagh BA, Ko WY, et al. Electrocardiogram screening for aortic valve stenosis using artificial intelligence. Eur Heart J. 2021;42(30):2885\u201396. https:\/\/doi.org\/10.1093\/eurheartj\/ehab153.","journal-title":"Eur Heart J"},{"issue":"3","key":"564_CR10","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/ehjdh\/ztad009","volume":"4","author":"S Ito","year":"2023","unstructured":"Ito S, Cohen-Shelly M, Attia ZI, Lee E, Friedman PA, Nkomo VT, et al. Correlation between artificial intelligence-enabled electrocardiogram and echocardiographic features in aortic stenosis. Eur Heart J Digit Health. 2023;4(3):196\u2013206. https:\/\/doi.org\/10.1093\/ehjdh\/ztad009.","journal-title":"Eur Heart J - Digit Health"},{"issue":"18","key":"564_CR11","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1001\/jama.291.18.2204","volume":"291","author":"DM Lloyd-Jones","year":"2004","unstructured":"Lloyd-Jones DM, Nam BH, D\u2019Agostino RB Sr, Levy D, Murabito JM, Wang TJ, et al. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA. 2004;291(18):2204\u201311. https:\/\/doi.org\/10.1001\/jama.291.18.2204.","journal-title":"JAMA"},{"issue":"2","key":"564_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jacbts.2018.01.003","volume":"3","author":"AM Dainis","year":"2018","unstructured":"Dainis AM, Ashley EA. Cardiovascular precision medicine in the genomics era. JACC Basic Transl Sci. 2018;3(2):313\u201326. https:\/\/doi.org\/10.1016\/j.jacbts.2018.01.003.","journal-title":"JACC Basic Transl Sci"},{"key":"564_CR13","doi-asserted-by":"publisher","unstructured":"Kazmi N, Gaunt TR. Diagnosis of coronary heart diseases using gene expression profiling; stable coronary artery disease, cardiac ischemia with and without myocardial necrosis. PLoS One. 2016;11(3):e0149475. https:\/\/doi.org\/10.1371\/journal.pone.0149475.","DOI":"10.1371\/journal.pone.0149475"},{"issue":"3","key":"564_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1586\/erm.12.10","volume":"12","author":"CS Ku","year":"2012","unstructured":"Ku CS, Wu M, Cooper DN, Naidoo N, Pawitan Y, Pang B, et al. Exome versus transcriptome sequencing in identifying coding region variants. Expert Rev Mol Diagn. 2012;12(3):241\u201351. https:\/\/doi.org\/10.1586\/erm.12.10.","journal-title":"Expert Rev Mol Diagn"},{"issue":"9","key":"564_CR15","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1002\/2211-5463.13261","volume":"11","author":"Z Ahmed","year":"2021","unstructured":"Ahmed Z, Renart EG, Mishra D, Zeeshan S. JWES: a new pipeline for whole genome\/exome sequence data processing, management, and gene-variant discovery, annotation, prediction, and genotyping. FEBS Open Bio. 2021;11(9):2441\u201352. https:\/\/doi.org\/10.1002\/2211-5463.13261.","journal-title":"FEBS Open Bio"},{"issue":"14","key":"564_CR16","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R. Fast and accurate short read alignment with Burrows\u2013Wheeler transform. Bioinformatics. 2009;25(14):1754\u201360. https:\/\/doi.org\/10.1093\/bioinformatics\/btp324.","journal-title":"Bioinformatics"},{"issue":"9","key":"564_CR17","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, et al. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 2010;20(9):1297\u2013303. https:\/\/doi.org\/10.1101\/gr.107524.110.","journal-title":"Genome Res"},{"key":"564_CR18","doi-asserted-by":"publisher","unstructured":"Narayanan R, DeGroat W, Peker E, Zeeshan S, Ahmed Z. VAREANT: a bioinformatics application for gene variant reduction and annotation. Bioinf Adv. 2024;5(1):vbae210. https:\/\/doi.org\/10.1093\/bioadv\/vbae210.","DOI":"10.1093\/bioadv\/vbae210"},{"issue":"8","key":"564_CR19","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/humu.24298","volume":"43","author":"SE Hunt","year":"2022","unstructured":"Hunt SE, Moore B, Amode RM, Armean IM, Lemos D, Mushtaq A, et al. Annotating and prioritizing genomic variants using the ensembl variant effect predictor\u2014a tutorial. Hum Mutat. 2022;43(8):986\u201397. https:\/\/doi.org\/10.1002\/humu.24298.","journal-title":"Hum Mutat"},{"issue":"3","key":"564_CR20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/humu.22932","volume":"37","author":"X Liu","year":"2016","unstructured":"Liu X, Wu C, Li C, Boerwinkle E. dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs. Hum Mutat. 2016;37(3):235\u201341. https:\/\/doi.org\/10.1002\/humu.22932.","journal-title":"Hum Mutat"},{"key":"564_CR21","doi-asserted-by":"publisher","unstructured":"Landrum MJ, Lee JM, Riley GR, Jang W, Rubinstein WS, Church DM, et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucl Acids Res. 2014;42(D1):D980\u201385. https:\/\/doi.org\/10.1093\/nar\/gkt1113.","DOI":"10.1093\/nar\/gkt1113"},{"issue":"8","key":"564_CR22","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/humu.24309","volume":"43","author":"S Gudmundsson","year":"2022","unstructured":"Gudmundsson S, Singer-Berk M, Watts NA, Phu W, Goodrich JK, Solomonson M, et al. Variant interpretation using population databases: lessons from gnomAD. Hum Mutat. 2022;43(8):1012\u201330. https:\/\/doi.org\/10.1002\/humu.24309.","journal-title":"Hum Mutat"},{"issue":"1","key":"564_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000;25(1):25\u201329. https:\/\/doi.org\/10.1038\/75556.","journal-title":"Nat Genet"},{"key":"564_CR24","doi-asserted-by":"publisher","unstructured":"Kanehisa M, Sato Y, Furumichi M, Morishima K, Tanabe M. New approach for understanding genome variations in KEGG. Nucleic Acids Res. 2019;47(D1):D590\u201395. https:\/\/doi.org\/10.1093\/nar\/gky962.","DOI":"10.1093\/nar\/gky962"},{"key":"564_CR25","doi-asserted-by":"publisher","unstructured":"Fabregat A, Jupe S, Matthews L, Sidiropoulos K, Gillespie M, Garapati P, et al. The reactome pathway knowledgebase. Nucleic Acids Res. 2018;46(D1):D649\u201355. https:\/\/doi.org\/10.1093\/nar\/gkx1132.","DOI":"10.1093\/nar\/gkx1132"},{"key":"564_CR26","doi-asserted-by":"publisher","unstructured":"K\u00f6hler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA, et al. The human phenotype ontology in 2021. Nucleic Acids Res. 2021;49(D1):D1207\u201317. https:\/\/doi.org\/10.1093\/nar\/gkaa1043.","DOI":"10.1093\/nar\/gkaa1043"},{"issue":"1","key":"564_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40246-021-00336-1","volume":"15","author":"Z Ahmed","year":"2021","unstructured":"Ahmed Z, Renart EG, Zeeshan S, Dong X. Advancing clinical genomics and precision medicine with GVViZ: FAIR bioinformatics platform for variable gene-disease annotation, visualization, and expression analysis. Hum Genomics. 2021;15(1):37. https:\/\/doi.org\/10.1186\/s40246-021-00336-1.","journal-title":"Hum Genomics"},{"issue":"4","key":"564_CR28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12(4):357\u201360. https:\/\/doi.org\/10.1038\/nmeth.3317.","journal-title":"Nat Methods"},{"issue":"4","key":"564_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with bowtie 2. Nat Methods. 2012;9(4):357\u201359. https:\/\/doi.org\/10.1038\/nmeth.1923.","journal-title":"Nat Methods"},{"issue":"1","key":"564_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. BMC Bioinf. 2011;12(1):323. https:\/\/doi.org\/10.1186\/1471-2105-12-323.","journal-title":"BMC Bioinf"},{"key":"564_CR31","doi-asserted-by":"publisher","unstructured":"Hu Y, Guo X, Yun Y, Lu L, Huang X, Jia S. DisGeNet: a disease-centric interaction database among diseases and various associated genes. Database (Oxford). 2025;2025:baae122. https:\/\/doi.org\/10.1093\/database\/baae122.","DOI":"10.1093\/database\/baae122"},{"issue":"4","key":"564_CR32","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/GIM.0b013e31816b5cae","volume":"10","author":"CS Richards","year":"2008","unstructured":"Richards CS, Bale S, Bellissimo DB, Das S, Grody WW, Hegde MR, et al. ACMG recommendations for standards for interpretation and reporting of sequence variations: revisions 2007. Genet Med. 2008;10(4):294\u2013300. https:\/\/doi.org\/10.1097\/GIM.0b013e31816b5cae.","journal-title":"Genet Med"},{"key":"564_CR33","doi-asserted-by":"publisher","unstructured":"Wable R, Nair AS, Pappu A, Pierre-Louis W, Abdelhalim H, Patel K, et al. Integrated ACMG-approved genes and ICD codes for the translational research and precision medicine. Database (Oxford). 2023;2023:baad033. https:\/\/doi.org\/10.1093\/database\/baad033.","DOI":"10.1093\/database\/baad033"},{"key":"564_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.atherosclerosis.2019.09.002","volume":"290","author":"M Haarhaus","year":"2019","unstructured":"Haarhaus M, Ray KK, Nicholls SJ, Schwartz GG, Kulikowski E, Johansson JO, et al. Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease. Atherosclerosis. 2019;290:59\u201365. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2019.09.002.","journal-title":"Atherosclerosis"},{"issue":"10","key":"564_CR35","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.3390\/nu14102124","volume":"14","author":"M Haarhaus","year":"2022","unstructured":"Haarhaus M, Cianciolo G, Barbuto S, La Manna G, Gasperoni L, Tripepi G, et al. Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic Kidney disease. Nutrients. 2022;14(10):2124. https:\/\/doi.org\/10.3390\/nu14102124.","journal-title":"Nutrients"},{"issue":"1","key":"564_CR36","doi-asserted-by":"publisher","first-page":"7555","DOI":"10.1038\/s41467-023-43369-x","volume":"14","author":"R Li","year":"2023","unstructured":"Li R, Chen B, Kubota A, Hanna A, Humeres C, Hernandez SC, et al. Protective effects of macrophage-specific integrin \u03b15 in myocardial infarction are associated with accentuated angiogenesis. Nat Commun. 2023;14(1):7555. https:\/\/doi.org\/10.1038\/s41467-023-43369-x.","journal-title":"Nat Commun"},{"issue":"16","key":"564_CR37","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1161\/CIRCULATIONAHA.124.070693","volume":"151","author":"SE Lemay","year":"2025","unstructured":"Lemay SE, Montesinos MS, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, et al. Exploring integrin \u03b15\u03b21 as a potential therapeutic target for pulmonary arterial hypertension: insights from comprehensive multicenter preclinical studies. Circulation. 2025;151(16):1162\u201383. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.070693.","journal-title":"Circulation"},{"issue":"7","key":"564_CR38","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.3390\/cimb45070369","volume":"45","author":"W Yuan","year":"2023","unstructured":"Yuan W, Zhang X, Fan X. The role of the Piezo1 mechanosensitive channel in heart failure. Curr Issues Mol Biol. 2023;45(7):5830\u201348. https:\/\/doi.org\/10.3390\/cimb45070369.","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"564_CR39","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1007\/s11033-025-10969-3","volume":"52","author":"JY Wang","year":"2025","unstructured":"Wang JY, Li BH, Liu CY, Wang QH, Wang J, Guo MJ, et al. Piezo1 in heart failure: a new perspective from cytomechanical sensing to diverse cellular pathways. Mol Biol Rep. 2025;52(1):862. https:\/\/doi.org\/10.1007\/s11033-025-10969-3.","journal-title":"Mol Biol Rep"},{"issue":"5","key":"564_CR40","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCRESAHA.123.322798","volume":"134","author":"B Coste","year":"2024","unstructured":"Coste B, Delmas P. PIEZO ion channels in cardiovascular functions and diseases. Circ Res. 2024;134(5):572\u201391. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322798.","journal-title":"Circ Res"},{"issue":"2","key":"564_CR41","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/dvdy.401","volume":"251","author":"V Shah","year":"2022","unstructured":"Shah V, Patel S, Shah J. Emerging role of Piezo ion channels in cardiovascular development. Dev Dyn. 2022;251(2):276\u201386. https:\/\/doi.org\/10.1002\/dvdy.401.","journal-title":"Dev Dyn"},{"issue":"22","key":"564_CR42","doi-asserted-by":"publisher","first-page":"15319","DOI":"10.1074\/jbc.M800021200","volume":"283","author":"CH Byon","year":"2008","unstructured":"Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem. 2008;283(22):15319\u201327. https:\/\/doi.org\/10.1074\/jbc.M800021200.","journal-title":"J Biol Chem"},{"issue":"6","key":"564_CR43","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1161\/CIRCRESAHA.115.306341","volume":"117","author":"U Raaz","year":"2015","unstructured":"Raaz U, Schellinger IN, Chernogubova E, Warnecke C, Kayama Y, Penov K, et al. Transcription factor Runx2 promotes aortic fibrosis and stiffness in type 2 diabetes mellitus. Circ Res. 2015;117(6):513\u201324. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306341.","journal-title":"Circ Res"},{"issue":"1","key":"564_CR44","doi-asserted-by":"publisher","first-page":"16656","DOI":"10.1038\/s41598-022-21202-7","volume":"12","author":"M Tomimatsu","year":"2022","unstructured":"Tomimatsu M, Matsumoto K, Ashizuka M, Kumagai S, Tanaka S, Nakae T, et al. Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling. Sci Rep. 2022;12(1):16656. https:\/\/doi.org\/10.1038\/s41598-022-21202-7.","journal-title":"Sci Rep"},{"key":"564_CR45","doi-asserted-by":"publisher","first-page":"111058","DOI":"10.1016\/j.clinbiochem.2025.111058","volume":"141","author":"EH Malick Ndour","year":"2026","unstructured":"Malick Ndour EH, Mnika K, Ousmane Sene EH, Tall FG, Nembaware V, Ly ID, et al. Association of hypertension and genetic variants in MYH9 and BMPR1B with increased proteinuria in sickle cell disease. Clin Biochem. 2026;141:111058. Advance online publication. https:\/\/doi.org\/10.1016\/j.clinbiochem.2025.111058.","journal-title":"Clin Biochem"},{"issue":"18","key":"564_CR46","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.121.057178","volume":"146","author":"C Bai","year":"2022","unstructured":"Bai C, Su M, Zhang Y, Lin Y, Sun Y, Song L, et al. Oviductal Glycoprotein 1 promotes Hypertension by inducing vascular remodeling through an interaction with MYH9. Circulation. 2022;146(18):1367\u201382. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.121.057178.","journal-title":"Circulation"},{"issue":"1","key":"564_CR47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s00018-025-05894-4","volume":"82","author":"T Etuze","year":"2025","unstructured":"Etuze T, Repesse Y, Vivien D, Dubois F. NDRG1 as a sensor and mediator of endothelial stress: from homeostasis to inflammation and cardiovascular disease. Cell Mol Life Sci. 2025;82(1):402. https:\/\/doi.org\/10.1007\/s00018-025-05894-4.","journal-title":"Cell. Mol. Life Sci"},{"issue":"13","key":"564_CR48","doi-asserted-by":"publisher","first-page":"10510","DOI":"10.3390\/ijms241310510","volume":"24","author":"BS Tudurachi","year":"2023","unstructured":"Tudurachi BS, Z\u0103voi A, Leonte A, \u021a\u0103poi L, Ureche C, B\u00eergoan SG, et al. An update on MYBPC3 gene mutation in hypertrophic cardiomyopathy. Int J Mol Sci. 2023;24(13):10510. https:\/\/doi.org\/10.3390\/ijms241310510.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"564_CR49","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1093\/hmg\/ddx418","volume":"27","author":"L Sheng","year":"2018","unstructured":"Sheng L, Wan B, Feng P, Sun J, Rigo F, Bennett CF, et al. Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model. Hum Mol Genet. 2018;27(3):486\u201398. https:\/\/doi.org\/10.1093\/hmg\/ddx418.","journal-title":"Hum Mol Genet"},{"issue":"8","key":"564_CR50","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/ng.2349","volume":"44","author":"ME Lindsay","year":"2012","unstructured":"Lindsay ME, Schepers D, Bolar NA, Doyle JJ, Gallo E, Fert-Bober J, et al. Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nat Genet. 2012;44(8):922\u201327. https:\/\/doi.org\/10.1038\/ng.2349.","journal-title":"Nat Genet"},{"key":"564_CR51","doi-asserted-by":"publisher","first-page":"114899","DOI":"10.1016\/j.intimp.2025.114899","volume":"159","author":"W Wu","year":"2025","unstructured":"Wu W, Tang W, Liang W, Li Q, Qi X, Gao R, et al. GDF15 suppresses abdominal aortic aneurysm by upregulating AREG expression to adjust macrophage polarization. Int Immunopharmacol. 2025;159:114899. https:\/\/doi.org\/10.1016\/j.intimp.2025.114899.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"564_CR52","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00380-007-1027-4","volume":"23","author":"ST Lee","year":"2008","unstructured":"Lee ST, Kim JA, Jang SY, Kim DK, Kim JW, Ki CS. A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. Heart Vessels. 2008;23(2):144\u201348. https:\/\/doi.org\/10.1007\/s00380-007-1027-4.","journal-title":"Heart Vessels"},{"issue":"12","key":"564_CR53","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/gim.2014.72","volume":"16","author":"MG Pepin","year":"2014","unstructured":"Pepin MG, Schwarze U, Rice KM, Liu M, Leistritz D, Byers PH. Survival is affected by mutation type and molecular mechanism in vascular Ehlers\u2013Danlos syndrome (EDS type IV). Genet Med. 2014;16(12):881\u201388. https:\/\/doi.org\/10.1038\/gim.2014.72.","journal-title":"Genet Med"},{"key":"564_CR54","doi-asserted-by":"publisher","unstructured":"Goumans MJ, Ten Dijke P. TGF-\u03b2 signaling in control of cardiovascular function. Cold Spring Harb Perspect Biol. 2018;10(2):a022210. https:\/\/doi.org\/10.1101\/cshperspect.a022210.","DOI":"10.1101\/cshperspect.a022210"},{"issue":"7","key":"564_CR55","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.3390\/cells10071681","volume":"10","author":"LS Kilian","year":"2021","unstructured":"Kilian LS, Frank D, Rangrez AY. RhoA signaling in immune cell response and cardiac disease. Cells. 2021;10(7):1681. https:\/\/doi.org\/10.3390\/cells10071681.","journal-title":"Cells"},{"issue":"2","key":"564_CR56","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.3390\/ijms24021756","volume":"24","author":"A Bertaud","year":"2023","unstructured":"Bertaud A, Joshkon A, Heim X, Bachelier R, Bardin N, Leroyer AS, et al. Signaling pathways and potential therapeutic strategies in cardiac fibrosis. Int J Mol Sci. 2023;24(2):1756. https:\/\/doi.org\/10.3390\/ijms24021756.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"564_CR57","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/biomedicines12030601","volume":"12","author":"J D\u0105bek","year":"2024","unstructured":"D\u0105bek J, Korze\u0144 D, Sierka O, Paluszkiewicz L, Milting H, G\u0105sior Z. Risk factors association with transcriptional activity of metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) genes in patients with heart failure. Biomedicines. 2024;12(3):601. https:\/\/doi.org\/10.3390\/biomedicines12030601.","journal-title":"Biomedicines"},{"issue":"6","key":"564_CR58","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1152\/physiol.00029.2013","volume":"28","author":"A Yabluchanskiy","year":"2013","unstructured":"Yabluchanskiy A, Ma Y, Iyer RP, Hall ME, Lindsey ML. Matrix metalloproteinase-9: many shades of function in cardiovascular disease. Physiology (Bethesda). 2013;28(6):391\u2013403. https:\/\/doi.org\/10.1152\/physiol.00029.2013.","journal-title":"Physiology (Bethesda)"},{"key":"564_CR59","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2147\/VHRM.S68415","volume":"11","author":"TP Vacek","year":"2015","unstructured":"Vacek TP, Rahman S, Yu S, Neamtu D, Givimani S, Tyagi SC. Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms. Vasc Health Risk Manag. 2015;11:173\u201383. https:\/\/doi.org\/10.2147\/VHRM.S68415.","journal-title":"Vasc Health Risk Manag"},{"issue":"7","key":"564_CR60","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1161\/CIRCRESAHA.124.325402","volume":"136","author":"R Ghazal","year":"2025","unstructured":"Ghazal R, Wang M, Liu D, Tschumperlin DJ, Pereira NL. Cardiac fibrosis in the multi-omics era: implications for heart failure. Circ Res. 2025;136(7):773\u2013802. https:\/\/doi.org\/10.1161\/CIRCRESAHA.124.325402.","journal-title":"Circ Res"},{"key":"564_CR61","doi-asserted-by":"publisher","unstructured":"Han Y, Shao Z, Zhang Y, Zhao H, Sun Z, Yang C, et al. 3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching. Sci Rep. 2024;14(1). https:\/\/doi.org\/10.1038\/s41598-024-67646-x.","DOI":"10.1038\/s41598-024-67646-x"},{"key":"564_CR62","doi-asserted-by":"publisher","first-page":"123084","DOI":"10.1016\/j.lfs.2024.123084","volume":"357","author":"C Ren","year":"2024","unstructured":"Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, et al. Inhibition of the FOXO1\u2013ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in tetralogy of fallot by maintaining mitochondrial quality control. Life Sci. 2024;357:123084. https:\/\/doi.org\/10.1016\/j.lfs.2024.123084.","journal-title":"Life Sci"},{"key":"564_CR63","doi-asserted-by":"publisher","first-page":"950927","DOI":"10.3389\/fcell.2022.950927","volume":"10","author":"HA Pahlavani","year":"2022","unstructured":"Pahlavani HA. Exercise-induced signaling pathways to counteracting cardiac apoptotic processes. Front Cell Dev Biol. 2022;10:950927. https:\/\/doi.org\/10.3389\/fcell.2022.950927.","journal-title":"Front. Cell Dev. Biol"},{"issue":"6","key":"564_CR64","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1002\/ehf2.13065","volume":"7","author":"W Yu","year":"2020","unstructured":"Yu W, Chen C, Cheng J. The role and molecular mechanism of FoxO1 in mediating cardiac hypertrophy. ESC Heart Fail. 2020;7(6):3497\u2013504. https:\/\/doi.org\/10.1002\/ehf2.13065.","journal-title":"ESC Heart Fail"},{"issue":"1","key":"564_CR65","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/CIRCRESAHA.115.304457","volume":"116","author":"Z Lin","year":"2015","unstructured":"Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, et al. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015;116(1):35\u201345. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.304457.","journal-title":"Circ Res"},{"issue":"17","key":"564_CR66","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","volume":"107","author":"NM Rajamannan","year":"2003","unstructured":"Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 2003;107(17):2181\u201384. https:\/\/doi.org\/10.1161\/01.CIR.0000070591.21548.69.","journal-title":"Circulation"},{"issue":"3","key":"564_CR67","doi-asserted-by":"publisher","first-page":"100448","DOI":"10.1016\/j.xhgg.2025.100448","volume":"6","author":"P Zamani","year":"2025","unstructured":"Zamani P, Houessou U, Manikpurage HD, Li Z, Dahmene M, Gaudreault N, et al. Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets. HGG Adv. 2025;6(3):100448. https:\/\/doi.org\/10.1016\/j.xhgg.2025.100448.","journal-title":"HGG Adv"},{"issue":"20","key":"564_CR68","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1007\/s00018-019-03204-3","volume":"76","author":"TW Lee","year":"2019","unstructured":"Lee TW, Kao YH, Chen YJ, Chao TF, Lee TI. Therapeutic potential of vitamin D in AGE\/RAGE-related cardiovascular diseases. Cell. Mol. Life Sci. 2019;76(20):4103\u201315. https:\/\/doi.org\/10.1007\/s00018-019-03204-3.","journal-title":"Cell. Mol. Life Sci"},{"issue":"6","key":"564_CR69","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s10557-024-07639-0","volume":"39","author":"B Wang","year":"2025","unstructured":"Wang B, Jiang T, Qi Y, Luo S, Xia Y, Lang B, et al. AGE-RAGE axis and cardiovascular diseases: pathophysiologic mechanisms and prospects for clinical applications. Cardiovasc Drugs Ther. 2025;39(6):1489\u2013506. https:\/\/doi.org\/10.1007\/s10557-024-07639-0.","journal-title":"Cardiovasc Drugs Ther"},{"key":"564_CR70","doi-asserted-by":"publisher","first-page":"100535","DOI":"10.1016\/j.cophys.2022.100535","volume":"26","author":"WE Knight","year":"2022","unstructured":"Knight WE, Woulfe KC. Dysfunctional sarcomeric relaxation in the heart. Curr Opin Physiol. 2022;26:100535. https:\/\/doi.org\/10.1016\/j.cophys.2022.100535.","journal-title":"Curr Opin Physiol"},{"issue":"4","key":"564_CR71","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","volume":"57","author":"H Bugger","year":"2014","unstructured":"Bugger H, Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2014;57(4):660\u201371. https:\/\/doi.org\/10.1007\/s00125-014-3171-6.","journal-title":"Diabetologia"},{"issue":"9","key":"564_CR72","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1001\/jamainternmed.2023.3087","volume":"183","author":"TM Johnson","year":"2023","unstructured":"Johnson TM, Mahabir CA, Yang Y, Roul P, Goldsweig AM, Binstadt BA, et al. Aortic stenosis risk in rheumatoid arthritis. JAMA Intern Med. 2023;183(9):973\u201381. Advance online publication. https:\/\/doi.org\/10.1001\/jamainternmed.2023.3087.","journal-title":"JAMA Intern Med"},{"issue":"1","key":"564_CR73","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1038\/s41598-018-21599-0","volume":"8","author":"RI Mincu","year":"2018","unstructured":"Mincu RI, Magda SL, Mihaila S, Florescu M, Mihalcea DJ, Velcea A, et al. Impaired cardiac function in patients with multiple sclerosis by comparison with normal subjects. Sci Rep. 2018;8(1):3300. https:\/\/doi.org\/10.1038\/s41598-018-21599-0.","journal-title":"Sci Rep"},{"issue":"12","key":"564_CR74","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.3390\/ijms22126212","volume":"22","author":"L Mourino-Alvarez","year":"2021","unstructured":"Mourino-Alvarez L, Corbacho-Alonso N, Sastre-Oliva T, Corros-Vicente C, Solis J, Tejerina T, et al. Diabetes mellitus and its implications in aortic stenosis patients. Int J Mol Sci. 2021;22(12):6212. https:\/\/doi.org\/10.3390\/ijms22126212.","journal-title":"Int J Mol Sci"},{"issue":"16","key":"564_CR75","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1136\/heartjnl-2021-319604","volume":"108","author":"JI Gupta","year":"2022","unstructured":"Gupta JI, Gualano SK, Bhave N. Aortic stenosis in chronic kidney disease: challenges in diagnosis and treatment. Heart (Br Card Soc). 2022;108(16):1260\u201366. https:\/\/doi.org\/10.1136\/heartjnl-2021-319604.","journal-title":"Heart (Br Card Soc)"},{"key":"564_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/3012509","volume":"2019","author":"DM Bunu","year":"2019","unstructured":"Bunu DM, Timofte CE, Ciocoiu M, Floria M, Tarniceriu CC, Barboi OB, et al. Cardiovascular manifestations of inflammatory Bowel disease: pathogenesis, diagnosis, and preventive Strategies. Gastroenterol Res Pract. 2019;2019:1\u201314. https:\/\/doi.org\/10.1155\/2019\/3012509.","journal-title":"Gastroenterol Res Pract"},{"issue":"4","key":"564_CR77","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/0002-9343(82)90485-5","volume":"72","author":"BB Lerman","year":"1982","unstructured":"Lerman BB, Thomas LC, Abrams GD, Pitt B. Aortic stenosis associated with systemic lupus erythematosus. Am J Med. 1982;72(4):707\u201310. https:\/\/doi.org\/10.1016\/0002-9343(82)90485-5.","journal-title":"Am J Med"},{"key":"564_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/9538527","volume":"2020","author":"A Bal\u010di\u016bnait\u0117","year":"2020","unstructured":"Bal\u010di\u016bnait\u0117 A, Budrikis A, Rumbinait\u0117 E, Sabaliauskien\u0117 J, Patamsyt\u0117 V, Lesauskait\u0117 V. Ankylosing spondyloarthritis resulting severe aortic insufficiency and aortitis: exacerbation of ankylosing spondyloarthritis and stenosis of the main left coronary artery after mechanical aortic valve implantation with cardiopulmonary bypass. Case Rep Rheumatol. 2020;2020:1\u20135. https:\/\/doi.org\/10.1155\/2020\/9538527.","journal-title":"Case Rep Rheumatol"},{"issue":"12","key":"564_CR79","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/eurheartj\/ehae054","volume":"45","author":"C Polcwiartek","year":"2024","unstructured":"Polcwiartek C, O\u2019Gallagher K, Friedman DJ, Correll CU, Solmi M, Jensen SE, et al. Severe mental illness: cardiovascular risk assessment and management. Eur Heart J. 2024;45(12):987\u201397. https:\/\/doi.org\/10.1093\/eurheartj\/ehae054.","journal-title":"Eur Heart J"},{"issue":"4","key":"564_CR80","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.aace.2024.04.006","volume":"10","author":"J Ambalavanan","year":"2024","unstructured":"Ambalavanan J, Hubbard C, Khan LZ. Acceleration of preexisting aortic stenosis after teriparatide initiation. AACE Clin Case Rep. 2024;10(4):152\u201355. https:\/\/doi.org\/10.1016\/j.aace.2024.04.006.","journal-title":"AACE Clin Case Rep"},{"issue":"21","key":"564_CR81","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/eurheartj\/eht034","volume":"34","author":"MR Dweck","year":"2013","unstructured":"Dweck MR, Khaw HJ, Sng GK, Luo EL, Baird A, Williams MC, et al. Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation? Eur Heart J. 2013;34(21):1567\u201374. https:\/\/doi.org\/10.1093\/eurheartj\/eht034.","journal-title":"Eur Heart J"},{"issue":"5","key":"564_CR82","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0300-8932(00)75137-2","volume":"53","author":"\u00c1 Fern\u00e1ndez-F\u00fanez","year":"2000","unstructured":"Fern\u00e1ndez-F\u00fanez \u00c1, Cabrera R, Hern\u00e1ndez A, Requejo R, Rueda A, Fern\u00e1ndez-Zamora F, et al. Insuficiencia card\u00edaca\/trasplante card\u00edaco. Rev Esp Cardiol. 2000;53(5):603\u201310. https:\/\/doi.org\/10.1016\/S0300-8932(00)75137-2.","journal-title":"Rev Esp Cardiol"},{"key":"564_CR83","doi-asserted-by":"publisher","unstructured":"Kashish, Singh T, Kumar A, Angrish A, Bansal S, K. Diastolic dysfunction in type 2 diabetes and its correlation with nephropathy and associated risk factors. Ann Afr Med. 2025. https:\/\/doi.org\/10.4103\/aam.aam_267_25. Advance online publication.","DOI":"10.4103\/aam.aam_267_25"},{"issue":"1","key":"564_CR84","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1177\/08465371241278523","volume":"76","author":"A Fawzy","year":"2025","unstructured":"Fawzy A, Warnica W, Hanneman K, Wald RM, Oechslin E, Thavendiranathan P, et al. Association between cardiac size, systolic function, and complications in vascular Ehlers-Danlos Syndrome. Can Assoc Radiol J. 2025;76(1):161\u201370. https:\/\/doi.org\/10.1177\/08465371241278523.","journal-title":"Can Assoc Radiol J"},{"issue":"11","key":"564_CR85","doi-asserted-by":"publisher","first-page":"102269","DOI":"10.1016\/j.jacadv.2025.102269","volume":"4","author":"HA Nabi","year":"2025","unstructured":"Nabi HA, Bcharah G, Bcharah H, Dreher L, Raslan MA, Youssef A, et al. The burden of cardiac arrhythmias in Loeys-Dietz Syndrome: prevalence, etiology, and therapeutic interventions. JACC Adv. 2025;4(11):102269. https:\/\/doi.org\/10.1016\/j.jacadv.2025.102269.","journal-title":"JACC Adv"},{"issue":"4","key":"564_CR86","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00408-021-00454-6","volume":"199","author":"GK Thomas","year":"2021","unstructured":"Thomas GK, Trankle CR, Carbone S, Billingsley H, Van Tassell BW, Evans RK, et al. Diastolic dysfunction contributes to impaired cardiorespiratory fitness in patients with lung cancer and reduced lung function following chest radiation. Lung. 2021;199(4):403\u201307. https:\/\/doi.org\/10.1007\/s00408-021-00454-6.","journal-title":"Lung"},{"issue":"6","key":"564_CR87","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1634\/theoncologist.2014-0299","volume":"20","author":"L Cao","year":"2015","unstructured":"Cao L, Cai G, Chang C, Miao AY, Yu XL, Yang ZZ, et al. Diastolic dysfunction occurs early in HER2-positive breast cancer patients treated concurrently with radiation therapy and trastuzumab. Oncologist. 2015;20(6):605\u201314. https:\/\/doi.org\/10.1634\/theoncologist.2014-0299.","journal-title":"Oncologist"},{"issue":"2","key":"564_CR88","doi-asserted-by":"publisher","first-page":"122","DOI":"10.12701\/yujm.2019.00332","volume":"37","author":"JT Byoun","year":"2020","unstructured":"Byoun JT, Cho JY. Fatal progressive right heart failure in a pancreatic cancer patient. Yeungnam Univ J Med. 2020;37(2):122\u201327. https:\/\/doi.org\/10.12701\/yujm.2019.00332.","journal-title":"Yeungnam Univ J Med"},{"issue":"6","key":"564_CR89","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3390\/cancers16061099","volume":"16","author":"J Beckhaus","year":"2024","unstructured":"Beckhaus J, Friedrich C, M\u00fcller HL. Vascular morbidity and mortality in Craniopharyngioma patients\u2014a scoping review. Cancers. 2024;16(6):1099. https:\/\/doi.org\/10.3390\/cancers16061099.","journal-title":"Cancers"},{"key":"564_CR90","doi-asserted-by":"publisher","first-page":"931917","DOI":"10.3389\/fcvm.2022.931917","volume":"9","author":"A Turk","year":"2022","unstructured":"Turk A, Kunej T. Shared genetic risk factors between cancer and cardiovascular diseases. Front Cardiovasc. Med. 2022;9:931917. https:\/\/doi.org\/10.3389\/fcvm.2022.931917.","journal-title":"Front. Cardiovasc. Med"}],"container-title":["BioData Mining"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13040-026-00564-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13040-026-00564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13040-026-00564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:04:04Z","timestamp":1785798244000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13040-026-00564-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":90,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s13040-026-00564-y","relation":{},"ISSN":["1756-0381"],"issn-type":[{"value":"1756-0381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"5 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Informed consent was obtained from all subjects. All human samples were used in accordance with relevant guidelines and regulations, and all experimental protocols were approved by the Institutional Review Board (IRB) at UConn Health and Rutgers University. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Z.A. is an Assistant Professor at the Department of Medicine, Division of Cardiovascular Diseases and Hypertension, Robert Wood Johnson Medical School (RWJMS), and a Core Faculty Member at the Rutgers Institute for Health, Health Care Policy, and Aging Research (IFH), Rutgers Health. Furthermore, ZA is the Adjunct Assistant Professor at the School of Medicine, UConn Health, CT.P.G. and J.M. are Research Assistant at the Ahmed lab, Rutgers IFH\/RWJMS.N.Y. is an Associate Professor of Medicine, Section Chief of Clinical Research & AI Innovation, and Director of Data Science and Machine Learning Research in the Division of Cardiology at Rutgers Robert Wood Johnson Medical School in New Brunswick, NJ. Additionally, she directs the Center for Innovation at RWJUH, serves as an Editorial Board Member for the American Society of Echocardiography (ASE), and holds roles as Associate Editor for Translational Systems Biology and In Silico Trials.P.S. is the Henry Rutgers Professor of Cardiology and the Chief of the Division of Cardiovascular Diseases & Hypertension at Rutgers Robert Wood Johnson Medical School and the Chief of Cardiac Services at the Robert Wood Johnson University Hospital.","order":3,"name":"Ethics","label":"Biographical note","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"56"}}