{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:35:09Z","timestamp":1790674509061,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III\/CIBERNED"},{"name":"Madrid Regional Government","award":["Neurodegmodels"],"award-info":[{"award-number":["Neurodegmodels"]}]},{"name":"AEI-FEDER, EU","award":["SAF2014-53412-R; SAF2017-89554-R"],"award-info":[{"award-number":["SAF2014-53412-R; SAF2017-89554-R"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13041-018-0359-6","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T08:13:46Z","timestamp":1520583226000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington\u2019s disease"],"prefix":"10.1186","volume":"11","author":[{"given":"Alejandro","family":"L\u00f3pez-Hurtado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xose M.","family":"Dopazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"R\u00e1bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-3469","authenticated-orcid":false,"given":"Jose R.","family":"Naranjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"issue":"5","key":"359_CR1","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","volume":"89","author":"F Saudou","year":"2016","unstructured":"Saudou F, Humbert S. The biology of huntingtin. Neuron. 2016;89(5):910\u201326.","journal-title":"Neuron"},{"issue":"3","key":"359_CR2","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1074\/jbc.R113.534743","volume":"289","author":"J Lee","year":"2014","unstructured":"Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem. 2014;289(3):1203\u201311.","journal-title":"J Biol Chem"},{"issue":"4","key":"359_CR3","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/nan.12211","volume":"41","author":"M Halliday","year":"2015","unstructured":"Halliday M, Mallucci GR. Modulating the unfolded protein response to prevent neurodegeneration and enhance memory. Neuropathol Appl Neurobiol. 2015;41(4):414\u201327.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"359_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrn3689","volume":"15","author":"C Hetz","year":"2014","unstructured":"Hetz C, Mollereau B. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci. 2014;15(4):233\u201349.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"359_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13024-017-0183-y","volume":"12","author":"NT Sprenkle","year":"2017","unstructured":"Sprenkle NT, Sims SG, Sanchez CL, Meares GP. Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener. 2017;12(1):42.","journal-title":"Mol Neurodegener"},{"key":"359_CR6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-pathol-012615-044216","volume":"11","author":"J Herms","year":"2016","unstructured":"Herms J, Dorostkar MM. Dendritic spine pathology in neurodegenerative diseases. Annu Rev Pathol. 2016;11:221\u201350.","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"359_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.nbd.2010.08.014","volume":"41","author":"MR Fernandez-Fernandez","year":"2011","unstructured":"Fernandez-Fernandez MR, Ferrer I, Lucas JJ. Impaired ATF6alpha processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease. Neurobiol Dis. 2011;41(1):23\u201332.","journal-title":"Neurobiol Dis"},{"issue":"2","key":"359_CR8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1172\/JCI82670","volume":"126","author":"JRZH Naranjo","year":"2016","unstructured":"Naranjo JRZH, Villar D, Gonz\u00e1lez P, Dopazo XM, Mor\u00f3n J, Higueras E, Oliveros JC, Arrabal MD, Prieto A, Cerc\u00f3s P, Gonz\u00e1lez T, De la Cruz A, Casado-Vela J, R\u00e1bano A, Valenzuela C, Gutierrez-Rodriguez M, Li JY, Mellstr\u00f6m B. Activating transcription factor 6 de-repression mediates neuroprotection in Huntington's disease. J Clin Invest. 2016;126(2):627\u201338.","journal-title":"J Clin Invest"},{"issue":"6722","key":"359_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/18044","volume":"398","author":"AM Carrion","year":"1999","unstructured":"Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR. DREAM is a Ca2+\u2212regulated transcriptional repressor. Nature. 1999;398(6722):80\u20134.","journal-title":"Nature"},{"issue":"10","key":"359_CR10","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1038\/2673","volume":"4","author":"JD Buxbaum","year":"1998","unstructured":"Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998;4(10):1177\u201381.","journal-title":"Nat Med"},{"issue":"6769","key":"359_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/35000592","volume":"403","author":"WF An","year":"2000","unstructured":"An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000;403(6769):553\u20136.","journal-title":"Nature"},{"issue":"2","key":"359_CR12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1152\/physrev.00041.2005","volume":"88","author":"B Mellstrom","year":"2008","unstructured":"Mellstrom B, Savignac M, Gomez-Villafuertes R, Naranjo JR. Ca2+\u2212operated transcriptional networks: molecular mechanisms and in vivo models. Physiol Rev. 2008;88(2):421\u201349.","journal-title":"Physiol Rev"},{"issue":"5","key":"359_CR13","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1128\/MCB.00360-13","volume":"34","author":"B Mellstrom","year":"2014","unstructured":"Mellstrom B, Sahun I, Ruiz-Nuno A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, et al. DREAM controls the on\/off switch of specific activity-dependent transcription pathways. Mol Cell Biol. 2014;34(5):877\u201387.","journal-title":"Mol Cell Biol"},{"key":"359_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13041-016-0204-8","volume":"9","author":"BKA Mellstr\u00f6m","year":"2016","unstructured":"Mellstr\u00f6m BKA, Knafo S, Gonzalez P, Dopazo XM, Ruiz-Nu\u00f1o A, Jefferys J, Zhuo M, Bliss TVP, Naranjo JR, De Felipe J, Unbalanced DREAM. Activity modifies hippocampal connectivity and cognition. Mol Brain. 2016;9:22\u201333.","journal-title":"Mol Brain"},{"key":"359_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1756-6606-3-3","volume":"3","author":"LJ Wu","year":"2010","unstructured":"Wu LJ, Mellstrom B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010;3:3\u201315.","journal-title":"Mol Brain"},{"issue":"27","key":"359_CR16","doi-asserted-by":"crossref","first-page":"9097","DOI":"10.1523\/JNEUROSCI.23-27-09097.2003","volume":"23","author":"C Lilliehook","year":"2003","unstructured":"Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, et al. Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003;23(27):9097\u2013106.","journal-title":"J Neurosci"},{"issue":"3","key":"359_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1101\/lm.1261709","volume":"16","author":"JC Alexander","year":"2009","unstructured":"Alexander JC, McDermott CM, Tunur T, Rands V, Stelly C, Karhson D, Bowlby MR, An WF, Sweatt JD, Schrader LA. The role of calsenilin\/DREAM\/KChIP3 in contextual fear conditioning. Learn Mem. 2009;16(3):167\u201377.","journal-title":"Learn Mem"},{"issue":"1","key":"359_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0092-8674(01)00629-8","volume":"108","author":"HY Cheng","year":"2002","unstructured":"Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, et al. DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002;108(1):31\u201343.","journal-title":"Cell"},{"issue":"22","key":"359_CR19","doi-asserted-by":"publisher","first-page":"7575","DOI":"10.1523\/JNEUROSCI.1312-10.2010","volume":"30","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, et al. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010;30(22):7575\u201386.","journal-title":"J Neurosci"},{"issue":"3","key":"359_CR20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell. 1996;87(3):493\u2013506.","journal-title":"Cell"},{"issue":"1","key":"359_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13041-018-0348-9","volume":"11","author":"VTY Tan","year":"2018","unstructured":"Tan VTY, Mockett BG, Ohline SM, Parfitt KD, Wicky HE, Peppercorn K, Schoderboeck L, Yahaya MFB, Tate WP, Hughes SM, et al. Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Mol Brain. 2018;11(1):7.","journal-title":"Mol Brain"},{"issue":"1","key":"359_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13041-016-0270-y","volume":"9","author":"L Cui","year":"2016","unstructured":"Cui L, Sun W, Yu M, Li N, Guo L, Gu H, Zhou Y. Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits. Mol Brain. 2016;9(1):89\u2013101.","journal-title":"Mol Brain"},{"issue":"20","key":"359_CR23","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1038\/sj.emboj.7600810","volume":"24","author":"M Savignac","year":"2005","unstructured":"Savignac M, Pintado B, Gutierrez-Adan A, Palczewska M, Mellstrom B, Naranjo JR. Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression. EMBO J. 2005;24(20):3555\u201364.","journal-title":"EMBO J"},{"issue":"1","key":"359_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.expneurol.2006.10.014","volume":"204","author":"K van der Borght","year":"2007","unstructured":"van der Borght K, Brundin P. Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6\/1 and R6\/2 mouse models of Huntington's disease. Exp Neurol. 2007;204(1):473\u20138.","journal-title":"Exp Neurol"},{"key":"359_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.nbd.2015.03.030","volume":"79","author":"W Li","year":"2015","unstructured":"Li W, Silva HB, Real J, Wang YM, Rial D, Li P, Payen MP, Zhou Y, Muller CE, Tome AR, et al. Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiol Dis. 2015;79:70\u201380.","journal-title":"Neurobiol Dis"},{"key":"359_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.nbd.2014.11.004","volume":"74","author":"S Tyebji","year":"2015","unstructured":"Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-Garcia JM, Alberch J, Cunha RA, Gruart A, Perez-Navarro E. Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. Neurobiol Dis. 2015;74:41\u201357.","journal-title":"Neurobiol Dis"},{"issue":"1\u20132","key":"359_CR27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0166-4328(01)00365-5","volume":"127","author":"H Eichenbaum","year":"2001","unstructured":"Eichenbaum H. The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behav Brain Res. 2001;127(1\u20132):199\u2013207.","journal-title":"Behav Brain Res"},{"issue":"Pt 1","key":"359_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/bj20030376","volume":"375","author":"M Okada","year":"2003","unstructured":"Okada M, Takezawa D, Tachibanaki S, Kawamura S, Tokumitsu H, Kobayashi R. Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide. Biochem J. 2003;375(Pt 1):87\u201397.","journal-title":"Biochem J"},{"issue":"2","key":"359_CR29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1471-4159.2009.06344.x","volume":"111","author":"N Rudinskiy","year":"2009","unstructured":"Rudinskiy N, Kaneko YA, Beesen AA, Gokce O, Regulier E, Deglon N, Luthi-Carter R. Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. J Neurochem. 2009;111(2):460\u201372.","journal-title":"J Neurochem"},{"key":"359_CR30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fnhum.2016.00317","volume":"10","author":"KD Bunner","year":"2016","unstructured":"Bunner KD, Rebec GV. Corticostriatal dysfunction in Huntington's disease: the basics. Front Hum Neurosci. 2016;10:317\u201329.","journal-title":"Front Hum Neurosci"},{"issue":"10","key":"359_CR31","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","volume":"60","author":"HD Rosas","year":"2003","unstructured":"Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Makris N, et al. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology. 2003;60(10):1615\u201320.","journal-title":"Neurology"},{"issue":"6","key":"359_CR32","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1503\/jpn.100143","volume":"36","author":"R Ille","year":"2011","unstructured":"Ille R, Schafer A, Scharmuller W, Enzinger C, Schoggl H, Kapfhammer HP, Schienle A. Emotion recognition and experience in Huntington disease: a voxel-based morphometry study. J Psychiatry Neurosci. 2011;36(6):383\u201390.","journal-title":"J Psychiatry Neurosci"},{"issue":"8","key":"359_CR33","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00415-004-0461-9","volume":"251","author":"J Lemiere","year":"2004","unstructured":"Lemiere J, Decruyenaere M, Evers-Kiebooms G, Vandenbussche E, Dom R. Cognitive changes in patients with Huntington's disease (HD) and asymptomatic carriers of the HD mutation--a longitudinal follow-up study. J Neurol. 2004;251(8):935\u201342.","journal-title":"J Neurol"},{"issue":"10","key":"359_CR34","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1016\/j.neuropsychologia.2006.01.015","volume":"44","author":"A Montoya","year":"2006","unstructured":"Montoya A, Pelletier M, Menear M, Duplessis E, Richer F, Lepage M. Episodic memory impairment in Huntington's disease: a meta-analysis. Neuropsychologia. 2006;44(10):1984\u201394.","journal-title":"Neuropsychologia"},{"issue":"5","key":"359_CR35","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s11910-011-0215-x","volume":"11","author":"JS Paulsen","year":"2011","unstructured":"Paulsen JS. Cognitive impairment in Huntington disease: diagnosis and treatment. Curr Neurol Neurosci Rep. 2011;11(5):474\u201383.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"359_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/a0020937","volume":"25","author":"JC Stout","year":"2011","unstructured":"Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, et al. Neurocognitive signs in prodromal Huntington disease. Neuropsychology. 2011;25(1):1\u201314.","journal-title":"Neuropsychology"},{"issue":"6","key":"359_CR37","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/bpa.12432","volume":"26","author":"M Puigdellivol","year":"2016","unstructured":"Puigdellivol M, Saavedra A, Perez-Navarro E. Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF. Brain Pathol. 2016;26(6):752\u201371.","journal-title":"Brain Pathol"},{"issue":"1","key":"359_CR38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1756-6606-5-2","volume":"5","author":"RD Burgoyne","year":"2012","unstructured":"Burgoyne RD, Haynes LP. Understanding the physiological roles of the neuronal calcium sensor proteins. Mol Brain. 2012;5(1):2\u201312.","journal-title":"Mol Brain"},{"issue":"9","key":"359_CR39","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.bbamcr.2014.10.029","volume":"1853","author":"RD Burgoyne","year":"2015","unstructured":"Burgoyne RD, Haynes LP. Sense and specificity in neuronal calcium signalling. Biochim Biophys Acta. 2015;1853(9):1921\u201332.","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"359_CR40","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1523\/JNEUROSCI.1460-04.2004","volume":"24","author":"WA Link","year":"2004","unstructured":"Link WA, Ledo F, Torres B, Palczewska M, Madsen TM, Savignac M, Albar JP, Mellstrom B, Naranjo JR. Day-night changes in downstream regulatory element antagonist modulator\/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland. J Neurosci. 2004;24(23):5346\u201355.","journal-title":"J Neurosci"},{"issue":"1","key":"359_CR41","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1073\/pnas.232693499","volume":"100","author":"PO Koh","year":"2003","unstructured":"Koh PO, Undie AS, Kabbani N, Levenson R, Goldman-Rakic PS, Lidow MS. Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients. Proc Natl Acad Sci U S A. 2003;100(1):313\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 8","key":"359_CR42","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1093\/brain\/awu131","volume":"137","author":"E Dragicevic","year":"2014","unstructured":"Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, et al. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain. 2014;137(Pt 8):2287\u2013302.","journal-title":"Brain"},{"issue":"24","key":"359_CR43","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1093\/hmg\/ddn300","volume":"17","author":"A Piton","year":"2008","unstructured":"Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafreniere RG, Hamdan FF, team SD, et al. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet. 2008;17(24):3965\u201374.","journal-title":"Hum Mol Genet"},{"issue":"5","key":"359_CR44","doi-asserted-by":"publisher","first-page":"e10534","DOI":"10.1371\/journal.pone.0010534","volume":"5","author":"MT Handley","year":"2010","unstructured":"Handley MT, Lian LY, Haynes LP, Burgoyne RD. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. PLoS One. 2010;5(5):e10534.","journal-title":"PLoS One"},{"issue":"1\u20132","key":"359_CR45","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0006-8993(96)00070-4","volume":"716","author":"S Shimohama","year":"1996","unstructured":"Shimohama S, Chachin M, Taniguchi T, Hidaka H, Kimura J. Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's disease. Brain Res. 1996;716(1\u20132):233\u20136.","journal-title":"Brain Res"},{"issue":"2","key":"359_CR46","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1159\/000051244","volume":"12","author":"K Braunewell","year":"2001","unstructured":"Braunewell K, Riederer P, Spilker C, Gundelfinger ED, Bogerts B, Bernstein HG. Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and \u22123, in neocortical brain areas of Alzheimer disease patients. Dement Geriatr Cogn Disord. 2001;12(2):110\u20136.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"359_CR47","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/ana.22448","volume":"70","author":"R Tarawneh","year":"2011","unstructured":"Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, et al. Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease. Ann Neurol. 2011;70(2):274\u201385.","journal-title":"Ann Neurol"},{"issue":"10","key":"359_CR48","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1212\/WNL.0b013e318248e568","volume":"78","author":"R Tarawneh","year":"2012","unstructured":"Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM. CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease. Neurology. 2012;78(10):709\u201319.","journal-title":"Neurology"},{"issue":"5","key":"359_CR49","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/jnc.12331","volume":"127","author":"X Luo","year":"2013","unstructured":"Luo X, Hou L, Shi H, Zhong X, Zhang Y, Zheng D, Tan Y, Hu G, Mu N, Chan J, et al. CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies. J Neurochem. 2013;127(5):681\u201390.","journal-title":"J Neurochem"},{"issue":"3","key":"359_CR50","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/JAD-141050","volume":"43","author":"B Mroczko","year":"2015","unstructured":"Mroczko B, Groblewska M, Zboch M, Muszynski P, Zajkowska A, Borawska R, Szmitkowski M, Kornhuber J, Lewczuk P. Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease. J Alzheimers Dis. 2015;43(3):1031\u20137.","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"359_CR51","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/jnen\/nlv018","volume":"75","author":"CM Kirkwood","year":"2016","unstructured":"Kirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun M, Kofler JK, Lopez OL, et al. Altered levels of Visinin-like protein 1 correspond to regional neuronal loss in Alzheimer disease and frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2016;75(2):175\u201382.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"359_CR52","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13024-016-0130-3","volume":"11","author":"C Cicognola","year":"2016","unstructured":"Cicognola C, Chiasserini D, Eusebi P, Andreasson U, Vanderstichele H, Zetterberg H, Parnetti L, Blennow K. No diurnal variation of classical and candidate biomarkers of Alzheimer's disease in CSF. Mol Neurodegener. 2016;11(1):65\u201373.","journal-title":"Mol Neurodegener"},{"issue":"3","key":"359_CR53","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3233\/JAD-170220","volume":"59","author":"P Muszynski","year":"2017","unstructured":"Muszynski P, Kulczynska-Przybik A, Borawska R, Litman-Zawadzka A, Slowik A, Klimkowicz-Mrowiec A, Pera J, Dziedzic T, Mroczko B. The relationship between markers of inflammation and degeneration in the central nervous system and the blood-brain barrier impairment in Alzheimer's disease. J Alzheimers Dis. 2017;59(3):903\u201312.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"359_CR54","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13024-016-0128-x","volume":"11","author":"C Agustin-Pavon","year":"2016","unstructured":"Agustin-Pavon C, Mielcarek M, Garriga-Canut M, Isalan M. Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant huntingtin repression in mice. Mol Neurodegener. 2016;11(1):64\u201379.","journal-title":"Mol Neurodegener"},{"issue":"6","key":"359_CR55","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1055\/s-2007-979955","volume":"27","author":"WJ Malaisse","year":"1995","unstructured":"Malaisse WJ. Stimulation of insulin release by non-sulfonylurea hypoglycemic agents: the meglitinide family. Horm Metab Res. 1995;27(6):263\u20136.","journal-title":"Horm Metab Res"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-018-0359-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13041-018-0359-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-018-0359-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T19:35:32Z","timestamp":1552073732000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/s13041-018-0359-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1186\/s13041-018-0359-6","relation":{},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"15 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Behavioral tests and animal care were conducted in accordance with standard ethical guidelines (European Communities Directive 86\/609 EEC; National Institutes of Health 1995). The CNB-CSIC and Community of Madrid ethical committees approved experiments with mice and use of human post-mortem samples (PROEX 28\/05).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"13"}}