{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:53:11Z","timestamp":1781106791490,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R15 NS101594"],"award-info":[{"award-number":["R15 NS101594"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R25 MD01397"],"award-info":[{"award-number":["R25 MD01397"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13041-019-0446-3","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T10:03:18Z","timestamp":1553594598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Jonathan","family":"Chacon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-9564","authenticated-orcid":false,"given":"Math P.","family":"Cuajungco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"issue":"3\u20134","key":"446_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1006\/nbdi.1997.0163","volume":"4","author":"MP Cuajungco","year":"1997","unstructured":"Cuajungco MP, Lees GJ. Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis. 1997;4(3\u20134):137\u201369.","journal-title":"Neurobiol Dis"},{"issue":"25","key":"446_CR2","doi-asserted-by":"publisher","first-page":"14934","DOI":"10.1073\/pnas.93.25.14934","volume":"93","author":"RD Palmiter","year":"1996","unstructured":"Palmiter RD, Cole TB, Quaife CJ, Findley SD. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996;93(25):14934\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"446_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1750-1326-4-53","volume":"4","author":"N Beyer","year":"2009","unstructured":"Beyer N, Coulson DT, Heggarty S, Ravid R, Irvine GB, Hellemans J, et al. ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain. Mol Neurodegener. 2009;4:53.","journal-title":"Mol Neurodegener"},{"issue":"12","key":"446_CR4","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/j.neurobiolaging.2014.06.015","volume":"35","author":"DR Whitfield","year":"2014","unstructured":"Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiol Aging. 2014;35(12):2836\u201344.","journal-title":"Neurobiol Aging"},{"issue":"2","key":"446_CR5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/jnr.23491","volume":"93","author":"M Kaneko","year":"2015","unstructured":"Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, et al. Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis. J Neurosci Res. 2015;93(2):370\u20139.","journal-title":"J Neurosci Res"},{"issue":"45","key":"446_CR6","doi-asserted-by":"publisher","first-page":"34304","DOI":"10.1074\/jbc.C110.165480","volume":"285","author":"JL Eichelsdoerfer","year":"2010","unstructured":"Eichelsdoerfer JL, Evans JA, Slaugenhaupt SA, Cuajungco MP. Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel. J Biol Chem. 2010;285(45):34304\u20138.","journal-title":"J Biol Chem"},{"issue":"11","key":"446_CR7","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1111\/tra.12205","volume":"15","author":"MP Cuajungco","year":"2014","unstructured":"Cuajungco MP, Basilio LC, Silva J, Hart T, Tringali J, Chen CC, et al. Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Traffic. 2014;15(11):1247\u201365.","journal-title":"Traffic."},{"issue":"2","key":"446_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1042\/BJ20121506","volume":"451","author":"I Kukic","year":"2013","unstructured":"Kukic I, Lee JK, Coblentz J, Kelleher SL, Kiselyov K. Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter. Biochem J. 2013;451(2):155\u201363.","journal-title":"Biochem J"},{"issue":"5","key":"446_CR9","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1086\/521954","volume":"81","author":"B Venugopal","year":"2007","unstructured":"Venugopal B, Browning MF, Curcio-Morelli C, Varro A, Michaud N, Nanthakumar N, et al. Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV. Am J Hum Genet. 2007;81(5):1070\u201383.","journal-title":"Am J Hum Genet"},{"issue":"10","key":"446_CR10","doi-asserted-by":"publisher","first-page":"8602","DOI":"10.1074\/jbc.M309730200","volume":"279","author":"JY Lee","year":"2004","unstructured":"Lee JY, Kim JH, Hong SH, Lee JY, Cherny RA, Bush AI, et al. Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain. J Biol Chem. 2004;279(10):8602\u20137.","journal-title":"J Biol Chem"},{"issue":"Pt 9","key":"446_CR11","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1242\/jcs.02319","volume":"118","author":"G Salazar","year":"2005","unstructured":"Salazar G, Craige B, Love R, Kalman D, Faundez V. Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci. 2005;118(Pt 9):1911\u201321.","journal-title":"J Cell Sci"},{"issue":"2","key":"446_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1042\/BJ20130647","volume":"457","author":"J Coblentz","year":"2014","unstructured":"Coblentz J, St Croix C, Kiselyov K. Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV? Biochem J. 2014;457(2):361\u20138.","journal-title":"Biochem J"},{"issue":"12","key":"446_CR13","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1523\/JNEUROSCI.0199-08.2008","volume":"28","author":"JJ Hwang","year":"2008","unstructured":"Hwang JJ, Lee SJ, Kim TY, Cho JH, Koh JY. Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons. J Neurosci. 2008;28(12):3114\u201322.","journal-title":"J Neurosci"},{"issue":"1","key":"446_CR14","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0006-8993(98)00463-6","volume":"799","author":"MP Cuajungco","year":"1998","unstructured":"Cuajungco MP, Lees GJ. Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya. Brain Res. 1998;799(1):118\u201329.","journal-title":"Brain Res"},{"issue":"2","key":"446_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.15252\/embr.201541542","volume":"17","author":"S Park","year":"2016","unstructured":"Park S, Ahuja M, Kim MS, Brailoiu GC, Jha A, Zeng M, et al. Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV. EMBO Rep. 2016;17(2):266\u201378.","journal-title":"EMBO Rep"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-019-0446-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13041-019-0446-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-019-0446-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T09:45:46Z","timestamp":1589535946000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/s13041-019-0446-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,26]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["446"],"URL":"https:\/\/doi.org\/10.1186\/s13041-019-0446-3","relation":{},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,26]]},"assertion":[{"value":"5 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The CSUF Institutional Animal Care and Use Committee (IACUC) approved the use of animals or their tissues in the study (IACUC protocol # 07-R-05 and 17-R-08).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"24"}}