{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:25:51Z","timestamp":1772166351974,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl\n                    <jats:sub>2<\/jats:sub>\n                    is not only a hypoxia-mimetic reagent but also an oxidative stress inducer. Here, we found that CoCl\n                    <jats:sub>2<\/jats:sub>\n                    induced significant EAAC1 overexpression in SH-SY5Y cells and the hippocampus of mice. Transient transfection of EAAC1 reduced CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced cytotoxicity in SH-SY5Y cells. Based on this result, upregulation of EAAC1 expression by CoCl\n                    <jats:sub>2<\/jats:sub>\n                    is thought to represent a compensatory response against oxidative stress in an acute hypoxic state. We further demonstrated that pretreatment with Neuregulin-1 (NRG1) rescued CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced upregulation of EAAC1 and tau expression. NRG1 plays a protective role in the CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced accumulation of reactive oxygen species (ROS) and reduction in antioxidative enzyme (SOD and GPx) activity. Moreover, NRG1 attenuated CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced apoptosis and cell death. NRG1 inhibited the CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced release of cleaved caspase-3 and reduction in Bcl-X\n                    <jats:sub>L<\/jats:sub>\n                    levels. Our novel finding suggests that NRG1 may play a protective role in hypoxia through the inhibition of oxidative stress and thereby maintain normal EAAC1 expression levels.\n                  <\/jats:p>","DOI":"10.1186\/s13041-020-00686-2","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T06:03:23Z","timestamp":1605247403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice"],"prefix":"10.1186","volume":"13","author":[{"given":"Han-Byeol","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Young","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Yeon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonseok","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Kyoung","family":"Baik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-9291","authenticated-orcid":false,"given":"Ran-Sook","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"issue":"1","key":"686_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00726-013-1481-5","volume":"45","author":"K Aoyama","year":"2013","unstructured":"Aoyama K, Nakaki T. Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1). Amino Acids. 2013;45(1):133\u201342.","journal-title":"Amino Acids"},{"issue":"11","key":"686_CR2","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00018-013-1484-0","volume":"71","author":"MG Bianchi","year":"2014","unstructured":"Bianchi MG, Bardelli D, Chiu M, Bussolati O. Changes in the expression of the glutamate transporter EAAT3\/EAAC1 in health and disease. Cell Mol Life Sci. 2014;71(11):2001\u201315.","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"686_CR3","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1111\/j.1471-4159.1993.tb09802.x","volume":"61","author":"JI Sagara","year":"1993","unstructured":"Sagara JI, Miura K, Bannai S. Maintenance of neuronal glutathione by glial cells. J Neurochem. 1993;61(5):1672\u20136.","journal-title":"J Neurochem"},{"issue":"3","key":"686_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0304-3940(96)13217-1","volume":"219","author":"O Kranich","year":"1996","unstructured":"Kranich O, Hamprecht B, Dringen R. Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain. Neurosci Lett. 1996;219(3):211\u20134.","journal-title":"Neurosci Lett"},{"issue":"15","key":"686_CR5","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1523\/JNEUROSCI.5465-10.2011","volume":"31","author":"D De Bundel","year":"2011","unstructured":"De Bundel D, Schallier A, Loyens E, Fernando R, Miyashita H, Van Liefferinge J, Vermoesen K, Bannai S, Sato H, Michotte Y, et al. Loss of system x(c)-does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. J Neurosci. 2011;31(15):5792\u2013803.","journal-title":"J Neurosci"},{"issue":"22","key":"686_CR6","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.3390\/ijms20225671","volume":"20","author":"AR Malik","year":"2019","unstructured":"Malik AR, Willnow TE. Excitatory amino acid transporters in physiology and disorders of the central nervous system. Int J Mol Sci. 2019;20(22):5671.","journal-title":"Int J Mol Sci."},{"issue":"1","key":"686_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00726-011-0861-y","volume":"42","author":"K Aoyama","year":"2012","unstructured":"Aoyama K, Watabe M, Nakaki T. Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18. Amino Acids. 2012;42(1):163\u20139.","journal-title":"Amino Acids"},{"issue":"12","key":"686_CR8","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1007\/s00702-003-0049-z","volume":"110","author":"T Himi","year":"2003","unstructured":"Himi T, Ikeda M, Yasuhara T, Nishida M, Morita I. Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons. J Neural Transm (Vienna). 2003;110(12):1337\u201348.","journal-title":"J Neural Transm (Vienna)"},{"issue":"5","key":"686_CR9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/jcb.25074","volume":"116","author":"S Movafagh","year":"2015","unstructured":"Movafagh S, Crook S, Vo K. Regulation of hypoxia-inducible factor-1a by reactive oxygen species: new developments in an old debate. J Cell Biochem. 2015;116(5):696\u2013703.","journal-title":"J Cell Biochem"},{"issue":"13","key":"686_CR10","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1523\/JNEUROSCI.21-13-04600.2001","volume":"21","author":"IA Fleidervish","year":"2001","unstructured":"Fleidervish IA, Gebhardt C, Astman N, Gutnick MJ, Heinemann U. Enhanced spontaneous transmitter release is the earliest consequence of neocortical hypoxia that can explain the disruption of normal circuit function. J Neurosci. 2001;21(13):4600\u20138.","journal-title":"J Neurosci"},{"issue":"3","key":"686_CR11","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/0306-4522(96)00314-4","volume":"75","author":"V Roettger","year":"1996","unstructured":"Roettger V, Lipton P. Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia. Neuroscience. 1996;75(3):677\u201385.","journal-title":"Neuroscience"},{"issue":"10","key":"686_CR12","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1073\/pnas.97.10.5610","volume":"97","author":"D Jabaudon","year":"2000","unstructured":"Jabaudon D, Scanziani M, Gahwiler BH, Gerber U. Acute decrease in net glutamate uptake during energy deprivation. Proc Natl Acad Sci USA. 2000;97(10):5610\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6300","key":"686_CR13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/348443a0","volume":"348","author":"M Szatkowski","year":"1990","unstructured":"Szatkowski M, Barbour B, Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature. 1990;348(6300):443\u20136.","journal-title":"Nature"},{"issue":"2","key":"686_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/jnr.1065","volume":"64","author":"L Hsu","year":"2001","unstructured":"Hsu L, Rockenstein E, Mallory M, Hashimoto M, Masliah E. Altered expression of glutamate transporters under hypoxic conditions in vitro. J Neurosci Res. 2001;64(2):193\u2013202.","journal-title":"J Neurosci Res"},{"issue":"6","key":"686_CR15","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1523\/JNEUROSCI.1596-03.2004","volume":"24","author":"C Romera","year":"2004","unstructured":"Romera C, Hurtado O, Botella SH, Lizasoain I, Cardenas A, Fernandez-Tome P, Leza JC, Lorenzo P, Moro MA. In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE\/ADAM17-tumor necrosis factor-alpha pathway. J Neurosci. 2004;24(6):1350\u20137.","journal-title":"J Neurosci"},{"issue":"3","key":"686_CR16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S1016-8478(23)15061-8","volume":"13","author":"SJ An","year":"2002","unstructured":"An SJ, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH. Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult. Mol Cells. 2002;13(3):476\u201380.","journal-title":"Mol Cells"},{"issue":"1","key":"686_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuron.2014.06.007","volume":"83","author":"L Mei","year":"2014","unstructured":"Mei L, Nave KA. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron. 2014;83(1):27\u201349.","journal-title":"Neuron"},{"issue":"1","key":"686_CR18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.brainres.2006.03.007","volume":"1087","author":"WP Guo","year":"2006","unstructured":"Guo WP, Wang J, Li RX, Peng YW. Neuroprotective effects of neuregulin-1 in rat models of focal cerebral ischemia. Brain Res. 2006;1087(1):180\u20135.","journal-title":"Brain Res"},{"key":"686_CR19","doi-asserted-by":"publisher","first-page":"e2117","DOI":"10.1038\/cddis.2016.30","volume":"7","author":"J Ryu","year":"2016","unstructured":"Ryu J, Hong BH, Kim YJ, Yang EJ, Choi M, Kim H, Ahn S, Baik TK, Woo RS, Kim HS. Neuregulin-1 attenuates cognitive function impairments in a transgenic mouse model of Alzheimer\u2019s disease. Cell Death Dis. 2016;7:e2117.","journal-title":"Cell Death Dis"},{"issue":"6","key":"686_CR20","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/j.1471-4159.2011.07284.x","volume":"117","author":"T Carlsson","year":"2011","unstructured":"Carlsson T, Schindler FR, Hollerhage M, Depboylu C, Arias-Carrion O, Schnurrbusch S, Rosler TW, Wozny W, Schwall GP, Groebe K, et al. Systemic administration of neuregulin-1beta1 protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease. J Neurochem. 2011;117(6):1066\u201374.","journal-title":"J Neurochem"},{"issue":"1","key":"686_CR21","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12974-018-1093-9","volume":"15","author":"A Alizadeh","year":"2018","unstructured":"Alizadeh A, Santhosh KT, Kataria H, Gounni AS, Karimi-Abdolrezaee S. Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury. J Neuroinflammation. 2018;15(1):53.","journal-title":"J Neuroinflammation"},{"key":"686_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12872-018-0768-6","volume":"18","author":"C Lan","year":"2018","unstructured":"Lan C, Chen X, Zhang Y, Wang W, Wang WE, Liu Y, Cai Y, Ren H, Zheng S, Zhou L, Zeng C. Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function. BMC Cardiovasc Disord. 2018;18:43.","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"686_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jphs.2018.05.004","volume":"137","author":"YJ Kim","year":"2018","unstructured":"Kim YJ, Yoo JY, Kim OS, Kim HB, Ryu J, Kim HS, Lee JH, Yoo HI, Song DY, Baik TK, et al. Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing. J Pharmacol Sci. 2018;137(2):146\u201353.","journal-title":"J Pharmacol Sci"},{"issue":"Suppl 2","key":"686_CR24","doi-asserted-by":"publisher","first-page":"S111","DOI":"10.5213\/inj.1938190.095","volume":"23","author":"SY Yoo","year":"2019","unstructured":"Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS. Neuregulin-1 protects neuronal cells against damage due to Cocl2-induced hypoxia by suppressing hypoxia-inducible factor-1alpha and P53 in SH-SY5Y Cells. Int Neurourol J. 2019;23(Suppl 2):S111-118.","journal-title":"Int Neurourol J"},{"issue":"4","key":"686_CR25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.5115\/acb.19.210","volume":"52","author":"JY Yoo","year":"2019","unstructured":"Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS. Neuregulin 1\/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons. Anat Cell Biol. 2019;52(4):462\u20138.","journal-title":"Anat Cell Biol"},{"issue":"33","key":"686_CR26","doi-asserted-by":"publisher","first-page":"25130","DOI":"10.1074\/jbc.M001914200","volume":"275","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275(33):25130\u20138.","journal-title":"J Biol Chem"},{"issue":"3","key":"686_CR27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","volume":"15","author":"FA Chaudhry","year":"1995","unstructured":"Chaudhry FA, Lehre KP, van Lookeren CM, Ottersen OP, Danbolt NC, Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron. 1995;15(3):711\u201320.","journal-title":"Neuron"},{"issue":"3 Pt 1","key":"686_CR28","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1523\/JNEUROSCI.15-03-01835.1995","volume":"15","author":"KP Lehre","year":"1995","unstructured":"Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J Neurosci. 1995;15(3 Pt 1):1835\u201353.","journal-title":"J Neurosci"},{"issue":"2","key":"686_CR29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0306-4522(92)90316-T","volume":"51","author":"NC Danbolt","year":"1992","unstructured":"Danbolt NC, Storm-Mathisen J, Kanner BI. An [Na+ + K+]coupled l-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience. 1992;51(2):295\u2013310.","journal-title":"Neuroscience"},{"issue":"17","key":"686_CR30","doi-asserted-by":"publisher","first-page":"6000","DOI":"10.1523\/JNEUROSCI.5347-11.2012","volume":"32","author":"S Holmseth","year":"2012","unstructured":"Holmseth S, Dehnes Y, Huang YH, Follin-Arbelet VV, Grutle NJ, Mylonakou MN, Plachez C, Zhou Y, Furness DN, Bergles DE, et al. The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS. J Neurosci. 2012;32(17):6000\u201313.","journal-title":"J Neurosci"},{"issue":"3","key":"686_CR31","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/0896-6273(94)90038-8","volume":"13","author":"JD Rothstein","year":"1994","unstructured":"Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW. Localization of neuronal and glial glutamate transporters. Neuron. 1994;13(3):713\u201325.","journal-title":"Neuron"},{"issue":"17","key":"686_CR32","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1097\/00001756-199511270-00020","volume":"6","author":"Y Kanai","year":"1995","unstructured":"Kanai Y, Bhide PG, DiFiglia M, Hediger MA. Neuronal high-affinity glutamate transport in the rat central nervous system. NeuroReport. 1995;6(17):2357\u201362.","journal-title":"NeuroReport"},{"issue":"33","key":"686_CR33","doi-asserted-by":"publisher","first-page":"20233","DOI":"10.1074\/jbc.M114.591867","volume":"290","author":"HN Yu","year":"2015","unstructured":"Yu HN, Park WK, Nam KH, Song DY, Kim HS, Baik TK, Woo RS. Neuregulin 1 controls glutamate uptake by up-regulating excitatory amino acid carrier 1 (EAAC1). J Biol Chem. 2015;290(33):20233\u201344.","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"686_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1113\/jphysiol.1996.sp021393","volume":"493","author":"N Zerangue","year":"1996","unstructured":"Zerangue N, Kavanaugh MP. Interaction of L-cysteine with a human excitatory amino acid transporter. J Physiol. 1996;493(Pt 2):419\u201323.","journal-title":"J Physiol"},{"issue":"6","key":"686_CR35","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1046\/j.1471-4159.2003.01630.x","volume":"84","author":"Y Chen","year":"2003","unstructured":"Chen Y, Swanson RA. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem. 2003;84(6):1332\u20139.","journal-title":"J Neurochem"},{"issue":"9\u201310","key":"686_CR36","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S0891-5849(99)00176-8","volume":"27","author":"OW Griffith","year":"1999","unstructured":"Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med. 1999;27(9\u201310):922\u201335.","journal-title":"Free Radic Biol Med"},{"issue":"6767","key":"686_CR37","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/35002090","volume":"403","author":"DJ Rossi","year":"2000","unstructured":"Rossi DJ, Oshima T, Attwell D. Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature. 2000;403(6767):316\u201321.","journal-title":"Nature"},{"issue":"5","key":"686_CR38","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/00004647-200205000-00008","volume":"22","author":"C Gebhardt","year":"2002","unstructured":"Gebhardt C, Korner R, Heinemann U. Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1. J Cereb Blood Flow Metab. 2002;22(5):569\u201375.","journal-title":"J Cereb Blood Flow Metab"},{"key":"686_CR39","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1001\/archpsyc.63.7.778","volume":"63","author":"DE Dickel","year":"2006","unstructured":"Dickel DE, Veenstra-VanderWeele J, Cox NJ, Wu X, Fischer DJ, Van Etten-Lee M, Himle JA, Leventhal BL, Cook EH Jr, Hanna GL. Association testing of the positional and functional candidate gene SLC1A1\/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry. 2006;63:778\u201385.","journal-title":"Arch Gen Psychiatry"},{"key":"686_CR40","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/s41386-018-0302-7","volume":"44","author":"C Delgado-Acevedo","year":"2019","unstructured":"Delgado-Acevedo C, Estay SF, Radke AK, Sengupta A, Escobar AP, Henriquez-Belmar F, Reyes CA, Haro-Acuna V, Utreras E, Sotomayor-Zarate R, Cho A, Wendland JR, Kulkarni AB, Holmes A, Murphy DL, Chavez AE. Moya PR\u202f: Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology. 2019;44:1163\u201373.","journal-title":"Neuropsychopharmacology"},{"key":"686_CR41","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1001\/archgenpsychiatry.2009.6","volume":"66","author":"JR Wendland","year":"2009","unstructured":"Wendland JR, Moya PR, Timpano KR, Anavitarte AP, Kruse MR, Wheaton MG, Ren-Patterson RF. Murphy DL\u202f: A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry. 2009;66:408\u201316.","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"686_CR42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2010.03.037","volume":"474","author":"H Fang","year":"2010","unstructured":"Fang H, Zhang LF, Meng FT, Du X, Zhou JN. Acute hypoxia promote the phosphorylation of tau via ERK pathway. Neurosci Lett. 2010;474(3):173\u20137.","journal-title":"Neurosci Lett"},{"issue":"8","key":"686_CR43","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1093\/carcin\/bgn125","volume":"29","author":"E Hervouet","year":"2008","unstructured":"Hervouet E, Cizkova A, Demont J, Vojtiskova A, Pecina P, Franssen-van Hal NL, Keijer J, Simonnet H, Ivanek R, Kmoch S, et al. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis. 2008;29(8):1528\u201337.","journal-title":"Carcinogenesis"},{"issue":"3","key":"686_CR44","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.biocel.2008.07.012","volume":"41","author":"V Battaglia","year":"2009","unstructured":"Battaglia V, Compagnone A, Bandino A, Bragadin M, Rossi CA, Zanetti F, Colombatto S, Grillo MA, Toninello A. Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures. Int J Biochem Cell Biol. 2009;41(3):586\u201394.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"686_CR45","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.taap.2012.05.001","volume":"262","author":"Y Li","year":"2012","unstructured":"Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD. Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicol Appl Pharmacol. 2012;262(2):194\u2013204.","journal-title":"Toxicol Appl Pharmacol"},{"key":"686_CR46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.brainres.2017.06.012","volume":"1670","author":"J Xu","year":"2017","unstructured":"Xu J, Hu C, Chen S, Shen H, Jiang Q, Huang P, Zhao W. Neuregulin-1 protects mouse cerebellum against oxidative stress and neuroinflammation. Brain Res. 2017;1670:32\u201343.","journal-title":"Brain Res"},{"issue":"2","key":"686_CR47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12640-018-9965-4","volume":"35","author":"JH Lee","year":"2019","unstructured":"Lee JH, Yoo JY, Kim HB, Yoo HI, Song DY, Min SS, Baik TK, Woo RS. Neuregulin1 attenuates H2O2-induced reductions in EAAC1 protein levels and reduces H2O2-induced oxidative stress. Neurotox Res. 2019;35(2):401\u20139.","journal-title":"Neurotox Res"},{"key":"686_CR48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.neuroscience.2011.11.026","volume":"202","author":"RS Woo","year":"2012","unstructured":"Woo RS, Lee JH, Kim HS, Baek CH, Song DY, Suh YH, Baik TK. Neuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor. Neuroscience. 2012;202:413\u201323.","journal-title":"Neuroscience"},{"issue":"Pt 6","key":"686_CR49","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.114.6.1179","volume":"114","author":"HN Dawson","year":"2001","unstructured":"Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci. 2001;114(Pt 6):1179\u201387.","journal-title":"J Cell Sci"},{"issue":"5","key":"686_CR50","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1083\/jcb.150.5.989","volume":"150","author":"Y Takei","year":"2000","unstructured":"Takei Y, Teng J, Harada A, Hirokawa N. Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes. J Cell Biol. 2000;150(5):989\u20131000.","journal-title":"J Cell Biol"},{"issue":"12","key":"686_CR51","first-page":"7591","volume":"11","author":"B Fang","year":"2019","unstructured":"Fang B, Zhao Q, Ling W, Zhang Y, Ou M. Hypoxia induces HT-22 neuronal cell death via Orai1\/CDK5 pathway-mediated Tau hyperphosphorylation. Am J Transl Res. 2019;11(12):7591\u2013603.","journal-title":"Am J Transl Res"},{"key":"686_CR52","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.3390\/ijms21093186","volume":"21","author":"R Pluta","year":"2020","unstructured":"Pluta R, Ulamek-Koziol M, Januszewski S, Czuczwar SJ. Shared genomic and proteomic contribution of amyloid and Tau protein characteristic of Alzheimer\u2019s disease to brain ischemia. Int J Mol Sci. 2020;21:3186.","journal-title":"Int J Mol Sci."},{"issue":"10","key":"686_CR53","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1089\/neu.2000.17.871","volume":"17","author":"A Lewen","year":"2000","unstructured":"Lewen A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma. 2000;17(10):871\u201390.","journal-title":"J Neurotrauma"},{"issue":"8","key":"686_CR54","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.neuint.2006.06.002","volume":"49","author":"P Maiti","year":"2006","unstructured":"Maiti P, Singh SB, Sharma AK, Muthuraju S, Banerjee PK, Ilavazhagan G. Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem Int. 2006;49(8):709\u201316.","journal-title":"Neurochem Int"},{"issue":"1","key":"686_CR55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1471-4159.2004.02988.x","volume":"93","author":"L Ramanathan","year":"2005","unstructured":"Ramanathan L, Gozal D, Siegel JM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons. J Neurochem. 2005;93(1):47\u201352.","journal-title":"J Neurochem"},{"key":"686_CR56","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.redox.2017.02.014","volume":"12","author":"D Coimbra-Costa","year":"2017","unstructured":"Coimbra-Costa D, Alva N, Duran M, Carbonell T, Rama R. Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain. Redox Biol. 2017;12:216\u201325.","journal-title":"Redox Biol"},{"issue":"6809","key":"686_CR57","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"T Finkel","year":"2000","unstructured":"Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239\u201347.","journal-title":"Nature"},{"issue":"2","key":"686_CR58","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00004647-200202000-00001","volume":"22","author":"DJ DeGracia","year":"2002","unstructured":"DeGracia DJ, Kumar R, Owen CR, Krause GS, White BC. Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death. J Cereb Blood Flow Metab. 2002;22(2):127\u201341.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"15","key":"686_CR59","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1096\/fj.04-2047com","volume":"18","author":"X Wang","year":"2004","unstructured":"Wang X, Zhang J, Kim HP, Wang Y, Choi AM, Ryter SW. Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia\/reoxygenation. FASEB J. 2004;18(15):1826\u201333.","journal-title":"FASEB J"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-020-00686-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13041-020-00686-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-020-00686-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T06:49:01Z","timestamp":1723877341000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/s13041-020-00686-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["686"],"URL":"https:\/\/doi.org\/10.1186\/s13041-020-00686-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-40884\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-40884\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-40884\/v1","asserted-by":"object"}]},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"9 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing financial interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"153"}}