{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:10:35Z","timestamp":1791483035683,"version":"4.3.4"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH072567"],"award-info":[{"award-number":["MH072567"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH098891"],"award-info":[{"award-number":["MH098891"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126559"],"award-info":[{"award-number":["HL126559"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA039576"],"award-info":[{"award-number":["DA039576"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA040537"],"award-info":[{"award-number":["DA040537"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA044579"],"award-info":[{"award-number":["DA044579"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"Office of AIDS Research","doi-asserted-by":"publisher","award":["P30AI073961"],"award-info":[{"award-number":["P30AI073961"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"crossref","award":["8AZ24"],"award-info":[{"award-number":["8AZ24"]}],"id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amyloid beta (A\u03b2) deposition was demonstrated to be elevated in the brains of HIV-infected patients and associated with neurocognitive decline; however, the mechanisms of these processes are poorly understood. The goal of the current study was to address the hypothesis that A\u03b2 can be transferred via extracellular vesicles (ECVs) from brain endothelial cells to neural progenitor cells (NPCs) and that this process can contribute to abnormal NPC differentiation. Mechanistically, we focused on the role of the receptor for advanced glycation end products (RAGE) and activation of the inflammasome in these events. ECVs loaded with A\u03b2 (A\u03b2-ECVs) were readily taken up by NPCs and A\u03b2 partly colocalized with the inflammasome markers ASC and NLRP3 in the nuclei of the recipient NPCs. This colocalization was affected by HIV and RAGE inhibition by a high-affinity specific inhibitor FPS-ZM1. Blocking RAGE resulted also in an increase in ECV number produced by brain endothelial cells, decreased A\u03b2 content in ECVs, and diminished A\u03b2-ECVs transfer to NPC nuclei. Interestingly, both A\u03b2-ECVs and RAGE inhibition altered NPC differentiation. Overall, these data indicate that RAGE inhibition affects brain endothelial ECV release and A\u03b2-ECVs transfer to NPCs. These events may modulate ECV-mediated amyloid pathology in the HIV-infected brain and contribute to the development of HIV-associated neurocognitive disorders.<\/jats:p>","DOI":"10.1186\/s13041-020-0562-0","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:09:04Z","timestamp":1581937744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Extracellular vesicle-mediated amyloid transfer to neural progenitor cells: implications for RAGE and HIV infection"],"prefix":"10.1186","volume":"13","author":[{"given":"Ibolya E.","family":"Andr\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garcia-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yanick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Sewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-2119","authenticated-orcid":false,"given":"Michal","family":"Toborek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"issue":"1","key":"562_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/jnnp.65.1.29","volume":"65","author":"MM Esiri","year":"1998","unstructured":"Esiri MM, Biddolph SC, Morris CS. Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry. 1998;65(1):29\u201333.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"562_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00002030-200501280-00004","volume":"19","author":"HC Rempel","year":"2005","unstructured":"Rempel HC, Pulliam L. HIV-1 tat inhibits neprilysin and elevates amyloid beta. AIDS. 2005;19(2):127\u201335.","journal-title":"AIDS."},{"issue":"2","key":"562_CR3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s11481-008-9136-0","volume":"4","author":"J Xu","year":"2009","unstructured":"Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. J NeuroImmune Pharmacol. 2009;4(2):200\u201312.","journal-title":"J NeuroImmune Pharmacol"},{"issue":"2","key":"562_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11481-008-9143-1","volume":"4","author":"BJ Brew","year":"2009","unstructured":"Brew BJ, Crowe SM, Landay A, Cysique LA, Guillemin G. Neurodegeneration and ageing in the HAART era. J NeuroImmune Pharmacol. 2009;4(2):163\u201374.","journal-title":"J NeuroImmune Pharmacol"},{"issue":"2","key":"562_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s11481-009-9152-8","volume":"4","author":"CL Achim","year":"2009","unstructured":"Achim CL, Adame A, Dumaop W, Everall IP, Masliah E, Neurobehavioral Research C. Increased accumulation of intraneuronal amyloid beta in HIV-infected patients. J NeuroImmune Pharmacol. 2009;4(2):190\u20139.","journal-title":"J NeuroImmune Pharmacol"},{"issue":"2","key":"562_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11481-009-9151-9","volume":"4","author":"L Pulliam","year":"2009","unstructured":"Pulliam L. HIV regulation of amyloid beta production. J NeuroImmune Pharmacol. 2009;4(2):213\u20137.","journal-title":"J NeuroImmune Pharmacol"},{"issue":"18","key":"562_CR7","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1097\/QAD.0b013e32835a117c","volume":"26","author":"V Soontornniyomkij","year":"2012","unstructured":"Soontornniyomkij V, Moore DJ, Gouaux B, Soontornniyomkij B, Tatro ET, Umlauf A, et al. Cerebral beta-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE epsilon4 carriers. AIDS. 2012;26(18):2327\u201335.","journal-title":"AIDS."},{"issue":"4","key":"562_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/01.aids.0000161770.06158.5c","volume":"19","author":"DA Green","year":"2005","unstructured":"Green DA, Masliah E, Vinters HV, Beizai P, Moore DJ, Achim CL. Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients. AIDS. 2005;19(4):407\u201311.","journal-title":"AIDS."},{"issue":"3","key":"562_CR9","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/ene.12006","volume":"20","author":"F Steinbrink","year":"2013","unstructured":"Steinbrink F, Evers S, Buerke B, Young P, Arendt G, Koutsilieri E, et al. Cognitive impairment in HIV infection is associated with MRI and CSF pattern of neurodegeneration. Eur J Neurol. 2013;20(3):420\u20138.","journal-title":"Eur J Neurol"},{"issue":"1","key":"562_CR10","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1038\/s41467-019-10046-x","volume":"10","author":"L Bertrand","year":"2019","unstructured":"Bertrand L, Meroth F, Tournebize M, Leda AR, Sun E, Toborek M. Targeting the HIV-infected brain to improve ischemic stroke outcome. Nat Commun. 2019;10(1):2009.","journal-title":"Nat Commun"},{"issue":"3","key":"562_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/brain\/awy339","volume":"142","author":"L Bertrand","year":"2019","unstructured":"Bertrand L, Cho HJ, Toborek M. Blood-brain barrier pericytes as a target for HIV-1 infection. Brain. 2019;142(3):502\u201311.","journal-title":"Brain."},{"issue":"2","key":"562_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2174\/156720507780362245","volume":"4","author":"R Deane","year":"2007","unstructured":"Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007;4(2):191\u20137.","journal-title":"Curr Alzheimer Res"},{"issue":"7","key":"562_CR13","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nm890","volume":"9","author":"R Deane","year":"2003","unstructured":"Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003;9(7):907\u201313.","journal-title":"Nat Med"},{"issue":"2","key":"562_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.mcn.2009.11.004","volume":"43","author":"IE Andras","year":"2010","unstructured":"Andras IE, Eum SY, Huang W, Zhong Y, Hennig B, Toborek M. HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Mol Cell Neurosci. 2010;43(2):232\u201343.","journal-title":"Mol Cell Neurosci"},{"issue":"3","key":"562_CR15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00249-007-0246-z","volume":"37","author":"LJ Vella","year":"2008","unstructured":"Vella LJ, Sharples RA, Nisbet RM, Cappai R, Hill AF. The role of exosomes in the processing of proteins associated with neurodegenerative diseases. Eur Biophys J. 2008;37(3):323\u201332.","journal-title":"Eur Biophys J"},{"issue":"1","key":"562_CR16","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s12035-013-8544-1","volume":"49","author":"A Kalani","year":"2014","unstructured":"Kalani A, Tyagi A, Tyagi N. Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol. 2014;49(1):590\u2013600.","journal-title":"Mol Neurobiol"},{"key":"562_CR17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1742-2094-11-68","volume":"11","author":"A Gupta","year":"2014","unstructured":"Gupta A, Pulliam L. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014;11:68.","journal-title":"J Neuroinflammation"},{"key":"562_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1756-6606-6-47","volume":"6","author":"K An","year":"2013","unstructured":"An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O\u2019Dowd ST, et al. Exosomes neutralize synaptic-plasticity-disrupting activity of Abeta assemblies in vivo. Mol Brain. 2013;6:47.","journal-title":"Mol Brain"},{"issue":"35","key":"562_CR19","doi-asserted-by":"publisher","first-page":"24488","DOI":"10.1074\/jbc.M114.577213","volume":"289","author":"K Yuyama","year":"2014","unstructured":"Yuyama K, Sun H, Sakai S, Mitsutake S, Okada M, Tahara H, et al. Decreased amyloid-beta pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice. J Biol Chem. 2014;289(35):24488\u201398.","journal-title":"J Biol Chem"},{"issue":"1","key":"562_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.febslet.2014.11.027","volume":"589","author":"K Yuyama","year":"2015","unstructured":"Yuyama K, Sun H, Usuki S, Sakai S, Hanamatsu H, Mioka T, et al. A potential function for neuronal exosomes: sequestering intracerebral amyloid-beta peptide. FEBS Lett. 2015;589(1):84\u20138.","journal-title":"FEBS Lett"},{"issue":"1","key":"562_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3233\/JAD-150088","volume":"46","author":"MB Dinkins","year":"2015","unstructured":"Dinkins MB, Dasgupta S, Wang G, Zhu G, He Q, Kong JN, et al. The 5XFAD mouse model of Alzheimer's disease exhibits an age-dependent increase in anti-Ceramide IgG and exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden. J Alzheimers Dis. 2015;46(1):55\u201361.","journal-title":"J Alzheimers Dis"},{"key":"562_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mcn.2016.12.006","volume":"79","author":"IE Andras","year":"2017","unstructured":"Andras IE, Leda A, Contreras MG, Bertrand L, Park M, Skowronska M, et al. Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology. Mol Cell Neurosci. 2017;79:12\u201322.","journal-title":"Mol Cell Neurosci"},{"issue":"5675","key":"562_CR23","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.1095505","volume":"304","author":"Q Shen","year":"2004","unstructured":"Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, Abramova N, et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science. 2004;304(5675):1338\u201340.","journal-title":"Science."},{"issue":"3","key":"562_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.stem.2008.07.026","volume":"3","author":"Q Shen","year":"2008","unstructured":"Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK, et al. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell. 2008;3(3):289\u2013300.","journal-title":"Cell Stem Cell"},{"issue":"14","key":"562_CR25","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1523\/JNEUROSCI.2052-12.2013","volume":"33","author":"V Meneghini","year":"2013","unstructured":"Meneghini V, Bortolotto V, Francese MT, Dellarole A, Carraro L, Terzieva S, et al. High-mobility group box-1 protein and beta-amyloid oligomers promote neuronal differentiation of adult hippocampal neural progenitors via receptor for advanced glycation end products\/nuclear factor-kappaB axis: relevance for Alzheimer's disease. J Neurosci. 2013;33(14):6047\u201359.","journal-title":"J Neurosci"},{"issue":"2","key":"562_CR26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1086\/422008","volume":"190","author":"MD Krathwohl","year":"2004","unstructured":"Krathwohl MD, Kaiser JL. HIV-1 promotes quiescence in human neural progenitor cells. J Infect Dis. 2004;190(2):216\u201326.","journal-title":"J Infect Dis"},{"issue":"5","key":"562_CR27","doi-asserted-by":"publisher","first-page":"e0156686","DOI":"10.1371\/journal.pone.0156686","volume":"11","author":"Q Chen","year":"2016","unstructured":"Chen Q, Bei JJ, Liu C, Feng SB, Zhao WB, Zhou Z, et al. HMGB1 induces secretion of matrix vesicles by macrophages to enhance ectopic mineralization. PLoS One. 2016;11(5):e0156686.","journal-title":"PLoS One"},{"issue":"7484","key":"562_CR28","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature12940","volume":"505","author":"G Doitsh","year":"2014","unstructured":"Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014;505(7484):509\u201314.","journal-title":"Nature."},{"issue":"8","key":"562_CR29","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008;9(8):857\u201365.","journal-title":"Nat Immunol"},{"issue":"3","key":"562_CR30","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3233\/JAD-170634","volume":"60","author":"ME Ahmed","year":"2017","unstructured":"Ahmed ME, Iyer S, Thangavel R, Kempuraj D, Selvakumar GP, Raikwar SP, et al. Co-localization of glia maturation factor with NLRP3 Inflammasome and Autophagosome markers in human Alzheimer's disease brain. J Alzheimers Dis. 2017;60(3):1143\u201360.","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"562_CR31","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1111\/jcmm.13067","volume":"21","author":"Y Song","year":"2017","unstructured":"Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, et al. Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells. J Cell Mol Med. 2017;21(7):1373\u201387.","journal-title":"J Cell Mol Med"},{"issue":"13","key":"562_CR32","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1096\/fj.04-3458fje","volume":"19","author":"BB Weksler","year":"2005","unstructured":"Weksler BB, Subileau EA, Perriere N, Charneau P, Holloway K, Leveque M, et al. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J. 2005;19(13):1872\u20134.","journal-title":"FASEB J"},{"issue":"1","key":"562_CR33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.yexcr.2014.01.027","volume":"323","author":"IE Andras","year":"2014","unstructured":"Andras IE, Toborek M. HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-beta\/Smad signaling. Exp Cell Res. 2014;323(1):66\u201376.","journal-title":"Exp Cell Res"},{"issue":"1\u20132","key":"562_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0090-6980(02)00111-9","volume":"70","author":"D Paris","year":"2002","unstructured":"Paris D, Townsend KP, Obregon DF, Humphrey J, Mullan M. Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain. Prostaglandins Other Lipid Mediat. 2002;70(1\u20132):1\u201312.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"4","key":"562_CR35","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1172\/JCI58642","volume":"122","author":"R Deane","year":"2012","unstructured":"Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, et al. A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012;122(4):1377\u201392.","journal-title":"J Clin Invest"},{"issue":"11","key":"562_CR36","doi-asserted-by":"publisher","first-page":"6960","DOI":"10.4049\/jimmunol.0902926","volume":"185","author":"S Jozefowski","year":"2010","unstructured":"Jozefowski S, Czerkies M, Lukasik A, Bielawska A, Bielawski J, Kwiatkowska K, et al. Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide. J Immunol. 2010;185(11):6960\u201373.","journal-title":"J Immunol"},{"issue":"3","key":"562_CR37","first-page":"199","volume":"20","author":"GC Sampey","year":"2014","unstructured":"Sampey GC, Meyering SS, Zadeh MA, Saifuddin M, Hakami RM, Kashanchi F. Exosomes and their role in CNS viral infections. J Neuro-Oncol. 2014;20(3):199\u2013208.","journal-title":"J Neuro-Oncol"},{"issue":"14","key":"562_CR38","doi-asserted-by":"publisher","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","volume":"287","author":"K Yuyama","year":"2012","unstructured":"Yuyama K, Sun H, Mitsutake S, Igarashi Y. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia. J Biol Chem. 2012;287(14):10977\u201389.","journal-title":"J Biol Chem"},{"issue":"Suppl 6","key":"562_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1167.2012.03696.x","volume":"53","author":"NJ Abbott","year":"2012","unstructured":"Abbott NJ, Friedman A. Overview and introduction: the blood-brain barrier in health and disease. Epilepsia. 2012;53(Suppl 6):1\u20136.","journal-title":"Epilepsia."},{"issue":"13","key":"562_CR40","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1523\/JNEUROSCI.3045-16.2017","volume":"37","author":"ET Chivero","year":"2017","unstructured":"Chivero ET, Guo ML, Periyasamy P, Liao K, Callen SE, Buch S. HIV-1 tat primes and activates microglial NLRP3 Inflammasome-mediated Neuroinflammation. J Neurosci. 2017;37(13):3599\u2013609.","journal-title":"J Neurosci"},{"issue":"5","key":"562_CR41","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.4049\/jimmunol.0802367","volume":"182","author":"NB Bryan","year":"2009","unstructured":"Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J Immunol. 2009;182(5):3173\u201382.","journal-title":"J Immunol"},{"key":"562_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijdevneu.2015.10.004","volume":"48","author":"M Frohlich","year":"2016","unstructured":"Frohlich M, Jaeger A, Weiss DG, Kriehuber R. Inhibition of BCL-2 leads to increased apoptosis and delayed neuronal differentiation in human ReNcell VM cells in vitro. Int J Dev Neurosci. 2016;48:9\u201317.","journal-title":"Int J Dev Neurosci"},{"issue":"8","key":"562_CR43","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s10571-015-0213-7","volume":"35","author":"A Jaeger","year":"2015","unstructured":"Jaeger A, Frohlich M, Klum S, Lantow M, Viergutz T, Weiss DG, et al. Characterization of apoptosis signaling cascades during the differentiation process of human neural ReNcell VM progenitor cells in vitro. Cell Mol Neurobiol. 2015;35(8):1203\u201316.","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"562_CR44","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jchemneu.2008.10.003","volume":"37","author":"W Hartig","year":"2009","unstructured":"Hartig W, Reichenbach A, Voigt C, Boltze J, Bulavina L, Schuhmann MU, et al. Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models. J Chem Neuroanat. 2009;37(2):128\u201338.","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"562_CR45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","volume":"116","author":"RJ Mullen","year":"1992","unstructured":"Mullen RJ, Buck CR, Smith AM. NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992;116(1):201\u201311.","journal-title":"Development."},{"issue":"1","key":"562_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.10874","volume":"467","author":"JP Brown","year":"2003","unstructured":"Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol. 2003;467(1):1\u201310.","journal-title":"J Comp Neurol"},{"issue":"1","key":"562_CR47","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.yexcr.2017.11.013","volume":"362","author":"K Farrell","year":"2018","unstructured":"Farrell K, Mahajan G, Srinivasan P, Lee MY, Kothapalli CR. Pediatric glioblastoma cells inhibit neurogenesis and promote astrogenesis, phenotypic transformation and migration of human neural progenitor cells within cocultures. Exp Cell Res. 2018;362(1):159\u201371.","journal-title":"Exp Cell Res"},{"issue":"1","key":"562_CR48","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/bit.26839","volume":"116","author":"GJ Nierode","year":"2019","unstructured":"Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnol Bioeng. 2019;116(1):168\u201380.","journal-title":"Biotechnol Bioeng"},{"issue":"8","key":"562_CR49","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.arcmed.2014.11.003","volume":"45","author":"IE Andras","year":"2014","unstructured":"Andras IE, Rampersaud E, Eum SY, Toborek M. Transcriptional profile of HIV-induced nuclear translocation of amyloid beta in brain endothelial cells. Arch Med Res. 2014;45(8):744\u201352.","journal-title":"Arch Med Res"},{"issue":"10","key":"562_CR50","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.4049\/jimmunol.0902517","volume":"186","author":"N Nasreddine","year":"2011","unstructured":"Nasreddine N, Borde C, Gozlan J, Belec L, Marechal V, Hocini H. Advanced glycation end products inhibit both infection and transmission in trans of HIV-1 from monocyte-derived dendritic cells to autologous T cells. J Immunol. 2011;186(10):5687\u201395.","journal-title":"J Immunol"},{"key":"562_CR51","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","volume":"27","author":"F Martinon","year":"2009","unstructured":"Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol. 2009;27:229\u201365.","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"562_CR52","doi-asserted-by":"publisher","first-page":"e1004082","DOI":"10.1371\/journal.ppat.1004082","volume":"10","author":"MA Chattergoon","year":"2014","unstructured":"Chattergoon MA, Latanich R, Quinn J, Winter ME, Buckheit RW 3rd, Blankson JN, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10(5):e1004082.","journal-title":"PLoS Pathog"},{"issue":"31","key":"562_CR53","doi-asserted-by":"publisher","first-page":"21716","DOI":"10.1074\/jbc.M114.566620","volume":"289","author":"H Guo","year":"2014","unstructured":"Guo H, Gao J, Taxman DJ, Ting JP, Su L. HIV-1 infection induces interleukin-1beta production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes. J Biol Chem. 2014;289(31):21716\u201326.","journal-title":"J Biol Chem"},{"issue":"10","key":"562_CR54","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/j.celrep.2015.08.011","volume":"12","author":"NL Galloway","year":"2015","unstructured":"Galloway NL, Doitsh G, Monroe KM, Yang Z, Munoz-Arias I, Levy DN, et al. Cell-to-cell transmission of HIV-1 is required to trigger Pyroptotic death of lymphoid-tissue-derived CD4 T cells. Cell Rep. 2015;12(10):1555\u201363.","journal-title":"Cell Rep"},{"issue":"3","key":"562_CR55","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/QAI.0b013e3181dd17d4","volume":"54","author":"A Pontillo","year":"2010","unstructured":"Pontillo A, Brandao LA, Guimaraes RL, Segat L, Athanasakis E, Crovella S. A 3\u2019UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection. J Acquir Immune Defic Syndr. 2010;54(3):236\u201340.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"2","key":"562_CR56","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/QAI.0b013e3182392ebe","volume":"59","author":"A Pontillo","year":"2012","unstructured":"Pontillo A, Oshiro TM, Girardelli M, Kamada AJ, Crovella S, Duarte AJ. Polymorphisms in inflammasome\u2019 genes and susceptibility to HIV-1 infection. J Acquir Immune Defic Syndr. 2012;59(2):121\u20135.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"3","key":"562_CR57","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/QAD.0000000000001693","volume":"32","author":"F Ahmad","year":"2018","unstructured":"Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, et al. Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients. AIDS. 2018;32(3):299\u2013307.","journal-title":"AIDS."},{"issue":"1","key":"562_CR58","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/QAD.0b013e32834d697f","volume":"26","author":"A Pontillo","year":"2012","unstructured":"Pontillo A, Silva LT, Oshiro TM, Finazzo C, Crovella S, Duarte AJ. HIV-1 induces NALP3-inflammasome expression and interleukin-1beta secretion in dendritic cells from healthy individuals but not from HIV-positive patients. AIDS. 2012;26(1):11\u20138.","journal-title":"AIDS."},{"key":"562_CR59","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1742-4690-11-35","volume":"11","author":"JG Walsh","year":"2014","unstructured":"Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, et al. Rapid inflammasome activation in microglia contributes to brain disease in HIV\/AIDS. Retrovirology. 2014;11:35.","journal-title":"Retrovirology."},{"issue":"2","key":"562_CR60","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11481-016-9708-3","volume":"12","author":"MK Mamik","year":"2017","unstructured":"Mamik MK, Hui E, Branton WG, McKenzie BA, Chisholm J, Cohen EA, et al. HIV-1 viral protein R activates NLRP3 Inflammasome in microglia: implications for HIV-1 associated Neuroinflammation. J NeuroImmune Pharmacol. 2017;12(2):233\u201348.","journal-title":"J NeuroImmune Pharmacol"},{"issue":"7","key":"562_CR61","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1074\/jbc.M116.749473","volume":"292","author":"A Toksoy","year":"2017","unstructured":"Toksoy A, Sennefelder H, Adam C, Hofmann S, Trautmann A, Goebeler M, et al. Potent NLRP3 Inflammasome activation by the HIV reverse transcriptase inhibitor Abacavir. J Biol Chem. 2017;292(7):2805\u201314.","journal-title":"J Biol Chem"},{"issue":"7434","key":"562_CR62","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice. Nature. 2013;493(7434):674\u20138.","journal-title":"Nature."},{"issue":"7685","key":"562_CR63","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature25158","volume":"552","author":"C Venegas","year":"2017","unstructured":"Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, et al. Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer\u2019s disease. Nature. 2017;552(7685):355\u201361.","journal-title":"Nature."},{"key":"562_CR64","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1476-9255-7-23","volume":"7","author":"NB Bryan","year":"2010","unstructured":"Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond). 2010;7:23.","journal-title":"J Inflamm (Lond)"},{"issue":"1","key":"562_CR65","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000477092","volume":"24","author":"PJ Wu","year":"2017","unstructured":"Wu PJ, Hung YF, Liu HY, Hsueh YP. Deletion of the Inflammasome sensor Aim2 mitigates Abeta deposition and microglial activation but increases inflammatory cytokine expression in an Alzheimer disease mouse model. Neuroimmunomodulation. 2017;24(1):29\u201339.","journal-title":"Neuroimmunomodulation."},{"key":"562_CR66","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3389\/fimmu.2018.01350","volume":"9","author":"D Marin-Palma","year":"2018","unstructured":"Marin-Palma D, Castro GA, Cardona-Arias JA, Urcuqui-Inchima S, Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. Front Immunol. 2018;9:1350.","journal-title":"Front Immunol"},{"issue":"6A","key":"562_CR67","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1111\/j.1582-4934.2008.00496.x","volume":"12","author":"A Salminen","year":"2008","unstructured":"Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer\u2019s pathology. J Cell Mol Med. 2008;12(6A):2255\u201362.","journal-title":"J Cell Mol Med"},{"key":"562_CR68","doi-asserted-by":"publisher","first-page":"e1382","DOI":"10.1038\/cddis.2014.348","volume":"5","author":"MS Tan","year":"2014","unstructured":"Tan MS, Tan L, Jiang T, Zhu XC, Wang HF, Jia CD, et al. Amyloid-beta induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death Dis. 2014;5:e1382.","journal-title":"Cell Death Dis"},{"key":"562_CR69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbi.2019.03.011","volume":"80","author":"P Periyasamy","year":"2019","unstructured":"Periyasamy P, Thangaraj A, Bendi VS, Buch S. HIV-1 tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFkappaB signaling axis. Brain Behav Immun. 2019;80:227\u201337.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"562_CR70","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nn1707","volume":"9","author":"JB Aimone","year":"2006","unstructured":"Aimone JB, Wiles J, Gage FH. Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci. 2006;9(6):723\u20137.","journal-title":"Nat Neurosci"},{"key":"562_CR71","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.brainres.2016.05.015","volume":"1644","author":"C Lieberwirth","year":"2016","unstructured":"Lieberwirth C, Pan Y, Liu Y, Zhang Z, Wang Z. Hippocampal adult neurogenesis: its regulation and potential role in spatial learning and memory. Brain Res. 2016;1644:127\u201340.","journal-title":"Brain Res"},{"issue":"4","key":"562_CR72","doi-asserted-by":"publisher","first-page":"a021287","DOI":"10.1101\/cshperspect.a021287","volume":"7","author":"B Winner","year":"2015","unstructured":"Winner B, Winkler J. Adult neurogenesis in neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2015;7(4):a021287.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"12","key":"562_CR73","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1002\/glia.22403","volume":"60","author":"YK Hahn","year":"2012","unstructured":"Hahn YK, Podhaizer EM, Hauser KF, Knapp PE. HIV-1 alters neural and glial progenitor cell dynamics in the central nervous system: coordinated response to opiates during maturation. Glia. 2012;60(12):1871\u201387.","journal-title":"Glia."},{"issue":"14","key":"562_CR74","doi-asserted-by":"publisher","first-page":"7319","DOI":"10.1128\/JVI.78.14.7319-7328.2004","volume":"78","author":"DM Lawrence","year":"2004","unstructured":"Lawrence DM, Durham LC, Schwartz L, Seth P, Maric D, Major EO. Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J Virol. 2004;78(14):7319\u201328.","journal-title":"J Virol"},{"issue":"1","key":"562_CR75","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1074\/jbc.RA117.000795","volume":"293","author":"M Skowronska","year":"2018","unstructured":"Skowronska M, McDonald M, Velichkovska M, Leda AR, Park M, Toborek M. Methamphetamine increases HIV infectivity in neural progenitor cells. J Biol Chem. 2018;293(1):296\u2013311.","journal-title":"J Biol Chem"},{"issue":"3","key":"562_CR76","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.nbd.2010.12.002","volume":"41","author":"MH Lee","year":"2011","unstructured":"Lee MH, Wang T, Jang MH, Steiner J, Haughey N, Ming GL, et al. Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease. Neurobiol Dis. 2011;41(3):678\u201387.","journal-title":"Neurobiol Dis"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-020-0562-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13041-020-0562-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-020-0562-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T16:02:37Z","timestamp":1665849757000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/s13041-020-0562-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["562"],"URL":"https:\/\/doi.org\/10.1186\/s13041-020-0562-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.17417\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.17417\/v2","asserted-by":"object"}]},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"14 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}