{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:16:16Z","timestamp":1788387376019,"version":"build-2803163510"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09231"],"award-info":[{"award-number":["21K09231"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08547"],"award-info":[{"award-number":["23K08547"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09361"],"award-info":[{"award-number":["22K09361"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Limited spontaneous recovery occurs after spinal cord injury (SCI). However, current knowledge indicates that multiple forms of axon growth in spared axons can lead to circuit reorganization. Intravenous infusion of mesenchymal stem cells (MSCs) provides functional improvements after SCI with an increased axonal network. In this study, we examined how intravenous infusion of MSCs facilitates axonal connections in the rubrospinal tract (RST), one of the significant descending tracts, using AAV neuronal tracing techniques. Our finding demonstrated that infused MSCs significantly enhanced axonal signal intensity in the RST, not only around the injury site but also in the rostral and caudal regions, suggesting that neural circuit reorganization is facilitated.<\/jats:p>","DOI":"10.1186\/s13041-025-01210-0","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T18:03:08Z","timestamp":1744826588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury"],"prefix":"10.1186","volume":"18","author":[{"given":"Ryosuke","family":"Hirota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery D.","family":"Kocsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Honmou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"issue":"3","key":"1210_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1089\/neu.2018.5793","volume":"36","author":"T Oshigiri","year":"2019","unstructured":"Oshigiri T, Sasaki T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Oka S, et al. Intravenous infusion of mesenchymal stem cells alters motor cortex gene expression in a rat model of acute spinal cord injury. J Neurotrauma. 2019;36(3):411\u201320.","journal-title":"J Neurotrauma"},{"key":"1210_CR2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.neuroscience.2016.08.037","volume":"335","author":"T Morita","year":"2016","unstructured":"Morita T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Oka S, et al. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury. Neuroscience. 2016;335:221\u201331.","journal-title":"Neuroscience"},{"key":"1210_CR3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.brainres.2010.05.011","volume":"1343","author":"M Osaka","year":"2010","unstructured":"Osaka M, Honmou O, Murakami T, Nonaka T, Houkin K, Hamada H, et al. Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome. Brain Res. 2010;1343:226\u201335.","journal-title":"Brain Res"},{"issue":"23\u201324","key":"1210_CR4","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1089\/neu.2022.0106","volume":"39","author":"R Hirota","year":"2022","unstructured":"Hirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, et al. Enhanced network in corticospinal tracts after infused mesenchymal stem cells in spinal cord injury. J Neurotrauma. 2022;39(23\u201324):1665\u201377.","journal-title":"J Neurotrauma"},{"key":"1210_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/B978-0-12-374247-6.50015-8","volume-title":"The spinal cord","author":"C Watson","year":"2009","unstructured":"Watson C, Harvey AR. Chapter 11 - Projections from the brain to the spinal cord. In: Watson C, Paxinos G, Kayalioglu G, editors. The spinal cord. San Diego: Academic; 2009. pp. 168\u201379."},{"key":"1210_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnins.2016.00005","volume":"10","author":"R Morris","year":"2016","unstructured":"Morris R, Whishaw IQ. A proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movement. Front Neurosci. 2016;10:5.","journal-title":"Front Neurosci"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-025-01210-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13041-025-01210-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13041-025-01210-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T18:03:09Z","timestamp":1744826589000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/s13041-025-01210-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1210"],"URL":"https:\/\/doi.org\/10.1186\/s13041-025-01210-0","relation":{},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"17 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of animals in this study was approved by the Animal Care and Use Committee and the Committee for Security of Recombinant DNA Experiments at Sapporo Medical University. All procedures were performed in accordance with institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"35"}}