{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T10:16:44Z","timestamp":1666952204685},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thyroid Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Palpitations due to Graves\u2019 disease are often caused by supraventricular arrhythmia. However, in rare cases, the background of coronary artery disease, genetic abnormalities, or channel abnormalities can cause ventricular fibrillation, which is a lethal arrhythmia. Here, we report a case of ventricular fibrillation after administration of beta-blockers early in the course of treatment for Graves\u2019 disease coexisting with atypical angina and long QT syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 48-year-old man consulted a local general physician for chest discomfort and palpitations for approximately 2\u00a0weeks. He was diagnosed with Graves\u2019 disease and treated with thiamazole 15\u00a0mg, bisoprolol 1.25\u00a0mg, and nitroglycerin 0.3\u00a0mg. The patient continued to experience chest discomfort the next day and visited our hospital. The patient was treated with landiolol 0.125\u00a0mg\/kg\/min for heart rate control, and 20\u00a0min later, electrocardiography showed a change from the R-on-T phenomenon to ventricular fibrillation. After cardiopulmonary resumption and improvement of thyroid function, a stress test was performed, which revealed coronary angina and long QT syndrome. An implantable cardioverter defibrillator (ICD) was implanted in the patient for secondary prevention. Since then, no fatal arrhythmia has been observed to date.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>When beta-blockers are administered to patients with Graves\u2019 disease who have severe chest symptoms, fatal arrhythmias are possible. ICD implantation should be considered for the secondary prevention of fatal arrhythmias.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13044-022-00136-2","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:02:11Z","timestamp":1664755331000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ventricular fibrillation immediately after the treatment of Graves\u2019 disease coexisting with atypical angina and long QT syndrome: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Hajime","family":"Iwasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Suwanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Satomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nagamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"136_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1113\/jphysiol.1970.sp009066","volume":"207","author":"AS Freedberg","year":"1970","unstructured":"Freedberg AS, Papp JG, Williams EM. The effect of altered thyroid state on atrial intracellular potentials. J Physiol. 1970;207:357\u201369.","journal-title":"J Physiol"},{"issue":"10","key":"136_CR2","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"26","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, et al. 2016 American thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343\u2013421.","journal-title":"Thyroid"},{"issue":"2","key":"136_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10840-010-9507-3","volume":"29","author":"A Ueno","year":"2010","unstructured":"Ueno A, Yamamoto T, Sato N, Tanaka K. Ventricular fibrillation associated with early repolarization in a patient with thyroid storm. J Interv Card Electrophysiol. 2010;29(2):93\u20136.","journal-title":"J Interv Card Electrophysiol"},{"key":"136_CR4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000437225","volume":"4","author":"H Kobayashi","year":"2015","unstructured":"Kobayashi H, Haketa A, Abe M, Tahira K, Hatanaka Y, Tanaka S, et al. Unusual manifestation of Graves\u2019 disease: ventricular fibrillation. Eur Thyroid J. 2015;4:207\u201312.","journal-title":"Eur Thyroid J"},{"key":"136_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1157\/13101650","volume":"60","author":"JF Mu\u00f1oz-Camacho","year":"2007","unstructured":"Mu\u00f1oz-Camacho JF, Sagrist\u00e1-Sauleda J. Malignant ventricular arrhythmias as the initial manifestation of hyperthyroidism. Rev Esp Cardiol. 2007;60:449\u201350.","journal-title":"Rev Esp Cardiol"},{"key":"136_CR6","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.amjcard.2012.06.054","volume":"110","author":"H Shimada","year":"2012","unstructured":"Shimada H, Nishizaki M, Fujii H, Yamawake N, Fukamizu S, Sakurada H, et al. Ambulatory electrocardiogram-based T-wave alternans in patients with vasospastic angina during asymptomatic periods. Am J Cardiol. 2012;110:1446\u201351.","journal-title":"Am J Cardiol"},{"key":"136_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0167-5273(97)00106-X","volume":"60","author":"YJ Lin","year":"1997","unstructured":"Lin YJ, Liu YB, Wu CC, Chen WJ, Lee YT. Painless Prinzmetal\u2019s ST elevation related to propranolol: a case report. Int J Cardiol. 1997;60:311\u20134.","journal-title":"Int J Cardiol"},{"key":"136_CR8","first-page":"7612748","volume":"2017","author":"Z Kulairi","year":"2017","unstructured":"Kulairi Z, Deol N, Tolly R, Manocha R, Naseer M. QT prolongation due to Graves\u2019 disease. Case Rep Cardiol. 2017;2017:7612748.","journal-title":"Case Rep Cardiol"}],"container-title":["Thyroid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13044-022-00136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13044-022-00136-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13044-022-00136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:03:02Z","timestamp":1664755382000},"score":1,"resource":{"primary":{"URL":"https:\/\/thyroidresearchjournal.biomedcentral.com\/articles\/10.1186\/s13044-022-00136-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["136"],"URL":"https:\/\/doi.org\/10.1186\/s13044-022-00136-2","relation":{},"ISSN":["1756-6614"],"issn-type":[{"value":"1756-6614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,3]]},"assertion":[{"value":"24 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is exempted from IRB as this is retrospectively presented for a single patient. We received written consent to participation from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have no competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18"}}