{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:44:22Z","timestamp":1776901462778,"version":"3.51.2"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:00:00Z","timestamp":1434758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Jiangsu Provincial Special Program of Medical Science","award":["BL2012005"],"award-info":[{"award-number":["BL2012005"]}]},{"name":"Jiangsu Province\u2019s Key Medical Center","award":["ZX201102"],"award-info":[{"award-number":["ZX201102"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20140285"],"award-info":[{"award-number":["BK20140285"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13045-015-0166-9","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T04:03:22Z","timestamp":1434686602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mutations in the D1 domain of von Willebrand factor impair their propeptide-dependent multimerization, intracellular trafficking and secretion"],"prefix":"10.1186","volume":"8","author":[{"given":"Jie","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenni","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgeng","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,20]]},"reference":[{"issue":"6","key":"166_CR1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1055\/s-0038-1649724","volume":"70","author":"AM Journet","year":"1993","unstructured":"Journet AM, Saffaripour S, Wagner DD. Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage. Thromb Haemost. 1993;70(6):1053\u20137.","journal-title":"Thromb Haemost"},{"issue":"5","key":"166_CR2","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1182\/blood-2002-03-0789","volume":"100","author":"JB Rosenberg","year":"2002","unstructured":"Rosenberg JB, Haberichter SL, Jozwiak MA, Vokac EA, Kroner PA, Fahs SA, et al. The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. Blood. 2002;100(5):1699\u2013706.","journal-title":"Blood"},{"issue":"7","key":"166_CR3","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1182\/blood-2003-02-0599","volume":"102","author":"G Michaux","year":"2003","unstructured":"Michaux G, Hewlett LJ, Messenger SL, Goodeve AC, Peake IR, Daly ME, et al. Analysis of intracellular storage and regulated secretion of 3 von Willebrand disease-causing variants of von Willebrand factor. Blood. 2003;102(7):2452\u20138. doi:10.1182\/blood-2003-02-0599.","journal-title":"Blood"},{"issue":"3","key":"166_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1365-2516.2008.01682.x","volume":"14","author":"L Baronciani","year":"2008","unstructured":"Baronciani L, Federici AB, Cozzi G, La Marca S, Punzo M, Rubini V, et al. Expression studies of missense mutations p.D141Y, p.C275S located in the propeptide of von Willebrand factor in patients with type 3 von Willebrand disease. Haemophilia. 2008;14(3):549\u201355.","journal-title":"Haemophilia"},{"issue":"2\u20133","key":"166_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000214851","volume":"121","author":"JJ Michiels","year":"2009","unstructured":"Michiels JJ, Gadisseur A, van der Planken M, Schroyens W, Berneman Z. Laboratory and molecular characteristics of recessive von Willebrand disease type 2C (2A subtype IIC) of variable severity due to homozygous or double heterozygous mutations in the D1 and D2 domains. Acta Haematol. 2009;121(2\u20133):111\u20138.","journal-title":"Acta Haematol"},{"issue":"10","key":"166_CR6","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","volume":"4","author":"JE Sadler","year":"2006","unstructured":"Sadler JE, Budde U, Eikenboom JC, Favaloro EJ, Hill FG, Holmberg L, et al. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. J Thromb Haemost. 2006;4(10):2103\u201314.","journal-title":"J Thromb Haemost"},{"issue":"48","key":"166_CR7","doi-asserted-by":"publisher","first-page":"49982","DOI":"10.1074\/jbc.M408727200","volume":"279","author":"AR Purvis","year":"2004","unstructured":"Purvis AR, Sadler JE. A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization. J Biol Chem. 2004;279(48):49982\u20138.","journal-title":"J Biol Chem"},{"issue":"29","key":"166_CR8","doi-asserted-by":"publisher","first-page":"25763","DOI":"10.1074\/jbc.M111.249151","volume":"286","author":"LT Dang","year":"2011","unstructured":"Dang LT, Purvis AR, Huang RH, Westfield LA, Sadler JE. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. J Biol Chem. 2011;286(29):25763\u20139.","journal-title":"J Biol Chem"}],"container-title":["Journal of Hematology &amp; Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-015-0166-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13045-015-0166-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-015-0166-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-015-0166-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T15:42:26Z","timestamp":1630597346000},"score":1,"resource":{"primary":{"URL":"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-015-0166-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,20]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["166"],"URL":"https:\/\/doi.org\/10.1186\/s13045-015-0166-9","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,20]]},"assertion":[{"value":"17 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"73"}}