{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:59:24Z","timestamp":1790834364995,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13045-016-0256-3","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T21:03:56Z","timestamp":1458335036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia"],"prefix":"10.1186","volume":"9","author":[{"given":"Yozo","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kurata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Sueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sakashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihaya","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"256_CR1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-2141.2008.07104.x","volume":"141","author":"K Koike","year":"2008","unstructured":"Koike K, Matsuda K. Recent advances in the pathogenesis and management of juvenile myelomonocytic leukemia. Br J Haematol. 2008;141:567\u201375.","journal-title":"Br J Haematol"},{"key":"256_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fped.2014.00025","volume":"2","author":"CC Dvorak","year":"2014","unstructured":"Dvorak CC, Loh ML. Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantation. Front Pediatr. 2014;2:1\u20138.","journal-title":"Front Pediatr"},{"key":"256_CR3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ng.2698","volume":"45","author":"H Sakaguchi","year":"2013","unstructured":"Sakaguchi H, Okuno Y, Muramatsu H, Yoshida K, Shiraishi Y, Takahashi M, et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet. 2013;45:937\u201341.","journal-title":"Nat Genet"},{"key":"256_CR4","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/leu.2014.58","volume":"287","author":"K Matsuda","year":"2014","unstructured":"Matsuda K, Nakazawa Y, Iwashita C, Kurata T, Hirabayashi K, Saito S, et al. Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia. Leukemia. 2014;287:1545\u20138.","journal-title":"Leukemia"},{"key":"256_CR5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1182\/blood-2014-09-601690","volume":"125","author":"E Stieglitz","year":"2015","unstructured":"Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, et al. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015;125:516\u201324.","journal-title":"Blood"},{"key":"256_CR6","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/ng.3420","volume":"47","author":"A Caye","year":"2015","unstructured":"Caye A, Strullu M, Guidez F, Cassinat B, Gazal S, Fenneteau O, et al. Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network. Nat Genet. 2015;47:1334\u201340.","journal-title":"Nat Genet"},{"key":"256_CR7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1182\/blood-2014-08-550483","volume":"125","author":"F Locatelli","year":"2015","unstructured":"Locatelli F, Niemeyer CM. How I treat juvenile myelomonocytic leukemia. Blood. 2015;125:1083\u201390.","journal-title":"Blood"},{"key":"256_CR8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2002-07-2011","volume":"101","author":"A Worth","year":"2003","unstructured":"Worth A, Rao K, Webb D, Chessells J, Passmore J, Veys P. Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion. Blood. 2003;101:1713\u20134.","journal-title":"Blood"},{"key":"256_CR9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.leu.2403721","volume":"19","author":"A1 Yoshimi","year":"2005","unstructured":"Yoshimi A1, Bader P, Matthes-Martin S, Star\u00fd J, Sedlacek P, Duffner U, et al. Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. Leukemia. 2005;19:971\u20137.","journal-title":"Leukemia"},{"key":"256_CR10","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/sj.leu.2403059","volume":"17","author":"S Nabarro","year":"2003","unstructured":"Nabarro S, Thrasher AJ, Kempski H, Amrolia P, Anderson J. Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia. Leukemia. 2003;17:1910\u20132.","journal-title":"Leukemia"},{"key":"256_CR11","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1182\/blood-2006-04-017566","volume":"108","author":"N Hirano","year":"2006","unstructured":"Hirano N, Butler MO, Xia Z, Berezovskaya A, Murray AP, Ans\u00e9n S, et al. Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. Blood. 2006;108:2662\u20138.","journal-title":"Blood"},{"key":"256_CR12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12185-013-1479-5","volume":"99","author":"ML Davila","year":"2014","unstructured":"Davila ML, Bouhassira DC, Park JH, Curran KJ, Smith EL, Pegram HJ, et al. Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies. Int J Hematol. 2014;99:361\u201371.","journal-title":"Int J Hematol"},{"key":"256_CR13","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMoa1407222","volume":"371","author":"SL Maude","year":"2014","unstructured":"Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371:1507\u201317.","journal-title":"N Engl J Med"},{"key":"256_CR14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0140-6736(14)61403-3","volume":"385","author":"DW Lee","year":"2015","unstructured":"Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015;385:517\u201328.","journal-title":"Lancet"},{"key":"256_CR15","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jcyt.2014.05.022","volume":"16","author":"S Saito","year":"2014","unstructured":"Saito S, Nakazawa Y, Sueki A, Matsuda K, Tanaka M, Yanagisawa R, et al. Anti-leukemic potency of piggyBac-mediated CD19-specific T cells against refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Cytotherapy. 2014;16:1257\u201369.","journal-title":"Cytotherapy"},{"key":"256_CR16","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1038\/mt.2011.179","volume":"19","author":"LE Huye","year":"2011","unstructured":"Huye LE, Nakazawa Y, Patel MP, Yvon E, Sun J, Savoldo B, et al. Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Mol Ther. 2011;19:2239\u201348.","journal-title":"Mol Ther"},{"key":"256_CR17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/leu.2014.239","volume":"29","author":"K Sakashita","year":"2015","unstructured":"Sakashita K, Kato I, Daifu T, Saida S, Hiramatsu H, Nishinaka Y, et al. In vitro expansion of CD34+CD38\u2212 cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia. Leukemia. 2015;29:606\u201314.","journal-title":"Leukemia"},{"key":"256_CR18","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3324\/haematol.2010.026310","volume":"95","author":"V Marin","year":"2010","unstructured":"Marin V, Pizzitola I, Agostoni V, Attianese GM, Finney H, Lawson A, et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica. 2010;95:2144\u201352.","journal-title":"Haematologica"},{"key":"256_CR19","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1182\/blood-2012-12-474056","volume":"122","author":"A Mardiros","year":"2013","unstructured":"Mardiros A, Dos Santos C, McDonald T, Brown CE, Wang X, Budde LE, et al. T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia. Blood. 2013;122:3138\u201348.","journal-title":"Blood"},{"key":"256_CR20","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/leu.2014.62","volume":"28","author":"I Pizzitola","year":"2014","unstructured":"Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, et al. Chimeric antigen receptors against CD33\/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo. Leukemia. 2014;28:1596\u2013605.","journal-title":"Leukemia"},{"key":"256_CR21","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood-2013-09-529537","volume":"123","author":"S Gill","year":"2014","unstructured":"Gill S, Tasian SK, Ruella M, Shestova O, Li Y, Porter DL, et al. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells. Blood. 2014;123:2343\u201354.","journal-title":"Blood"},{"key":"256_CR22","first-page":"4279","volume":"92","author":"AE Frankel","year":"1998","unstructured":"Frankel AE, Lilly M, Kreitman R, Hogge D, Beran M, Freedman MH, et al. Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Blood. 1998;92:4279\u201386.","journal-title":"Blood"},{"key":"256_CR23","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1182\/blood-2006-09-046649","volume":"109","author":"K Matsuda","year":"2007","unstructured":"Matsuda K, Shimada A, Yoshida N, Ogawa A, Watanabe A, Yajima S, et al. Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood. 2007;109:5477\u201380.","journal-title":"Blood"},{"key":"256_CR24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1203\/PDR.0b013e3181961d2a","volume":"65","author":"N Yoshida","year":"2009","unstructured":"Yoshida N, Yagasaki H, Xu Y, Matsuda K, Yoshimi A, Takahashi Y, et al. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. Pediatr Res. 2009;65:334\u201340.","journal-title":"Pediatr Res"},{"key":"256_CR25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/ng.641","volume":"42","author":"CM Niemeyer","year":"2010","unstructured":"Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, et al. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010;42:794\u2013800.","journal-title":"Nat Genet"},{"key":"256_CR26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2141.2012.09063.x","volume":"157","author":"K Matsuda","year":"2012","unstructured":"Matsuda K, Yoshida N, Miura S, Nakazawa Y, Sakashita K, Hyakuna N, et al. Long-term hematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukemia and poor correlation with adult myelodysplasia spliceosome-related mutations. Br J Haematol. 2012;157:647\u201350.","journal-title":"Br J Haematol"},{"key":"256_CR27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cell.2008.05.053","volume":"134","author":"G Hansen","year":"2008","unstructured":"Hansen G, Hercus TR, McClure BJ, Stomski FC, Dottore M, Powell J, et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell. 2008;134:496\u2013507.","journal-title":"Cell"},{"key":"256_CR28","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1182\/blood-2008-12-164004","volume":"114","author":"TR Hercus","year":"2009","unstructured":"Hercus TR, Thomas D, Guthridge MA, Ekert PG, King-Scott J, Parker MW, et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood. 2009;114:1289\u201398.","journal-title":"Blood"},{"key":"256_CR29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1182\/blood.V93.2.509","volume":"93","author":"N Sawai","year":"1999","unstructured":"Sawai N, Koike K, Ito S, Mwamtemi HH, Kurokawa Y, Kinoshita T, et al. Neutrophilic cell production by combination of stem cell factor and thrombopoietin from CD34+ cord blood cells in long-term serum-deprived liquid culture. Blood. 1999;93:509\u201318.","journal-title":"Blood"},{"key":"256_CR30","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1182\/blood-2009-12-260729","volume":"115","author":"K Matsuda","year":"2010","unstructured":"Matsuda K, Taira C, Sakashita K, Saito S, Tanaka-Yanagisawa M, Yanagisawa R, et al. Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations. Blood. 2010;115:5429\u201331.","journal-title":"Blood"}],"container-title":["Journal of Hematology &amp; Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-016-0256-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T10:42:09Z","timestamp":1600339329000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jhoonline.org\/content\/9\/1\/27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["256"],"URL":"https:\/\/doi.org\/10.1186\/s13045-016-0256-3","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]},"article-number":"27"}}