{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:01:03Z","timestamp":1792591263921,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13045-016-0272-3","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T17:11:25Z","timestamp":1472836285000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Immune phenotypes predict survival in patients with glioblastoma multiforme"],"prefix":"10.1186","volume":"9","author":[{"given":"Haouraa","family":"Mostafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Pala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"H\u00f6gel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Hlavac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Andrew","family":"Westhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nonnenmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Burster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Georgieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Rainer","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Marion","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"issue":"2","key":"272_CR1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2217\/cns.14.55","volume":"4","author":"C Kamiya-Matsuoka","year":"2015","unstructured":"Kamiya-Matsuoka C, Gilbert MR. Treating recurrent glioblastoma: an update. CNS Oncol. 2015;4(2):91\u2013104.","journal-title":"CNS Oncol"},{"issue":"4","key":"272_CR2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1750-3639.2005.tb00119.x","volume":"15","author":"JP Gagner","year":"2005","unstructured":"Gagner JP, Law M, Fischer I, Newcomb EW, Zagzag D. Angiogenesis in gliomas: imaging and experimental therapeutics. Brain Pathol. 2005;15(4):342\u201363.","journal-title":"Brain Pathol"},{"key":"272_CR3","doi-asserted-by":"crossref","unstructured":"Wurth R, Barbieri F, Florio T. New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells. Biomed Res Int. 2014;2014.","DOI":"10.1155\/2014\/126586"},{"issue":"2","key":"272_CR4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrclinonc.2014.223","volume":"12","author":"DA Reardon","year":"2015","unstructured":"Reardon DA, Wen PY. Glioma in 2014: unravelling tumour heterogeneity-implications for therapy. Nat Rev Clin Oncol. 2015;12(2):69\u201370.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"272_CR5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-065X.2012.01130.x","volume":"248","author":"DE Lowther","year":"2012","unstructured":"Lowther DE, Hafler DA. Regulatory T cells in the central nervous system. Immunol Rev. 2012;248(1):156\u201369.","journal-title":"Immunol Rev"},{"key":"272_CR6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-4614-3146-6_5","volume":"746","author":"CE Rolle","year":"2012","unstructured":"Rolle CE, Sengupta S, Lesniak MS. Mechanisms of immune evasion by gliomas. Adv Exp Med Biol. 2012;746:53\u201376.","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"272_CR7","first-page":"307","volume":"18","author":"K Urbanska","year":"2014","unstructured":"Urbanska K, Sokolowska J, Szmidt M, Sysa P. Glioblastoma multiforme\u2014an overview. Contemp Oncol (Pzn). 2014;18(5):307\u201312.","journal-title":"Contemp Oncol (Pzn)"},{"issue":"8","key":"272_CR8","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/ijc.25770","volume":"128","author":"L Baglietto","year":"2011","unstructured":"Baglietto L, Giles GG, English DR, Karahalios A, Hopper JL, Severi G. Alcohol consumption and risk of glioblastoma; evidence from the Melbourne Collaborative Cohort Study. Int J Cancer. 2011;128(8):1929\u201334.","journal-title":"Int J Cancer"},{"issue":"1","key":"272_CR9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nrclinonc.2012.204","volume":"10","author":"S Tanaka","year":"2013","unstructured":"Tanaka S, Louis DN, Curry WT, Batchelor TT, Dietrich J. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end? Nat Rev Clin Oncol. 2013;10(1):14\u201326.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1-2","key":"272_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2013.08.013","volume":"264","author":"J Kmiecik","year":"2013","unstructured":"Kmiecik J, Poli A, Brons NH, Waha A, Eide GE, Enger PO, Zimmer J, Chekenya M. Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level. J Neuroimmunol. 2013;264(1-2):71\u201383.","journal-title":"J Neuroimmunol"},{"issue":"12","key":"272_CR11","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT, Jr., Carter BS, Krichevsky AM, Breakefield XO. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470\u20136.","journal-title":"Nat Cell Biol"},{"issue":"9","key":"272_CR12","doi-asserted-by":"crossref","first-page":"e46153","DOI":"10.1371\/journal.pone.0046153","volume":"7","author":"P Gautam","year":"2012","unstructured":"Gautam P, Nair SC, Gupta MK, Sharma R, Polisetty RV, Uppin MS, Sundaram C, Puligopu AK, Ankathi P, Purohit AK, Chandak GR, Harsha HC, Sirdeshmukh R. Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis. PLoS One. 2012;7(9):e46153.","journal-title":"PLoS One"},{"issue":"2","key":"272_CR13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3171\/jns.2004.100.2.0310","volume":"100","author":"I Yang","year":"2004","unstructured":"Yang I, Kremen TJ, Giovannone AJ, Paik E, Odesa SK, Prins RM, Liau LM. Modulation of major histocompatibility complex class I molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-alpha and interferon-gamma treatment of human glioblastoma multiforme. J Neurosurg. 2004;100(2):310\u20139.","journal-title":"J Neurosurg"},{"issue":"2","key":"272_CR14","first-page":"593","volume":"125","author":"L Bunse","year":"2015","unstructured":"Bunse L, Schumacher T, Sahm F, Pusch S, Oezen I, Rauschenbach K, Gonzalez M, Solecki G, Osswald M, Capper D, Wiestler B, Winkler F, Herold-Mende C, von Deimling A, Wick W, Platten M. Proximity ligation assay evaluates IDH1R132H presentation in gliomas. J Clin Invest. 2015;125(2):593\u2013606.","journal-title":"J Clin Invest"},{"issue":"2","key":"272_CR15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ajh.1082","volume":"67","author":"L Ginaldi","year":"2001","unstructured":"Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto F, Modesti M, Quaglino D. Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis. Am J Hematol. 2001;67(2):63\u201372.","journal-title":"Am J Hematol"},{"key":"272_CR16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1479-5876-11-83","volume":"11","author":"J Jiang","year":"2013","unstructured":"Jiang J, Wu C, Lu B. Cytokine-induced killer cells promote antitumor immunity. J Transl Med. 2013;11:83.","journal-title":"J Transl Med"},{"key":"272_CR17","doi-asserted-by":"crossref","unstructured":"Huehn J, Beyer M. Epigenetic and transcriptional control of Foxp3(+) regulatory T cells. Semin Immunol. 2015;27(1):10\u201318.","DOI":"10.1016\/j.smim.2015.02.002"},{"issue":"11","key":"272_CR18","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/ijc.29309","volume":"136","author":"A Authier","year":"2015","unstructured":"Authier A, Farrand KJ, Broadley KW, Ancelet LR, Hunn MK, Stone S, McConnell MJ, Hermans IF. Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells. Int J Cancer. 2015;136(11):2566\u201378.","journal-title":"Int J Cancer"},{"key":"272_CR19","doi-asserted-by":"crossref","unstructured":"Mittal SK, Roche PA. Suppression of antigen presentation by IL-10. Curr Opin Immunol. 2015;34:22\u201327.","DOI":"10.1016\/j.coi.2014.12.009"},{"issue":"5A","key":"272_CR20","first-page":"3217","volume":"17","author":"C Huettner","year":"1997","unstructured":"Huettner C, Czub S, Kerkau S, Roggendorf W, Tonn JC. Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro. Anticancer Res. 1997;17(5A):3217\u201324.","journal-title":"Anticancer Res"},{"issue":"2","key":"272_CR21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cellimm.2014.12.012","volume":"293","author":"G Ni","year":"2015","unstructured":"Ni G, Wang T, Walton S, Zhu B, Chen S, Wu X, Wang Y, Wei MQ, Liu X. Manipulating IL-10 signalling blockade for better immunotherapy. Cell Immunol. 2015;293(2):126\u20139.","journal-title":"Cell Immunol"},{"issue":"6","key":"272_CR22","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1158\/0008-5472.CAN-10-1375","volume":"71","author":"X Liu","year":"2011","unstructured":"Liu X, Madhankumar AB, Slagle-Webb B, Sheehan JM, Surguladze N, Connor JR. Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents. Cancer Res. 2011;71(6):2240\u20139.","journal-title":"Cancer Res"},{"issue":"3","key":"272_CR23","doi-asserted-by":"crossref","first-page":"e0122269","DOI":"10.1371\/journal.pone.0122269","volume":"10","author":"C Lapa","year":"2015","unstructured":"Lapa C, Linsenmann T, Luckerath K, Samnick S, Herrmann K, Stoffer C, Ernestus RI, Buck AK, Lohr M, Monoranu CM. Tumor-associated macrophages in glioblastoma multiforme-a suitable target for somatostatin receptor-based imaging and therapy? PLoS One. 2015;10(3):e0122269.","journal-title":"PLoS One"},{"issue":"2","key":"272_CR24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.1012356108","volume":"108","author":"A Maria De","year":"2011","unstructured":"De Maria A, Bozzano F, Cantoni C, Moretta L. Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation. Proc Natl Acad Sci U S A. 2011;108(2):728\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"272_CR25","first-page":"2525","volume":"33","author":"TY Jung","year":"2013","unstructured":"Jung TY, Choi YD, Kim YH, Lee JJ, Kim HS, Kim JS, Kim SK, Jung S, Cho D. Immunological characterization of glioblastoma cells for immunotherapy. Anticancer Res. 2013;33(6):2525\u201333.","journal-title":"Anticancer Res"},{"issue":"5","key":"272_CR26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.exphem.2009.01.010","volume":"37","author":"M Franceschetti","year":"2009","unstructured":"Franceschetti M, Pievani A, Borleri G, Vago L, Fleischhauer K, Golay J, Introna M. Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes. Exp Hematol. 2009;37(5):616\u201328. e612.","journal-title":"Exp Hematol"},{"issue":"2","key":"272_CR27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1399-0039.1990.tb01761.x","volume":"35","author":"LA Terry","year":"1990","unstructured":"Terry LA, DiSanto JP, Small TN, Flomenberg N. Differential expression and regulation of the human CD8 alpha and CD8 beta chains. Tissue Antigens. 1990;35(2):82\u201391.","journal-title":"Tissue Antigens"},{"issue":"2","key":"272_CR28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1006456421177","volume":"48","author":"GW Wood","year":"2000","unstructured":"Wood GW, Holladay FP, Turner T, Wang YY, Chiga M. A pilot study of autologous cancer cell vaccination and cellular immunotherapy using anti-CD3 stimulated lymphocytes in patients with recurrent grade III\/IV astrocytoma. J Neurooncol. 2000;48(2):113\u201320.","journal-title":"J Neurooncol"},{"issue":"24","key":"272_CR29","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1158\/1078-0432.CCR-06-1727","volume":"12","author":"CA Learn","year":"2006","unstructured":"Learn CA, Fecci PE, Schmittling RJ, Xie W, Karikari I, Mitchell DA, Archer GE, Wei Z, Dressman H, Sampson JH. Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals differential expression of the immunologic transcriptome compared with T cells from healthy volunteers. Clin Cancer Res. 2006;12(24):7306\u201315.","journal-title":"Clin Cancer Res"},{"issue":"3","key":"272_CR30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.0902-4441.2003.00199.x","volume":"72","author":"LR Bisset","year":"2004","unstructured":"Bisset LR, Lung TL, Kaelin M, Ludwig E, Dubs RW. Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland. Eur J Haematol. 2004;72(3):203\u201312.","journal-title":"Eur J Haematol"},{"issue":"6","key":"272_CR31","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1158\/0008-5472.CAN-05-3773","volume":"66","author":"PE Fecci","year":"2006","unstructured":"Fecci PE, Mitchell DA, Whitesides JF, Xie W, Friedman AH, Archer GE, Herndon JE, 2nd, Bigner DD, Dranoff G, Sampson JH. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 2006;66(6):3294\u2013302.","journal-title":"Cancer Res"},{"issue":"3","key":"272_CR32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3171\/jns.2006.105.3.430","volume":"105","author":"A Andaloussi El","year":"2006","unstructured":"El Andaloussi A, Han Y, Lesniak MS. Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors. J Neurosurg. 2006;105(3):430\u20137.","journal-title":"J Neurosurg"},{"issue":"3","key":"272_CR33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1593\/neo.101332","volume":"13","author":"L Feng","year":"2011","unstructured":"Feng L, Sun X, Csizmadia E, Han L, Bian S, Murakami T, Wang X, Robson SC, Wu Y. Vascular CD39\/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia. 2011;13(3):206\u201316.","journal-title":"Neoplasia"},{"issue":"5","key":"272_CR34","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00262-013-1392-z","volume":"62","author":"A Parodi","year":"2013","unstructured":"Parodi A, Battaglia F, Kalli F, Ferrera F, Conteduca G, Tardito S, Stringara S, Ivaldi F, Negrini S, Borgonovo G, Simonato A, Traverso P, Carmignani G, Fenoglio D, Filaci G. CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes. Cancer Immunol Immunother. 2013;62(5):851\u201362.","journal-title":"Cancer Immunol Immunother"},{"issue":"1-2","key":"272_CR35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2009.05.004","volume":"346","author":"M Mandapathil","year":"2009","unstructured":"Mandapathil M, Lang S, Gorelik E, Whiteside TL. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods. 2009;346(1-2):55\u201363.","journal-title":"J Immunol Methods"},{"issue":"9","key":"272_CR36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/neuonc\/not067","volume":"15","author":"S Xu","year":"2013","unstructured":"Xu S, Shao QQ, Sun JT, Yang N, Xie Q, Wang DH, Huang QB, Huang B, Wang XY, Li XG, Qu X. Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas. Neuro Oncol. 2013;15(9):1160\u201372.","journal-title":"Neuro Oncol"},{"key":"272_CR37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-61779-367-7_20","volume":"806","author":"H Su","year":"2012","unstructured":"Su H, Longhi MS, Wang P, Vergani D, Ma Y. Human CD4+CD25(high)CD127 (low\/neg) regulatory T cells. Methods Mol Biol. 2012;806:287\u201399.","journal-title":"Methods Mol Biol"},{"issue":"6","key":"272_CR38","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s10753-012-9496-8","volume":"35","author":"N Yu","year":"2012","unstructured":"Yu N, Li X, Song W, Li D, Yu D, Zeng X, Li M, Leng X, Li X. CD4(+)CD25 (+)CD127 (low\/-) T cells: a more specific Treg population in human peripheral blood. Inflammation. 2012;35(6):1773\u201380.","journal-title":"Inflammation"},{"issue":"3B","key":"272_CR39","first-page":"2429","volume":"26","author":"M Valeriani","year":"2006","unstructured":"Valeriani M, Ferretti A, Franzese P, Tombolini V. High-grade gliomas: results in patients treated with adjuvant radiotherapy alone and with adjuvant radio-chemotherapy. Anticancer Res. 2006;26(3B):2429\u201335.","journal-title":"Anticancer Res"},{"issue":"1","key":"272_CR40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clineuro.2012.04.005","volume":"115","author":"P Bonis De","year":"2013","unstructured":"De Bonis P, Anile C, Pompucci A, Fiorentino A, Balducci M, Chiesa S, Lauriola L, Maira G, Mangiola A. The influence of surgery on recurrence pattern of glioblastoma. Clin Neurol Neurosurg. 2013;115(1):37\u201343.","journal-title":"Clin Neurol Neurosurg"},{"issue":"1","key":"272_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.aller.2011.01.002","volume":"40","author":"A Todo-Bom","year":"2012","unstructured":"Todo-Bom A, Mota-Pinto A, Alves V, Santos-Rosa M. Aging and asthma\u2014changes in CD45RA, CD29 and CD95 T cells subsets. Allergol Immunopathol. 2012;40(1):14\u20139.","journal-title":"Allergol Immunopathol"},{"issue":"2","key":"272_CR42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11060-006-9265-3","volume":"83","author":"A Wu","year":"2007","unstructured":"Wu A, Wiesner S, Xiao J, Ericson K, Chen W, Hall WA, Low WC, Ohlfest JR. Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy. J Neurooncol. 2007;83(2):121\u201331.","journal-title":"J Neurooncol"},{"issue":"5","key":"272_CR43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.prp.2013.12.012","volume":"210","author":"FP Saggioro","year":"2014","unstructured":"Saggioro FP, Neder L, Stavale JN, Paixao-Becker AN, Malheiros SM, Soares FA, Pittella JE, Matias CC, Colli BO, Carlotti CG, Jr., Franco M. Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: a tissue microarray-based study. Pathol Res Pract. 2014;210(5):267\u201373.","journal-title":"Pathol Res Pract"},{"issue":"9","key":"272_CR44","first-page":"3563","volume":"33","author":"G Eisele","year":"2013","unstructured":"Eisele G, Wolpert F, Decrey G, Weller M. APO010, a synthetic hexameric CD95 ligand, induces death of human glioblastoma stem-like cells. Anticancer Res. 2013;33(9):3563\u201371.","journal-title":"Anticancer Res"},{"issue":"1-2","key":"272_CR45","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneuroim.2010.04.009","volume":"225","author":"A Cagigi","year":"2010","unstructured":"Cagigi A, Nilsson A, Levitsky V, Sabri F. Cytotoxic T-lymphocytes secrete soluble factors that induce caspase-mediated apoptosis in glioblastoma cell lines. J Neuroimmunol. 2010;225(1-2):34\u201342.","journal-title":"J Neuroimmunol"},{"issue":"22","key":"272_CR46","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1158\/1078-0432.CCR-12-2801","volume":"18","author":"BD Choi","year":"2012","unstructured":"Choi BD, Fecci PE, Sampson JH. Regulatory T cells move in when gliomas say \"I Do\". Clin Cancer Res. 2012;18(22):6086\u20138.","journal-title":"Clin Cancer Res"},{"issue":"9","key":"272_CR47","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1007\/s13277-014-2262-9","volume":"35","author":"DA Chistiakov","year":"2014","unstructured":"Chistiakov DA, Chekhonin VP. Extracellular vesicles shed by glioma cells: pathogenic role and clinical value. Tumour Biol. 2014;35(9):8425\u201338.","journal-title":"Tumour Biol"},{"issue":"9","key":"272_CR48","doi-asserted-by":"crossref","first-page":"e2583","DOI":"10.1097\/MD.0000000000002583","volume":"95","author":"JR Chen","year":"2016","unstructured":"Chen JR, Yao Y, Xu HZ, Qin ZY. Isocitrate dehydrogenase (IDH)1\/2 mutations as prognostic markers in patients with glioblastomas. Medicine. 2016;95(9):e2583.","journal-title":"Medicine"}],"container-title":["Journal of Hematology & Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-016-0272-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:59:26Z","timestamp":1568350766000},"score":1,"resource":{"primary":{"URL":"http:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-016-0272-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["272"],"URL":"https:\/\/doi.org\/10.1186\/s13045-016-0272-3","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]},"article-number":"77"}}