{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:35:22Z","timestamp":1789914922662,"version":"4.0.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572570"],"award-info":[{"award-number":["81572570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502250"],"award-info":[{"award-number":["81502250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372801"],"award-info":[{"award-number":["81372801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472783"],"award-info":[{"award-number":["81472783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230038"],"award-info":[{"award-number":["81230038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13045-017-0400-8","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T07:42:31Z","timestamp":1485157351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer"],"prefix":"10.1186","volume":"10","author":[{"given":"Xiaoxue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"issue":"26","key":"400_CR1","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1056\/NEJMoa1103799","volume":"365","author":"TJ Perren","year":"2011","unstructured":"Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Kurzeder C, du Bois A, Sehouli J, Kimmig R, Stahle A, Collinson F, Essapen S, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med. 2011;365(26):2484\u201396.","journal-title":"N Engl J Med"},{"issue":"1","key":"400_CR2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13045-016-0325-7","volume":"9","author":"L Zhang","year":"2016","unstructured":"Zhang L, Han J, Jackson AL, Clark LN, Kilgore J, Guo H, Livingston N, Batchelor K, Yin Y, Gilliam TP, Gehrig PA, Sheng X, Zhou C, Bae-Jump VL. NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo. J Hematol Oncol. 2016;9(1):91.","journal-title":"J Hematol Oncol"},{"issue":"8","key":"400_CR3","doi-asserted-by":"crossref","first-page":"e2803","DOI":"10.1097\/MD.0000000000002803","volume":"95","author":"D Wang","year":"2016","unstructured":"Wang D, Zhu H, Ye Q, Wang C, Xu Y. Prognostic value of KIF2A and HER2-Neu overexpression in patients with epithelial ovarian cancer. Medicine. 2016;95(8):e2803.","journal-title":"Medicine"},{"issue":"1","key":"400_CR4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13045-016-0279-9","volume":"9","author":"Y Song","year":"2016","unstructured":"Song Y, Wu F, Wu J. Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol. 2016;9(1):49.","journal-title":"J Hematol Oncol"},{"key":"400_CR5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2016.01.014","volume":"162","author":"RA Jackson","year":"2016","unstructured":"Jackson RA, Chen ES. Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs. Pharmacol Ther. 2016;162:69\u201385.","journal-title":"Pharmacol Ther"},{"issue":"13","key":"400_CR6","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.2057811","volume":"25","author":"AT Nguyen","year":"2011","unstructured":"Nguyen AT, Zhang Y. The diverse functions of Dot1 and H3K79 methylation. Genes Dev. 2011;25(13):1345\u201358.","journal-title":"Genes Dev"},{"issue":"9","key":"400_CR7","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1038\/emboj.2012.50","volume":"31","author":"TP Wakeman","year":"2012","unstructured":"Wakeman TP, Wang Q, Feng J, Wang XF. Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1\/G2 cell-cycle phases. EMBO J. 2012;31(9):2169\u201381.","journal-title":"EMBO J"},{"issue":"24","key":"400_CR8","doi-asserted-by":"crossref","first-page":"10234","DOI":"10.1158\/0008-5472.CAN-10-3294","volume":"70","author":"MJ Chang","year":"2010","unstructured":"Chang MJ, Wu H, Achille NJ, Reisenauer MR, Chou CW, Zeleznik-Le NJ, Hemenway CS, Zhang W. Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res. 2010;70(24):10234\u201342.","journal-title":"Cancer Res"},{"issue":"10","key":"400_CR9","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1073\/pnas.1301045110","volume":"110","author":"E Wang","year":"2013","unstructured":"Wang E, Kawaoka S, Yu M, Shi J, Ni T, Yang W, Zhu J, Roeder RG, Vakoc CR. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2013;110(10):3901\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"400_CR10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2011.06.010","volume":"20","author":"KM Bernt","year":"2011","unstructured":"Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011;20(1):66\u201378.","journal-title":"Cancer Cell"},{"key":"400_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1756-8722-6-57","volume":"6","author":"SE Gutierrez","year":"2013","unstructured":"Gutierrez SE, Romero-Oliva FA. Epigenetic changes: a common theme in acute myelogenous leukemogenesis. J Hematol Oncol. 2013;6:57.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"400_CR12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13045-016-0337-3","volume":"9","author":"J Xu","year":"2016","unstructured":"Xu J, Zhang W, Yan XJ, Lin XQ, Li W, Mi JQ, Li JM, Zhu J, Chen Z, Chen SJ. DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1. J Hematol Oncol. 2016;9(1):106.","journal-title":"J Hematol Oncol"},{"key":"400_CR13","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1038\/ncomms8821","volume":"6","author":"MH Cho","year":"2015","unstructured":"Cho MH, Park JH, Choi HJ, Park MK, Won HY, Park YJ, Lee CH, Oh SH, Song YS, Kim HS, Oh YH, Lee JY, Kong G. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat Commun. 2015;6:7821.","journal-title":"Nat Commun"},{"key":"400_CR14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biochi.2016.01.005","volume":"123","author":"D Oktyabri","year":"2016","unstructured":"Oktyabri D, Ishimura A, Tange S, Terashima M, Suzuki T. DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines. Biochimie. 2016;123:20\u201331.","journal-title":"Biochimie"},{"issue":"3","key":"400_CR15","first-page":"979","volume":"5","author":"V Singh","year":"2015","unstructured":"Singh V, Singh LC, Singh AP, Sharma J, Borthakur BB, Debnath A, Rai AK, Phukan RK, Mahanta J, Kataki AC, Kapur S, Saxena S. Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population. Am J Cancer Res. 2015;5(3):979\u201399.","journal-title":"Am J Cancer Res"},{"issue":"5","key":"400_CR16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.immuni.2014.03.010","volume":"40","author":"I Kryczek","year":"2014","unstructured":"Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, Vatan L, Szeliga W, Dou Y, Owens S, Zgodzinski W, Majewski M, Wallner G, Fang J, Huang E, Zou W. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity. 2014;40(5):772\u201384.","journal-title":"Immunity"},{"issue":"2","key":"400_CR17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/1008-682X.122364","volume":"16","author":"RG Pestell","year":"2014","unstructured":"Pestell RG, Yu Z. Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo. Asian J Androl. 2014;16(2):268\u20139.","journal-title":"Asian J Androl"},{"issue":"9","key":"400_CR18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.15252\/emmm.201404210","volume":"6","author":"M Annala","year":"2014","unstructured":"Annala M, Kivinummi K, Leinonen K, Tuominen J, Zhang W, Visakorpi T, Nykter M. DOT1L-HES6 fusion drives androgen independent growth in prostate cancer. EMBO Mol Med. 2014;6(9):1121\u20133.","journal-title":"EMBO Mol Med"},{"issue":"2","key":"400_CR19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10689-015-9778-z","volume":"14","author":"I Donner","year":"2015","unstructured":"Donner I, Kiviluoto T, Ristimaki A, Aaltonen LA, Vahteristo P. Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer. Familial Cancer. 2015;14(2):241\u20136.","journal-title":"Familial Cancer"},{"issue":"21","key":"400_CR20","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.18632\/oncotarget.2496","volume":"5","author":"L Zhang","year":"2014","unstructured":"Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014;5(21):10665\u201377.","journal-title":"Oncotarget"},{"issue":"3","key":"400_CR21","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3892\/ijo.2014.2510","volume":"45","author":"D Liu","year":"2014","unstructured":"Liu D, Zhang XX, Xi BX, Wan DY, Li L, Zhou J, Wang W, Ma D, Wang H, Gao QL. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. Int J Oncol. 2014;45(3):1232\u201340.","journal-title":"Int J Oncol"},{"key":"400_CR22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13000-016-0485-3","volume":"11","author":"MC Vos","year":"2016","unstructured":"Vos MC, van der Wurff AA, Bulten J, Kruitwagen R, Feijen H, van Kuppevelt TH, Hendriks T, Massuger LF. Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer. Diagn Pathol. 2016;11:34.","journal-title":"Diagn Pathol"},{"issue":"6","key":"400_CR23","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1158\/1078-0432.CCR-05-2338","volume":"12","author":"AA Kamat","year":"2006","unstructured":"Kamat AA, Fletcher M, Gruman LM, Mueller P, Lopez A, Landen Jr CN, Han L, Gershenson DM, Sood AK. The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res. 2006;12(6):1707\u201314.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"400_CR24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1158\/1078-0432.CCR-16-0741","volume":"23","author":"JC Wei","year":"2017","unstructured":"Wei JC, Yang J, Liu D, Wu MF, Qiao L, Wang JN, Ma QF, Zeng Z, Ye SM, Guo ES, Jiang XF, You LY, Chen Y, Zhou L, Huang XY, Zhu T, et al. Tumor-associated lymphatic endothelial cells promote lymphatic metastasis by highly expressing and secreting SEMA4C. Clin Cancer Res. 2017; 23(1):214\u2013224.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"400_CR25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-016-0311-0","volume":"9","author":"Y Tian","year":"2016","unstructured":"Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, Chen Y. Modification of platinum sensitivity by KEAP1\/NRF2 signals in non-small cell lung cancer. J Hematol Oncol. 2016;9(1):83.","journal-title":"J Hematol Oncol"},{"issue":"2","key":"400_CR26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.canlet.2013.08.022","volume":"341","author":"T Ji","year":"2013","unstructured":"Ji T, Gong D, Han Z, Wei X, Yan Y, Ye F, Ding W, Wang J, Xia X, Li F, Hu W, Lu Y, Wang S, Zhou J, Ma D, Gao Q. Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer. Cancer Lett. 2013;341(2):231\u20139.","journal-title":"Cancer Lett"},{"key":"400_CR27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-8722-1-4","volume":"1","author":"E Selvakumar","year":"2008","unstructured":"Selvakumar E, Hsieh TC. Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy. J Hematol Oncol. 2008;1:4.","journal-title":"J Hematol Oncol"},{"key":"400_CR28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-016-0252-7","volume":"9","author":"Z Feng","year":"2016","unstructured":"Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016;9:24.","journal-title":"J Hematol Oncol"},{"key":"400_CR29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-61779-376-9_12","volume":"809","author":"AD Truax","year":"2012","unstructured":"Truax AD, Greer SF. ChIP and Re-ChIP assays: investigating interactions between regulatory proteins, histone modifications, and the DNA sequences to which they bind. Methods Mol Biol. 2012;809:175\u201388.","journal-title":"Methods Mol Biol"},{"issue":"19","key":"400_CR30","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1158\/0008-5472.CAN-13-3598","volume":"74","author":"D Liu","year":"2014","unstructured":"Liu D, Li L, Zhang XX, Wan DY, Xi BX, Hu Z, Ding WC, Zhu D, Wang XL, Wang W, Feng ZH, Wang H, Ma D, Gao QL. SIX1 promotes tumor lymphangiogenesis by coordinating TGFbeta signals that increase expression of VEGF-C. Cancer Res. 2014;74(19):5597\u2013607.","journal-title":"Cancer Res"},{"issue":"2","key":"400_CR31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbrc.2014.03.002","volume":"446","author":"D Liu","year":"2014","unstructured":"Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL. Sine oculis homeobox homolog 1 promotes alpha5beta1-mediated invasive migration and metastasis of cervical cancer cells. Biochem Biophys Res Commun. 2014;446(2):549\u201354.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"400_CR32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13045-016-0318-6","volume":"9","author":"R Dong","year":"2016","unstructured":"Dong R, Qiang W, Guo H, Xu X, Kim JJ, Mazar A, Kong B, Wei JJ. Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma. J Hematol Oncol. 2016;9(1):92.","journal-title":"J Hematol Oncol"},{"issue":"9","key":"400_CR33","doi-asserted-by":"crossref","first-page":"e103988","DOI":"10.1371\/journal.pone.0103988","volume":"9","author":"CM Beaufort","year":"2014","unstructured":"Beaufort CM, Helmijr JC, Piskorz AM, Hoogstraat M, Ruigrok-Ritstier K, Besselink N, Murtaza M, van IJcken WF, Heine AA, Smid M, Koudijs MJ, Brenton JD, Berns EM, Helleman J. Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes. PLoS One. 2014;9(9):e103988.","journal-title":"PLoS One"},{"issue":"2","key":"400_CR34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(03)01080-8","volume":"116","author":"AW Murray","year":"2004","unstructured":"Murray AW. Recycling the cell cycle: cyclins revisited. Cell. 2004;116(2):221\u201334.","journal-title":"Cell"},{"issue":"6494","key":"400_CR35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","volume":"371","author":"GJ Hannon","year":"1994","unstructured":"Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994;371(6494):257\u201361.","journal-title":"Nature"},{"issue":"6","key":"400_CR36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1182\/blood-2013-04-497644","volume":"122","author":"SR Daigle","year":"2013","unstructured":"Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013;122(6):1017\u201325.","journal-title":"Blood"},{"issue":"9","key":"400_CR37","first-page":"2823","volume":"5","author":"M Wong","year":"2015","unstructured":"Wong M, Polly P, Liu T. The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target. Am J Cancer Res. 2015;5(9):2823\u201337.","journal-title":"Am J Cancer Res"},{"issue":"6","key":"400_CR38","doi-asserted-by":"crossref","first-page":"e1003542","DOI":"10.1371\/journal.pgen.1003542","volume":"9","author":"H Fu","year":"2013","unstructured":"Fu H, Maunakea AK, Martin MM, Huang L, Zhang Y, Ryan M, Kim R, Lin CM, Zhao K, Aladjem MI. Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet. 2013;9(6):e1003542.","journal-title":"PLoS Genet"},{"issue":"7","key":"400_CR39","doi-asserted-by":"crossref","first-page":"e1003611","DOI":"10.1371\/journal.pgen.1003611","volume":"9","author":"V Oksenych","year":"2013","unstructured":"Oksenych V, Zhovmer A, Ziani S, Mari PO, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly JM, Coin F. Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. PLoS Genet. 2013;9(7):e1003611.","journal-title":"PLoS Genet"},{"issue":"8","key":"400_CR40","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1074\/jbc.M111.328138","volume":"287","author":"W Kim","year":"2012","unstructured":"Kim W, Kim R, Park G, Park JW, Kim JE. Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation. J Biol Chem. 2012;287(8):5588\u201399.","journal-title":"J Biol Chem"},{"issue":"15","key":"400_CR41","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1101\/gad.12.15.2245","volume":"12","author":"N Dyson","year":"1998","unstructured":"Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998;12(15):2245\u201362.","journal-title":"Genes Dev"},{"issue":"22","key":"400_CR42","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1101\/gad.1256504","volume":"18","author":"CJ Sherr","year":"2004","unstructured":"Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 2004;18(22):2699\u2013711.","journal-title":"Genes Dev"},{"issue":"8","key":"400_CR43","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1182\/blood-2008-03-147967","volume":"113","author":"I Joshi","year":"2009","unstructured":"Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1\/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 2009;113(8):1689\u201398.","journal-title":"Blood"},{"issue":"10","key":"400_CR44","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1101\/gad.511109","volume":"23","author":"M Barradas","year":"2009","unstructured":"Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a\/ARF by oncogenic RAS. Genes Dev. 2009;23(10):1177\u201382.","journal-title":"Genes Dev"},{"issue":"11","key":"400_CR45","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nsmb.1499","volume":"15","author":"J He","year":"2008","unstructured":"He J, Kallin EM, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b\/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol. 2008;15(11):1169\u201375.","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"400_CR46","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2015.06.013","volume":"162","author":"S Ruijtenberg","year":"2015","unstructured":"Ruijtenberg S, van den Heuvel S. G1\/S inhibitors and the SWI\/SNF complex control cell-cycle exit during muscle differentiation. Cell. 2015;162(2):300\u201313.","journal-title":"Cell"},{"issue":"5","key":"400_CR47","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4161\/cc.28104","volume":"13","author":"W Kim","year":"2014","unstructured":"Kim W, Choi M, Kim JE. The histone methyltransferase Dot1\/DOT1L as a critical regulator of the cell cycle. Cell Cycle. 2014;13(5):726\u201338.","journal-title":"Cell Cycle"},{"issue":"5","key":"400_CR48","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0092-8674(03)00114-4","volume":"112","author":"J Min","year":"2003","unstructured":"Min J, Feng Q, Li Z, Zhang Y, Xu RM. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell. 2003;112(5):711\u201323.","journal-title":"Cell"},{"issue":"12","key":"400_CR49","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0960-9822(02)00901-6","volume":"12","author":"Q Feng","year":"2002","unstructured":"Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol. 2002;12(12):1052\u20138.","journal-title":"Curr Biol"}],"container-title":["Journal of Hematology & Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13045-017-0400-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T18:00:56Z","timestamp":1568743256000},"score":1,"resource":{"primary":{"URL":"http:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-017-0400-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["400"],"URL":"https:\/\/doi.org\/10.1186\/s13045-017-0400-8","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]},"article-number":"29"}}