{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:59:23Z","timestamp":1778914763026,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T00:00:00Z","timestamp":1405814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s13046-014-0060-2","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T09:06:00Z","timestamp":1405760760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["IMP3 as a cytoplasmic biomarker for early serous tubal carcinogenesis"],"prefix":"10.1186","volume":"33","author":[{"given":"Yiying","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,20]]},"reference":[{"key":"60_CR1","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1056\/NEJM199311183292108","volume":"329","author":"SA Cannistra","year":"1993","unstructured":"Cannistra SA: Cancer of the ovary.\n\t\t\t\t\t                      N Engl J Med 1993, 329:1550\u20131559.","journal-title":"N Engl J Med"},{"key":"60_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1365-2559.2011.04167.x","volume":"61","author":"D Delair","year":"2012","unstructured":"Delair D, Soslow RA: Key features of extrauterine pelvic serous tumours (fallopian tube, ovary, and peritoneum).\n\t\t\t\t\t                      Histopathology 2012, 61:329\u2013339.","journal-title":"Histopathology"},{"key":"60_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1756-8722-5-8","volume":"5","author":"J Li","year":"2012","unstructured":"Li J, Fadare O, Xiang L, Kong B, Zheng W: Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis.\n\t\t\t\t\t                      J Hematol Oncol 2012, 5:8.","journal-title":"J Hematol Oncol"},{"key":"60_CR4","first-page":"20","volume":"9","author":"MA Brewer","year":"2003","unstructured":"Brewer MA, Johnson K, Follen M, Gershenson D, Bast R Jr: Prevention of ovarian cancer: intraepithelial neoplasia.\n\t\t\t\t\t                      Clin Cancer Res 2003, 9:20\u201330.","journal-title":"Clin Cancer Res"},{"key":"60_CR5","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1200\/JCO.2007.12.2622","volume":"25","author":"MJ Callahan","year":"2007","unstructured":"Callahan MJ, Crum CP, Medeiros F, Kindelberger DW, Elvin JA, Garber JE, Feltmate CM, Berkowitz RS, Muto MG: Primary Fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction.\n\t\t\t\t\t                      J Clin Oncol 2007, 25:3985\u20133990.","journal-title":"J Clin Oncol"},{"key":"60_CR6","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1200\/JCO.2008.16.4814","volume":"26","author":"JW Carlson","year":"2008","unstructured":"Carlson JW, Miron A, Jarboe EA, Parast MM, Hirsch MS, Lee YH, Muto MG, Kindelberger D, Crum CP: Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention.\n\t\t\t\t\t                      Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2008, 26:4160\u20134165.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"60_CR7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.molonc.2009.01.004","volume":"3","author":"CP Crum","year":"2009","unstructured":"Crum CP: Intercepting pelvic cancer in the distal fallopian tube: Theories and realities.\n\t\t\t\t\t                      Mol Oncol 2009, 3:165\u2013170.","journal-title":"Mol Oncol"},{"key":"60_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/GCO.0b013e328011a21f","volume":"19","author":"CP Crum","year":"2007","unstructured":"Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW, Lee YH: The distal fallopian tube: a new model for pelvic serous carcinogenesis.\n\t\t\t\t\t                      Curr Opin Obstet Gyn 2007, 19:3\u20139.","journal-title":"Curr Opin Obstet Gyn"},{"key":"60_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/path.2091","volume":"211","author":"Y Lee","year":"2007","unstructured":"Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garder J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP: A candidate precursor to serous carcinoma that originates in the distal fallopian tube.\n\t\t\t\t\t                      J Pathol 2007, 211:26\u201335.","journal-title":"J Pathol"},{"key":"60_CR10","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/modpathol.2011.106","volume":"24","author":"J Li","year":"2011","unstructured":"Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B, Zheng W: Tubal origin of \u2018ovarian\u2019 low-grade serous carcinoma.\n\t\t\t\t\t                      Mod Pathol 2011, 24:1488\u20131499.","journal-title":"Mod Pathol"},{"key":"60_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/modpathol.2011.175","volume":"25","author":"CM Quick","year":"2012","unstructured":"Quick CM, Ning G, Bijron J, Laury A, Wei TS, Chen EY, Vargas SO, Betensky RA, McKeon FD, Xian W, Crum CP: PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer.\n\t\t\t\t\t                      Mod Pathol 2012, 25:449\u2013455.","journal-title":"Mod Pathol"},{"key":"60_CR12","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1097\/PAS.0b013e3181ef7b16","volume":"34","author":"CG Przybycin","year":"2010","unstructured":"Przybycin CG, Kurman RJ, Ronnett BM, Shih IM, Vang R: Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?\n\t\t\t\t\t                      Am J Surg Pathol 2010, 34:1407\u20131416.","journal-title":"Am J Surg Pathol"},{"key":"60_CR13","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1177\/1947601911408889","volume":"2","author":"N Rivlin","year":"2011","unstructured":"Rivlin N, Brosh R, Oren M, Rotter V: Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.\n\t\t\t\t\t                      Genes Cancer 2011, 2:466\u2013474.","journal-title":"Genes Cancer"},{"key":"60_CR14","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.1200\/JCO.2008.18.1107","volume":"26","author":"K Levanon","year":"2008","unstructured":"Levanon K, Crum C, Drapkin R: New Insights Into the Pathogenesis of Serous Ovarian Cancer and Its Clinical Impact.\n\t\t\t\t\t                      J Clin Oncol 2008, 26:5284\u20135293.","journal-title":"J Clin Oncol"},{"key":"60_CR15","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ygyno.2008.01.012","volume":"109","author":"AK Folkins","year":"2008","unstructured":"Folkins AK, Jarboe EA, Saleemuddin A, Lee Y, Callahan MJ, Drapkin R, Garber JE, Muto MG, Tworoger S, Crum CP: A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations.\n\t\t\t\t\t                      Gynecol Oncol 2008, 109:168\u2013173.","journal-title":"Gynecol Oncol"},{"key":"60_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/path.3023","volume":"226","author":"E Kuhn","year":"2012","unstructured":"Kuhn E, Kurman RJ, Vang R, Sehdev AS, Han GM, Soslow R, Wang TL, Shih IM: TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions.\n\t\t\t\t\t                      J Pathol 2012, 226:421\u2013426.","journal-title":"J Pathol"},{"key":"60_CR17","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1038\/sj.onc.1201110","volume":"14","author":"F Mueller-Pillasch","year":"1997","unstructured":"Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM: Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein.\n\t\t\t\t\t                      Oncogene 1997, 14:2729\u20132733.","journal-title":"Oncogene"},{"key":"60_CR18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0925-4773(99)00160-4","volume":"88","author":"F Mueller-Pillasch","year":"1999","unstructured":"Mueller-Pillasch F, Pohl B, Wilda M, Lacher U, Beil M, Wallrapp C, Hameister H, Knochel W, Adler G, Gress TM: Expression of the highly conserved RNA binding protein KOC in embryogenesis.\n\t\t\t\t\t                      Mech Dev 1999, 88:95\u201399.","journal-title":"Mech Dev"},{"key":"60_CR19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/modpathol.2008.206","volume":"22","author":"M Kobel","year":"2009","unstructured":"Kobel M, Xu HD, Bourne PA, Spaulding BO, Shih IM, Mao TL, Soslow RA, Ewanowich CA, Kalloger SE, Mehl E, Lee CH, Huntsman D, Gilks CB: IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype.\n\t\t\t\t\t                      Mod Pathol 2009, 22:469\u2013475.","journal-title":"Mod Pathol"},{"key":"60_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0378-1119(01)00866-6","volume":"287","author":"K Yaniv","year":"2002","unstructured":"Yaniv K, Yisraeli JK: The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis.\n\t\t\t\t\t                      Gene 2002, 287:49\u201354.","journal-title":"Gene"},{"key":"60_CR21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/PAS.0b013e3181483ff8","volume":"32","author":"W Zheng","year":"2008","unstructured":"Zheng W, Yi X, Fadare O, Liang SX, Martel M, Schwartz PE, Jiang Z: The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinoma.\n\t\t\t\t\t                      Am J Surg Pathol 2008, 32:304\u2013315.","journal-title":"Am J Surg Pathol"},{"key":"60_CR22","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1097\/PAS.0b013e31823272d4","volume":"35","author":"D Lu","year":"2011","unstructured":"Lu D, Yang XF, Jiang NY, Woda BA, Liu Q, Dresser K, Mercurio AM, Rock KL, Jiang Z: IMP3, a New Biomarker to Predict Progression of Cervical Intraepithelial Neoplasia Into Invasive Cancer.\n\t\t\t\t\t                      Am J Surg Pathol 2011, 35:1638\u20131645.","journal-title":"Am J Surg Pathol"},{"key":"60_CR23","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/modpathol.3800735","volume":"20","author":"CZ Li","year":"2007","unstructured":"Li CZ, Rock KL, Woda BA, Jiang Z, Fraire AE, Dresser K: IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression.\n\t\t\t\t\t                      Mod Pathol 2007, 20:242\u2013247.","journal-title":"Mod Pathol"},{"key":"60_CR24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3109\/10520295.2011.591831","volume":"87","author":"JJ Findeis-Hosey","year":"2012","unstructured":"Findeis-Hosey JJ, Xu H: Insulin-like growth factor II-messenger RNA-binding protein-3 and lung cancer.\n\t\t\t\t\t                      Biotech Histochem 2012, 87:24\u201329.","journal-title":"Biotech Histochem"},{"key":"60_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","volume":"30","author":"F Medeiros","year":"2006","unstructured":"Medeiros F, Muto MG, Lee Y, Elvin JA, Callahan MJ, Feltmate C, Garber JE, Cramer DW, Crum CP: The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome.\n\t\t\t\t\t                      Am J Surg Pathol 2006, 30:230\u2013236.","journal-title":"Am J Surg Pathol"},{"key":"60_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/pgp.0b013e31814b191f","volume":"27","author":"E Jarboe","year":"2008","unstructured":"Jarboe E, Folkins A, Nucci MR, Kindelberger D, Drapkin R, Miron A, Lee YH, Crum CP: Serous carcinogenesis in the fallopian tube: A descriptive classification.\n\t\t\t\t\t                      Int J Gynecol Pathol 2008, 27:1\u20139.","journal-title":"Int J Gynecol Pathol"},{"key":"60_CR27","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S1470-2045(06)70732-X","volume":"7","author":"Z Jiang","year":"2006","unstructured":"Jiang Z, Chu PGG, Woda BA, Rock KL, Liu Q, Hsieh CC, Li CZ, Chen WG, Duan HO, McDougal S, Wu CL: Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.\n\t\t\t\t\t                      Lancet Oncol 2006, 7:556\u2013564.","journal-title":"Lancet Oncol"},{"key":"60_CR28","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/01.pas.0000149688.98333.54","volume":"29","author":"RK Yantiss","year":"2005","unstructured":"Yantiss RK, Woda BA, Fanger GR, Kalos M, Whalen GF, Tada H, Andersen DK, Rock KL, Dresser K: KOC (K homology domain containing protein overexpressed in cancer) - A novel molecular marker that distinguishes between benign and malignant lesions of the pancreas.\n\t\t\t\t\t                      Am J Surg Pathol 2005, 29:188\u2013195.","journal-title":"Am J Surg Pathol"},{"key":"60_CR29","first-page":"1","volume":"1","author":"LM Han","year":"2013","unstructured":"Han LM, Linxuan W, Ferguson DC, Chambers SK, Oluwole F, Yiying W, Wenxin Z: From endometrial glandular dysplasia to endometrial serous carcinoma: insights into underlying biological aspects.\n\t\t\t\t\t                      Am J Clin Exp Obstet Gynecol 2013, 1:1\u201316.","journal-title":"Am J Clin Exp Obstet Gynecol"},{"key":"60_CR30","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.ygyno.2013.09.018","volume":"131","author":"J Li","year":"2013","unstructured":"Li J, Ning Y, Abushahin N, Yuan Z, Wang YY, Wang Y, Yuan BB, Cragun JM, Chambers SK, Hatch K, Kong BH, Zheng WX: Secretory cell expansion with aging: Risk for pelvic serous carcinogenesis.\n\t\t\t\t\t                      Gynecol Oncol 2013, 131:555\u2013560.","journal-title":"Gynecol Oncol"},{"key":"60_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.pap.0000201826.46978.e5","volume":"13","author":"Y Lee","year":"2006","unstructured":"Lee Y, Medeiros F, Kindelberger D, Callahan MJ, Muto MG, Crum CP: Advances in the recognition of tubal intraepithelial carcinoma - Applications to cancer screening and the pathogenesis of ovarian cancer.\n\t\t\t\t\t                      Adv Anat Pathol 2006, 13:1\u20137.","journal-title":"Adv Anat Pathol"},{"key":"60_CR32","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1097\/00000478-199812000-00003","volume":"22","author":"WX Zheng","year":"1998","unstructured":"Zheng WX, Khurana R, Farahmand S, Wang YL, Zhang ZF, Felix JC: p53 immunostaining as a significant adjunct diagnostic method for uterine surface carcinoma - Precursor of uterine papillary serous carcinoma.\n\t\t\t\t\t                      Am J Surg Pathol 1998, 22:1463\u20131473.","journal-title":"Am J Surg Pathol"},{"key":"60_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/PGP.0b013e318189a724","volume":"28","author":"A Noske","year":"2009","unstructured":"Noske A, Faggad A, Wirtz R, Darb-Esfahani S, Sehouli J, Sinn B, Nielsen FC, Weichert W, Buckendahl AC, Roske A, Muller B, Dietel M, Denkert C: IMP3 Expression in Human Ovarian Cancer is Associated With Improved Survival.\n\t\t\t\t\t                      Int J Gynecol Pathol 2009, 28:203\u2013210.","journal-title":"Int J Gynecol Pathol"},{"key":"60_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","volume":"34","author":"RJ Kurman","year":"2010","unstructured":"Kurman RJ, Shih IM: The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory.\n\t\t\t\t\t                      Am J Surg Pathol 2010, 34:433\u2013443.","journal-title":"Am J Surg Pathol"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-014-0060-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13046-014-0060-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-014-0060-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-014-0060-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T04:44:50Z","timestamp":1630557890000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-014-0060-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,20]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["60"],"URL":"https:\/\/doi.org\/10.1186\/s13046-014-0060-2","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,20]]},"assertion":[{"value":"8 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"60"}}