{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:49:45Z","timestamp":1790524185857,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13046-015-0199-5","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:49:06Z","timestamp":1439236146000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements"],"prefix":"10.1186","volume":"34","author":[{"given":"David","family":"D\u00edaz-Carballo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Haydar","family":"Acikelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Jastrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wyganowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Guemues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gustmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Bardenheuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Malak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Sophia","family":"Tefett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veria","family":"Khosrawipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Giger-Pabst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tannapfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Strumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"issue":"11","key":"199_CR1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1089\/dna.2014.2375","volume":"33","author":"D D\u00edaz-Carballo","year":"2014","unstructured":"D\u00edaz-Carballo D, Gustmann S, Jastrow H, Acikelli AH, Dammann P, Klein J, et al. Atypical cell populations associated with acquired resistance to cytostatics and cancer stem cell features: the role of mitochondria in nuclear encapsulation. DNA Cell Biol. 2014;33(11):749\u201374.","journal-title":"DNA Cell Biol"},{"issue":"20","key":"199_CR2","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1158\/0008-5472.CAN-05-1927","volume":"65","author":"JJ Mezhir","year":"2005","unstructured":"Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, et al. Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res. 2005;65(20):9479\u201384.","journal-title":"Cancer Res"},{"issue":"1","key":"199_CR3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1186\/s12879-014-0680-3","volume":"14","author":"P Fonteh","year":"2014","unstructured":"Fonteh P, Meyer D. In vitro reactivation of latent HIV-1 by cytostatic bis(thiosemicarbazonate) gold(III) complexes. BMC Infect Dis. 2014;14(1):680.","journal-title":"BMC Infect Dis"},{"issue":"6","key":"199_CR4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrmicro2783","volume":"10","author":"JP Stoye","year":"2012","unstructured":"Stoye JP. Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol. 2012;10(6):395\u2013406.","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"199_CR5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/ijmm.2013.1460","volume":"32","author":"HL Yu","year":"2013","unstructured":"Yu HL, Zhao ZK, Zhu F. The role of human endogenous retroviral long terminal repeat sequences in human cancer (Review). Int J Mol Med. 2013;32(4):755\u201362.","journal-title":"Int J Mol Med"},{"issue":"3","key":"199_CR6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.nbt.2012.11.009","volume":"30","author":"J Paces","year":"2013","unstructured":"Paces J, Huang YT, Pa\u010des V, R\u00eddl J, Chang CM. New insight into transcription of human endogenous retroviral elements. N Biotechnol. 2013;30(3):314\u20138.","journal-title":"N Biotechnol"},{"issue":"6","key":"199_CR7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.coviro.2013.08.005","volume":"3","author":"M Dewannieux","year":"2013","unstructured":"Dewannieux M, Heidmann T. Endogenous retroviruses: acquisition, amplification and taming of genome invaders. Curr Opin Virol. 2013;3(6):646\u201356.","journal-title":"Curr Opin Virol"},{"issue":"1","key":"199_CR8","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1371\/journal.ppat.0030010","volume":"3","author":"YN Lee","year":"2007","unstructured":"Lee YN, Bieniasz PD. Reconstitution of an infectious human endogenous retrovirus. PLoS Pathog. 2007;3(1):e10.","journal-title":"PLoS Pathog"},{"issue":"24","key":"199_CR9","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1128\/JVI.01368-09","volume":"83","author":"K Hanke","year":"2009","unstructured":"Hanke K, Kramer P, Seeher S, Beimforde N, Kurth R, Bannert N. Reconstitution of the ancestral glycoprotein of human endogenous retrovirus k and modulation of its functional activity by truncation of the cytoplasmic domain. J Virol. 2009;83(24):12790\u2013800.","journal-title":"J Virol"},{"issue":"14","key":"199_CR10","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1073\/pnas.0307800101","volume":"101","author":"R Belshaw","year":"2004","unstructured":"Belshaw R, Pereira V, Katzourakis A, Talbot G, Paces J, Burt A, et al. Long-term reinfection of the human genome by endogenous retroviruses. PNAS. 2004;101(14):4894\u20139.","journal-title":"PNAS"},{"issue":"1","key":"199_CR11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/JVI.79.1.341-352.2005","volume":"79","author":"W Seifarth","year":"2005","unstructured":"Seifarth W, Frank O, Zeilfelder U, Spiess B, Greenwood AD, Hehlmann R, et al. Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray. J Virol. 2005;79(1):341\u201352.","journal-title":"J Virol"},{"issue":"11","key":"199_CR12","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.3390\/v6114609","volume":"6","author":"AG Lokossou","year":"2014","unstructured":"Lokossou AG, Toudic C, Barbeau B. Implication of human endogenous retrovirus envelope proteins in placental functions. Viruses. 2014;6(11):4609\u201327.","journal-title":"Viruses"},{"issue":"8","key":"199_CR13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00705-008-0159-x","volume":"153","author":"HS Kim","year":"2008","unstructured":"Kim HS, Ahn K, Kim DS. Quantitative expression of the HERV-W env gene in human tissues. Arch Virol. 2008;153(8):1587\u201391.","journal-title":"Arch Virol"},{"issue":"1-2","key":"199_CR14","first-page":"1","volume":"91","author":"U Kammerer","year":"2011","unstructured":"Kammerer U, Germeyer A, Stengel S, Kapp M, Denner J. Human endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta. J Reprod Immunol. 2011;91(1-2):1\u20138.","journal-title":"J Reprod Immunol"},{"issue":"4","key":"199_CR15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/00313020701444572","volume":"39","author":"MD Hayward","year":"2007","unstructured":"Hayward MD, P\u00f6tgens AJ, Drewlo S, Kaufmann P, Rasko JE. Distribution of human endogenous retrovirus type W receptor in normal human villous placenta. Pathology. 2007;39(4):406\u201312.","journal-title":"Pathology"},{"issue":"1","key":"199_CR16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/0141076813509981","volume":"107","author":"C Fei","year":"2014","unstructured":"Fei C, Atterby C, Edqvist PH, Pont\u00e9n F, Zhang WW, Larsson E, et al. Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics. J R Soc Med. 2014;107(1):22\u20139.","journal-title":"J R Soc Med"},{"issue":"Pt 3","key":"199_CR17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/BST0350629","volume":"35","author":"RC Crowell","year":"2007","unstructured":"Crowell RC, Kiessling AA. Endogenous retrovirus expression in testis and epididymis. Biochem Soc Trans. 2007;35(Pt 3):629\u201333.","journal-title":"Biochem Soc Trans"},{"key":"199_CR18","first-page":"97","volume":"2","author":"Y Liu","year":"2009","unstructured":"Liu Y, Soper C. The Natural History of Retroviruses: Exogenization vs Endogenization. Answers Res J. 2009;2:97\u2013106.","journal-title":"Answers Res J"},{"issue":"2","key":"199_CR19","first-page":"21","volume":"54","author":"NB Seniuta","year":"2009","unstructured":"Seniuta NB, Kle\u012dman AM, Karseladze AI, Triakin AA, Goncharova EV, Tiuliandin SA, et al. HERV-K-associated carcinogenesis: co-expression of viral and cellular proteins in the development of human germ-cell tumors. Vopr Virusol. 2009;54(2):21\u20136.","journal-title":"Vopr Virusol"},{"issue":"4","key":"199_CR20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.4049\/jimmunol.1302972","volume":"192","author":"G Kassiotis","year":"2014","unstructured":"Kassiotis G. Endogenous retroviruses and the development of cancer. J Immunol. 2014;192(4):1343\u20139.","journal-title":"J Immunol"},{"key":"199_CR21","doi-asserted-by":"crossref","unstructured":"Downey RF, Sullivan FJ, Wang-Johanning F, Ambs S, Giles FJ, Glynn SA. Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice? Int J Cancer. 2015;137(6):1249\u201357.","DOI":"10.1002\/ijc.29003"},{"key":"199_CR22","doi-asserted-by":"crossref","unstructured":"Liang Q, Xu Z, Xu R, Wu L, Zheng S. Expression patterns of non-coding spliced transcripts from human endogenous retrovirus HERV-H elements in colon cancer. PLoS One. 7(1):e29950.","DOI":"10.1371\/journal.pone.0029950"},{"issue":"9","key":"199_CR23","first-page":"840","volume":"67","author":"SH Lee","year":"2011","unstructured":"Lee SH, Kang YJ, Jo JO, Ock MS, Baek KW, Eo J, et al. Elevation of human ERV3-1 env protein expression in colorectal cancer. J Clin Pathol. 2011;67(9):840\u20134.","journal-title":"J Clin Pathol"},{"key":"199_CR24","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1158\/0008-5472.CAN-04-4231","volume":"65","author":"JP Marianne Mangeney","year":"2005","unstructured":"Marianne Mangeney JP. Martial Renard, Bertrand Ducos, and Thierry Heidmann, Endogenous Retrovirus Expression Is Required for Murine Melanoma Tumor Growth In vivo. Cancer Res. 2005;65:2588\u201391.","journal-title":"Cancer Res"},{"issue":"7","key":"199_CR25","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/leu.2011.57","volume":"25","author":"BC Kraljacic","year":"2011","unstructured":"Kraljacic BC, Arguello M, Amri A, Cormack G, Borden K. Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens. Leukemia. 2011;25(7):1197\u2013200.","journal-title":"Leukemia"},{"issue":"10","key":"199_CR26","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3109\/10428194.2010.496506","volume":"51","author":"KL Borden","year":"2010","unstructured":"Borden KL, Culjkovic-Kraljacic B. Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leuk Lymphoma. 2010;51(10):1805\u201315.","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"199_CR27","doi-asserted-by":"crossref","first-page":"E315","DOI":"10.25011\/cim.v34i6.15889","volume":"34","author":"KL Borden","year":"2011","unstructured":"Borden KL. Targeting the oncogene eIF4E in cancer: From the bench to clinical trials. Clin Invest Med. 2011;34(6):E315.","journal-title":"Clin Invest Med"},{"issue":"2","key":"199_CR28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood-2009-02-205153","volume":"114","author":"S Assouline","year":"2009","unstructured":"Assouline S, Culjkovic B, Cocolakis E, Rousseau C, Beslu N, Amri A, et al. Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood. 2009;114(2):257\u201360.","journal-title":"Blood"},{"issue":"1","key":"199_CR29","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3324\/haematol.2014.111245","volume":"100","author":"S Assouline","year":"2015","unstructured":"Assouline S, Culjkovic-Kraljacic B, Bergeron J, Caplan S, Cocolakis E, Lambert C. A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E. Haematologica. 2015;100(1):e7\u20139.","journal-title":"Haematologica"},{"issue":"6B","key":"199_CR30","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1111\/j.1582-4934.2008.00232.x","volume":"12","author":"D D\u00edaz-Carballo","year":"2008","unstructured":"D\u00edaz-Carballo D, Malak S, Bardenheuer W, Freistuehler M, Reusch HP. Cytotoxic activity of nemorosone in neuroblastoma cells. J Cell Mol Med. 2008;12(6B):2598\u2013608.","journal-title":"J Cell Mol Med"},{"issue":"1","key":"199_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104117","volume":"319","author":"RJ Tallarida","year":"2006","unstructured":"Tallarida RJ. An overview of drug combination analysis with isobolograms. J Pharmacol Exp Ther. 2006;319(1):1\u20137.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"199_CR32","first-page":"146","volume":"6","author":"D D\u00edaz-Carballo","year":"2010","unstructured":"D\u00edaz-Carballo D, Acikelli AH, Gustmann S, Bardenheuer W, Strumberg D. Acquired resistance to cytostatics triggers cancer stem-cell-like phenotype in different tumor entities. J Stem Cells Regen Med. 2010;6(2):146\u20137.","journal-title":"J Stem Cells Regen Med"},{"issue":"3","key":"199_CR33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ijc.28389","volume":"134","author":"F Wang-Johanning","year":"2014","unstructured":"Wang-Johanning F, Li M, Esteva FJ, Hess KR, Yin B, Rycaj K, et al. Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early-stage breast cancer. Int J Cancer. 2014;134(3):587\u201395.","journal-title":"Int J Cancer"},{"issue":"10","key":"199_CR34","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.onc.1206241","volume":"22","author":"F Wang-Johanning","year":"2003","unstructured":"Wang-Johanning F, Frost AR, Jian B, Epp L, Lu DW, Johanning GL. Quantitation of HERV-K env gene expression and splicing in human breast cancer. Oncogene. 2003;22(10):1528\u201335.","journal-title":"Oncogene"},{"issue":"6","key":"199_CR35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1593\/neo.07986","volume":"10","author":"M Golan","year":"2008","unstructured":"Golan M, Hizi A, Resau JH, Yaal-Hahoshen N, Reichman H, Keydar I, et al. Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker. Neoplasia. 2008;10(6):521\u201333.","journal-title":"Neoplasia"},{"issue":"34","key":"199_CR36","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.1073\/pnas.1413299111","volume":"111","author":"M Ohnuki","year":"2014","unstructured":"Ohnuki M, Tanabe K, Sutou K, Teramoto I, Sawamura Y, Narita M, et al. Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential. PNAS. 2014;111(34):12426\u201331.","journal-title":"PNAS"},{"issue":"8-9","key":"199_CR37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.placenta.2004.02.008","volume":"25","author":"NS Rote","year":"2004","unstructured":"Rote NS, Chakrabarti S, Stetzer BP. The role of human endogenous retroviruses in trophoblast differentiation and placental development. Placenta. 2004;25(8-9):673\u201383.","journal-title":"Placenta"},{"key":"199_CR38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/1477-3163.109032","volume":"12","author":"G Huang","year":"2013","unstructured":"Huang G, Li Z, Wan X, Wang Y, Dong J. Human endogenous retroviral K element encodes fusogenic activity in melanoma cells. J Carcinog. 2013;12:5.","journal-title":"J Carcinog"},{"issue":"3","key":"199_CR39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jnci\/djr540","volume":"104","author":"F Wang-Johanning","year":"2012","unstructured":"Wang-Johanning F, Rycaj K, Plummer JB, Li M, Yin B, Frerich K, et al. Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors. J Natl Cancer Inst. 2012;104(3):189\u2013210.","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"199_CR40","doi-asserted-by":"crossref","first-page":"670","DOI":"10.5414\/CPP48670","volume":"48","author":"D D\u00edaz-Carballo","year":"2010","unstructured":"D\u00edaz-Carballo D, Ueberla K, Kleff V, Ergun S, Malak S, Freistuehler M, et al. Antiretroviral activity of two polyisoprenylated acylphloroglucinols, 7-epi-nemorosone and plukenetione A, isolated from Caribbean propolis. Int J Clin Pharmacol Ther. 2010;48(10):670\u20137.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"22","key":"199_CR41","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1016\/j.bmc.2008.10.019","volume":"16","author":"D D\u00edaz-Carballo","year":"2008","unstructured":"D\u00edaz-Carballo D, Malak S, Bardenheuer W, Freistuehler M, Peter Reusch H. The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis. Bioorg Med Chem. 2008;16(22):9635\u201343.","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"199_CR42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5414\/CPP51054","volume":"51","author":"D D\u00edaz-Carballo","year":"2013","unstructured":"D\u00edaz-Carballo D, Gustmann S, Acikelli AH, Bardenheuer W, Klein J, Dembinski U, et al. Multi-targeted polycyclic polyprenylated acylphloroglucinols are major constituents of Cuban propolis and contributors to its anticancer activity. Int J Clin Pharmacol Ther. 2013;51(1):54\u20135.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"9","key":"199_CR43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.5414\/CP202154","volume":"52","author":"D D\u00edaz-Carballo","year":"2014","unstructured":"D\u00edaz-Carballo D, Acikelli AH, Bardenheuer W, Gustmann S, Malak S, Stoll R, et al. Identification of compounds that selectively target highly chemotherapy refractory neuroblastoma cancer stem cells. Int J Clin Pharmacol Ther. 2014;52(9):787\u2013801.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"30","key":"199_CR44","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1038\/onc.2013.366","volume":"33","author":"H Yu","year":"2014","unstructured":"Yu H, Liu T, Zhao Z, Chen Y, Zeng J, Liu S, et al. Mutations in 3'-long terminal repeat of HRV-W family in chromomsome 7 upregulate syncytion-1 expression in urothelial cell carcinoma of the bladder through interacting with c-Myb. Oncogene. 2014;33(30):3947\u201358.","journal-title":"Oncogene"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-015-0199-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T02:35:04Z","timestamp":1567046104000},"score":1,"resource":{"primary":{"URL":"http:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-015-0199-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,12]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["199"],"URL":"https:\/\/doi.org\/10.1186\/s13046-015-0199-5","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,12]]},"article-number":"81"}}