{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:43Z","timestamp":1791919483653,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Science and Technology Project of Guangzhou City, China","award":["14570006"],"award-info":[{"award-number":["14570006"]}]},{"name":"Planned Science and Technology project of Guangdong Province","award":["2013B020400004"],"award-info":[{"award-number":["2013B020400004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function and mechanism in NPC has not been systematically explored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We evaluated YPEL3 expression in NPC cell lines and tissues using real-time PCR and western blotting. Then, we established NPC cell lines that stably overexpressed YPEL3 and knocked down YPEL3 expression to explore its function in NPC <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Additionally, we investigated the potential mechanism of YPEL3 action by identifying the Wnt\/\u03b2-catenin signaling pathway downstream genes using western blotting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>YPEL3 was downregulated in NPC cell lines and tissue samples. Ectopic expression of YPEL3 inhibited NPC cell migration and invasion <jats:italic>in vitro<\/jats:italic>; while silencing of YPEL3 promoted NPC cell migration and invasion. Further study indicated that overexpression of YPEL3 inhibited NPC cell epithelial\u2013mesenchymal transition (EMT) and that silencing it enhanced EMT. Overexpression of YPEL3 suppressed NPC cell lung metastasis <jats:italic>in vivo<\/jats:italic>. The mechanism study determined that YPEL3 suppressed the expression levels of Wnt\/\u03b2-catenin signaling pathway downstream genes and the nuclear translocation of \u03b2-catenin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>YPEL3 suppresses NPC EMT and metastasis by suppressing the Wnt\/\u03b2-catenin signaling pathway, which would help better understanding the molecular mechanisms of NPC metastasis and provide novel therapeutic targets for NPC treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13046-016-0384-1","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T10:57:54Z","timestamp":1468234674000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["YPEL3 suppresses epithelial\u2013mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1186","volume":"35","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Yue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ran","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Mei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"issue":"6","key":"384_CR1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1470-2045(12)70102-X","volume":"13","author":"N Liu","year":"2012","unstructured":"Liu N, Chen NY, Cui RX, Li WF, Li Y, Wei RR, et al. Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol. 2012;13(6):633\u201341.","journal-title":"Lancet Oncol"},{"issue":"8","key":"384_CR2","first-page":"350","volume":"34","author":"LF Zhang","year":"2015","unstructured":"Zhang LF, Li YH, Xie SH, Ling W, Chen SH, Liu Q, et al. Incidence trend of nasopharyngeal carcinoma from 1987 to 2011 in Sihui County, Guangdong Province, South China: an age-period-cohort analysis. Chin J Cancer. 2015;34(8):350\u20137.","journal-title":"Chin J Cancer"},{"issue":"3","key":"384_CR3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ijrobp.2010.03.024","volume":"80","author":"SZ Lai","year":"2011","unstructured":"Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol, Biol, Phys. 2011;80(3):661\u20138.","journal-title":"Int J Radiat Oncol, Biol, Phys"},{"issue":"1","key":"384_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/annonc\/mdu507","volume":"26","author":"YP Chen","year":"2015","unstructured":"Chen YP, Wang ZX, Chen L, Liu X, Tang LL, Mao YP, et al. A Bayesian network meta-analysis comparing concurrent chemoradiotherapy followed by adjuvant chemotherapy, concurrent chemoradiotherapy alone and radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. Ann Oncol. 2015;26(1):205\u201311.","journal-title":"Ann Oncol"},{"issue":"1","key":"384_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gene.2004.06.014","volume":"340","author":"K Hosono","year":"2004","unstructured":"Hosono K, Sasaki T, Minoshima S, Shimizu N. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene. 2004;340(1):31\u201343.","journal-title":"Gene"},{"issue":"1","key":"384_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1046\/j.1365-2583.2001.00239.x","volume":"10","author":"K Roxstrom-Lindquist","year":"2001","unstructured":"Roxstrom-Lindquist K, Faye I. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. Insect Mol Biol. 2001;10(1):77\u201386.","journal-title":"Insect Mol Biol"},{"issue":"3","key":"384_CR7","first-page":"705","volume":"63","author":"SJ Baker","year":"2003","unstructured":"Baker SJ. Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells. Cancer Res. 2003;63(3):705\u201312.","journal-title":"Cancer Res"},{"issue":"10","key":"384_CR8","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/ijc.26239","volume":"130","author":"R Tuttle","year":"2012","unstructured":"Tuttle R, Miller KR, Maiorano JN, Termuhlen PM, Gao Y, Berberich SJ. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. Int J Cancer. 2012;130(10):2291\u20139.","journal-title":"Int J Cancer"},{"issue":"6","key":"384_CR9","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1245\/s10434-011-1558-x","volume":"18","author":"R Tuttle","year":"2011","unstructured":"Tuttle R, Simon M, Hitch DC, Maiorano JN, Hellan M, Ouellette J, et al. Senescence-associated gene YPEL3 is downregulated in human colon tumors. Ann Surg Oncol. 2011;18(6):1791\u20136.","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"384_CR10","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1158\/0008-5472.CAN-09-3219","volume":"70","author":"KD Kelley","year":"2010","unstructured":"Kelley KD, Miller KR, Todd A, Kelley AR, Tuttle R, Berberich SJ. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res. 2010;70(9):3566\u201375.","journal-title":"Cancer Res"},{"key":"384_CR11","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1186\/1471-2407-13-537","volume":"13","author":"N Dey","year":"2013","unstructured":"Dey N, Barwick BG, Moreno CS, Ordanic-Kodani M, Chen Z, Oprea-Ilies G, et al. Wnt signaling in triple negative breast cancer is associated with metastasis. BMC Cancer. 2013;13:537.","journal-title":"BMC Cancer"},{"key":"384_CR12","doi-asserted-by":"publisher","unstructured":"Hubaux R, Thu KL, Lam WL. Re: the Wnt signaling pathway in non-small cell lung cancer. J Natl Cancer Inst 2014;106(8):doi: 10.1093\/jnci\/dju188.","DOI":"10.1093\/jnci\/dju188"},{"issue":"2","key":"384_CR13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/hep.27081","volume":"60","author":"JR Wands","year":"2014","unstructured":"Wands JR, Kim M. WNT\/beta-catenin signaling and hepatocellular carcinoma. Hepatology. 2014;60(2):452\u20134.","journal-title":"Hepatology"},{"issue":"7","key":"384_CR14","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/hed.20833","volume":"30","author":"J Chou","year":"2008","unstructured":"Chou J, Lin YC, Kim J, You L, Xu Z, He B, et al. Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis. Head Neck. 2008;30(7):946\u201363.","journal-title":"Head Neck"},{"issue":"5663","key":"384_CR15","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","volume":"303","author":"WJ Nelson","year":"2004","unstructured":"Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 2004;303(5663):1483\u20137.","journal-title":"Science"},{"issue":"10","key":"384_CR16","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1158\/1940-6207.CAPR-14-0369","volume":"8","author":"XY Ren","year":"2015","unstructured":"Ren XY, Zhou GQ, Jiang W, Sun Y, Xu YF, Li YQ, et al. Low SFRP1 Expression Correlates with Poor Prognosis and Promotes Cell Invasion by Activating the Wnt\/beta-Catenin Signaling Pathway in NPC. Cancer PrevRes (Phila). 2015;8(10):968\u201377.","journal-title":"Cancer PrevRes (Phila)"},{"issue":"1","key":"384_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13046-016-0344-9","volume":"35","author":"B Tang","year":"2016","unstructured":"Tang B, Tang F, Wang Z, Qi G, Liang X, Li B, et al. Overexpression of CTNND1 in hepatocellular carcinoma promotes carcinous characters through activation of Wnt\/beta-catenin signaling. J Exp Clin Cancer Res. 2016;35(1):82.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"384_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.canlet.2012.10.032","volume":"329","author":"N Liu","year":"2013","unstructured":"Liu N, Tang LL, Sun Y, Cui RX, Wang HY, Huang BJ, et al. MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma. Cancer Lett. 2013;329(2):181\u20138.","journal-title":"Cancer Lett"},{"issue":"3","key":"384_CR19","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1158\/0008-5472.CAN-10-2695","volume":"71","author":"Y Nakazawa","year":"2011","unstructured":"Nakazawa Y, Arai H, Fujita N. The novel metastasis promoter Merm1\/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1\/p53-dependent apoptosis. Cancer Res. 2011;71(3):1146\u201355.","journal-title":"Cancer Res"},{"issue":"2","key":"384_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","volume":"23","author":"AW Lee","year":"1992","unstructured":"Lee AW, Poon YF, Foo W, Law SC, Cheung FK, Chan DK, et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol, Biol, Phys. 1992;23(2):261\u201370.","journal-title":"Int J Radiat Oncol, Biol, Phys"},{"issue":"39","key":"384_CR21","doi-asserted-by":"publisher","first-page":"e1457","DOI":"10.1097\/MD.0000000000001457","volume":"94","author":"T Xu","year":"2015","unstructured":"Xu T, Shen C, Zhu G, Hu C. Omission of Chemotherapy in Early Stage Nasopharyngeal Carcinoma Treated with IMRT: A Paired Cohort Study. Medicine (Baltimore). 2015;94(39):e1457.","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"384_CR22","first-page":"912","volume":"7","author":"YE Lee","year":"2015","unstructured":"Lee YE, He HL, Chen TJ, Lee SW, Chang IW, Hsing CH, et al. The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area. Am J Transl Res. 2015;7(5):912\u201321.","journal-title":"Am J Transl Res"},{"key":"384_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.clim.2016.01.004","volume":"164","author":"L Ke","year":"2016","unstructured":"Ke L, Xiang Y, Xia W, Yang J, Yu Y, Ye Y, et al. A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment interleukin 6 and clinical stage. Clin Immunol. 2016;164:45\u201351.","journal-title":"Clin Immunol"},{"issue":"4","key":"384_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.oraloncology.2015.01.009","volume":"51","author":"W Xiao","year":"2015","unstructured":"Xiao W, Xu A, Han F, Lin X, Lu L, Shen G, et al. Positron emission tomography-computed tomography before treatment is highly prognostic of distant metastasis in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy treatment: a prospective study with long-term follow-up. Oral Oncol. 2015;51(4):363\u20139.","journal-title":"Oral Oncol"},{"issue":"4","key":"384_CR25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrc2620","volume":"9","author":"K Polyak","year":"2009","unstructured":"Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9(4):265\u201373.","journal-title":"Nat Rev Cancer"},{"key":"384_CR26","doi-asserted-by":"publisher","unstructured":"Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W, et al. Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt\/beta-catenin signaling. Oncogene 2016, doi: 10.1038\/onc.","DOI":"10.1038\/onc"},{"issue":"10","key":"384_CR27","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.1074\/jbc.M115.713123","volume":"291","author":"S Gu","year":"2016","unstructured":"Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, et al. Loss of alpha-Tubulin Acetylation Is Associated with TGF-beta-induced Epithelial-Mesenchymal Transition. J Biol Chem. 2016;291(10):5396\u2013405.","journal-title":"J Biol Chem"},{"issue":"11","key":"384_CR28","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1002\/jcb.25196","volume":"116","author":"AW Fender","year":"2015","unstructured":"Fender AW, Nutter JM, Fitzgerald TL, Bertrand FE, Sigounas G. Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer. J Cell Biochem. 2015;116(11):2517\u201327.","journal-title":"J Cell Biochem"},{"key":"384_CR29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13046-014-0107-4","volume":"33","author":"L Qi","year":"2014","unstructured":"Qi L, Sun B, Liu Z, Cheng R, Li Y, Zhao X. Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression. J Exp Clin Cancer Res. 2014;33:107.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"384_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.canlet.2015.02.020","volume":"361","author":"P Shyamsunder","year":"2015","unstructured":"Shyamsunder P, Verma RS, Lyakhovich A. ROMO1 regulates RedOx states and serves as an inducer of NF-kappaB-driven EMT factors in Fanconi anemia. Cancer Lett. 2015;361(1):33\u20138.","journal-title":"Cancer Lett"},{"issue":"3","key":"384_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S Lamouille","year":"2014","unstructured":"Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178\u201396.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"344","key":"384_CR32","doi-asserted-by":"publisher","first-page":"re8","DOI":"10.1126\/scisignal.2005189","volume":"7","author":"DM Gonzalez","year":"2014","unstructured":"Gonzalez DM, Medici D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 2014;7(344):re8.","journal-title":"Sci Signal"},{"issue":"3","key":"384_CR33","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/abbs\/gmv134","volume":"48","author":"R Jiang","year":"2016","unstructured":"Jiang R, Niu X, Huang Y, Wang X. beta-Catenin is important for cancer stem cell generation and tumorigenic activity in nasopharyngeal carcinoma. Acta Biochim Biophys Sin Shanghai. 2016;48(3):229\u201337.","journal-title":"Acta Biochim Biophys Sin Shanghai"},{"issue":"16","key":"384_CR34","doi-asserted-by":"publisher","first-page":"14428","DOI":"10.18632\/oncotarget.3982","volume":"6","author":"Y Cheng","year":"2015","unstructured":"Cheng Y, Phoon YP, Jin X, Chong SY, Ip JC, Wong BW, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015;6(16):14428\u201339.","journal-title":"Oncotarget"},{"issue":"5","key":"384_CR35","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/path.2820","volume":"223","author":"Z QingLing","year":"2011","unstructured":"QingLing Z, LiNa Y, Li L, Shuang W, YuFang Y, Yi D, et al. LMP1 antagonizes WNT\/beta-catenin signalling through inhibition of WTX and promotes nasopharyngeal dysplasia but not tumourigenesis in LMP1(B95-8) transgenic mice. J Pathol. 2011;223(5):574\u201383.","journal-title":"J Pathol"},{"key":"384_CR36","doi-asserted-by":"publisher","unstructured":"Bao Z, Wang Y, Yang L, Wang L, Zhu L, Ban N, et al. Nucleostemin promotes the proliferation of human glioma via Wnt\/beta-Catenin pathway. Neuropathology 2015. doi: 10.1111\/neup.12265.","DOI":"10.1111\/neup.12265"},{"issue":"7","key":"384_CR37","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.humpath.2012.10.025","volume":"44","author":"L Xu","year":"2013","unstructured":"Xu L, Jiang Y, Zheng J, Xie G, Li J, Shi L, et al. Aberrant expression of beta-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. Hum Pathol. 2013;44(7):1357\u201364.","journal-title":"Hum Pathol"},{"issue":"3","key":"384_CR38","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/syn.20839","volume":"65","author":"TV Lipina","year":"2011","unstructured":"Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, et al. Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse. 2011;65(3):234\u201348.","journal-title":"Synapse"},{"issue":"10","key":"384_CR39","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","volume":"8","author":"MJ Hart","year":"1998","unstructured":"Hart MJ, Do Los Santos R, Albert IN, Runinfeld B, Polakis P. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol. 1998;8(10):573\u201381.","journal-title":"Curr Biol"},{"issue":"6","key":"384_CR40","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","volume":"149","author":"H Clevers","year":"2012","unstructured":"Clevers H, Nusse R. Wnt\/beta-catenin signaling and disease. Cell. 2012;149(6):1192\u2013205.","journal-title":"Cell"},{"issue":"3","key":"384_CR41","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","volume":"127","author":"H Clevers","year":"2006","unstructured":"Clevers H. Wnt\/beta-catenin signaling in development and disease. Cell. 2006;127(3):469\u201380.","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1186\/s13046-020-01710-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000}},{"DOI":"10.1186\/s13046-021-02189-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000}}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-016-0384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13046-016-0384-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-016-0384-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-016-0384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T12:02:38Z","timestamp":1640347358000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-016-0384-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["384"],"URL":"https:\/\/doi.org\/10.1186\/s13046-016-0384-1","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s13046-021-02189-x","asserted-by":"object"},{"id-type":"doi","id":"10.1186\/s13046-020-01710-y","asserted-by":"object"}]},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]},"assertion":[{"value":"25 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An amendment to this paper has been published and can be accessed via the original article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"109"}}