{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:48:34Z","timestamp":1789742914952,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81301688, 81272192, 81572965"],"award-info":[{"award-number":["81301688, 81272192, 81572965"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ph.D. Programs Foundation of Ministry of Education of China","award":["20130162110050 ; 20130162120093"],"award-info":[{"award-number":["20130162110050 ; 20130162120093"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2015JJ4053"],"award-info":[{"award-number":["2015JJ4053"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Post-doctoral Foundation of Central South University","award":["131425"],"award-info":[{"award-number":["131425"]}]},{"name":"125 Talent Project\/New xiangya Project of the Third Xiangya Hospital of Central South University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13046-017-0580-7","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T12:12:38Z","timestamp":1502799158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism"],"prefix":"10.1186","volume":"36","author":[{"given":"Li","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianda","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"580_CR1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bpg.2014.08.007","volume":"28","author":"C Bosetti","year":"2014","unstructured":"Bosetti C, Turati F, La Vecchia C. Hepatocellular carcinoma epidemiology. Best Pract Res Clin Gastroenterol. 2014;28:753\u201370.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"580_CR2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4143\/crt.2013.218","volume":"47","author":"TH Kim","year":"2015","unstructured":"Kim TH, Park JW, Kim YJ, Kim BH, Woo SM, Moon SH, Kim SS, Koh YH, Lee WJ, Park SJ, et al. Phase I dose-escalation study of proton beam therapy for inoperable hepatocellular carcinoma. Cancer Res Treat. 2015;47:34\u201345.","journal-title":"Cancer Res Treat"},{"key":"580_CR3","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.jceh.2014.03.050","volume":"4","author":"J Ramachandran","year":"2014","unstructured":"Ramachandran J. Surveillance for hepatocellular carcinoma. J Clin Exp Hepatol. 2014;4:S50\u20136.","journal-title":"J Clin Exp Hepatol"},{"key":"580_CR4","doi-asserted-by":"crossref","first-page":"16630","DOI":"10.3748\/wjg.v20.i44.16630","volume":"20","author":"X Chen","year":"2014","unstructured":"Chen X, Liu HP, Li M, Qiao L. Advances in non-surgical management of primary liver cancer. World J Gastroenterol. 2014;20:16630\u20138.","journal-title":"World J Gastroenterol"},{"key":"580_CR5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.addr.2014.10.029","volume":"81","author":"N Yang","year":"2015","unstructured":"Yang N, Ekanem NR, Sakyi CA, Ray SD. Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnostics. Adv Drug Deliv Rev. 2015;81:62\u201374.","journal-title":"Adv Drug Deliv Rev"},{"key":"580_CR6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3748\/wjg.v8.i5.797","volume":"8","author":"ZC Zeng","year":"2002","unstructured":"Zeng ZC, Jiang GL, Wang GM, Tang ZY, Curran WJ, Iliakis G. DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line. World J Gastroenterol. 2002;8:797\u2013803.","journal-title":"World J Gastroenterol"},{"key":"580_CR7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1159\/000368018","volume":"32","author":"JI Yu","year":"2014","unstructured":"Yu JI, Park HC. Considerations for radiation therapy in hepatocellular carcinoma: the radiation oncologists\u2019 perspective. Dig Dis. 2014;32:755\u201363.","journal-title":"Dig Dis"},{"key":"580_CR8","first-page":"1599","volume":"16","author":"S Ursino","year":"2012","unstructured":"Ursino S, Greco C, Cartei F, Colosimo C, Stefanelli A, Cacopardo B, Berretta M, Fiorica F. Radiotherapy and hepatocellular carcinoma: update and review of the literature. Eur Rev Med Pharmacol Sci. 2012;16:1599\u2013604.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"580_CR9","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3748\/wjg.14.2394","volume":"14","author":"YS Seo","year":"2008","unstructured":"Seo YS, Kim JN, Keum B, Park S, Kwon YD, Kim YS, Jeen YT, Chun HJ, Kim CY, Kim CD, et al. Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma. World J Gastroenterol. 2008;14:2394\u2013400.","journal-title":"World J Gastroenterol"},{"key":"580_CR10","first-page":"014","volume":"6","author":"SX Liang","year":"2006","unstructured":"Liang SX, Zhu XD, Jiang GL, Chen L, Yang YL. Three-dimensional conformal radiotherapy (3-DCRT) for 69 cases of massive primary liver cancer. China Oncol. 2006;6:014.","journal-title":"China Oncol"},{"key":"580_CR11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12072-014-9592-y","volume":"9","author":"H Onishi","year":"2015","unstructured":"Onishi H, Nouso K, Nakamura S, Katsui K, Wada N, Morimoto Y, Miyahara K, Takeuchi Y, Kuwaki K, Yasunaka T, et al. Efficacy of hepatic arterial infusion chemotherapy in combination with irradiation for advanced hepatocellular carcinoma with portal vein invasion. Hepatol Int. 2015;9:105\u201312.","journal-title":"Hepatol Int"},{"key":"580_CR12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029\u201333.","journal-title":"Science"},{"key":"580_CR13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/cbt.22958","volume":"14","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Yang JM. Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention. Cancer Biol Ther. 2013;14:81\u20139.","journal-title":"Cancer Biol Ther"},{"key":"580_CR14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.radonc.2009.11.007","volume":"94","author":"UG Sattler","year":"2010","unstructured":"Sattler UG, Meyer SS, Quennet V, Hoerner C, Knoerzer H, Fabian C, Yaromina A, Zips D, Walenta S, Baumann M, Mueller-Klieser W. Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol. 2010;94:102\u20139.","journal-title":"Radiother Oncol"},{"key":"580_CR15","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1038\/cddis.2013.60","volume":"4","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013;4:e532.","journal-title":"Cell Death Dis"},{"key":"580_CR16","doi-asserted-by":"crossref","first-page":"13703","DOI":"10.18632\/oncotarget.3800","volume":"6","author":"W Dai","year":"2015","unstructured":"Dai W, Wang F, Lu J, Xia Y, He L, Chen K, Li J, Li S, Liu T, Zheng Y, et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget. 2015;6:13703\u201317.","journal-title":"Oncotarget"},{"key":"580_CR17","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1128\/MCB.23.20.7315-7328.2003","volume":"23","author":"JC Rathmell","year":"2003","unstructured":"Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol. 2003;23:7315\u201328.","journal-title":"Mol Cell Biol"},{"key":"580_CR18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/jmcb\/mjw010","volume":"8","author":"H Han","year":"2016","unstructured":"Han H, Li W, Shen H, Zhang J, Zhu Y, Li Y. microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect. J Mol Cell Biol. 2016;8:400\u201310.","journal-title":"J Mol Cell Biol"},{"key":"580_CR19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13046-016-0358-3","volume":"35","author":"S Lei","year":"2016","unstructured":"Lei S, Yang J, Chen C, Sun J, Yang L, Tang H, Yang T, Chen A, Zhao H, Li Y, et al. FLIP L is critical for aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2016;35:79.","journal-title":"J Exp Clin Cancer Res"},{"key":"580_CR20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13046-017-0514-4","volume":"36","author":"D Xu","year":"2017","unstructured":"Xu D, Jin J, Yu H, Zhao Z, Ma D, Zhang C, Jiang H. Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2. J Exp Clin Cancer Res. 2017;36:44.","journal-title":"J Exp Clin Cancer Res"},{"key":"580_CR21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.devcel.2005.08.001","volume":"9","author":"A Enomoto","year":"2005","unstructured":"Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M. Akt\/PKB regulates actin organization and cell motility via Girdin\/APE. Dev Cell. 2005;9:389\u2013402.","journal-title":"Dev Cell"},{"key":"580_CR22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1196\/annals.1377.016","volume":"1086","author":"A Enomoto","year":"2006","unstructured":"Enomoto A, Ping J, Takahashi M. Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways. Ann N Y Acad Sci. 2006;1086:169\u201384.","journal-title":"Ann N Y Acad Sci"},{"key":"580_CR23","doi-asserted-by":"crossref","first-page":"e36681","DOI":"10.1371\/journal.pone.0036681","volume":"7","author":"K Ohara","year":"2012","unstructured":"Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani-Sakakibara M, Asai N, Ishida-Takagishi M, Weng L, Nakayama M, Watanabe T, et al. Involvement of Girdin in the determination of cell polarity during cell migration. PLoS One. 2012;7:e36681.","journal-title":"PLoS One"},{"key":"580_CR24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ncb1695","volume":"10","author":"T Kitamura","year":"2008","unstructured":"Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, et al. Regulation of VEGF-mediated angiogenesis by the Akt\/PKB substrate Girdin. Nat Cell Biol. 2008;10:329\u201337.","journal-title":"Nat Cell Biol"},{"key":"580_CR25","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCRESAHA.110.236174","volume":"108","author":"H Miyake","year":"2011","unstructured":"Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T. The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. Circ Res. 2011;108:1170\u20139.","journal-title":"Circ Res"},{"key":"580_CR26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.yjmcc.2015.09.012","volume":"88","author":"S Hayano","year":"2015","unstructured":"Hayano S, Takefuji M, Maeda K, Noda T, Ichimiya H, Kobayashi K, Enomoto A, Asai N, Takahashi M, Murohara T. Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction. J Mol Cell Cardiol. 2015;88:55\u201363.","journal-title":"J Mol Cell Cardiol"},{"key":"580_CR27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1096\/fj.10-167304","volume":"25","author":"M Garcia-Marcos","year":"2011","unstructured":"Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. Expression of GIV\/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011;25:590\u20139.","journal-title":"FASEB J"},{"key":"580_CR28","doi-asserted-by":"crossref","first-page":"986073","DOI":"10.1155\/2013\/986073","volume":"2013","author":"L Zhao","year":"2013","unstructured":"Zhao L, Ma S, Liu Q, Liang P. Clinical implications of Girdin protein expression in glioma. Sci World J. 2013;2013:986073.","journal-title":"Sci World J"},{"key":"580_CR29","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1158\/0008-5472.CAN-07-5111","volume":"68","author":"P Jiang","year":"2008","unstructured":"Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 2008;68:1310\u20138.","journal-title":"Cancer Res"},{"key":"580_CR30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1091\/mbc.E10-08-0738","volume":"22","author":"M Garcia-Marcos","year":"2011","unstructured":"Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011;22:673\u201386.","journal-title":"Mol Biol Cell"},{"key":"580_CR31","first-page":"551","volume":"8","author":"K Cao","year":"2015","unstructured":"Cao K, Lu C, Han S, Zou Q, Li J, Xie D, He S, Yu L, Zhou J, Peng X, Cao P. Expression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion. Int J Clin Exp Pathol. 2015;8:551\u20139.","journal-title":"Int J Clin Exp Pathol"},{"key":"580_CR32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","volume":"34","author":"GJ Yoshida","year":"2015","unstructured":"Yoshida GJ. Metabolic reprogramming: the emerging concept and associated therapeutic strategies. J Exp Clin Cancer Res. 2015;34:111.","journal-title":"J Exp Clin Cancer Res"},{"key":"580_CR33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/jappl.2000.89.1.169","volume":"89","author":"C Groussard","year":"2000","unstructured":"Groussard C, Morel I, Chevanne M, Monnier M, Cillard J, Delamarche A. Free radical scavenging and antioxidant effects of lactate ion: an in vitro study. J Appl Physiol (1985). 2000;89:169\u201375.","journal-title":"J Appl Physiol (1985)"},{"key":"580_CR34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ijc.24314","volume":"125","author":"B Zhang","year":"2009","unstructured":"Zhang B, Gu F, She C, Guo H, Li W, Niu R, Fu L, Zhang N, Ma Y. Reduction of Akt2 inhibits migration and invasion of glioma cells. Int J Cancer. 2009;125:585\u201395.","journal-title":"Int J Cancer"},{"key":"580_CR35","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.2741\/2367","volume":"12","author":"W Liu","year":"2007","unstructured":"Liu W, Bagaitkar J, Watabe K. Roles of AKT signal in breast cancer. Front Biosci. 2007;12:4011\u20139.","journal-title":"Front Biosci"},{"key":"580_CR36","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.urolonc.2011.12.007","volume":"31","author":"M Yamasaki","year":"2013","unstructured":"Yamasaki M, Nomura T, Sato F, Mimata H. Chronic hypoxia induces androgen-independent and invasive behavior in LNCaP human prostate cancer cells. Urol Oncol. 2013;31:1124\u201331.","journal-title":"Urol Oncol"},{"key":"580_CR37","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1158\/0008-5472.CAN-10-1516","volume":"71","author":"F Pez","year":"2011","unstructured":"Pez F, Dayan F, Durivault J, Kaniewski B, Aimond G, Le Provost GS, Deux B, Clezardin P, Sommer P, Pouyssegur J, Reynaud C. The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res. 2011;71:1647\u201357.","journal-title":"Cancer Res"},{"key":"580_CR38","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2174\/138955709788922610","volume":"9","author":"A Marin-Hernandez","year":"2009","unstructured":"Marin-Hernandez A, Gallardo-Perez JC, Ralph SJ, Rodriguez-Enriquez S, Moreno-Sanchez R. HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Rev Med Chem. 2009;9:1084\u2013101.","journal-title":"Mini Rev Med Chem"},{"issue":"Suppl 1","key":"580_CR39","doi-asserted-by":"crossref","first-page":"i99","DOI":"10.1093\/jrr\/rrw012","volume":"57","author":"H Harada","year":"2016","unstructured":"Harada H. Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance. J Radiat Res. 2016;57(Suppl 1):i99\u2013i105.","journal-title":"J Radiat Res"},{"key":"580_CR40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/00016489.2013.850176","volume":"134","author":"C Zhang","year":"2014","unstructured":"Zhang C, Yang X, Zhang Q, Yang B, Xu L, Qin Q, Zhu H, Liu J, Cai J, Tao G, et al. Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1alpha expression. Acta Otolaryngol. 2014;134:185\u201392.","journal-title":"Acta Otolaryngol"},{"key":"580_CR41","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3892\/ijo.2014.2745","volume":"46","author":"Y Sun","year":"2015","unstructured":"Sun Y, Xing X, Liu Q, Wang Z, Xin Y, Zhang P, Hu C, Liu Y. Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1alpha\/miR-210\/Bcl-2 pathway in colon cancer cells. Int J Oncol. 2015;46:750\u20136.","journal-title":"Int J Oncol"},{"key":"580_CR42","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.yexcr.2010.02.028","volume":"316","author":"J Liu","year":"2010","unstructured":"Liu J, Zhang J, Wang X, Li Y, Chen Y, Li K, Zhang J, Yao L, Guo G. HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells. Exp Cell Res. 2010;316:1985\u201393.","journal-title":"Exp Cell Res"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-017-0580-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T22:54:30Z","timestamp":1750805670000},"score":1,"resource":{"primary":{"URL":"http:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-017-0580-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["580"],"URL":"https:\/\/doi.org\/10.1186\/s13046-017-0580-7","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]},"article-number":"110"}}