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We evaluated zinc finger protein 671 (\n                      <jats:italic>ZNF671<\/jats:italic>\n                      ) expression in NPC cell lines and clinical tissues using real-time PCR and western blotting. Then, we established NPC cell lines that stably overexpressed\n                      <jats:italic>ZNF671<\/jats:italic>\n                      and knocked down\n                      <jats:italic>ZNF671<\/jats:italic>\n                      expression to explore its function in NPC in vitro and in vivo. Additionally, we investigated the potential mechanism of\n                      <jats:italic>ZNF671<\/jats:italic>\n                      by identifying the mitotic spindle and G2\/M checkpoint pathways pathway downstream genes using gene set enrichment analysis, flow cytometry and western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ZNF671<\/jats:italic>\n                      was hypermethylated in NPC tissues and cell lines. The mRNA and protein expression of\n                      <jats:italic>ZNF671<\/jats:italic>\n                      was down-regulated in NPC tissues and cell lines and the mRNA expression could be upregulated after the demethylation agent 5-aza-2\u2032-deoxycytidine treatment. Overexpression of\n                      <jats:italic>ZNF671<\/jats:italic>\n                      suppressed NPC cell proliferation and colony formation in vitro; silencing\n                      <jats:italic>ZNF671<\/jats:italic>\n                      using a siRNA had the opposite effects. Additionally, overexpression of\n                      <jats:italic>ZNF671<\/jats:italic>\n                      reduced the tumorigenicity of NPC cells in xenograft model in vivo. The mechanism study determined that overexpressing\n                      <jats:italic>ZNF671<\/jats:italic>\n                      induced S phase arrest in NPC cells by upregulating p21 and downregulating cyclin D1 and c-myc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and enhances tumorigenicity by inhibiting cell cycle arrest in NPC, which may represent a novel potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13046-017-0621-2","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T07:06:22Z","timestamp":1508396782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest"],"prefix":"10.1186","volume":"36","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ran","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Mei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Pan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"621_CR1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5732\/cjc.010.10377","volume":"30","author":"SM Cao","year":"2011","unstructured":"Cao SM, Simons MJ, Qian CN. 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