{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:14:20Z","timestamp":1790766860463,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572745"],"award-info":[{"award-number":["81572745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91539115"],"award-info":[{"award-number":["91539115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603134"],"award-info":[{"award-number":["81603134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773606"],"award-info":[{"award-number":["81773606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Fund for Distinguished Young Scholars","award":["81525026"],"award-info":[{"award-number":["81525026"]}]},{"name":"Jiangsu Provincial Natural Science Fund for Distinguished Young Scholars","award":["BK20170029"],"award-info":[{"award-number":["BK20170029"]}]},{"name":"Jiangsu Provincial Natural Science Fund for Young Scholars","award":["BK20160758"],"award-info":[{"award-number":["BK20160758"]}]},{"name":"State Key Laboratory of Natural Medicines of China Pharmaceutical University","award":["SKLNMZZCX201808"],"award-info":[{"award-number":["SKLNMZZCX201808"]}]},{"name":"Shenzhen Government\u2019s Plan of Science and Technology","award":["JCYJ20170412110504956"],"award-info":[{"award-number":["JCYJ20170412110504956"]}]},{"name":"\u201cDouble First-Class\u201d University project","award":["CPU2018GF02"],"award-info":[{"award-number":["CPU2018GF02"]}]},{"DOI":"10.13039\/501100010259","name":"Collaborative Innovation Center of Major Machine Manufacturing in Liaoning","doi-asserted-by":"crossref","award":["YP201608"],"award-info":[{"award-number":["YP201608"]}],"id":[{"id":"10.13039\/501100010259","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13046-019-1130-2","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T15:03:01Z","timestamp":1553180581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGF\u03b2\/BMP signaling in triple-negative breast cancer"],"prefix":"10.1186","volume":"38","author":[{"given":"Lei","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Xian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Qiu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"1130_CR1","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrd3810","volume":"11","author":"RJ Akhurst","year":"2012","unstructured":"Akhurst RJ, Hata A. Targeting the TGF-beta signalling pathway in disease. Nat Rev Drug Discov. 2012;11:790\u2013811.","journal-title":"Nat Rev Drug Discov"},{"key":"1130_CR2","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massague","year":"2012","unstructured":"Massague J. TGF-beta signalling in context. Nat Rev Mol Cell Biol. 2012;13:616\u201330.","journal-title":"Nat Rev Mol Cell Biol."},{"key":"1130_CR3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nrc3603","volume":"13","author":"M Pickup","year":"2013","unstructured":"Pickup M, Novitskiy S, Moses HL. The roles of TGF-beta in the tumour microenvironment. Nat Rev Cancer. 2013;13:788\u201399.","journal-title":"Nat Rev Cancer"},{"key":"1130_CR4","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/nrm2297","volume":"8","author":"B Schmierer","year":"2007","unstructured":"Schmierer B, Hill CS. TGF-beta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8:970\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1130_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/emboj.2008.266","volume":"28","author":"IM Liu","year":"2009","unstructured":"Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. TGF-beta-stimulated Smad1\/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGF-beta switch. EMBO J. 2009;28:88\u201398.","journal-title":"EMBO J"},{"key":"1130_CR6","volume-title":"The discovery and early days of TGF-beta: a historical perspective","author":"HL Moses","year":"2016","unstructured":"Moses HL, Roberts AB, Derynck R. The discovery and early days of TGF-beta: a historical perspective, vol. 8; 2016. pii: a021865"},{"key":"1130_CR7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","volume":"134","author":"J Massague","year":"2008","unstructured":"Massague J. TGF-beta in Cancer. Cell. 2008;134:215\u201330.","journal-title":"Cell."},{"key":"1130_CR8","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-06-3045","volume":"13","author":"R Dent","year":"2007","unstructured":"Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res. 2007;13:4429\u201334.","journal-title":"Clin Cancer Res"},{"key":"1130_CR9","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","volume":"28","author":"H Kennecke","year":"2010","unstructured":"Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol. 2010;28:3271\u20137.","journal-title":"J Clin Oncol"},{"key":"1130_CR10","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/S0959-8049(02)00502-6","volume":"39","author":"V Ivanovi\u0107","year":"2003","unstructured":"Ivanovi\u0107 V, Todorovi\u0107-Rakovi\u0107 N, Demajo M, Ne\u0161kovi\u0107-Konstantinovi\u0107 Z, Subota V, Ivani\u0161evi\u0107-Milovanovi\u0107 O, et al. Elevated plasma levels of transforming growth factor-\u03b21 (TGF-\u03b21) in patients with advanced breast cancer: association with disease progression. Eur J Cancer. 2003;39:454\u201361.","journal-title":"Eur J Cancer"},{"key":"1130_CR11","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1038\/sj.onc.1208964","volume":"25","author":"RS Muraoka-Cook","year":"2006","unstructured":"Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, et al. Activated type I TGF-beta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene. 2006;25:3408\u201323.","journal-title":"Oncogene."},{"key":"1130_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1517\/13543780903382609","volume":"19","author":"NS Nagaraj","year":"2010","unstructured":"Nagaraj NS, Datta PK. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs. 2010;19:77\u201391.","journal-title":"Expert Opin Investig Drugs"},{"key":"1130_CR13","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1038\/onc.2014.189","volume":"34","author":"P Owens","year":"2015","unstructured":"Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, et al. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. 2015;34:2437\u201349.","journal-title":"Oncogene."},{"key":"1130_CR14","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1021\/np030096l","volume":"66","author":"DJ Newman","year":"2003","unstructured":"Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003;66:1022\u201337.","journal-title":"J Nat Prod"},{"key":"1130_CR15","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/ncb3425","volume":"18","author":"T Ni","year":"2016","unstructured":"Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, et al. Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Nat Cell Biol. 2016;18:1221\u201332.","journal-title":"Nat Cell Biol"},{"key":"1130_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.ccell.2015.04.009","volume":"27","author":"PG Fournier","year":"2015","unstructured":"Fournier PG, Juarez P, Jiang G, Clines GA, Niewolna M, Kim HS, et al. The TGF-beta signaling regulator PMEPA1 suppresses prostate cancer metastases to bone. Cancer Cell. 2015;27:809\u201321.","journal-title":"Cancer Cell"},{"key":"1130_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41556-018-0062-y","volume":"20","author":"HW Yeh","year":"2018","unstructured":"Yeh HW, Hsu EC, Lee SS, Lang YD, Lin YC, Chang CY, et al. PSPC1 mediates TGF-beta1 autocrine signalling and Smad2\/3 target switching to promote EMT, stemness and metastasis. Nat Cell Biol. 2018;20:479\u201391.","journal-title":"Nat Cell Biol"},{"key":"1130_CR18","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.ccr.2013.08.012","volume":"24","author":"T Shibue","year":"2013","unstructured":"Shibue T, Brooks MW, Weinberg RA. An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 2013;24:481\u201398.","journal-title":"Cancer Cell"},{"key":"1130_CR19","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.yexcr.2005.12.012","volume":"312","author":"ET Bowden","year":"2006","unstructured":"Bowden ET, Onikoyi E, Slack R, Myoui A, Yoneda T, Yamada KM, et al. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res. 2006;312:1240\u201353.","journal-title":"Exp Cell Res"},{"key":"1130_CR20","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704\u201315.","journal-title":"Cell."},{"key":"1130_CR21","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/ncb2672","volume":"15","author":"J Chou","year":"2013","unstructured":"Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013;15:201\u201313.","journal-title":"Nat Cell Biol"},{"key":"1130_CR22","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nature14897","volume":"525","author":"X Ye","year":"2015","unstructured":"Ye X, Tam WL, Shibue T, Kaygusuz Y, Reinhardt F, Ng Eaton E, et al. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature. 2015;525:256\u201360.","journal-title":"Nature."},{"key":"1130_CR23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","volume":"1","author":"C Ginestier","year":"2007","unstructured":"Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007;1:555\u201367.","journal-title":"Cell Stem Cell"},{"key":"1130_CR24","doi-asserted-by":"publisher","first-page":"13909","DOI":"10.1073\/pnas.0506517102","volume":"102","author":"Y Kang","year":"2005","unstructured":"Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A. 2005;102:13909\u201314.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1130_CR25","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/nm.1943","volume":"15","author":"M Korpal","year":"2009","unstructured":"Korpal M, Yan J, Lu X, Xu S, Lerit DA, Kang Y. Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med. 2009;15:960\u20136.","journal-title":"Nat Med"},{"key":"1130_CR26","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1016\/S0002-9440(10)63568-7","volume":"163","author":"EY Lin","year":"2003","unstructured":"Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol. 2003;163:2113\u201326.","journal-title":"Am J Pathol"},{"key":"1130_CR27","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.cell.2013.11.029","volume":"155","author":"KJ Cheung","year":"2013","unstructured":"Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 2013;155:1639\u201351.","journal-title":"Cell."},{"key":"1130_CR28","doi-asserted-by":"publisher","first-page":"5194","DOI":"10.1158\/0008-5472.CAN-10-4374","volume":"71","author":"YC Lee","year":"2011","unstructured":"Lee YC, Cheng CJ, Bilen MA, Lu JF, Satcher RL, Yu-Lee LY, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res. 2011;71:5194\u2013203.","journal-title":"Cancer Res"},{"key":"1130_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1021\/cb9002865","volume":"5","author":"J Hao","year":"2010","unstructured":"Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010;5:245\u201353.","journal-title":"ACS Chem Biol"},{"key":"1130_CR30","doi-asserted-by":"publisher","first-page":"e90748","DOI":"10.1371\/journal.pone.0090748","volume":"9","author":"J Hao","year":"2014","unstructured":"Hao J, Lee R, Chang A, Fan J, Labib C, Parsa C, et al. DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. PLoS One. 2014;9:e90748.","journal-title":"PLoS One"},{"key":"1130_CR31","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871\u201390.","journal-title":"Cell."},{"key":"1130_CR32","doi-asserted-by":"publisher","first-page":"1234850","DOI":"10.1126\/science.1234850","volume":"342","author":"MA Nieto","year":"2013","unstructured":"Nieto MA. Epithelial plasticity: a common theme in embryonic and cancer cells. Science. 2013;342:1234850.","journal-title":"Science."},{"key":"1130_CR33","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrc2131","volume":"7","author":"H Peinado","year":"2007","unstructured":"Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7:415\u201328.","journal-title":"Nat Rev Cancer"},{"key":"1130_CR34","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrc3447","volume":"13","author":"B Craene De","year":"2013","unstructured":"De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13:97\u2013110.","journal-title":"Nat Rev Cancer"},{"key":"1130_CR35","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010;29:4741\u201351.","journal-title":"Oncogene."},{"key":"1130_CR36","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","volume":"21","author":"D Hanahan","year":"2012","unstructured":"Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21:309\u201322.","journal-title":"Cancer Cell"},{"key":"1130_CR37","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1038\/ncomms2766","volume":"4","author":"Y Jung","year":"2013","unstructured":"Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, et al. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun. 2013;4:1795.","journal-title":"Nat Commun"},{"key":"1130_CR38","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ccr.2011.01.020","volume":"19","author":"M Quante","year":"2011","unstructured":"Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011;19:257\u201372.","journal-title":"Cancer Cell"},{"key":"1130_CR39","doi-asserted-by":"publisher","first-page":"7160","DOI":"10.1073\/pnas.1014506108","volume":"108","author":"R Navab","year":"2011","unstructured":"Navab R, Strumpf D, Bandarchi B, Zhu CQ, Pintilie M, Ramnarine VR, et al. Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2011;108:7160\u20135.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1130-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13046-019-1130-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1130-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:20:19Z","timestamp":1584663619000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-019-1130-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1130"],"URL":"https:\/\/doi.org\/10.1186\/s13046-019-1130-2","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]},"assertion":[{"value":"20 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was approved by the Animal Welfare and Ethics Committee of China Pharmaceutical University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"134"}}