{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:11Z","timestamp":1790542691337,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81572346"],"award-info":[{"award-number":["81572346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13046-019-1279-8","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T16:03:09Z","timestamp":1561996989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop"],"prefix":"10.1186","volume":"38","author":[{"given":"Bing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuijian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"1279_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.20138","volume":"62","author":"R Siegel","year":"2012","unstructured":"Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10\u201329.","journal-title":"CA Cancer J Clin"},{"key":"1279_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1172\/JCI30111","volume":"117","author":"JG Fox","year":"2007","unstructured":"Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest. 2007;117:60\u20139.","journal-title":"J Clin Invest"},{"key":"1279_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrc1251","volume":"4","author":"MA Hollingsworth","year":"2004","unstructured":"Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004;4:45\u201360.","journal-title":"Nat Rev Cancer"},{"key":"1279_CR4","doi-asserted-by":"publisher","first-page":"D1192","DOI":"10.2741\/Moniaux","volume":"6","author":"N Moniaux","year":"2001","unstructured":"Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK. Structural organization and classification of the human mucin genes. Front Biosci. 2001;6:D1192\u2013206.","journal-title":"Front Biosci"},{"key":"1279_CR5","first-page":"1541","volume":"23","author":"S Senapati","year":"2008","unstructured":"Senapati S, Sharma P, Bafna S, Roy HK, Batra SK. The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol. 2008;23:1541\u201352.","journal-title":"Histol Histopathol"},{"key":"1279_CR6","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1126\/science.1069094","volume":"295","author":"A Velcich","year":"2002","unstructured":"Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, Viani S, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002;295:1726\u20139.","journal-title":"Science"},{"key":"1279_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1165\/rcmb.2009-0313OC","volume":"45","author":"T Fujisawa","year":"2011","unstructured":"Fujisawa T, Chang MM, Velichko S, Thai P, Hung LY, Huang F, et al. NF-kappaB mediates IL-1beta- and IL-17A-induced MUC5B expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2011;45:246\u201352.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1279_CR8","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.4049\/jimmunol.0803022","volume":"183","author":"MV Bautista","year":"2009","unstructured":"Bautista MV, Chen Y, Ivanova VS, Rahimi MK, Watson AM, Rose MC. IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells. J Immunol. 2009;183:2159\u201366.","journal-title":"J Immunol"},{"key":"1279_CR9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1046\/j.1440-1711.2003.t01-1-01163.x","volume":"81","author":"J Iwashita","year":"2003","unstructured":"Iwashita J, Sato Y, Sugaya H, Takahashi N, Sasaki H, Abe T. mRNA of MUC2 is stimulated by IL-4, IL-13 or TNF-alpha through a mitogen-activated protein kinase pathway in human colon cancer cells. Immunol Cell Biol. 2003;81:275\u201382.","journal-title":"Immunol Cell Biol"},{"key":"1279_CR10","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1158\/0008-5472.CAN-06-3424","volume":"67","author":"S Hojo","year":"2007","unstructured":"Hojo S, Koizumi K, Tsuneyama K, Arita Y, Cui Z, Shinohara K, et al. High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res. 2007;67:4725\u201331.","journal-title":"Cancer Res"},{"key":"1279_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1349-7006.2006.00346.x","volume":"98","author":"T Ishiyama","year":"2007","unstructured":"Ishiyama T, Kano J, Anami Y, Onuki T, Iijima T, Morisita Y, et al. OCIA domain containing 2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis. Cancer Sci. 2007;98:50\u20137.","journal-title":"Cancer Sci"},{"key":"1279_CR12","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1073\/pnas.0307190101","volume":"101","author":"NA Wong","year":"2004","unstructured":"Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL, et al. Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc Natl Acad Sci U S A. 2004;101:574\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1279_CR13","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1126\/science.aam7304","volume":"355","author":"MA Dawson","year":"2017","unstructured":"Dawson MA. The cancer epigenome: concepts, challenges, and therapeutic opportunities. Science. 2017;355:1147\u201352.","journal-title":"Science"},{"key":"1279_CR14","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.1248627","volume":"343","author":"D Schramek","year":"2014","unstructured":"Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, et al. Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science. 2014;343:309\u201313.","journal-title":"Science"},{"key":"1279_CR15","doi-asserted-by":"crossref","unstructured":"Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, et al. The E3 ligase Ubr3 regulates usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. Elife. 2016;5.","DOI":"10.7554\/eLife.15258"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1279-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13046-019-1279-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1279-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T23:12:19Z","timestamp":1593472339000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-019-1279-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1279"],"URL":"https:\/\/doi.org\/10.1186\/s13046-019-1279-8","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]},"assertion":[{"value":"15 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Experiments were conducted in accordance with the Helsinki Declaration 2013 and were approved by the Institutional Ethical Standards Committee of Beijing Cancer Hospital. Animal experiments were performed in according with the National Institutes of Health Guide for the Care and Use of Laboratory Animals with protocols approved by the Animal Care and Use Committee at Peking University Cancer Hospital & Institute.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors confirmed that we have obtained written consent from the patients to publish this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"283"}}