{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:04:26Z","timestamp":1792793066693,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","award":["81601528"],"award-info":[{"award-number":["81601528"]}],"id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770178"],"award-info":[{"award-number":["81770178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13046-019-1328-3","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T15:02:50Z","timestamp":1563807770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["HMGB1-mediated autophagy regulates sodium\/iodide symporter protein degradation in thyroid cancer cells"],"prefix":"10.1186","volume":"38","author":[{"given":"Wenwen","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"1328_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1210\/er.2012-1015","volume":"34","author":"IM Colin","year":"2013","unstructured":"Colin IM, Denef JF, Lengele B, Many MC, Gerard AC. Recent insights into the cell biology of thyroid angiofollicular units. Endocr Rev. 2013;34:209\u201338.","journal-title":"Endocr Rev"},{"key":"1328_CR2","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/379458a0","volume":"379","author":"G Dai","year":"1996","unstructured":"Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996;379:458\u201360.","journal-title":"Nature."},{"key":"1328_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.7150\/thno.3722","volume":"2","author":"BC Ahn","year":"2012","unstructured":"Ahn BC. Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back. Theranostics. 2012;2:392\u2013402.","journal-title":"Theranostics."},{"key":"1328_CR4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s12094-015-1307-x","volume":"17","author":"W Chai","year":"2015","unstructured":"Chai W, Yin X, Ren L, Cai M, Long T, Zhou M, et al. Sodium\/iodide symporter gene transfection increases radionuclide uptake in human cisplatin-resistant lung cancer cells. Clin Transl Oncol. 2015;17:795\u2013802.","journal-title":"Clin Transl Oncol"},{"key":"1328_CR5","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/jc.2005-2838","volume":"91","author":"C Durante","year":"2006","unstructured":"Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab. 2006;91:2892\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"1328_CR6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/ncpendmet0449","volume":"3","author":"M Schlumberger","year":"2007","unstructured":"Schlumberger M, Lacroix L, Russo D, Filetti S, Bidart JM. Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients. Nat Clin Pract Endocrinol Metab. 2007;3:260\u20139.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"1328_CR7","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","volume":"159","author":"Integrated genomic characterization of papillary thyroid carcinoma","year":"2014","unstructured":"Integrated genomic characterization of papillary thyroid carcinoma. Cell. 2014;159:676\u201390.","journal-title":"Cell."},{"key":"1328_CR8","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1172\/JCI85271","volume":"126","author":"I Landa","year":"2016","unstructured":"Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, et al. Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. J Clin Invest. 2016;126:1052\u201366.","journal-title":"J Clin Invest"},{"key":"1328_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/thy.2013.0041","volume":"24","author":"RM Abdulrahman","year":"2014","unstructured":"Abdulrahman RM, Boon MR, Sips HC, Guigas B, Rensen PC, Smit JW, et al. Impact of metformin and compound C on NIS expression and iodine uptake in vitro and in vivo: a role for CRE in AMPK modulation of thyroid function. Thyroid. 2014;24:78\u201387.","journal-title":"Thyroid."},{"key":"1328_CR10","doi-asserted-by":"publisher","first-page":"21458","DOI":"10.1074\/jbc.M100561200","volume":"276","author":"C Riedel","year":"2001","unstructured":"Riedel C, Levy O, Carrasco N. Post-transcriptional regulation of the sodium\/iodide symporter by thyrotropin. J Biol Chem. 2001;276:21458\u201363.","journal-title":"J Biol Chem"},{"key":"1328_CR11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-0034-1371803","volume":"46","author":"JM Cazarin","year":"2014","unstructured":"Cazarin JM, Andrade BM, Carvalho DP. AMP-activated protein kinase activation leads to lysome-mediated NA(+)\/I(\u2212)-symporter protein degradation in rat thyroid cells. Horm Metab Res. 2014;46:313\u20137.","journal-title":"Horm Metab Res"},{"key":"1328_CR12","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nrc1692","volume":"5","author":"Y Kondo","year":"2005","unstructured":"Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer. 2005;5:726\u201334.","journal-title":"Nat Rev Cancer"},{"key":"1328_CR13","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1126\/science.1193497","volume":"330","author":"JD Rabinowitz","year":"2010","unstructured":"Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010;330:1344\u20138.","journal-title":"Science."},{"key":"1328_CR14","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.surg.2009.09.019","volume":"146","author":"CI Lin","year":"2009","unstructured":"Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, et al. Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery. 2009;146:1208\u201314.","journal-title":"Surgery."},{"key":"1328_CR15","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1158\/1541-7786.MCR-10-0162","volume":"8","author":"CI Lin","year":"2010","unstructured":"Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, et al. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through met inhibition in papillary thyroid cancer. Mol Cancer Res. 2010;8:1217\u201326.","journal-title":"Mol Cancer Res"},{"key":"1328_CR16","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1210\/jc.2016-1999","volume":"102","author":"W Wang","year":"2017","unstructured":"Wang W, Kang H, Zhao Y, Min I, Wyrwas B, Moore M, et al. Targeting autophagy sensitizes BRAF-mutant thyroid cancer to vemurafenib. J Clin Endocrinol Metab. 2017;102:634\u201343.","journal-title":"J Clin Endocrinol Metab"},{"key":"1328_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pneurobio.2013.03.001","volume":"105","author":"MJ Lee","year":"2013","unstructured":"Lee MJ, Lee JH, Rubinsztein DC. Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol. 2013;105:49\u201359.","journal-title":"Prog Neurobiol"},{"key":"1328_CR18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1530\/ERC-12-0342","volume":"20","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, Beyer S, Jhiang SM. MEK inhibition leads to lysosome-mediated Na+\/I- symporter protein degradation in human breast cancer cells. Endocr Relat Cancer. 2013;20:241\u201350.","journal-title":"Endocr Relat Cancer"},{"key":"1328_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nri1594","volume":"5","author":"MT Lotze","year":"2005","unstructured":"Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5:331\u201342.","journal-title":"Nat Rev Immunol"},{"key":"1328_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbagrm.2009.11.014","volume":"1799","author":"D Tang","year":"2010","unstructured":"Tang D, Kang R, Zeh HR, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010;1799:131\u201340.","journal-title":"Biochim Biophys Acta"},{"key":"1328_CR21","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1083\/jcb.200911078","volume":"190","author":"D Tang","year":"2010","unstructured":"Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010;190:881\u201392.","journal-title":"J Cell Biol"},{"key":"1328_CR22","first-page":"714","volume":"5","author":"L Yang","year":"2015","unstructured":"Yang L, Chai W, Wang Y, Cao L, Xie M, Yang M, et al. Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy. Am J Cancer Res. 2015;5:714\u201325.","journal-title":"Am J Cancer Res"},{"key":"1328_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","volume":"40","author":"R Kang","year":"2014","unstructured":"Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, et al. HMGB1 in health and disease. Mol Asp Med. 2014;40:1\u2013116.","journal-title":"Mol Asp Med"},{"key":"1328_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3109\/10428194.2011.616962","volume":"53","author":"L Yang","year":"2012","unstructured":"Yang L, Yu Y, Kang R, Yang M, Xie M, Wang Z, et al. Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells. Leuk Lymphoma. 2012;53:315\u201322.","journal-title":"Leuk Lymphoma"},{"key":"1328_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1158\/0008-5472.CAN-11-2001","volume":"72","author":"J Huang","year":"2012","unstructured":"Huang J, Ni J, Liu K, Yu Y, Xie M, Kang R, et al. HMGB1 promotes drug resistance in osteosarcoma. Cancer Res. 2012;72:230\u20138.","journal-title":"Cancer Res"},{"key":"1328_CR26","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","volume":"19","author":"R Kang","year":"2013","unstructured":"Kang R, Zhang Q, Zeh HR, Lotze MT, Tang D. HMGB1 in cancer: good, bad, or both? Clin Cancer Res. 2013;19:4046\u201357.","journal-title":"Clin Cancer Res"},{"key":"1328_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/leu.2010.225","volume":"25","author":"L Liu","year":"2011","unstructured":"Liu L, Yang M, Kang R, Wang Z, Zhao Y, Yu Y, et al. HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia. 2011;25:23\u201331.","journal-title":"Leukemia."},{"key":"1328_CR28","first-page":"549","volume":"29","author":"M Xie","year":"2008","unstructured":"Xie M, Kang R, Yu Y, Zhu S, He YL, Xu WQ, et al. Enhancive effect of HMGB1 gene silence on adriamycin-induced apoptosis in K562\/A02 drug resistance leukemia cells. Zhonghua Xue Ye Xue Za Zhi. 2008;29:549\u201352.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"1328_CR29","doi-asserted-by":"publisher","first-page":"22657","DOI":"10.1074\/jbc.273.35.22657","volume":"273","author":"O Levy","year":"1998","unstructured":"Levy O, De la Vieja A, Ginter CS, Riedel C, Dai G, Carrasco N. N-linked glycosylation of the thyroid Na+\/I- symporter (NIS). Implications for its secondary structure model. J Biol Chem. 1998;273:22657\u201363.","journal-title":"J Biol Chem"},{"key":"1328_CR30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1093\/gerona\/63.6.550","volume":"63","author":"A Donati","year":"2008","unstructured":"Donati A, Recchia G, Cavallini G, Bergamini E. Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy. J Gerontol A Biol Sci Med Sci. 2008;63:550\u20135.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1328_CR31","first-page":"1269","volume":"10","author":"KM Livesey","year":"2009","unstructured":"Livesey KM, Tang D, Zeh HJ, Lotze MT. Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs. 2009;10:1269\u201379.","journal-title":"Curr Opin Investig Drugs"},{"key":"1328_CR32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010;140:313\u201326.","journal-title":"Cell."},{"key":"1328_CR33","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","volume":"137","author":"R Mathew","year":"2009","unstructured":"Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137:1062\u201375.","journal-title":"Cell."},{"key":"1328_CR34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.cell.2011.08.037","volume":"147","author":"J Liu","year":"2011","unstructured":"Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 2011;147:223\u201334.","journal-title":"Cell."},{"key":"1328_CR35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","volume":"36","author":"R Scherz-Shouval","year":"2011","unstructured":"Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci. 2011;36:30\u20138.","journal-title":"Trends Biochem Sci"},{"key":"1328_CR36","doi-asserted-by":"publisher","first-page":"891S","DOI":"10.3945\/ajcn.110.001925","volume":"93","author":"DG Hardie","year":"2011","unstructured":"Hardie DG. Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr. 2011;93:891S\u20136S.","journal-title":"Am J Clin Nutr"},{"key":"1328_CR37","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.freeradbiomed.2009.02.019","volume":"46","author":"BM Emerling","year":"2009","unstructured":"Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, et al. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP\/ATP ratio. Free Radic Biol Med. 2009;46:1386\u201391.","journal-title":"Free Radic Biol Med"},{"key":"1328_CR38","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41419-019-1501-9","volume":"10","author":"II Suvorova","year":"2019","unstructured":"Suvorova II, Pospelov VA. AMPK\/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency. Cell Death Dis. 2019;10:260.","journal-title":"Cell Death Dis"},{"key":"1328_CR39","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2147\/OTT.S185876","volume":"12","author":"T Xu","year":"2019","unstructured":"Xu T, Jiang L, Wang Z. The progression of HMGB1-induced autophagy in cancer biology. Onco Targets Ther. 2019;12:365\u201377.","journal-title":"Onco Targets Ther"},{"key":"1328_CR40","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fendo.2015.00022","volume":"6","author":"RT Netea-Maier","year":"2015","unstructured":"Netea-Maier RT, Kluck V, Plantinga TS, Smit JW. Autophagy in thyroid cancer: present knowledge and future perspectives. Front Endocrinol (Lausanne). 2015;6:22.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1328_CR41","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","volume":"26","author":"R Scherz-Shouval","year":"2007","unstructured":"Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007;26:1749\u201360.","journal-title":"EMBO J"},{"key":"1328_CR42","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/cdd.2009.49","volume":"16","author":"Y Chen","year":"2009","unstructured":"Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 2009;16:1040\u201352.","journal-title":"Cell Death Differ"},{"key":"1328_CR43","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/ars.2008.2270","volume":"11","author":"MB Azad","year":"2009","unstructured":"Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal. 2009;11:777\u201390.","journal-title":"Antioxid Redox Signal"},{"key":"1328_CR44","doi-asserted-by":"publisher","first-page":"904","DOI":"10.4161\/auto.7.8.15704","volume":"7","author":"R Kang","year":"2011","unstructured":"Kang R, Livesey KM, Zeh HR, Lotze MT, Tang D. HMGB1 as an autophagy sensor in oxidative stress. Autophagy. 2011;7:904\u20136.","journal-title":"Autophagy."},{"key":"1328_CR45","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1101\/gad.17420111","volume":"25","author":"DG Hardie","year":"2011","unstructured":"Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011;25:1895\u2013908.","journal-title":"Genes Dev"},{"key":"1328_CR46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1089\/met.2010.0026","volume":"9","author":"J Rezzonico","year":"2011","unstructured":"Rezzonico J, Rezzonico M, Pusiol E, Pitoia F, Niepomniszcze H. Metformin treatment for small benign thyroid nodules in patients with insulin resistance. Metab Syndr Relat Disord. 2011;9:69\u201375.","journal-title":"Metab Syndr Relat Disord"},{"key":"1328_CR47","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1210\/jc.2012-3799","volume":"98","author":"J Klubo-Gwiezdzinska","year":"2013","unstructured":"Klubo-Gwiezdzinska J, Costello JJ, Patel A, Bauer A, Jensen K, Mete M, et al. Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer. J Clin Endocrinol Metab. 2013;98:3269\u201379.","journal-title":"J Clin Endocrinol Metab"},{"key":"1328_CR48","first-page":"10824","volume":"8","author":"X Xu","year":"2015","unstructured":"Xu X, Gao H, Qin J, He L, Liu W. TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK\/mTOR pathway. Int J Clin Exp Pathol. 2015;8:10824\u201331.","journal-title":"Int J Clin Exp Pathol"},{"key":"1328_CR49","doi-asserted-by":"publisher","first-page":"E748","DOI":"10.1210\/jc.2014-1777","volume":"100","author":"RL Plews","year":"2015","unstructured":"Plews RL, Mohd YA, Wang C, Saji M, Zhang X, Chen CS, et al. A novel dual AMPK activator\/mTOR inhibitor inhibits thyroid cancer cell growth. J Clin Endocrinol Metab. 2015;100:E748\u201356.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1328-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13046-019-1328-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1328-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T23:26:56Z","timestamp":1595287616000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-019-1328-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1328"],"URL":"https:\/\/doi.org\/10.1186\/s13046-019-1328-3","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Research Ethics Committee of Hunan Cancer Hospital. And written informed consent was obtained from each participating subject. Animal study was approved by the Animal Ethics Committee of Xiangya Medical College, Central South University and conducted under the Guide for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Non-applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"325"}}