{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:05Z","timestamp":1792788125150,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872443"],"award-info":[{"award-number":["81872443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173089"],"award-info":[{"award-number":["81173089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science Advancement Program (Basic Medical Science) of Wuhan University","award":["TFJC 2018003"],"award-info":[{"award-number":["TFJC 2018003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13046-019-1361-2","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T06:02:42Z","timestamp":1566453762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1"],"prefix":"10.1186","volume":"38","author":[{"given":"Chenlong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengpeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"1361_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1056\/NEJM197108122850711","volume":"285","author":"J Folkman","year":"1971","unstructured":"Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182\u20136.","journal-title":"N Engl J Med"},{"key":"1361_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrclinonc.2018.29","volume":"15","author":"D Fukumura","year":"2018","unstructured":"Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018;15:325\u201340.","journal-title":"Nat Rev Clin Oncol"},{"key":"1361_CR3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ccr.2009.01.027","volume":"15","author":"M P\u00e0ez-Ribes","year":"2016","unstructured":"P\u00e0ez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vi\u00f1als F, Inoue M, Bergers G, Hanahan D, Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2016;15:220\u201331.","journal-title":"Cancer Cell"},{"key":"1361_CR4","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1152\/physrev.00038.2010","volume":"91","author":"S Goel","year":"2011","unstructured":"Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011;91:1071\u2013121.","journal-title":"Physiol Rev"},{"key":"1361_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nrd3455","volume":"10","author":"P Carmeliet","year":"2017","unstructured":"Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2017;10:417\u201327.","journal-title":"Nat Rev Drug Discov"},{"key":"1361_CR6","doi-asserted-by":"publisher","first-page":"242ra84","DOI":"10.1126\/scitranslmed.3008455","volume":"6","author":"L Xu","year":"2014","unstructured":"Xu L, Stevens J, Hilton MB, Seaman S, Conrads TP, Veenstra TD, Logsdon D, Morris H, Swing DA, Patel NL, Kalen J, Haines DC, Zudaire E, St Croix B. COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. Sci Transl Med. 2014;6:242ra84.","journal-title":"Sci Transl Med"},{"key":"1361_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1124\/jpet.113.210120","volume":"348","author":"L Chen","year":"2016","unstructured":"Chen L, Ackerman R, Saleh M, Gotlinger KH, Kessler M, Mendelowitz LG, Falck JR, Arbab AS, Scicli AG, Schwartzman ML, Yang J, Guo AM. 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo. J Pharmacol Exp Ther. 2016;348:442\u201351.","journal-title":"J Pharmacol Exp Ther"},{"key":"1361_CR8","doi-asserted-by":"publisher","first-page":"29781","DOI":"10.1074\/jbc.M115.669481","volume":"290","author":"M Inada","year":"2015","unstructured":"Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C. Direct melanoma cell contact induces stromal cell autocrine prostaglandin E2-EP4 receptor signaling that drives tumor growth, Angiogenesis, and Metastasis. J Biol Chem. 2015;290:29781\u201393.","journal-title":"J Biol Chem"},{"key":"1361_CR9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00280-010-1521-8","volume":"68","author":"W Yu","year":"2011","unstructured":"Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Li Y, Yang J. Cytochrome P450 omega-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 2011;68:619\u201329.","journal-title":"Cancer Chemother Pharmacol"},{"key":"1361_CR10","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1124\/jpet.105.088567","volume":"315","author":"M Guo","year":"2005","unstructured":"Guo M, Roman RJ, Falck JR, Edwards PA, Scicli AG. Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. J Pharmacol Exp Ther. 2005;315:526\u201333.","journal-title":"J Pharmacol Exp Ther"},{"key":"1361_CR11","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/med.21424","volume":"37","author":"C Pereira-Leite","year":"2017","unstructured":"Pereira-Leite C, Nunes C, Jamal SK, Cuccovia IM. Reis S nonsteroidal anti-inflammatory therapy: a journey toward safety. Med Res Rev. 2017;37:802\u201359.","journal-title":"Med Res Rev"},{"key":"1361_CR12","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/bjc.2015.25","volume":"112","author":"JL Petrick","year":"2017","unstructured":"Petrick JL, Steck SE, Bradshaw PT, Trivers KF, Abrahamson PE, Engel LS, He K, Chow WH, Mayne ST, Risch HA, Vaughan TL, Gammon MD. Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). Br J Cancer. 2017;112:1291\u2013300.","journal-title":"Br J Cancer"},{"key":"1361_CR13","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1080\/01635581.2013.783601","volume":"66","author":"O Hashimoto","year":"2014","unstructured":"Hashimoto O, Nakamura A, Nakamura T, Iwamoto H, Hiroshi M, Inoue K, Torimura T, Ueno T, Sata M. Methylated-(3\u2033)-epigallocatechin gallate analog suppresses tumor growth in Huh7 hepatoma cells via inhibition of angiogenesis. Nutr Cancer. 2014;66:728\u201335.","journal-title":"Nutr Cancer"},{"key":"1361_CR14","doi-asserted-by":"publisher","first-page":"e68566","DOI":"10.1371\/journal.pone.0068566","volume":"8","author":"Z Wang","year":"2013","unstructured":"Wang Z, Wang N, Han S, Wang D, Mo S, Yu L, Huang H, Tsui K, Shen J, Chen J. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF\/VEGFR-2 signaling pathway. PLoS One. 2013;8:e68566.","journal-title":"PLoS One"},{"key":"1361_CR15","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1158\/0008-5472.CAN-07-6247","volume":"68","author":"RP Singh","year":"2008","unstructured":"Singh RP, Gu M, Agarwal R. Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res. 2008;68:2043\u201350.","journal-title":"Cancer Res"},{"key":"1361_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.canlet.2017.05.030","volume":"402","author":"C Wang","year":"2017","unstructured":"Wang C, Li Y, Chen H, Zhang J, Zhang J, Qin T, Duan C, Chen X, Liu Y, Zhou X, Yang J. Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma. Cancer Lett. 2017;402:131\u201341.","journal-title":"Cancer Lett"},{"key":"1361_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13046-017-0625-y","volume":"36","author":"J Tian","year":"2017","unstructured":"Tian J, Wang Y, Zhang X, Ren Q, Li R, Huang Y, Lu H, Chen J. Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 signaling. J Exp Clin Cancer Res. 2017;36:153.","journal-title":"J Exp Clin Cancer Res"},{"key":"1361_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nprot.2008.197","volume":"4","author":"L Bordoli","year":"2009","unstructured":"Bordoli L, Kiefer F, Arnold K, Benkert P, Battey J, Schwede T. Protein structure homology modeling using SWISS-MODEL workspace. Nat Protoc. 2009;4:1\u201313.","journal-title":"Nat Protoc"},{"key":"1361_CR19","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"P Emsley","year":"2010","unstructured":"Emsley P, Lohkamp B, Scott WG, Cowtan K. Features and development of coot. Acta Crystallogr D Biol Crystallogr. 2010;66:486\u2013501.","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"1361_CR20","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"S Pronk","year":"2013","unstructured":"Pronk S, P\u00e1ll S, Schulz R, Larsson P, Bjelkmar P, Apostolov R, Shirts MR, Smith JC, Kasson PM, van der Spoel D, et al. GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics. 2013;29:845\u201354.","journal-title":"Bioinformatics."},{"key":"1361_CR21","doi-asserted-by":"publisher","first-page":"5231424","DOI":"10.1155\/2017\/5231424","volume":"2017","author":"MJ LaGier","year":"2017","unstructured":"LaGier MJ. Predicted cold shock proteins from the extremophilic bacterium deinococcus maricopensis and related deinococcus species. Int J Microbiol. 2017;2017:5231424.","journal-title":"Int J Microbiol"},{"key":"1361_CR22","doi-asserted-by":"publisher","first-page":"e5896","DOI":"10.1073\/pnas.1801745115","volume":"115","author":"J Dai","year":"2018","unstructured":"Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J, Cao C, Chen T, Zhuang S, et al. Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A. 2018;115:e5896\u2013905.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1361_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.taap.2012.07.019","volume":"264","author":"W Yu","year":"2012","unstructured":"Yu W, Chai H, Li Y, Zhao H, Xie X, Zheng H, Wang C, Wang X, Yang G, Cai X, Falck JR, Yang J. Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicol Appl Pharmacol. 2012;264:73\u201383.","journal-title":"Toxicol Appl Pharmacol"},{"key":"1361_CR24","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1097\/ICO.0000000000001016","volume":"35","author":"RY Kim","year":"2016","unstructured":"Kim RY, Chung SK, Kim MS, Ra H. Effects of combined photodynamic therapy and topical bevacizumab treatment on corneal neovascularization in rabbits. Cornea. 2016;35:1615\u201320.","journal-title":"Cornea."},{"key":"1361_CR25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1124\/jpet.117.247130","volume":"365","author":"C Wang","year":"2018","unstructured":"Wang C, Li Y, Chen H, Huang K, Liu X, Qiu M, Liu Y, Yang Y, Yang J. CYP4X1 inhibition by flavonoid CH625 normalizes glioma vasculature through reprogramming TAMs via CB2 and EGFR-STAT3 Axis. J Pharmacol Exp Ther. 2018;365:72\u201383.","journal-title":"J Pharmacol Exp Ther"},{"key":"1361_CR26","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/sj.bjp.0704101","volume":"133","author":"N Miyata","year":"2001","unstructured":"Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato-Watanabe M, Yasuda Y, Doi M, Kametani S, Tomishima Y, Ueki T, Sato M, Kameo K. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol. 2001;133:325\u20139.","journal-title":"Br J Pharmacol"},{"key":"1361_CR27","doi-asserted-by":"publisher","first-page":"7181","DOI":"10.1158\/0008-5472.CAN-16-0300","volume":"76","author":"ME Gilles","year":"2016","unstructured":"Gilles ME, Maione F, Cossutta M, Carpentier G, Caruana L, Di Maria S, Houppe C, Destouches D, Shchors K, Prochasson C. Nucleolin targeting impairs the progression of pancreatic cancer and promotes the normalization of tumor vasculature. Cancer Res. 2016;76:7181\u201393.","journal-title":"Cancer Res"},{"key":"1361_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ijrobp.2014.11.012","volume":"91","author":"BJ Fisher","year":"2015","unstructured":"Fisher BJ, Hu C, Macdonald DR, Lesser GJ, Coons SW, Brachman DG, Ryu S, Werner-Wasik M, Bahary JP, Liu J, Chakravarti A, Mehta M. Phase 2 study of temozolomide-based chemoradiation therapy for high-risk low-grade gliomas: preliminary results of radiation therapy oncology group 0424. Int J Radiat Oncol Biol Phys. 2015;91:497\u2013504.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1361_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1124\/jpet.108.140889","volume":"327","author":"AM Guo","year":"2008","unstructured":"Guo AM, Sheng J, Scicli GM, Arbab AS, Lehman NL, Edwards PA, Falck JR, Roman RJ, Scicli AG. Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. J Pharmacol Exp Ther. 2008;327:10\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"1361_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.biocel.2017.12.005","volume":"94","author":"W Xiong","year":"2018","unstructured":"Xiong W, Huang C, Deng H, Jian C, Zen C, Ye K, Zhong Z, Zhao X, Zhu L. Oncogenic non-coding RNA NEAT1 promotes the prostate cancer cell growth through the SRC3\/IGF1R\/AKT pathway. Int J Biochem Cell Biol. 2018;94:125\u201332.","journal-title":"Int J Biochem Cell Biol"},{"key":"1361_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.taap.2014.07.018","volume":"280","author":"H Zheng","year":"2014","unstructured":"Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, Tang T, Yue J, Guo AM, Yang J. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Toxicol Appl Pharmacol. 2014;280:10\u201320.","journal-title":"Toxicol Appl Pharmacol"},{"key":"1361_CR32","doi-asserted-by":"publisher","first-page":"R693","DOI":"10.1152\/ajpregu.00422.2013","volume":"307","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Hoda MN, Zheng X, et al. Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. Am J Physiol Regul Integr Comp Physiol. 2014;307:R693\u2013703.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1361_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.05.010","volume":"351","author":"Y Liu","year":"2018","unstructured":"Liu Y, Duan C, Chen H, Wang C, Liu X, Qiu M, Tang H, Zhang F, Zhou X, Yang J. Inhibition of COX-2\/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Toxicol Appl Pharmacol. 2018;351:1\u201311.","journal-title":"Toxicol Appl Pharmacol"},{"key":"1361_CR34","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/neuonc\/now030","volume":"18","author":"Y Piao","year":"2016","unstructured":"Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Novel MET\/TIE2\/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Neuro-Oncology. 2016;18:1230\u201341.","journal-title":"Neuro-Oncology"},{"key":"1361_CR35","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1093\/neuonc\/now112","volume":"18","author":"D Mangani","year":"2016","unstructured":"Mangani D, Weller M, Seyed Sadr E, Willscher E, Seystahl K, Reifenberger G, Tabatabai G, Binder H, Schneider H. Limited role for transforming growth factor-\u03b2 pathway activation-mediated escape from VEGF inhibition in murine glioma models. Neuro-Oncology. 2016;18:1610\u201321.","journal-title":"Neuro-Oncology"},{"key":"1361_CR36","doi-asserted-by":"crossref","unstructured":"Grisanti S, Ferrari VD, Buglione M, Agazzi GM, Liserre R, Poliani L, Buttolo L, Gipponi S, Pedersini R, Consoli F, Panciani P, Roca E, Spena G, Triggiani L, Berruti A. Second line treatment of recurrent glioblastoma with sunitinib: results of a phase II study and systematic review of literature. J Neurosurg Sci. 2019;63:458\u201367.","DOI":"10.23736\/S0390-5616.16.03874-1"},{"key":"1361_CR37","doi-asserted-by":"crossref","unstructured":"Wroblewski M, Bauer R, Cubas C\u00f3rdova M, Udonta F, Ben-Batalla I, Legler K, Hauser C, Egberts J, Janning M, Velthaus J, Schulze C, Pantel K, Bokemeyer C, Loges S. Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B. Nat Commun. 2017;8:269.","DOI":"10.1038\/s41467-017-00327-8"},{"key":"1361_CR38","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-018-0812-2","volume":"17","author":"Z Peng","year":"2018","unstructured":"Peng Z, Liu C, Wu M. New insights into long noncoding RNAs and their roles in glioma. Mol Cancer. 2018;17:61.","journal-title":"Mol Cancer"},{"key":"1361_CR39","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1002\/jcp.27051","volume":"234","author":"NH Goradel","year":"2019","unstructured":"Goradel NH, Mohammadi N, Haghi-Aminjan H, Farhood B, Negahdari B, Sahebkar A. Regulation of tumor angiogenesis by microRNAs: state of the art. J Cell Physiol. 2019;234:1099\u2013110.","journal-title":"J Cell Physiol"},{"key":"1361_CR40","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1159\/000485883","volume":"44","author":"BL Zhang","year":"2017","unstructured":"Zhang BL, Dong FL, Guo TW, Gu XH, Huang LY, Gao DS. MiRNAs mediate GDNF-induced proliferation and migration of glioma cells. Cell Physiol Biochem. 2017;44:1923\u201338.","journal-title":"Cell Physiol Biochem"},{"key":"1361_CR41","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1158\/1078-0432.CCR-17-0605","volume":"24","author":"Q Chen","year":"2018","unstructured":"Chen Q, Cai J, Wang Q, Wang Y, Liu M, Yang J, Zhou J, Kang C, Li M, Jiang C. Long noncoding RNA NEAT1, regulated by the EGFR pathway, contributes to glioblastoma progression through the WNT\/\u03b2-catenin pathway by scaffolding EZH2. Clin Cancer Res. 2018;24:684\u201395.","journal-title":"Clin Cancer Res"},{"key":"1361_CR42","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/nrd941","volume":"1","author":"J Bajorath","year":"2002","unstructured":"Bajorath J. Integration of virtual and high-throughput screening. Nat Rev Drug Discov. 2002;1:882\u201394.","journal-title":"Nat Rev Drug Discov"},{"key":"1361_CR43","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1002\/mnfr.201600025","volume":"60","author":"RK Lall","year":"2016","unstructured":"Lall RK, Adhami VM, Mukhtar H. Dietary flavonoid fisetin for cancer prevention and treatment. Mol Nutr Food Res. 2016;60:1396\u2013405.","journal-title":"Mol Nutr Food Res"},{"key":"1361_CR44","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1002\/mnfr.201100680","volume":"56","author":"IK Lam","year":"2012","unstructured":"Lam IK, Alex D, Wang YH, Liu P, et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012;56:945\u201356.","journal-title":"Mol Nutr Food Res"},{"key":"1361_CR45","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1124\/jpet.110.167692","volume":"334","author":"ZJ Sun","year":"2010","unstructured":"Sun ZJ, Chen G, Zhang W, Hu X, Huang CF, Wang YF, Jia J, Zhao YF. Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. J Pharmacol Exp Ther. 2010;334:500\u201312.","journal-title":"J Pharmacol Exp Ther"},{"key":"1361_CR46","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/jssc.201101031","volume":"35","author":"L Han","year":"2012","unstructured":"Han L, Yuan Y, Zhao L, He Q, Li Y, Chen X, Liu X, Liu K. Tracking antiangiogenic components from Glycyrrhiza uralensis Fisch. Based on zebrafish assays using high-speed countercurrent chromatography. J Sep Sci. 2012;35:1167\u201372.","journal-title":"J Sep Sci"},{"key":"1361_CR47","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1136\/bjophthalmol-2011-300110","volume":"95","author":"V Jhanji","year":"2011","unstructured":"Jhanji V, Liu H, Law K, Lee VY, Huang SF, Pang CP, Yam GH. Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. Br J Ophthalmol. 2011;95:1309\u201315.","journal-title":"Br J Ophthalmol"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13046-019-1361-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-019-1361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T19:19:37Z","timestamp":1597951177000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-019-1361-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1361"],"URL":"https:\/\/doi.org\/10.1186\/s13046-019-1361-2","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"13 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal studies were approved by the Animal Research Committee of Wuhan University and maintained in accordance with the guidelines by the Association for Assessment and Accreditation of Laboratory Animal Care International.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"371"}}