{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:00Z","timestamp":1790185260777,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["222102310088"],"award-info":[{"award-number":["222102310088"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["222102520014"],"award-info":[{"award-number":["222102520014"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["201300310700"],"award-info":[{"award-number":["201300310700"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700578"],"award-info":[{"award-number":["81700578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770725"],"award-info":[{"award-number":["81770725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100731"],"award-info":[{"award-number":["82100731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103292"],"award-info":[{"award-number":["82103292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410401"],"award-info":[{"award-number":["202300410401"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001102","name":"Cancer Council NSW","doi-asserted-by":"publisher","award":["RG20-01"],"award-info":[{"award-number":["RG20-01"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001102","name":"Cancer Council NSW","doi-asserted-by":"publisher","award":["RG21-10"],"award-info":[{"award-number":["RG21-10"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["2021\/ECF1359"],"award-info":[{"award-number":["2021\/ECF1359"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood. With the increasing appreciation of the role of long non-coding RNAs (lncRNAs) in cancer development, progression, and treatment resistance, the list of aberrantly expressed lncRNAs contributing to ccRCC pathogenesis is expanding rapidly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Bioinformatics analysis was carried out to interrogate publicly available ccRCC datasets. In situ hybridization and qRT-PCR assays were used to test lncRNA expression in human ccRCC tissues and cell lines, respectively. Chromatin immunoprecipitation and luciferase reporter assays were used to examine transcriptional regulation of gene expression. Wound healing as well as transwell migration and invasion assays were employed to monitor ccRCC cell migration and invasion in vitro. ccRCC metastasis was also examined using mouse models in vivo. RNA pulldown and RNA immunoprecipitation were performed to test RNA\u2013protein associations, whereas RNA-RNA interactions were tested using domain-specific chromatin isolation by RNA purification.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>MILIP expression was upregulated in metastatic compared with primary ccRCC tissues. The increased MILIP expression in metastatic ccRCC cells was driven by the transcription factor AP-2 gamma (TFAP2C). Knockdown of MILIP diminished the potential of ccRCC cell migration and invasion in vitro and reduced the formation of ccRCC metastatic lesions in vivo. The effect of MILIP on ccRCC cells was associated with alterations in the expression of epithelial-to-mesenchymal transition (EMT) hallmark genes. Mechanistically, MILIP formed an RNA-RNA duplex with the snail family transcriptional repressor 1 (Snai1) mRNA and bound to Y-box binding protein 1 (YBX1). This promoted the association between the YBX1 protein and the Snai1 mRNA, leading to increased translation of the latter. Snai1 in turn played an important role in MILIP-driven ccRCC metastasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The TFAP2C-responsive lncRNA MILIP drives ccRCC metastasis. Targeting MILIP may thus represent a potential avenue for ccRCC treatment.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13046-022-02452-9","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:03:03Z","timestamp":1661490183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma"],"prefix":"10.1186","volume":"41","author":[{"given":"Yanliang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Chen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick F.","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Min","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"issue":"4","key":"2452_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41581-020-00359-2","volume":"17","author":"E Jonasch","year":"2021","unstructured":"Jonasch E, Walker CL, Rathmell WK. Clear cell renal cell carcinoma ontogeny and mechanisms of lethality. Nat Rev Nephrol. 2021;17(4):245\u201361.","journal-title":"Nat Rev Nephrol"},{"key":"2452_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4797","volume":"349","author":"E Jonasch","year":"2014","unstructured":"Jonasch E, Gao J, Rathmell WK. Renal cell carcinoma. BMJ. 2014;349: g4797.","journal-title":"BMJ"},{"issue":"10021","key":"2452_CR3","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/S0140-6736(15)00046-X","volume":"387","author":"U Capitanio","year":"2016","unstructured":"Capitanio U, Montorsi F. Renal cancer. Lancet. 2016;387(10021):894\u2013906.","journal-title":"Lancet"},{"issue":"7","key":"2452_CR4","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1158\/1535-7163.MCT-17-1299","volume":"17","author":"P Makhov","year":"2018","unstructured":"Makhov P, Joshi S, Ghatalia P, Kutikov A, Uzzo RG, Kolenko VM. Resistance to systemic therapies in clear cell renal cell carcinoma: mechanisms and management strategies. Mol Cancer Ther. 2018;17(7):1355\u201364.","journal-title":"Mol Cancer Ther"},{"key":"2452_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2147\/OTT.S56370","volume":"7","author":"V Nerich","year":"2014","unstructured":"Nerich V, Hugues M, Paillard MJ, Borowski L, Nai T, Stein U, et al. Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinoma. Onco Targets Ther. 2014;7:365\u201374.","journal-title":"Onco Targets Ther"},{"issue":"4","key":"2452_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.5858\/arpa.2012-0085-RA","volume":"137","author":"R Goyal","year":"2013","unstructured":"Goyal R, Gersbach E, Yang XJ, Rohan SM. Differential diagnosis of renal tumors with clear cytoplasm: clinical relevance of renal tumor subclassification in the era of targeted therapies and personalized medicine. Arch Pathol Lab Med. 2013;137(4):467\u201380.","journal-title":"Arch Pathol Lab Med"},{"issue":"9669","key":"2452_CR7","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/S0140-6736(09)60229-4","volume":"373","author":"BI Rini","year":"2009","unstructured":"Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet. 2009;373(9669):1119\u201332.","journal-title":"Lancet"},{"issue":"8","key":"2452_CR8","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1056\/NEJMoa1303989","volume":"369","author":"RJ Motzer","year":"2013","unstructured":"Motzer RJ, McCann L, Deen K. Pazopanib versus sunitinib in renal cancer. N Engl J Med. 2013;369(8):1970.","journal-title":"N Engl J Med"},{"key":"2452_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.09.014","volume":"522","author":"Y Lu","year":"2021","unstructured":"Lu Y, Qin H, Jiang B, Lu W, Hao J, Cao W, et al. KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma. Cancer Lett. 2021;522:1\u201313.","journal-title":"Cancer Lett"},{"issue":"7","key":"2452_CR10","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3390\/molecules21070965","volume":"21","author":"B Du","year":"2016","unstructured":"Du B, Shim JS. Targeting epithelial-mesenchymal transition (EMT) to overcome drug resistance in cancer. Molecules. 2016;21(7):965.","journal-title":"Molecules"},{"issue":"3","key":"2452_CR11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","volume":"29","author":"I Pastushenko","year":"2019","unstructured":"Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212\u201326.","journal-title":"Trends Cell Biol"},{"key":"2452_CR12","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","volume":"13","author":"V Mittal","year":"2018","unstructured":"Mittal V. Epithelial mesenchymal transition in tumor metastasis. Annu Rev Pathol: Mech Dis. 2018;13:395\u2013412.","journal-title":"Annu Rev Pathol: Mech Dis"},{"issue":"5","key":"2452_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ccr.2009.03.017","volume":"15","author":"V Evdokimova","year":"2009","unstructured":"Evdokimova V, Tognon C, Ng T, Ruzanov P, Melnyk N, Fink D, et al. Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell. 2009;15(5):402\u201315.","journal-title":"Cancer Cell"},{"issue":"8","key":"2452_CR14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/cancers9080098","volume":"9","author":"E Forte","year":"2017","unstructured":"Forte E, Chimenti I, Rosa P, Angelini F, Pagano F, Calogero A, et al. EMT\/MET at the crossroad of stemness, regeneration and oncogenesis: the ying-yang equilibrium recapitulated in cell spheroids. Cancers. 2017;9(8):98.","journal-title":"Cancers"},{"issue":"5","key":"2452_CR15","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1093\/bib\/bbx042","volume":"19","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Tao Y, Liao Q. Long noncoding RNA: a crosslink in biological regulatory network. Briefings Bioinf. 2018;19(5):930\u201345.","journal-title":"Briefings Bioinf"},{"issue":"15","key":"2452_CR16","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","volume":"77","author":"A Bhan","year":"2017","unstructured":"Bhan A, Soleimani M, Mandal SS. long noncoding rna and cancer: a new paradigm. Cancer Res. 2017;77(15):3965\u201381.","journal-title":"Cancer Res"},{"key":"2452_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2019.04.011","volume":"112","author":"S Dahariya","year":"2019","unstructured":"Dahariya S, Paddibhatla I, Kumar S, Raghuwanshi S, Pallepati A, Gutti RK. Long non-coding RNA: Classification, biogenesis and functions in blood cells. Mol immunol. 2019;112:82\u201392.","journal-title":"Mol immunol"},{"issue":"7","key":"2452_CR18","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1111\/cas.13642","volume":"109","author":"A Sanchez Calle","year":"2018","unstructured":"Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F, Ochiya T. Emerging roles of long non-coding RNA in cancer. Cancer Sci. 2018;109(7):2093\u2013100.","journal-title":"Cancer Sci"},{"issue":"1","key":"2452_CR19","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1038\/s41467-020-18735-8","volume":"11","author":"YC Feng","year":"2020","unstructured":"Feng YC, Liu XY, Teng L, Ji Q, Wu Y, Li JM, et al. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nat Commun. 2020;11(1):4980.","journal-title":"Nat Commun"},{"issue":"1","key":"2452_CR20","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1038\/s41467-021-24099-4","volume":"12","author":"L Teng","year":"2021","unstructured":"Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, et al. The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Nat Commun. 2021;12(1):3734.","journal-title":"Nat Commun"},{"issue":"1","key":"2452_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12943-019-0998-y","volume":"18","author":"W Zhai","year":"2019","unstructured":"Zhai W, Zhu R, Ma J, Gong D, Zhang H, Zhang J, et al. A positive feed-forward loop between LncRNA-URRCC and EGFL7\/P-AKT\/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma. Mol cancer. 2019;18(1):81.","journal-title":"Mol cancer"},{"issue":"4","key":"2452_CR22","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1158\/0008-5472.CAN-20-1619","volume":"81","author":"Y Gu","year":"2021","unstructured":"Gu Y, Niu S, Wang Y, Duan L, Pan Y, Tong Z, et al. DMDRMR-Mediated Regulation of m(6)A-Modified CDK4 by m(6)A Reader IGF2BP3 Drives ccRCC Progression. Cancer Res. 2021;81(4):923\u201334.","journal-title":"Cancer Res"},{"issue":"35","key":"2452_CR23","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1038\/s41388-021-01948-6","volume":"40","author":"D Li","year":"2021","unstructured":"Li D, She J, Hu X, Zhang M, Sun R, Qin S. The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p\/ITGA2 axis. Oncogene. 2021;40(35):5403\u201315.","journal-title":"Oncogene"},{"issue":"5","key":"2452_CR24","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.cell.2016.04.028","volume":"165","author":"Z Lu","year":"2016","unstructured":"Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, et al. RNA duplex map in living cells reveals higher-order transcriptome structure. Cell. 2016;165(5):1267\u201379.","journal-title":"Cell"},{"issue":"4","key":"2452_CR25","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41556-018-0066-7","volume":"20","author":"WL Hu","year":"2018","unstructured":"Hu WL, Jin L, Xu A, Wang YF, Thorne RF, Zhang XD, et al. GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. Nat Cell Biol. 2018;20(4):492\u2013502.","journal-title":"Nat Cell Biol"},{"issue":"5","key":"2452_CR26","doi-asserted-by":"publisher","first-page":"E693","DOI":"10.1002\/ijc.27419","volume":"131","author":"D Wuttig","year":"2012","unstructured":"Wuttig D, Zastrow S, F\u00fcssel S, Toma MI, Meinhardt M, Kalman K, et al. CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. Int J Cancer. 2012;131(5):E693-704.","journal-title":"Int J Cancer"},{"issue":"6","key":"2452_CR27","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"KC Wang","year":"2012","unstructured":"Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell. 2012;43(6):904\u201314.","journal-title":"Mol Cell"},{"issue":"1","key":"2452_CR28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/wrna.1200","volume":"5","author":"DN Lyabin","year":"2014","unstructured":"Lyabin DN, Eliseeva IA, Ovchinnikov LP. YB-1 protein: functions and regulation. Wiley interdiscip Rev: RNA. 2014;5(1):95\u2013110.","journal-title":"Wiley interdiscip Rev: RNA"},{"issue":"6","key":"2452_CR29","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3322\/caac.21411","volume":"67","author":"PC Barata","year":"2017","unstructured":"Barata PC, Rini BI. Treatment of renal cell carcinoma: Current status and future directions. CA Cancer J Clin. 2017;67(6):507\u201324.","journal-title":"CA Cancer J Clin"},{"issue":"17","key":"2452_CR30","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1002\/cncr.32144","volume":"125","author":"A Gul","year":"2019","unstructured":"Gul A, Rini BI. Adjuvant therapy in renal cell carcinoma. Cancer. 2019;125(17):2935\u201344.","journal-title":"Cancer"},{"issue":"4","key":"2452_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1177\/1758834012443725","volume":"4","author":"YG Najjar","year":"2012","unstructured":"Najjar YG, Rini BI. Novel agents in renal carcinoma: a reality check. Ther Adv Med Oncol. 2012;4(4):183\u201394.","journal-title":"Ther Adv Med Oncol"},{"issue":"1","key":"2452_CR32","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13046-014-0062-0","volume":"33","author":"S Kaufhold","year":"2014","unstructured":"Kaufhold S, Bonavida B. Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. J Exp Clin Cancer Res. 2014;33(1):62.","journal-title":"J Exp Clin Cancer Res"},{"issue":"9","key":"2452_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107016","volume":"9","author":"G Hu","year":"2014","unstructured":"Hu G, Lou Z, Gupta M. The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. PLoS ONE. 2014;9(9): e107016.","journal-title":"PLoS ONE"},{"issue":"21","key":"2452_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1182\/blood.V122.21.81.81","volume":"122","author":"G Hu","year":"2013","unstructured":"Hu G, Witzig TE, Gupta M. A novel long non-coding rna, snhg4 complex with eukaryotic initiation factor-4e and regulate aberrant protein translation in mantle cell lymphoma: Implications For novel biomarker. Blood. 2013;122(21):81\u201381.","journal-title":"Blood"},{"issue":"1","key":"2452_CR35","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12943-018-0920-z","volume":"17","author":"Z Peng","year":"2018","unstructured":"Peng Z, Wang J, Shan B, Li B, Peng W, Dong Y, et al. The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1. Mol cancer. 2018;17(1):167.","journal-title":"Mol cancer"},{"issue":"1","key":"2452_CR36","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13059-018-1523-0","volume":"19","author":"E Zhang","year":"2018","unstructured":"Zhang E, He X, Zhang C, Su J, Lu X, Si X, et al. A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1. Genome biol. 2018;19(1):154.","journal-title":"Genome biol"},{"issue":"4","key":"2452_CR37","first-page":"779","volume":"9","author":"W Zhang","year":"2019","unstructured":"Zhang W, Du M, Wang T, Chen W, Wu J, Li Q, et al. Long non-coding RNA LINC01133 mediates nasopharyngeal carcinoma tumorigenesis by binding to YBX1. Am J Cancer Res. 2019;9(4):779\u201390.","journal-title":"Am J Cancer Res"},{"issue":"2","key":"2452_CR38","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000732RR","volume":"35","author":"P Zhao","year":"2021","unstructured":"Zhao P, Deng Y, Wu Y, Guo Q, Zhou L, Yang X, et al. Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1\u03b1 in clear cell renal cell carcinoma. FASEB J. 2021;35(2): e21160.","journal-title":"FASEB J"},{"key":"2452_CR39","doi-asserted-by":"crossref","unstructured":"D\u2019Costa NM, Lowerison MR, Raven PA, Tan Z, Roberts ME, Shrestha R, et al. Y-box binding protein-1 is crucial in acquired drug resistance development in metastatic clear-cell renal cell carcinoma. J Exp Clin Cancer Res. 2020;39(1):33.","DOI":"10.1186\/s13046-020-1527-y"},{"issue":"13","key":"2452_CR40","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/gb-2005-6-13-246","volume":"6","author":"D Eckert","year":"2005","unstructured":"Eckert D, Buhl S, Weber S, J\u00e4ger R, Schorle H. The AP-2 family of transcription factors. Genome Biol. 2005;6(13):246.","journal-title":"Genome Biol"},{"issue":"1","key":"2452_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13046-018-0683-9","volume":"37","author":"X Wang","year":"2018","unstructured":"Wang X, Sun D, Tai J, Chen S, Yu M, Ren D, et al. TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway. J Exp Clin Cancer Res. 2018;37(1):27.","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"2452_CR42","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41419-020-2684-9","volume":"11","author":"Y Wang","year":"2020","unstructured":"Wang Y, Chen S, Jiang Q, Deng J, Cheng F, Lin Y, et al. TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition. Cell Death Dis. 2020;11(6):482.","journal-title":"Cell Death Dis"},{"issue":"1","key":"2452_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12943-021-01474-9","volume":"20","author":"T Jiang","year":"2021","unstructured":"Jiang T, Wang H, Liu L, Song H, Zhang Y, Wang J, et al. CircIL4R activates the PI3K\/AKT signaling pathway via the miR-761\/TRIM29\/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer. Mol Cancer. 2021;20(1):167.","journal-title":"Mol Cancer"},{"key":"2452_CR44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.canlet.2017.06.002","volume":"402","author":"TH Chang","year":"2017","unstructured":"Chang TH, Tsai MF, Gow CH, Wu SG, Liu YN, Chang YL, et al. Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. Cancer Lett. 2017;402:190\u2013202.","journal-title":"Cancer Lett"},{"issue":"11","key":"2452_CR45","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1038\/s41418-019-0301-1","volume":"26","author":"L Li","year":"2019","unstructured":"Li L, Zheng YL, Jiang C, Fang S, Zeng TT, Zhu YH, et al. HN1L-mediated transcriptional axis AP-2\u03b3\/METTL13\/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma. Cell Death Differ. 2019;26(11):2268\u201383.","journal-title":"Cell Death Differ"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-022-02452-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13046-022-02452-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-022-02452-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T06:05:22Z","timestamp":1661493922000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-022-02452-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["2452"],"URL":"https:\/\/doi.org\/10.1186\/s13046-022-02452-9","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,26]]},"assertion":[{"value":"5 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Human Research Ethics Committees of Henan Provincial People's Hospital (No. 2019\u201344) and was carried out following the principles embodied in the Declaration of Helsinki. Studies on animals were conducted in accordance with relevant guidelines and regulations and were approved by the Animal Research Ethics Committee of Zhengzhou University (No. ZZU-LAC2021101214).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"260"}}