{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T16:29:42Z","timestamp":1780849782364,"version":"3.54.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM), a hematologic malignancy characterized by the clonal expansion of plasma cells within the bone marrow, is associated with severe health complications, including osteolytic bone lesions that significantly increase the risk of fractures, leading to higher morbidity and mortality rates. One intriguing protein in this context is the RNA polymerase binding factor Che-1\/AATF (Che-1), which has emerged as a potential player in the survival and proliferation of myeloma cells. Hippo pathway has been shown to be an important mediator of oncogenesis in solid tumors, especially for its role in shaping a tumor microenvironment favorable to cancer maintenance and spread. The Hippo pathway is also implicated in the pathogenesis of the osteolytic lesions that occurs in MM, since it deregulates the activities of mesenchymal populations of the bone matrix. In this commentary we wish to highlight some new molecular aspects elucidated in the paper by Bruno et al. regarding the proliferation of MM and the onset of bone lesions [Leukemia 38:877\u2013882, 1]. A series of recent findings has revealed a crosstalk between the RNA polymerase binding factor Che-1 and the HIPPO downstream co-transcriptional factor TAZ, bringing to light new emerging molecular targets in MM to limit the development of bone lesions.<\/jats:p>","DOI":"10.1186\/s13046-024-03248-9","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T08:59:02Z","timestamp":1734512342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular insights unlocking therapeutic potential for multiple myeloma and bone disease management"],"prefix":"10.1186","volume":"43","author":[{"given":"Tiziana","family":"Bruno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Catena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Blandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3730-1125","authenticated-orcid":false,"given":"Silvia","family":"Di Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"3248_CR1","doi-asserted-by":"publisher","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","volume":"3","author":"SK Kumar","year":"2017","unstructured":"Kumar SK, Rajkumar V, Kyle RA, et al. Multiple myeloma. Nat Rev Dis Primers. 2017;3:17046. https:\/\/doi.org\/10.1038\/nrdp.2017.46.","journal-title":"Nat Rev Dis Primers"},{"issue":"494","key":"3248_CR2","doi-asserted-by":"publisher","first-page":"eaau9087","DOI":"10.1126\/scitranslmed.aau9087","volume":"11","author":"H Liu","year":"2019","unstructured":"Liu H, He J, Koh SP, et al. Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. Sci Transl Med. 2019;11(494):eaau9087. https:\/\/doi.org\/10.1126\/scitranslmed.aau9087.","journal-title":"Sci Transl Med"},{"key":"3248_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3389\/fgene.2015.00141","volume":"6","author":"S Iezzi","year":"2015","unstructured":"Iezzi S, Fanciulli M. Discovering Che-1\/AATF: a new attractive target for cancer therapy. Front Genet. 2015;6:141. https:\/\/doi.org\/10.3389\/fgene.2015.00141.","journal-title":"Front Genet"},{"issue":"22","key":"3248_CR4","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1182\/bloodadvances.2020002566","volume":"4","author":"T Bruno","year":"2020","unstructured":"Bruno T, De Nicola F, Corleone G, et al. Che-1\/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma. Blood Adv. 2020;4(22):5616\u201330. https:\/\/doi.org\/10.1182\/bloodadvances.2020002566.","journal-title":"Blood Adv"},{"issue":"9","key":"3248_CR5","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1038\/s41375-018-0111-3","volume":"32","author":"E Donato","year":"2018","unstructured":"Donato E, Biagioni F, Bisso A, Caganova M, Amati B, Campaner S. YAP and TAZ are dispensable for physiological and malignant haematopoiesis. Leukemia. 2018;32(9):2037\u201340. https:\/\/doi.org\/10.1038\/s41375-018-0111-3.","journal-title":"Leukemia"},{"issue":"1","key":"3248_CR6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s13046-023-02793-z","volume":"42","author":"F Liccardo","year":"2023","unstructured":"Liccardo F, \u015aniegocka M, Tito C, Iaiza A, Ottone T, Divona M, Travaglini S, Mattei M, Cicconi R, Miglietta S, Familiari G, Nottola SA, Petrozza V, Tamagnone L, Voso MT, Masciarelli S, Fazi F. Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection. J Exp Clin Cancer Res. 2023;42(1):223. https:\/\/doi.org\/10.1186\/s13046-023-02793-z.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"3248_CR7","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1038\/s41467-024-46531-1","volume":"15","author":"I Baroja","year":"2024","unstructured":"Baroja I, Kyriakidis NC, Halder G, Moya IM. Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer. Nat Commun. 2024;15(1):2700. https:\/\/doi.org\/10.1038\/s41467-024-46531-1.","journal-title":"Nat Commun"},{"issue":"22","key":"3248_CR8","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1182\/bloodadvances.2019000374","volume":"3","author":"S Grieve","year":"2019","unstructured":"Grieve S, Wajnberg G, Lees M, et al. TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC. Blood Adv. 2019;3(22):3613\u201325. https:\/\/doi.org\/10.1182\/bloodadvances.2019000374.","journal-title":"Blood Adv"},{"issue":"19","key":"3248_CR9","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1158\/0008-5472.CAN-20-0125","volume":"80","author":"M Shreberk-Shaked","year":"2020","unstructured":"Shreberk-Shaked M, Dassa B, Sinha S, et al. A Division of Labor between YAP and TAZ in Non-small Cell Lung Cancer. Cancer Res. 2020;80(19):4145\u201357. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-0125.","journal-title":"Cancer Res"},{"issue":"4","key":"3248_CR10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/s41375-024-02168-z","volume":"38","author":"T Bruno","year":"2024","unstructured":"Bruno T, Catena V, Corleone G, et al. Che-1\/miR-590-3p\/TAZ axis sustains multiple myeloma disease. Leukemia. 2024;38(4):877\u201382. https:\/\/doi.org\/10.1038\/s41375-024-02168-z.","journal-title":"Leukemia"},{"issue":"2","key":"3248_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215\u201333. https:\/\/doi.org\/10.1016\/j.cell.2009.01.002.","journal-title":"Cell"},{"issue":"12","key":"3248_CR12","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41417-020-00291-4","volume":"28","author":"D Chen","year":"2021","unstructured":"Chen D, Yang X, Liu M, Zhang Z, Xing E. Roles of miRNA dysregulation in the pathogenesis of multiple myeloma. Cancer Gene Ther. 2021;28(12):1256\u201368. https:\/\/doi.org\/10.1038\/s41417-020-00291-4.","journal-title":"Cancer Gene Ther"},{"issue":"1","key":"3248_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40364-023-00469-6","volume":"11","author":"S Li","year":"2023","unstructured":"Li S, Zhang E, Cai Z. Liquid biopsy by analysis of circulating myeloma cells and cell-free nucleic acids: a novel noninvasive approach of disease evaluation in multiple myeloma. Biomark Res. 2023;11(1):27. https:\/\/doi.org\/10.1186\/s40364-023-00469-6.","journal-title":"Biomark Res"},{"issue":"21","key":"3248_CR14","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.3390\/cancers13215258","volume":"13","author":"SR Moura","year":"2021","unstructured":"Moura SR, Abreu H, Cunha C, et al. Circulating microRNAs correlate with multiple myeloma and skeletal osteolytic lesions. Cancers (Basel). 2021;13(21):5258. https:\/\/doi.org\/10.3390\/cancers13215258.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"3248_CR15","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/hep.31082]","volume":"71","author":"DP Kumar","year":"2019","unstructured":"Kumar DP, Santhekadur PK, Seneshaw M, Mirshahi F, Uram-Tuculescu C, Sanyal AJ. A Regulatory Role of apoptosis antagonizing transcription factor in the pathogenesis of nonalcoholic fatty liver Disease and Hepatocellular Carcinoma [published correction appears in Hepatology. Hepatology. 2019;71(1):404. https:\/\/doi.org\/10.1002\/hep.31082].","journal-title":"Hepatology"},{"key":"3248_CR16","doi-asserted-by":"publisher","first-page":"102351","DOI":"10.1016\/j.jceh.2024.102351","volume":"14","author":"DP Kumar","year":"2024","unstructured":"Kumar DP, Srinivas AN, Suresh D, et al. Silencing of hepatic AATF ameliorates metabolic dysfunction associated steatohepatitis by promoting fatty acid alpha-oxidation in experimental models. J Clin Exp Hepatol. 2024;14:102351. https:\/\/doi.org\/10.1016\/j.jceh.2024.102351.","journal-title":"J Clin Exp Hepatol"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-024-03248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13046-024-03248-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-024-03248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:07:05Z","timestamp":1734512825000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-024-03248-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3248"],"URL":"https:\/\/doi.org\/10.1186\/s13046-024-03248-9","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"6 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors have commented on and approved the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No potential conflict of interest was reported by the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"322"}}