{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:50Z","timestamp":1791260810594,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Triple-negative breast cancer (TNBC) is highly aggressive and has strong metastatic potential, and effective targeted therapies remain limited. There is growing evidence that the adipocyte microenvironment plays an important role in tumor progression, but its specific mechanism remains to be studied. As a key enzyme for the activation of long-chain fatty acids, the role and regulatory mechanism of ACSL5 in TNBC have not been clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ACSL5 expression and clinical relevance were assessed using public datasets, clinical specimens, and TNBC cell models. The effect of ACSL5 knockdown and overexpression on the malignant phenotype of TNBC cells were evaluated. An adipocyte-TNBC co-culture system, PA\/OA treatment, SIRT6 manipulation, co-immunoprecipitation, pan-acetylation assays, and ACSL5 K212\/213 mutant analysis were used to investigate the SIRT6-ACSL5 regulatory mechanism. Lipid-associated phenotypes were examined by Oil Red O staining, TG measurement, FASN\/CPT1A detection, and Seahorse analysis. In vivo validation was performed using an orthotopic mammary fat pad model in female NOD\/SCID mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ACSL5 expression was reduced in TNBC tissues and cell lines, and lower ACSL5 expression was associated with aggressive disease features. Functionally, ACSL5 knockdown promoted TNBC cell viability, colony formation, migration, invasion, and EMT-associated changes, whereas ACSL5 overexpression exerted opposite effects. Adipocyte co-culture and PA exposure induced SIRT6 upregulation and ACSL5 downregulation, while SIRT6 knockdown partially restored ACSL5 expression. Mechanistically, SIRT6 interacted with ACSL5 and regulated ACSL5 pan-acetylation. Mutagenesis of a candidate K212\/213-containing lysine motif suggested that this region may contribute to ACSL5 acetylation-associated functional regulation. Adipocyte co-culture and SIRT6 overexpression increased lipid droplet accumulation, intracellular TG storage, FASN expression, and EMT-associated changes, while reducing CPT1A expression. ACSL5 restoration partially reversed these lipid storage-associated malignant phenotypes. In an orthotopic mammary fat pad model using female NOD\/SCID mice, ACSL5 overexpression suppressed tumor growth, lung metastatic involvement, Ki67 expression, tumor TG accumulation, and lipid metabolism-related marker changes, whereas ACSL5 knockdown produced the opposite effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that adipocyte-derived fatty-acid cues may promote TNBC progression partly through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypic changes, highlighting ACSL5 as a potential lipid-related regulatory node in adipocyte-driven TNBC progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13046-026-03769-5","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:07:52Z","timestamp":1782907672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes"],"prefix":"10.1186","volume":"45","author":[{"given":"Yingnan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"issue":"11","key":"3769_CR1","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1158\/0008-5472.CAN-23-2491","volume":"84","author":"Y Qiu","year":"2024","unstructured":"Qiu Y, Wang X, Sun Y, Jin T, Tang R, Zhou X, et al. ACSL4-Mediated membrane phospholipid remodeling induces integrin beta1 activation to facilitate triple-negative breast cancer metastasis. Cancer Res. 2024;84(11):1856\u201371.","journal-title":"Cancer Res"},{"issue":"12","key":"3769_CR2","doi-asserted-by":"publisher","first-page":"e1993","DOI":"10.1016\/S2214-109X(24)00376-0","volume":"12","author":"J Dubner","year":"2024","unstructured":"Dubner J, Neugut AI, Joffe M, O\u2019Neil DS, Ayeni OA, Chen WC, et al. The association of HIV status with triple-negative breast cancer in patients with breast cancer in South Africa: a cross-sectional analysis of case-only data from a prospective cohort study. Lancet Glob Health. 2024;12(12):e1993\u20132002.","journal-title":"Lancet Glob Health"},{"issue":"1","key":"3769_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13058-025-02135-1","volume":"27","author":"D Wang","year":"2025","unstructured":"Wang D, Luo S, Yu R, Wen D, Jiang H, Xu K, et al. ALDH3A2 targets arachidonic acid to promote cell metastasis in TNBC via AMPK\/m-TOR signaling pathway. Breast Cancer Res. 2025;27(1):217.","journal-title":"Breast Cancer Res"},{"issue":"3","key":"3769_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/jleuko\/qiae065","volume":"116","author":"D Zhang","year":"2024","unstructured":"Zhang D, Wang M, Wang W, Ma S, Yu W, Ren X, et al. PGAM1 suppression remodels the tumor microenvironment in triple-negative breast cancer and synergizes with anti-PD-1 immunotherapy. J Leukoc Biol. 2024;116(3):579\u201388.","journal-title":"J Leukoc Biol"},{"key":"3769_CR5","doi-asserted-by":"publisher","first-page":"118095","DOI":"10.1016\/j.biopha.2025.118095","volume":"187","author":"D Delmas","year":"2025","unstructured":"Delmas D, Mialhe A, Cotte AK, Connat JL, Bouyer F, Hermetet F, et al. Lipid metabolism in cancer: exploring phospholipids as potential biomarkers. Biomed Pharmacother. 2025;187:118095.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3769_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12935-022-02645-4","volume":"22","author":"X Liu","year":"2022","unstructured":"Liu X, Zhang P, Xu J, Lv G, Li Y. Lipid metabolism in tumor microenvironment: novel therapeutic targets. Cancer Cell Int. 2022;22(1):224.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"3769_CR7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13046-025-03458-9","volume":"44","author":"D Yin","year":"2025","unstructured":"Yin D, Fang N, Zhu Y, Bao X, Yang J, Zhang Q, et al. Adipocytes-induced ANGPTL4\/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer. J Exp Clin Cancer Res. 2025;44(1):192.","journal-title":"J Exp Clin Cancer Res"},{"key":"3769_CR8","doi-asserted-by":"publisher","first-page":"215616","DOI":"10.1016\/j.canlet.2022.215616","volume":"534","author":"X Lyu","year":"2022","unstructured":"Lyu X, Zhang Q, Fares HM, Wang Y, Han Y, Sun L. Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism. Cancer Lett. 2022;534:215616.","journal-title":"Cancer Lett"},{"key":"3769_CR9","doi-asserted-by":"publisher","first-page":"216306","DOI":"10.1016\/j.canlet.2023.216306","volume":"569","author":"J Cremer","year":"2023","unstructured":"Cremer J, Brohee L, Dupont L, Lefevre C, Peiffer R, Saarinen AM, et al. Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression. Cancer Lett. 2023;569:216306.","journal-title":"Cancer Lett"},{"issue":"1","key":"3769_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13045-022-01297-1","volume":"15","author":"Y Xie","year":"2022","unstructured":"Xie Y, Wang B, Zhao Y, Tao Z, Wang Y, Chen G, et al. Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis. J Hematol Oncol. 2022;15(1):72.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"3769_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-025-02258-1","volume":"24","author":"M Wan","year":"2025","unstructured":"Wan M, Pan S, Shan B, Diao H, Jin H, Wang Z, et al. Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment. Mol Cancer. 2025;24(1):61.","journal-title":"Mol Cancer"},{"issue":"1","key":"3769_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41523-021-00324-7","volume":"7","author":"J Gyamfi","year":"2021","unstructured":"Gyamfi J, Yeo JH, Kwon D, Min BS, Cha YJ, Koo JS, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7(1):129.","journal-title":"NPJ Breast Cancer"},{"issue":"5","key":"3769_CR13","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3181\/0710-MR-287","volume":"233","author":"E Soupene","year":"2008","unstructured":"Soupene E, Kuypers FA. Mammalian long-chain acyl-CoA synthetases. Exp Biol Med (Maywood). 2008;233(5):507\u201321.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"2","key":"3769_CR14","doi-asserted-by":"publisher","first-page":"e13316","DOI":"10.1016\/j.heliyon.2023.e13316","volume":"9","author":"Q Luo","year":"2023","unstructured":"Luo Q, Das A, Oldoni F, Wu P, Wang J, Luo F, et al. Role of ACSL5 in fatty acid metabolism. Heliyon. 2023;9(2):e13316.","journal-title":"Heliyon"},{"issue":"6","key":"3769_CR15","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/s41418-025-01642-0","volume":"33","author":"T Hu","year":"2026","unstructured":"Hu T, Ma T, Huo M, Liu J, Zhang D, Li Y, et al. JAB1\/CRL4B complex represses PPARG\/ACSL5 expression to promote breast tumorigenesis. Cell Death Differ. 2026;33(6):1175\u201391.","journal-title":"Cell Death Differ"},{"issue":"1","key":"3769_CR16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","volume":"122","author":"N Koundouros","year":"2020","unstructured":"Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122(1):4\u201322.","journal-title":"Br J Cancer"},{"key":"3769_CR17","doi-asserted-by":"crossref","unstructured":"Tian S, Zhang Q, Sun X, Thorne RF, Shi Z, Ji Q, et al. ACSL5 regulates glucose metabolism and chemotherapy sensitivity in colorectal cancer cells under glutamine deficiency. Adv Sci (Weinh). 2026;13(7):e10801.","DOI":"10.1002\/advs.202510801"},{"key":"3769_CR18","doi-asserted-by":"publisher","first-page":"174397","DOI":"10.1016\/j.ejphar.2021.174397","volume":"909","author":"J Quan","year":"2021","unstructured":"Quan J, Bode AM, Luo X. ACSL family: The regulatory mechanisms and therapeutic implications in cancer. Eur J Pharmacol. 2021;909:174397.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"3769_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.prp.2016.09.002","volume":"213","author":"F Hartmann","year":"2017","unstructured":"Hartmann F, Sparla D, Tute E, Tamm M, Schneider U, Jeon MK, et al. Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence. Pathol Res Pract. 2017;213(3):261\u20136.","journal-title":"Pathol Res Pract"},{"issue":"34","key":"3769_CR20","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1038\/s41388-025-03474-1","volume":"44","author":"Y Luo","year":"2025","unstructured":"Luo Y, Zeng Y, Liu Y, Liu S, Dai Y, Pan W, et al. ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation. Oncogene. 2025;44(34):3096\u2013112.","journal-title":"Oncogene"},{"issue":"19","key":"3769_CR21","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1038\/s41388-023-02665-y","volume":"42","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Xiong L, Wei T, Liu Q, Yan L, Chen J, et al. Hypoxia-responsive PPARGC1A\/BAMBI\/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma. Oncogene. 2023;42(19):1509\u201323.","journal-title":"Oncogene"},{"key":"3769_CR22","doi-asserted-by":"publisher","first-page":"108507","DOI":"10.1016\/j.compbiolchem.2025.108507","volume":"119","author":"MZ Liang","year":"2025","unstructured":"Liang MZ, Huang XF, Zhu JC, Bao JX, Chen CL, Wang XW, et al. A machine learning-based glycolysis and fatty acid metabolism-related prognostic signature is constructed and identified ACSL5 as a novel marker inhibiting the proliferation of breast cancer. Comput Biol Chem. 2025;119:108507.","journal-title":"Comput Biol Chem"},{"issue":"21","key":"3769_CR23","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1016\/j.molcel.2022.09.018","volume":"82","author":"T Hou","year":"2022","unstructured":"Hou T, Tian Y, Cao Z, Zhang J, Feng T, Tao W, et al. Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation. Mol Cell. 2022;82(21):4099\u2013115. e9.","journal-title":"Mol Cell"},{"issue":"12","key":"3769_CR24","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.tem.2022.10.004","volume":"33","author":"M Zang","year":"2022","unstructured":"Zang M, Gao B. SIRT6: therapeutic target for nonalcoholic fatty liver disease. Trends Endocrinol Metab. 2022;33(12):801\u20133.","journal-title":"Trends Endocrinol Metab"},{"key":"3769_CR25","doi-asserted-by":"publisher","first-page":"103834","DOI":"10.1016\/j.redox.2025.103834","volume":"86","author":"M Guo","year":"2025","unstructured":"Guo M, Wang YJ, Shi J, Cao LX, Ou Y, Jia X, et al. Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer. Redox Biol. 2025;86:103834.","journal-title":"Redox Biol"},{"issue":"52","key":"3769_CR26","doi-asserted-by":"publisher","first-page":"e2408049121","DOI":"10.1073\/pnas.2408049121","volume":"121","author":"A Sinha","year":"2024","unstructured":"Sinha A, Saini KK, Chandramouli A, Tripathi K, Khan MA, Satrusal SR, et al. ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis. Proc Natl Acad Sci U S A. 2024;121(52):e2408049121.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"3769_CR27","doi-asserted-by":"publisher","first-page":"112939","DOI":"10.1016\/j.celrep.2023.112939","volume":"42","author":"K Zhao","year":"2023","unstructured":"Zhao K, Zheng M, Su Z, Ghosh S, Zhang C, Zhong W, et al. MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. Cell Rep. 2023;42(8):112939.","journal-title":"Cell Rep"},{"issue":"9","key":"3769_CR28","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/s41388-020-01637-w","volume":"40","author":"YLN Abril","year":"2021","unstructured":"Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, et al. Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene. 2021;40(9):1644\u201358.","journal-title":"Oncogene"},{"issue":"5","key":"3769_CR29","first-page":"2315","volume":"39","author":"L Xu","year":"2018","unstructured":"Xu L, Che X, Wu Y, Song N, Shi S, Wang S, et al. SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer. Oncol Rep. 2018;39(5):2315\u201323.","journal-title":"Oncol Rep"},{"issue":"1","key":"3769_CR30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40170-021-00240-1","volume":"9","author":"P Becherini","year":"2021","unstructured":"Becherini P, Caffa I, Piacente F, Damonte P, Vellone VG, Passalacqua M, et al. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice. Cancer Metab. 2021;9(1):6.","journal-title":"Cancer Metab"},{"issue":"12","key":"3769_CR31","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1038\/s41591-024-03011-9","volume":"30","author":"P Bhat-Nakshatri","year":"2024","unstructured":"Bhat-Nakshatri P, Gao H, Khatpe AS, Adebayo AK, McGuire PC, Erdogan C, et al. Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry. Nat Med. 2024;30(12):3482\u201394.","journal-title":"Nat Med"},{"issue":"1","key":"3769_CR32","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/s13046-025-03568-4","volume":"44","author":"Z Zhou","year":"2025","unstructured":"Zhou Z, Hua Y, Ma J, Cong W, Zhan R, Kang K, et al. Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism. J Exp Clin Cancer Res. 2025;44(1):323.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"3769_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12935-024-03505-z","volume":"24","author":"G Wang","year":"2024","unstructured":"Wang G, Shi C, He L, Li Y, Song W, Chen Z, et al. Identification of the tumor metastasis-related tumor subgroups overexpressed NENF in triple-negative breast cancer by single-cell transcriptomics. Cancer Cell Int. 2024;24(1):319.","journal-title":"Cancer Cell Int"},{"key":"3769_CR34","doi-asserted-by":"publisher","first-page":"843515","DOI":"10.3389\/fimmu.2022.843515","volume":"13","author":"Y Tang","year":"2022","unstructured":"Tang Y, Tian W, Xie J, Zou Y, Wang Z, Li N, et al. Prognosis and Dissection of Immunosuppressive Microenvironment in Breast Cancer Based on Fatty Acid Metabolism-Related Signature. Front Immunol. 2022;13:843515.","journal-title":"Front Immunol"},{"key":"3769_CR35","doi-asserted-by":"publisher","first-page":"133812","DOI":"10.1016\/j.jhazmat.2024.133812","volume":"468","author":"L Zhang","year":"2024","unstructured":"Zhang L, Shi WY, Xu JY, Liu Y, Wang SJ, Zheng JY, et al. Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage. J Hazard Mater. 2024;468:133812.","journal-title":"J Hazard Mater"},{"key":"3769_CR36","doi-asserted-by":"crossref","unstructured":"Richardson DS, Spehar JM, Han DT, Chakravarthy PA, Sizemore ST. The RAL Enigma: Distinct Roles of RALA and RALB in Cancer. Cells. 2022;11(10):1645.","DOI":"10.3390\/cells11101645"},{"issue":"1","key":"3769_CR37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s43556-025-00366-4","volume":"6","author":"X Deng","year":"2025","unstructured":"Deng X, Luo Y, Gao Y, Wu T. Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets. Mol Biomed. 2025;6(1):117.","journal-title":"Mol Biomed"},{"issue":"10","key":"3769_CR38","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1002\/ijc.34859","volume":"154","author":"I Rybinska","year":"2024","unstructured":"Rybinska I, Mangano N, Romero-Cordoba SL, Regondi V, Ciravolo V, De Cecco L, et al. SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness. Int J Cancer. 2024;154(10):1842\u201356.","journal-title":"Int J Cancer"},{"issue":"1","key":"3769_CR39","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41420-025-02713-4","volume":"11","author":"GT Ruan","year":"2025","unstructured":"Ruan GT, Zhu LC, Xie HL, Zhang HY, Song MM, Deng L, et al. Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3\/NF-kappaB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells. Cell Death Discov. 2025;11(1):395.","journal-title":"Cell Death Discov"},{"key":"3769_CR40","doi-asserted-by":"publisher","first-page":"217271","DOI":"10.1016\/j.canlet.2024.217271","volume":"604","author":"L Yu","year":"2024","unstructured":"Yu L, Wei W, Lv J, Lu Y, Wang Z, Cai C. FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity. Cancer Lett. 2024;604:217271.","journal-title":"Cancer Lett"},{"issue":"42","key":"3769_CR41","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1038\/s41388-025-03534-6","volume":"44","author":"Z Wu","year":"2025","unstructured":"Wu Z, Duan W, Xiong Y, Liu J, Wen X, Zhao F, et al. NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation. Oncogene. 2025;44(42):4017\u201331.","journal-title":"Oncogene"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13046-026-03769-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-026-03769-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13046-026-03769-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:08:02Z","timestamp":1789520882000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13046-026-03769-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3769"],"URL":"https:\/\/doi.org\/10.1186\/s13046-026-03769-5","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Animal Ethics Committee of the Affiliated Hospital of Qingdao University and were performed in accordance with institutional guidelines. All experiments involved in this study have been approved by the Medical Ethics Committee of the Affiliated Hospital of Qingdao University. All patients provided informed consent.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree to the publication of this article.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"197"}}