{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:48:02Z","timestamp":1787237282786,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Foot and Ankle Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of the present study was to examine the relationship between ankle joint laxity and general joint laxity (GJL) in relation to the menstrual cycle, which was divided into four phases based on basal body temperature and ovulation, assessed using an ovulation kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 14 female college students (21\u201322 years) with normal menstrual cycles (cis gender). Anterior drawer stress to a magnitude of 120\u00a0N was applied for all participants. Anterior talofibular ligament (ATFL) length was measured as the linear distance (mm) between its points of attachment on the lateral malleolus and talus using ultrasonography. Data on ATFL length from each subject were used to calculate each subject's normalized length change with anterior drawer stress (AD%). The University of Tokyo method was used for evaluation of GJL. AD% and GJL were measured once in each menstrual phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistically significant difference between AD% in each phase. GJL score was significantly higher in the ovulation and luteal phases compared with the early follicular phase. AD% and GJL showed a positive correlation with each other in the ovulation phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although it is unclear whether estrogen receptors are present in the ATFL, the present study suggests that women with high GJL scores might be more sensitive to the effects of estrogen, resulting in ATFL length change in the ovulation phase.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13047-021-00459-7","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T05:02:52Z","timestamp":1616562172000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A preliminary study exploring the change in ankle joint laxity and general joint laxity during the menstrual cycle in cis women"],"prefix":"10.1002","volume":"14","author":[{"given":"Tomomi","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiya","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ikezu","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-6466","authenticated-orcid":false,"given":"Mutsuaki","family":"Edama","sequence":"additional","affiliation":[{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare 950\u20103198 Shimami\u2010cho 1398, Kita\u2010Ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506295699"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508330146"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505282624"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010007\u20100461\u20101"},{"key":"e_1_2_11_6_1","first-page":"19","article-title":"Periodicity of noncontact anterior cruciate ligament injuries during the menstrual cycle","volume":"5","author":"Arendt EA","year":"2002","journal-title":"J Gend Specif Med"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465020300020601"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967117718781"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140405"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"YuWD PanossianV HatchJD LiuSH FinermanGA. 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November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the families of all subjects. This study was approved by the ethics committee of the Niigata University of Health and Welfare, Niigata, Japan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}