{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:45:08Z","timestamp":1762508708569,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Foot and Ankle Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To systematically evaluate the literature investigating the relationship between cutaneous microvascular reactivity in the foot of adults with diabetes\u2010related Charcot neuroarthropathy compared to a non\u2010Charcot adult control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted to June 2021 using the biomedical databases EBSCO Megafile Ultimate, Cochrane Library and EMBASE. Original research conducting comparative investigation of cutaneous microvascular reactivity in the foot of adults with diabetes and any pattern of acute or chronic Charcot neuroarthropathy and any non\u2010Charcot adult control groups were included. A modified Critical Appraisal Skills Programme tool was used for quality appraisal. Cutaneous microvascular reactivity in diabetes\u2010related Charcot neuroarthropathy data were synthesised and meta\u2010analysis conducted where possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search strategy identified 1,684 articles, with seven eligible for inclusion. Included studies used various methodologies and equipment to assess cutaneous microvascular reactivity in 553 participants (162 with Charcot neuroarthropathy). Cutaneous microvascular reactivity in Charcot neuroarthropathy groups was impaired compared to uncomplicated diabetes groups. Meta\u2010analysis investigating the difference in response to thermal hyperaemia demonstrated a significant difference in cutaneous microvascular reactivity between Charcot neuroarthropathy and peripheral neuropathy with a large, pooled effect size (SMD 1.46 95% CI: 0.89\u20132.02) and low heterogeneity (<jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009=\u20094%, <jats:italic>T<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009<jats:italic>=<\/jats:italic>\u20090.01) indicating that the cutaneous microvascular response is more impaired in peripheral neuropathy than in Charcot neuroarthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Charcot neuroarthropathy is associated with greater cutaneous microvascular reactivity in the periphery relative to diabetes cohorts with diabetes\u2010related peripheral neuropathy alone. It is unknown if this occurs prior to, or as a result of, Charcot neuroarthropathy.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13047-022-00522-x","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T07:02:37Z","timestamp":1646118157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous microvascular reactivity in Charcot neuroarthropathy: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Sean Michael","family":"Lanting","sequence":"first","affiliation":[{"name":"College of Health, Medicine and Wellbeing School of Health Sciences University of Newcastle Ourimbah NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsz Long","family":"Chan","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing School of Health Sciences University of Newcastle Ourimbah NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Louise","family":"Casey","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing School of Health Sciences University of Newcastle Ourimbah NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin John","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Podiatry School of Health Medical and Applied Sciences CQUniversity Rockhampton QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne Helaine","family":"Chuter","sequence":"additional","affiliation":[{"name":"School of Health Sciences Western Sydney University Campbelltown NSW Australia"},{"name":"College of Health, Medicine and Wellbeing School of Health Sciences University of Newcastle Ourimbah NSW 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