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A national expert panel aimed to systematically identify and adapt suitable international guidelines to the Australian context to create new Australian evidence\u2010based guidelines on prevention of first\u2010ever and\/or recurrent DFU. These guidelines will include for the first\u2010time considerations for rural and remote, and Aboriginal and Torres Strait Islander peoples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Health and Medical Research Council procedures were followed to adapt suitable international guidelines on DFU prevention to the Australian health context. This included a search of public databases after which the International Working Group on the Diabetic Foot (IWGDF) prevention guideline was deemed the most appropriate for adaptation. The 16 IWGDF prevention recommendations were assessed using the ADAPTE and GRADE systems to decide if they should be adopted, adapted or excluded for the new Australian guideline. The quality of evidence and strength of recommendation ratings were re\u2010evaluated with reference to the Australian context. This guideline underwent public consultation, further revision, and approval by national peak bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 16 original IWGDF prevention recommendations, nine were adopted, six were adapted and one was excluded. It is recommended that all people at increased risk of DFU are assessed at intervals corresponding to the IWGDF risk ratings. For those at increased risk, structured education about appropriate foot protection, inspection, footwear, weight\u2010bearing activities, and foot self\u2010care is recommended. Prescription of orthotic interventions and\/or medical grade footwear, providing integrated foot care, and self\u2010monitoring of foot skin temperatures (contingent on validated, user\u2010friendly and affordable systems becoming available in Australia) may also assist in preventing DFU. If the above recommended non\u2010surgical treatment fails, the use of various surgical interventions for the prevention of DFU can be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This new Australian evidence\u2010based guideline on prevention of DFU, endorsed by 10\u00a0national peak bodies, provides specific recommendations for relevant health professionals and consumers in the Australian context to prevent DFU. 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September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The funding\/supporting bodies below provided oversight and final approval for this guideline, however, did not have any input into the decisions on recommendations and rationale contained in these guidelines or in the writing of these guidelines. 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