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There is a pressing need for updated guidelines on wound healing interventions to improve outcomes for people living with DFU. A national expert panel was convened to develop new Australian evidence\u2010based guidelines on wound healing interventions for people with DFU by adapting suitable international guidelines to the Australian context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The panel followed National Health and Medical Research Council (NHMRC) procedures to adapt suitable international guidelines by the International Working Group of the Diabetic Foot (IWGDF) to the Australian context. The panel systematically screened, assessed and judged all IWGDF wound healing recommendations using ADAPTE and GRADE frameworks for adapting guidelines to decide which recommendations should be adopted, adapted or excluded in the Australian context. Each recommendation had their wording, quality of evidence, and strength of recommendation re\u2010evaluated, plus rationale, justifications and implementation considerations provided for the Australian context. This guideline underwent public consultation, further revision and approval by ten national peak bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen IWGDF wound healing recommendations were evaluated in this process. After screening, nine recommendations were adopted and four were adapted after full assessment. Two recommendations had their strength of recommendations downgraded, one intervention was not currently approved for use in Australia, one intervention specified the need to obtain informed consent to be acceptable in Australia, and another was reworded to clarify best standard of care. Overall, five wound healing interventions have been recommended as having the evidence\u2010based potential to improve wound healing in specific types of DFU when used in conjunction with other best standards of DFU care, including sucrose\u2010octasulfate impregnated dressing, systemic hyperbaric oxygen therapy, negative pressure wound therapy, placental\u2010derived products, and the autologous combined leucocyte, platelet and fibrin dressing. The six new guidelines and the full protocol can be found at: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/diabetesfeetaustralia.org\/new-guidelines\/\">https:\/\/diabetesfeetaustralia.org\/new\u2010guidelines\/<\/jats:ext-link><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IWGDF guideline for wound healing interventions has been adapted to suit the Australian context, and in particular for geographically remote and Aboriginal and Torres Strait Islander people. This new national wound healing guideline, endorsed by ten national peak bodies, also highlights important considerations for implementation, monitoring, and future research priorities in Australia.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13047-022-00544-5","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T03:51:44Z","timestamp":1653450704000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Australian guideline on wound healing interventions to enhance healing of foot ulcers: part of the 2021 Australian evidence\u2010based guidelines for diabetes\u2010related foot disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-5050","authenticated-orcid":false,"given":"Pamela","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine University of Tasmania Hobart Australia"},{"name":"Podiatric Medicine and Surgery, School of Allied Health The University of Western Australia Perth Australia"},{"name":"Joondalup Health Campus, Ramsay Healthcare Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keryln","family":"Carville","sequence":"additional","affiliation":[{"name":"Silver Chain Group and Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Swanson","sequence":"additional","affiliation":[{"name":"Nurse Practitioner Warrnambool Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Lazzarini","sequence":"additional","affiliation":[{"name":"School of Public Health and Social Work Queensland University of Technology Brisbane Australia"},{"name":"Allied Health Research Collaborative, The Prince Charles Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Charles","sequence":"additional","affiliation":[{"name":"First Peoples Health Unit, Faculty of Health Griffith University Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Cheney","sequence":"additional","affiliation":[{"name":"Diabetes Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Prentice","sequence":"additional","affiliation":[{"name":"Hall and Prior Health and Aged Care Group Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Australian Diabetes\u2010related Foot Disease Guidelines & Pathways Project","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20101614"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(05)67698\u20102"},{"key":"e_1_2_12_4_1","unstructured":"National Diabetes Service Scheme(2019)The Australian diabetes map. 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October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The funding\/supporting bodies below provided oversight and final approval for this guideline, however, did not have any input into the decisions on recommendations and rationale contained in these guidelines or in the writing of these guidelines. PC is the president of the Advanced Practicing Podiatrists \u2013 High Risk Foot Group and a member of the National Association of Diabetes Centres Foot Network Committee. TS participates on several industry related and specialty boards as well as providing education on behalf of industry partners; however, notes no relevant competing interests for this project. PAL has been a speaker consultant with Sanofi Australia, is chair of Diabetes Feet Australia, and is a member of the Journal of Foot & Ankle Editorial Board, National Association of Diabetes Centres Foot Network Committee, and Aboriginal and Torres Strait Islander Diabetic Foot Complications Program Expert Advisory Committee. JChe is employed by Diabetes Victoria and is fully funded by the National Diabetes Services Scheme. All other authors declare that they have no relevant competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40"}}