{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:42Z","timestamp":1787020842836,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13048-019-0525-1","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T13:03:52Z","timestamp":1558789432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Development of Peritoneal Carcinoma in women diagnosed with Serous Tubal Intraepithelial Carcinoma (STIC) following Risk-Reducing Salpingo-Oophorectomy (RRSO)"],"prefix":"10.1186","volume":"12","author":[{"given":"P. I.","family":"Stanciu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E. J.","family":"Ind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. P. J.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Vroobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Attygalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A. E.","family":"Nobbenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,25]]},"reference":[{"issue":"5","key":"525_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrclinonc.2016.191","volume":"14","author":"A George","year":"2017","unstructured":"George A, Kaye S, Banerjee S. Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer. Nat Rev Clin Oncol. 2017;14(5):284\u201396.","journal-title":"Nat Rev Clin Oncol"},{"key":"525_CR2","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1001\/jama.2017.7112","volume":"317","author":"KB Kuchenbaecker","year":"2017","unstructured":"Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317:2402\u201316.","journal-title":"JAMA"},{"key":"525_CR3","volume-title":"Frontiers in ovarian Cancer science","author":"M Sekine","year":"2017","unstructured":"Sekine M, Enomoto T. Hereditary ovarian Cancer. In: Katabuchi H, editor. Frontiers in ovarian Cancer science. Singapore: Comprehensive Gynecology and Obstetrics. Springer; 2017."},{"key":"525_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/PGP.0b013e31822ea955","volume":"31","author":"S Tang","year":"2012","unstructured":"Tang S, Onuma K, Deb P, Wang E, Lytwyn A, Sur M, Daya D. Frequency of serous tubal intraepithelial carcinoma in various gynecologic malignancies: a study of 300 consecutive cases. Int J Gynecol Pathol. 2012;31:103\u201310.","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"525_CR5","first-page":"848","volume":"7","author":"H-X Li","year":"2014","unstructured":"Li H-X, Lu Z-H, Shen K, et al. Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis. Int J Clin Exp Pathol. 2014;7(3):848\u201357.","journal-title":"Int J Clin Exp Pathol"},{"key":"525_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/path.2091","volume":"211","author":"Y Lee","year":"2007","unstructured":"Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2007;211:26\u201335.","journal-title":"J Pathol"},{"key":"525_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/01.pgp.0000101082.35393.84","volume":"23","author":"ML Carcangiu","year":"2004","unstructured":"Carcangiu ML, Radice P, Manoukian S, Spatti G, Gobbo M, Pensotti V, Crucianelli R, Pasini B. Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers. Int J Gynecol Pathol. 2004;23:35\u201340.","journal-title":"Int J Gynecol Pathol"},{"issue":"7","key":"525_CR8","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","volume":"42","author":"RJ Kurman","year":"2011","unstructured":"Kurman RJ, Shih IM. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. Hum Pathol. 2011;42(7):918\u201331.","journal-title":"Hum Pathol"},{"key":"525_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/path.2784","volume":"223","author":"AM Goh","year":"2011","unstructured":"Goh AM, Coffill CR, Lane DP. The role of mutant p53 in human cancer. J Pathol. 2011;223:116\u201326.","journal-title":"J Pathol"},{"key":"525_CR10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/path.2696","volume":"221","author":"AA Ahmed","year":"2010","unstructured":"Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, Sharma R, Stewart C, Fereday S, Caldas C, Defazio A, Bowtell D, Brenton JD. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol. 2010;221:49\u201356.","journal-title":"J Pathol"},{"key":"525_CR11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nrc2946","volume":"10","author":"DD Bowtell","year":"2010","unstructured":"Bowtell DD. The genesis and evolution of high-grade serous ovarian cancer. Nat Rev Cancer. 2010;10:803\u20138.","journal-title":"Nat Rev Cancer"},{"key":"525_CR12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/path.3023","volume":"226","author":"E Kuhn","year":"2012","unstructured":"Kuhn E, Kurman RJ, Vang R, Sehdev AS, Han G, Soslow R, Wang TL, Shih Ie M. TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma--evidence supporting the clonal relationship of the two lesions. J Pathol. 2012;226:421\u20136.","journal-title":"J Pathol"},{"issue":"10022","key":"525_CR13","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/S0140-6736(15)01224-6","volume":"387","author":"IJ Jacobs","year":"2016","unstructured":"Jacobs IJ, et al. Ovarian cancer screening and mortality in the UK collaborative trial of ovarian Cancer screening (UKCTOCS): a randomised controlled trial. Lancet. 2016;387(10022):945\u201356.","journal-title":"Lancet."},{"key":"525_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/jnci\/djn442","volume":"101","author":"TR Rebbeck","year":"2009","unstructured":"Rebbeck TR, Kauff ND, Domchek SM. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst. 2009;101:80\u20137.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"525_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1001\/jama.296.2.185","volume":"296","author":"A Finch","year":"2006","unstructured":"Finch A, Beiner M, Lubinski J, et al. Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 mutation. JAMA. 2006;296(2):185\u201392.","journal-title":"JAMA."},{"issue":"15","key":"525_CR16","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1200\/JCO.2013.53.2820","volume":"32","author":"AP Finch","year":"2014","unstructured":"Finch AP, Lubinski J, M\u00f8ller P, Singer CF, Karlan B, Senter L, et al. Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol. 2014;32(15):1547\u201353.","journal-title":"J Clin Oncol"},{"issue":"9","key":"525_CR17","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1001\/jama.2010.1237","volume":"304","author":"SM Domchek","year":"2010","unstructured":"Domchek SM, Friebel TM, Singer CF, Evans DG, Lynch HT, Isaacs C, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA. 2010;304(9):967\u201375.","journal-title":"JAMA."},{"issue":"5","key":"525_CR18","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1097\/AOG.0b013e3181a11c64","volume":"113","author":"WH Parker","year":"2009","unstructured":"Parker WH, Broder MS, Chang E, Feskanich D, Farquhar C, Liu Z, et al. Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses\u2019 health study. Obstet Gynecol. 2009;113(5):1027\u201337.","journal-title":"Obstet Gynecol"},{"key":"525_CR19","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1056\/NEJMra1503523","volume":"374","author":"LC Hartmann","year":"2016","unstructured":"Hartmann LC, Lindor NM. The role of risk-reducing surgery in hereditary breast and ovarian cancer. N Engl J Med. 2016;374:454\u201368.","journal-title":"N Engl J Med"},{"key":"525_CR20","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1056\/NEJMoa012158","volume":"346","author":"TR Rebbeck","year":"2002","unstructured":"Rebbeck TR, Lynch HT, Neuhausen SL, et al. Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med. 2002;346:1616\u201322.","journal-title":"N Engl J Med"},{"issue":"1","key":"525_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1006\/gyno.2002.6779","volume":"87","author":"K Leeper","year":"2002","unstructured":"Leeper K, Garcia R, Swisher E, Goff B, Greer B, Paley P. Pathologic findings in prophylactic oophorectomy specimens in high-risk women. Gynecol Oncol. 2002;87(1):52\u20136.","journal-title":"Gynecol Oncol"},{"issue":"14","key":"525_CR22","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1200\/JCO.2000.18.14.2728","volume":"18","author":"KH Lu","year":"2000","unstructured":"Lu KH, Garber JE, Cramer DW, Welch WR, Niloff J, Schrag D, et al. Occult ovarian tumors in women with BRCA1 or BRCA2 mutations undergoing prophylactic oophorectomy. J Clin Oncol. 2000;18(14):2728\u201332.","journal-title":"J Clin Oncol"},{"key":"525_CR23","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1097\/IGC.0b013e3182a80ac8","volume":"23","author":"SL Wethington","year":"2013","unstructured":"Wethington SL, Park KJ, Soslow RA, Kauff ND, Brown CL, Dao F, et al. Clinical outcome of isolated serous tubal intraepithelial carcinomas (STIC). Int J Gynecol Cancer. 2013;23:1603\u201311.","journal-title":"Int J Gynecol Cancer"},{"key":"525_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.pap.0000201826.46978.e5","volume":"13","author":"Y Lee","year":"2006","unstructured":"Lee Y, Medeiros F, Kindelberger D, et al. Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the patho- genesis of ovarian cancer. Adv Anat Pathol. 2006;13:1\u20137.","journal-title":"Adv Anat Pathol"},{"key":"525_CR25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/j.1471-0528.2011.02920.x","volume":"118","author":"R Manchanda","year":"2011","unstructured":"Manchanda R, Abdelraheim A, Johnson M, et al. Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status. BJOG. 2011;118:814\u201324.","journal-title":"BJOG."},{"issue":"8","key":"525_CR26","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.clon.2018.03.036","volume":"30","author":"NMA Van der Hoeven","year":"2018","unstructured":"Van der Hoeven NMA, Van Wijk K, Bonfrer SE, et al. Outcome and prognostic impact of surgical staging in serous tubal intraepithelial carcinoma: a cohort study and systematic review. Oncol (R Coll Radiol). 2018;30(8):463\u201371.","journal-title":"Oncol (R Coll Radiol)"},{"issue":"3","key":"525_CR27","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ygyno.2015.09.018","volume":"139","author":"MG Patrono","year":"2015","unstructured":"Patrono MG, Iniesta MD, Malpica A, Lu KH, Fernandez RO, Salvo G, Ramirez PT. Clinical outcomes in patients with isolated serous tubal intraepithelial carcinoma (STIC): a comprehensive review. Gynecol Oncol. 2015;139(3):568\u201372.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"525_CR28","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ygyno.2013.01.029","volume":"129","author":"CB Powell","year":"2013","unstructured":"Powell CB, Swisher EM, Cass I, McLennan J, Norquist B, Garcia RL, Lester J, Karlan BY, Chen L. Long term follow up of BRCA1 and BRCA2 mutation carriers with unsuspected neoplasia identified at risk reducing salpingo-oophorectomy. Gynecol Oncol. 2013;129(2):364\u201371.","journal-title":"Gynecol Oncol"},{"issue":"12","key":"525_CR29","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1080\/14737140.2016.1247699","volume":"16","author":"V Weinberger","year":"2016","unstructured":"Weinberger V, Bednarikova M, Cibula D, Zikan M. Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management. Expert Rev Anticancer Ther. 2016;16(12):1311\u201321.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"2","key":"525_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.5152\/jtgga.2016.15223","volume":"17","author":"C Iavazzo","year":"2016","unstructured":"Iavazzo C, Gkegkes ID, Vrachnis N. Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy. J Turk Ger Gynecol Assoc. 2016;17(2):73\u20136.","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"525_CR31","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.critrevonc.2013.03.004","volume":"88","author":"G Chene","year":"2013","unstructured":"Chene G, Dauplat J, Radosevic-Robin N, Cayre A, Penault-Llorca F. Tu-be or not tu-be: that is the question\u2026 about serous ovarian carcinogenesis. Crit Rev Oncol Hematol. 2013;88:134\u201343.","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-019-0525-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13048-019-0525-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-019-0525-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T19:06:04Z","timestamp":1590260764000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-019-0525-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,25]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["525"],"URL":"https:\/\/doi.org\/10.1186\/s13048-019-0525-1","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,25]]},"assertion":[{"value":"22 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All the patients that were included in the study signed the consent for the procedure, for research, teaching and publication purposes. For this retrospective study, the Royal Marsden Ethics Committee approval was waived.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the patients that were included in the study signed the consent for the procedure, for research, teaching and publication purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"50"}}