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Cells were divided into four groups: Control, 100\u2009\u03bcmol\/L, 200\u2009\u03bcmol\/L and 300\u2009\u03bcmol\/L. Compared with the control group, the viability, colony formation, migration and invasion of SKOV3 cells were inhibited, and the apoptosis of SKOV3 cells were enhanced significantly at 200\u2009\u03bcmol\/L and 300\u2009\u03bcmol\/L baclofen. Moreover, they changed significantly with the increase of baclofen concentration. Compared with the control group, the expression of E-cadherin and GABAB1 increased and the N-cadherin expression decreased significantly in 200\u2009\u03bcmol\/L and 300\u2009\u03bcmol\/L groups. Higher concentration of baclofen induced higher expression of E-cadherin and lower expression of N-cadherin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baclofen inhibited the proliferation, cloning, migration, invasion and EMT of ovarian cancer cells by activating GABAB1 receptor. These results might contribute a lot to clarify the role and possible mechanism of GABAB1 receptor in ovarian cancer.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13048-020-00726-4","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T17:02:29Z","timestamp":1603558949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells"],"prefix":"10.1186","volume":"13","author":[{"given":"Jun","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-2798","authenticated-orcid":false,"given":"Hong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-5417","authenticated-orcid":false,"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"726_CR1","first-page":"3439","volume":"19","author":"A Ginestra","year":"2016","unstructured":"Ginestra A, Miceli D, Dolo V, et al. 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