{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:54:28Z","timestamp":1794563668530,"version":"4.9.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Department of Finance of JiLin Province, China","award":["JLSCZD2019-078"],"award-info":[{"award-number":["JLSCZD2019-078"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Microcystic stromal tumor (MCST) of the ovary is an extremely rare subtype of sex cord-stromal neoplasm first described by Irving and Young in 2009. Tumors from all previously reported cases (fewer than 40 total) were benign, but one was a case of ovarian MCST that reoccurred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Herein, we present a unique single case of ovarian MCST with omental metastasis in a 47-year-old Chinese female along with its histologic and immunohistochemical profile and genetic alterations. The tumor exhibited the previously described classic microscopic features and immunoprofiles of MCST. The tumorlet in the omentum presented the same histological structures and characteristically expressed \u03b2-catenin protein (localized in the nucleus). Molecular analysis identified a point mutation (c.98C\u2009&gt;\u2009G) in exon 3 of <jats:italic>CTNNB1<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To the best of our knowledge, no such report has been documented for ovarian MCST with omental metastasis. The study may provide new insights into the tumor biology of MCST and provide a better understanding of this rare entity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13048-021-00812-1","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T10:08:37Z","timestamp":1622110117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ovarian microcystic stromal tumor with omental metastasis: the first case report and literature review"],"prefix":"10.1186","volume":"14","author":[{"given":"Xiaxia","family":"Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baogang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"3","key":"812_CR1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/PAS.0b013e31818479c3","volume":"33","author":"JA Irving","year":"2009","unstructured":"Irving JA, Young RH. Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm. Am J Surg Pathol. 2009;33(3):367\u201375. https:\/\/doi.org\/10.1097\/PAS.0b013e31818479c3.","journal-title":"Am J Surg Pathol"},{"key":"812_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.humpath.2018.02.012","volume":"78","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Tao L, Yin C, Wang W, Zou H, Ren Y, et al. Ovarian microcystic stromal tumor with undetermined potential: case study with molecular analysis and literature review. Hum Pathol. 2018;78:171\u20136. https:\/\/doi.org\/10.1016\/j.humpath.2018.02.012.","journal-title":"Hum Pathol"},{"issue":"10","key":"812_CR3","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1097\/PAS.0000000000000482","volume":"39","author":"JA Irving","year":"2015","unstructured":"Irving JA, Lee CH, Yip S, Oliva E, McCluggage WG, Young RH. Microcystic stromal tumor: a distinctive ovarian sex cord-stromal neoplasm characterized by FOXL2, SF-1, WT-1, Cyclin D1, and \u03b2-catenin nuclear expression and CTNNB1 mutations. Am J Surg Pathol. 2015;39(10):1420\u20136. https:\/\/doi.org\/10.1097\/PAS.0000000000000482.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"812_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/PAS.0000000000000981","volume":"42","author":"WG McCluggage","year":"2018","unstructured":"McCluggage WG, Irving JA, Chong AS, Clarke BA, Young RH, Foulkes WD, et al. Ovarian microcystic stromal tumors are characterized by alterations in the Beta-catenin-APC pathway and may be an Extracolonic manifestation of familial adenomatous polyposis. Am J Surg Pathol. 2018;42(1):137\u20139. https:\/\/doi.org\/10.1097\/PAS.0000000000000981.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"812_CR5","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1097\/PAS.0b013e31822d6c71","volume":"35","author":"D Maeda","year":"2011","unstructured":"Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, et al. \u03b2-Catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors. Am J Surg Pathol. 2011;35(10):1429\u201340. https:\/\/doi.org\/10.1097\/PAS.0b013e31822d6c71.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"812_CR6","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/his.12722","volume":"67","author":"R Bi","year":"2015","unstructured":"Bi R, Bai QM, Yang F, Wu LJ, Cheng YF, Shen XX, et al. Microcystic stromal tumour of the ovary: frequent mutations of \u03b2-catenin (CTNNB1) in six cases. Histopathology. 2015;67(6):872\u20139. https:\/\/doi.org\/10.1111\/his.12722.","journal-title":"Histopathology."},{"issue":"2","key":"812_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/PGP.0000000000000122","volume":"34","author":"YN Kang","year":"2015","unstructured":"Kang YN, Cho CH, Kwon SY. Microcystic stromal tumor of the ovary with mutation in exon 3 of \u03b2-catenin: a case report. Int J Gynecol Pathol. 2015;34(2):121\u20135. https:\/\/doi.org\/10.1097\/PGP.0000000000000122.","journal-title":"Int J Gynecol Pathol"},{"issue":"6","key":"812_CR8","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.21873\/anticanres.11688","volume":"37","author":"K Na","year":"2017","unstructured":"Na K, Kim EK, Jang W, Kim HS. CTNNB1 mutations in ovarian microcystic stromal tumors: identification of a novel deletion mutation and the use of pyrosequencing to identify reported point mutation. 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