{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:44:47Z","timestamp":1773294287303,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Serous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is an intraepithelial lesion but has been reported to cause extrauterine metastases. We report a case of SEIC with serous ovarian carcinoma and lymph node metastasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 57-year-old post-menopausal woman (gravida 3, para 2, SA1) was referred to our hospital with lower abdominal pain. An ultrasound and MRI showed that the ovary had swollen to 8\u00a0cm in size and had a solid lesion. The uterus was normal. The patient underwent exploratory laparoscopy on the suspicion of torsion of the ovarian tumor. Intraoperative findings showed a right ovarian tumor, but no ovarian tumor torsion was observed. A small amount of bloody ascites was found in the Douglas fossa, and bleeding was observed from the tumor itself. A right salpingo-oophorectomy was then performed. Histopathological results revealed a high-grade serous carcinoma. Forty days after the first surgery, we performed a staging laparotomy: a total abdominal hysterectomy, left salpingo-oophorectomy, systematic pelvic and paraaortic lymphadenectomy, and a partial omentectomy. A complete cytoreduction was achieved. In the pathological examination, the invasion of the serous carcinoma was observed in the left ovarian ligament, and lymph node metastasis was found in the paraaortic lymph nodes. Atypical columnar cells formed irregular papillary lesions which had proliferated in the endometrium, and this was diagnosed as SEIC. The final diagnosis was serous ovarian cancer, FIGO stage IIIA1(ii), pT2bN1M0, with SEIC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We report a case of SEIC with synchronous serous carcinoma of the adnexa uteri. Both were serous carcinomas and, thus, it was difficult to identify the primary lesion. The distinction between metastatic cancer and two independent primary tumors is important for an accurate diagnosis and tumor staging. Histological diagnostic criteria remain controversial, and further development of a method for differentiating between both diseases is required.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13048-021-00835-8","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T22:02:29Z","timestamp":1625004149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case of synchronous serous ovarian cancer and uterine serous endometrial intraepithelial carcinoma"],"prefix":"10.1186","volume":"14","author":[{"given":"Maho","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maho","family":"Azumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Tomimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Washio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nagamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8518","authenticated-orcid":false,"given":"Yoshito","family":"Terai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"6","key":"835_CR1","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/00000478-199206000-00008","volume":"16","author":"ME Sherman","year":"1992","unstructured":"Sherman ME, Bitterman P, Rosenchein NB, Delgado G, Kurman RJ. Uterine serous carcinoma. A morphologically diverse neoplasm with unifying clinicopathologic features. Am J Surg Pathol. 1992;16(6):600\u201310.","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"835_CR2","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/GRF.0b013e318218c755","volume":"54","author":"KN Moore","year":"2011","unstructured":"Moore KN, Nickles FA. Uterine papillary serous carcinoma. Clin Obstet Gynecol. 2011;54(2):278\u201391.","journal-title":"Clin Obstet Gynecol"},{"issue":"4","key":"835_CR3","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1177\/1933719113503414","volume":"21","author":"JY Hou","year":"2014","unstructured":"Hou JY, McAndrew TC, Goldberg GL, Whitney K, Shahabi S. A clinical and pathologic comparison between stage-matched endometrial intraepithelial carcinoma and uterine serous carcinoma: Is there a difference? Reprod Sci. 2014;21(4):532\u20137.","journal-title":"Reprod Sci"},{"issue":"11","key":"835_CR4","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/0046-8177(95)90203-1","volume":"26","author":"RA Ambros","year":"1995","unstructured":"Ambros RA, Sherman ME, Zahn CM, Bitterman P, Kurman RJ. Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol. 1995;26(11):1260\u20137.","journal-title":"Hum Pathol"},{"issue":"6","key":"835_CR5","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1097\/00000478-200006000-00004","volume":"24","author":"DT Wheeler","year":"2000","unstructured":"Wheeler DT, Bell KA, Kurman RJ, Sherman ME. Minimal uterine serous carcinoma: diagnosis and clinicopathologic correlation. Am J Surg Pathol. 2000;24(6):797\u2013806.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"835_CR6","first-page":"153","volume":"97","author":"PA Gehrig","year":"2001","unstructured":"Gehrig PA, Groben PA, Fowler WC, Walton LA, Van Le L. Noninvasive papillary serous carcinoma of the endometrium. Obstet Gynecol. 2001;97(1):153\u20137.","journal-title":"Obstet Gynecol"},{"key":"835_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1006\/gyno.1994.1208","volume":"54","author":"BA Goff","year":"1994","unstructured":"Goff BA, Kato D, Schmidt RA, Ek M, Ferry JA, Muntz HG, Howerd GM, et al. Uterine papillary serous carcinoma: patterns of metastatic spread. Gynecol Oncol. 1994;54:264\u20138.","journal-title":"Gynecol Oncol"},{"issue":"5","key":"835_CR8","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1097\/00000478-200005000-00012","volume":"24","author":"RA Soslow","year":"2000","unstructured":"Soslow RA, Pirog E, Isacson C. Endometrial intraepithelial carcinoma with associated peritoneal carcinomatosis. Am J Surg Pathol. 2000;24(5):726\u201332.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"835_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.29271\/jcpsp.2019.06.577","volume":"29","author":"M Xu","year":"2019","unstructured":"Xu M, Zhou F, Huang L. Metastatic carcinoma of endometrium from primary ovarian serous carcinoma mimicking a primary uterine tumour. J Coll Physicians Surg Pakistan. 2019;29(6):577\u20139.","journal-title":"J Coll Physicians Surg Pakistan"},{"issue":"6","key":"835_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.17772\/gp\/1750","volume":"85","author":"B Saatli","year":"2014","unstructured":"Saatli B, Yildirim N, Ozay AC, Koyuncuoglu M, Demirkan B, Saygili U. Synchronous tumors of the female genital tract: A 20-year experience in a single center. Ginekol Pol. 2014;85(6):441\u20135.","journal-title":"Ginekol Pol"},{"issue":"4","key":"835_CR11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1309\/K84K-005F-TCB8-FV4B","volume":"117","author":"NS Goldstein","year":"2002","unstructured":"Goldstein NS, Uzieblo A. WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas. Am J Clin Pathol. 2002;117(4):541\u20135.","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"835_CR12","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1365-2559.2009.03390.x","volume":"55","author":"L Hirschowitz","year":"2009","unstructured":"Hirschowitz L, Ganesan R, McCluggage WG. WT1, p53 and hormone receptor expression in uterine serous carcinoma: correspondence. Histopathology. 2009;55(4):478\u201382.","journal-title":"Histopathology"},{"issue":"9","key":"835_CR13","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.humpath.2014.05.009","volume":"45","author":"C Hedley","year":"2014","unstructured":"Hedley C, Sriraksa R, Showeil R, Van Noorden S, El-Bahrawy M. The frequency and significance of WT-1 expression in serous endometrial carcinoma. Hum Pathol. 2014;45(9):1879\u201384. https:\/\/doi.org\/10.1016\/j.humpath.2014.05.009.","journal-title":"Hum Pathol"},{"issue":"9","key":"835_CR14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/modpathol.2008.108","volume":"21","author":"S Nofech-Mozes","year":"2008","unstructured":"Nofech-Mozes S, Khalifa MA, Ismiil N, Saad RS, Hanna WM, Covens A, et al. Immunophenotyping of serous carcinoma of the female genital tract. Mod Pathol. 2008;21(9):1147\u201355.","journal-title":"Mod Pathol"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-021-00835-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-021-00835-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-021-00835-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T22:02:30Z","timestamp":1625004150000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-021-00835-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["835"],"URL":"https:\/\/doi.org\/10.1186\/s13048-021-00835-8","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"1 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No institutional review board approval was required. Written informed consent for clinical use of clinical data was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this Case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"87"}}