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Patients were randomly allocated consumed a capsule containing 200\u00a0mg of EA per day (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) for 8\u00a0weeks. The fasting blood sugar (FBS), insulin, IR, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), total antioxidant capacity (TAC), Malondialdehyde (MDA), C-reactive protein (CRP), Tumor necrosis factor-alpha (TNF-\u03b1), sex hormones and anti-mullerian hormone (AMH) were measured at the beginning and end of the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      At the end of the study, the mean of FBS, insulin, IR, TC, TG, LDL, MDA, CRP, TNF-\u03b1, total testosterone, prolactin and AMH were significantly decreased in the intervention group compared to the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Also, there was a significant increase in the mean of TAC after supplementation with EA (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). At the end of the study, no significant changes were observed in the mean of anthropometric factors, physical activity and food intake (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EA supplementation can be helpful as a diet supplement in women with PCOS through improvement in insulin resistance. This supplement may be used to reduce metabolic disorders in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      This study was retrospectively (07\u201307-2019) registered in the Iranian website (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.irct.ir\">www.irct.ir<\/jats:ext-link>\n                      ) for registration of clinical trials (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/en.irct.ir\/trial\/39654\">IRCT20141025019669N12<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13048-021-00849-2","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:15:09Z","timestamp":1627690509000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome"],"prefix":"10.1186","volume":"14","author":[{"given":"Mahnaz","family":"Kazemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-7958","authenticated-orcid":false,"given":"Fatemeh","family":"Lalooha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-0094","authenticated-orcid":false,"given":"Mohammadreza Rashidi","family":"Nooshabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Dashti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-8754","authenticated-orcid":false,"given":"Maria","family":"Kavianpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-1846","authenticated-orcid":false,"given":"Hossein Khadem","family":"Haghighian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"issue":"3","key":"849_CR1","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/aogs.13489","volume":"98","author":"M Forslund","year":"2019","unstructured":"Forslund M, Landin-Wilhelmsen K, Schmidt J, Br\u00e4nnstr\u00f6m M, Trimpou P, Dahlgren E. 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