{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:49:34Z","timestamp":1794444574315,"version":"4.9.1"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2022YFC2702500"],"award-info":[{"award-number":["2022YFC2702500"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101714\uff0c81925013, 82288102, 82203453"],"award-info":[{"award-number":["82101714\uff0c81925013, 82288102, 82203453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M740320"],"award-info":[{"award-number":["2023M740320"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["7234411"],"award-info":[{"award-number":["7234411"]}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["3332023008"],"award-info":[{"award-number":["3332023008"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut. Here, we summarize the role of gut microbiota dysbiosis in the development of PCOS and demonstrate the ability of different polyphenols - including anthocyanin, catechins, and resveratrol - to regulate gut microbes and alleviate chronic inflammation, thus providing new insights that may assist in the development of novel therapeutic strategies to treat women with PCOS.<\/jats:p>","DOI":"10.1186\/s13048-024-01354-y","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T06:02:14Z","timestamp":1711519334000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome"],"prefix":"10.1186","volume":"17","author":[{"given":"Ping","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianliu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"issue":"5","key":"1354_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1210\/er.2015-1104","volume":"37","author":"RL Rosenfield","year":"2016","unstructured":"Rosenfield RL, Ehrmann DA. The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocr Rev. 2016;37(5):467\u2013520.","journal-title":"Endocr Rev"},{"issue":"4","key":"1354_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4103\/ijmr.IJMR_1937_17","volume":"150","author":"MA Ganie","year":"2019","unstructured":"Ganie MA, et al. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian J Med Res. 2019;150(4):333\u201344.","journal-title":"Indian J Med Res"},{"issue":"6","key":"1354_CR3","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/humupd\/dmy022","volume":"24","author":"MA Skiba","year":"2018","unstructured":"Skiba MA, et al. Understanding variation in prevalence estimates of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2018;24(6):694\u2013709.","journal-title":"Hum Reprod Update"},{"issue":"4","key":"1354_CR4","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1210\/jc.2017-02153","volume":"103","author":"PJ Torres","year":"2018","unstructured":"Torres PJ, et al. Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab. 2018;103(4):1502\u201311.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1354_CR5","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"X Qi","year":"2019","unstructured":"Qi X, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019;25(8):1225\u201333.","journal-title":"Nat Med"},{"issue":"6","key":"1354_CR6","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.fertnstert.2020.01.027","volume":"113","author":"W Chu","year":"2020","unstructured":"Chu W, et al. Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome. Fertil Steril. 2020;113(6):1286\u201398. e4.","journal-title":"Fertil Steril"},{"key":"1354_CR7","doi-asserted-by":"publisher","first-page":"854796","DOI":"10.3389\/fcimb.2022.854796","volume":"12","author":"H Zhao","year":"2022","unstructured":"Zhao H, et al. Modified Banxia Xiexin decoction ameliorates polycystic ovarian syndrome with insulin resistance by regulating intestinal microbiota. Front Cell Infect Microbiol. 2022;12:854796.","journal-title":"Front Cell Infect Microbiol"},{"key":"1354_CR8","doi-asserted-by":"crossref","unstructured":"Yang YL et al. Intestinal flora is a key factor in insulin resistance and contributes to the development of polycystic ovary syndrome. Endocrinology. 2021;162(10).","DOI":"10.1210\/endocr\/bqab118"},{"key":"1354_CR9","doi-asserted-by":"crossref","unstructured":"Ascani A et al. The role of B cells in immune cell activation in polycystic ovary syndrome. Elife. 2023;12.","DOI":"10.7554\/eLife.86454"},{"key":"1354_CR10","doi-asserted-by":"crossref","unstructured":"Kicinska AM et al. Immunological and metabolic causes of infertility in polycystic ovary syndrome. Biomedicines. 2023;11(6).","DOI":"10.3390\/biomedicines11061567"},{"key":"1354_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fmicb.2019.00175","volume":"10","author":"F Zhang","year":"2019","unstructured":"Zhang F, et al. Diversity of the gut microbiota in dihydrotestosterone-induced PCOS rats and the pharmacologic effects of Diane-35, probiotics, and berberine. Front Microbiol. 2019;10:175.","journal-title":"Front Microbiol"},{"issue":"3","key":"1354_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrneph.2016.191","volume":"13","author":"NO Camara","year":"2017","unstructured":"Camara NO, et al. Kidney disease and obesity: epidemiology, mechanisms and treatment. Nat Rev Nephrol. 2017;13(3):181\u201390.","journal-title":"Nat Rev Nephrol"},{"key":"1354_CR13","doi-asserted-by":"publisher","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","volume":"2","author":"R Azziz","year":"2016","unstructured":"Azziz R, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.","journal-title":"Nat Rev Dis Primers"},{"key":"1354_CR14","doi-asserted-by":"crossref","unstructured":"Dumesic DA, Abbott DH, Chazenbalk GD. An evolutionary model for the ancient origins of polycystic ovary syndrome. J Clin Med. 2023;12(19).","DOI":"10.3390\/jcm12196120"},{"issue":"6","key":"1354_CR15","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1210\/jc.2005-1494","volume":"91","author":"JM Vink","year":"2006","unstructured":"Vink JM, et al. Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab. 2006;91(6):2100\u20134.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1354_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0015-0282(00)01662-9","volume":"75","author":"MD Kahsar-Miller","year":"2001","unstructured":"Kahsar-Miller MD, et al. Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS. Fertil Steril. 2001;75(1):53\u20138.","journal-title":"Fertil Steril"},{"issue":"7","key":"1354_CR17","doi-asserted-by":"publisher","first-page":"E1342","DOI":"10.1210\/jc.2011-3478","volume":"97","author":"CK Welt","year":"2012","unstructured":"Welt CK, et al. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab. 2012;97(7):E1342\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1354_CR18","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1093\/humrep\/dev085","volume":"30","author":"R Saxena","year":"2015","unstructured":"Saxena R, et al. Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance. Hum Reprod. 2015;30(6):1454\u20139.","journal-title":"Hum Reprod"},{"issue":"8","key":"1354_CR19","doi-asserted-by":"publisher","first-page":"e1005455","DOI":"10.1371\/journal.pgen.1005455","volume":"11","author":"MR Jones","year":"2015","unstructured":"Jones MR, et al. Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity. PLoS Genet. 2015;11(8):e1005455.","journal-title":"PLoS Genet"},{"issue":"9","key":"1354_CR20","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/ng.2384","volume":"44","author":"Y Shi","year":"2012","unstructured":"Shi Y, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012;44(9):1020\u20135.","journal-title":"Nat Genet"},{"key":"1354_CR21","doi-asserted-by":"publisher","first-page":"7502","DOI":"10.1038\/ncomms8502","volume":"6","author":"MG Hayes","year":"2015","unstructured":"Hayes MG, et al. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015;6:7502.","journal-title":"Nat Commun"},{"key":"1354_CR22","doi-asserted-by":"crossref","unstructured":"Stavridis K et al. Bisphenol-A and female fertility: an update of existing epidemiological studies. J Clin Med. 2022;11(23).","DOI":"10.3390\/jcm11237227"},{"key":"1354_CR23","doi-asserted-by":"publisher","first-page":"115962","DOI":"10.1016\/j.envpol.2020.115962","volume":"272","author":"J Jurewicz","year":"2021","unstructured":"Jurewicz J, et al. Serum bisphenol a analogues in women diagnosed with the polycystic ovary syndrome - is there an association? Environ Pollut. 2021;272:115962.","journal-title":"Environ Pollut"},{"key":"1354_CR24","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.envres.2018.09.014","volume":"168","author":"J Gu","year":"2019","unstructured":"Gu J, et al. Urinary concentration of personal care products and polycystic ovary syndrome: a case-control study. Environ Res. 2019;168:48\u201353.","journal-title":"Environ Res"},{"issue":"23","key":"1354_CR25","doi-asserted-by":"publisher","first-page":"64025","DOI":"10.1007\/s11356-023-26820-w","volume":"30","author":"NB Prabhu","year":"2023","unstructured":"Prabhu NB, et al. Distinct metabolic signatures in blood plasma of bisphenol A-exposed women with polycystic ovarian syndrome. Environ Sci Pollut Res Int. 2023;30(23):64025\u201335.","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"1354_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10815-017-1047-7","volume":"35","author":"J Bellver","year":"2018","unstructured":"Bellver J, et al. Polycystic ovary syndrome throughout a woman\u2019s life. J Assist Reprod Genet. 2018;35(1):25\u201339.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"1354_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng.732","volume":"43","author":"ZJ Chen","year":"2011","unstructured":"Chen ZJ, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011;43(1):55\u20139.","journal-title":"Nat Genet"},{"issue":"2","key":"1354_CR28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1161\/CIRCHEARTFAILURE.112.000115","volume":"6","author":"LH Lund","year":"2013","unstructured":"Lund LH, et al. Association of spironolactone use with all-cause mortality in heart failure: a propensity scored cohort study. Circ Heart Fail. 2013;6(2):174\u201383.","journal-title":"Circ Heart Fail"},{"issue":"4","key":"1354_CR29","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1093\/biolre\/ioy096","volume":"99","author":"PDA Lima","year":"2018","unstructured":"Lima PDA, et al. Polycystic ovary syndrome: possible involvement of androgen-induced, chemerin-mediated ovarian recruitment of monocytes\/macrophages. Biol Reprod. 2018;99(4):838\u201352.","journal-title":"Biol Reprod"},{"issue":"11","key":"1354_CR30","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1093\/humrep\/dew243","volume":"31","author":"S Cassar","year":"2016","unstructured":"Cassar S, et al. Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies. Hum Reprod. 2016;31(11):2619\u201331.","journal-title":"Hum Reprod"},{"key":"1354_CR31","doi-asserted-by":"crossref","unstructured":"Chen Z et al. Impact of preservation method and 16S rRNA hypervariable region on gut microbiota profiling. mSystems. 2019;4(1).","DOI":"10.1128\/mSystems.00271-18"},{"issue":"6","key":"1354_CR32","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","volume":"174","author":"N Zmora","year":"2018","unstructured":"Zmora N, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell. 2018;174(6):1388\u2013405. e21.","journal-title":"Cell"},{"issue":"1","key":"1354_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","volume":"16","author":"N Zmora","year":"2019","unstructured":"Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2019;16(1):35\u201356.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"1354_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55\u201371.","journal-title":"Nat Rev Microbiol"},{"issue":"6416","key":"1354_CR35","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1126\/science.aau5812","volume":"362","author":"CL Gentile","year":"2018","unstructured":"Gentile CL, Weir TL. The gut microbiota at the intersection of diet and human health. Science. 2018;362(6416):776\u201380.","journal-title":"Science"},{"issue":"4","key":"1354_CR36","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nm.4517","volume":"24","author":"JA Gilbert","year":"2018","unstructured":"Gilbert JA, et al. Current understanding of the human microbiome. Nat Med. 2018;24(4):392\u2013400.","journal-title":"Nat Med"},{"issue":"2","key":"1354_CR37","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/17843286.2019.1583782","volume":"74","author":"G Falony","year":"2019","unstructured":"Falony G, et al. The human microbiome in health and disease: hype or hope. Acta Clin Belg. 2019;74(2):53\u201364.","journal-title":"Acta Clin Belg"},{"issue":"1","key":"1354_CR38","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.mehy.2012.04.016","volume":"79","author":"K Tremellen","year":"2012","unstructured":"Tremellen K, Pearce K. Dysbiosis of gut microbiota (DOGMA)--a novel theory for the development of polycystic ovarian syndrome. Med Hypotheses. 2012;79(1):104\u201312.","journal-title":"Med Hypotheses"},{"issue":"1","key":"1354_CR39","doi-asserted-by":"publisher","first-page":"e0168390","DOI":"10.1371\/journal.pone.0168390","volume":"12","author":"L Lindheim","year":"2017","unstructured":"Lindheim L, et al. Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study. PLoS ONE. 2017;12(1):e0168390.","journal-title":"PLoS ONE"},{"issue":"7480","key":"1354_CR40","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Y Furusawa","year":"2013","unstructured":"Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480):446\u201350.","journal-title":"Nature"},{"key":"1354_CR41","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ejogrb.2015.12.003","volume":"197","author":"L Qin","year":"2016","unstructured":"Qin L, et al. Differential expression profile of immunological cytokines in local ovary in patients with polycystic ovarian syndrome: analysis by flow cytometry. Eur J Obstet Gynecol Reprod Biol. 2016;197:136\u201341.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"7461","key":"1354_CR42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature12331","volume":"500","author":"K Atarashi","year":"2013","unstructured":"Atarashi K, et al. Treg induction by a rationally selected mixture of clostridia strains from the human microbiota. Nature. 2013;500(7461):232\u20136.","journal-title":"Nature"},{"issue":"1","key":"1354_CR43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s13048-021-00867-0","volume":"14","author":"Y Yang","year":"2021","unstructured":"Yang Y, et al. The abnormal level of HSP70 is related to Treg\/Th17 imbalance in PCOS patients. J Ovarian Res. 2021;14(1):155.","journal-title":"J Ovarian Res"},{"issue":"1","key":"1354_CR44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12958-021-00861-7","volume":"19","author":"M Zhu","year":"2021","unstructured":"Zhu M, et al. Involvement of impaired CD8(+) mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome. Reprod Biol Endocrinol. 2021;19(1):175.","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"1354_CR45","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.fertnstert.2010.11.036","volume":"95","author":"HF Escobar-Morreale","year":"2011","unstructured":"Escobar-Morreale HF, Luque-Ramirez M, Gonzalez F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril. 2011;95(3):1048\u201358e1.","journal-title":"Fertil Steril"},{"issue":"4","key":"1354_CR46","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00281-019-00737-4","volume":"41","author":"M Popovic","year":"2019","unstructured":"Popovic M, Sartorius G, Christ-Crain M. Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1? Semin Immunopathol. 2019;41(4):447\u201359.","journal-title":"Semin Immunopathol"},{"issue":"4","key":"1354_CR47","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.fertnstert.2008.10.070","volume":"93","author":"C Kaya","year":"2010","unstructured":"Kaya C, et al. Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. Fertil Steril. 2010;93(4):1200\u20137.","journal-title":"Fertil Steril"},{"issue":"12","key":"1354_CR48","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1111\/obr.12750","volume":"19","author":"ICL van den Munckhof","year":"2018","unstructured":"van den Munckhof ICL, et al. Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies. Obes Rev. 2018;19(12):1719\u201334.","journal-title":"Obes Rev"},{"issue":"8","key":"1354_CR49","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1111\/ijfs.13479","volume":"52","author":"X Guo","year":"2017","unstructured":"Guo X, et al. Green tea polyphenols reduce obesity in high-fat diet\u2010induced mice by modulating intestinal microbiota composition. Int J Food Sci Technol. 2017;52(8):1723\u201330.","journal-title":"Int J Food Sci Technol"},{"key":"1354_CR50","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3389\/fimmu.2019.00286","volume":"10","author":"M Zhang","year":"2019","unstructured":"Zhang M, et al. Inonotus sanghuang polyphenols attenuate inflammatory response via modulating the crosstalk between macrophages and adipocytes. Front Immunol. 2019;10:286.","journal-title":"Front Immunol"},{"key":"1354_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.fct.2018.01.022","volume":"113","author":"AB Santhakumar","year":"2018","unstructured":"Santhakumar AB, Battino M, Alvarez-Suarez JM. Dietary polyphenols: structures, bioavailability and protective effects against atherosclerosis. Food Chem Toxicol. 2018;113:49\u201365.","journal-title":"Food Chem Toxicol"},{"key":"1354_CR52","doi-asserted-by":"publisher","first-page":"104963","DOI":"10.1016\/j.jff.2022.104963","volume":"89","author":"Y Wang","year":"2022","unstructured":"Wang Y, et al. Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice. J Funct Foods. 2022;89:104963.","journal-title":"J Funct Foods"},{"key":"1354_CR53","doi-asserted-by":"publisher","first-page":"133443","DOI":"10.1016\/j.foodchem.2022.133443","volume":"393","author":"T Xia","year":"2022","unstructured":"Xia T, et al. The anti-diabetic activity of polyphenols-rich vinegar extract in mice via regulating gut microbiota and liver inflammation. Food Chem. 2022;393:133443.","journal-title":"Food Chem"},{"key":"1354_CR54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.nutres.2020.03.002","volume":"78","author":"MJ Banez","year":"2020","unstructured":"Banez MJ, et al. A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health. Nutr Res. 2020;78:11\u201326.","journal-title":"Nutr Res"},{"issue":"1","key":"1354_CR55","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1573399814666180914094520","volume":"16","author":"DE Barre","year":"2019","unstructured":"Barre DE, Mizier-Barre KA. Lignans\u2019 potential in pre and post-onset type 2 diabetes management. Curr Diabetes Rev. 2019;16(1):2\u201311.","journal-title":"Curr Diabetes Rev"},{"key":"1354_CR56","doi-asserted-by":"publisher","first-page":"133959","DOI":"10.1016\/j.foodchem.2022.133959","volume":"399","author":"Z Li","year":"2023","unstructured":"Li Z, et al. Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: current understanding and future perspectives. Food Chem. 2023;399:133959.","journal-title":"Food Chem"},{"key":"1354_CR57","doi-asserted-by":"publisher","first-page":"625782","DOI":"10.3389\/fmicb.2021.625782","volume":"12","author":"S Molino","year":"2021","unstructured":"Molino S, et al. Enrichment of food with tannin extracts promotes healthy changes in the human gut microbiota. Front Microbiol. 2021;12:625782.","journal-title":"Front Microbiol"},{"key":"1354_CR58","doi-asserted-by":"publisher","first-page":"129532","DOI":"10.1016\/j.foodchem.2021.129532","volume":"357","author":"B Zhang","year":"2021","unstructured":"Zhang B, et al. Intestinal pharmacokinetics of resveratrol and regulatory effects of resveratrol metabolites on gut barrier and gut microbiota. Food Chem. 2021;357:129532.","journal-title":"Food Chem"},{"issue":"Suppl 3","key":"1354_CR59","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1038\/ejcn.2010.221","volume":"64","author":"J Perez-Jimenez","year":"2010","unstructured":"Perez-Jimenez J, et al. Identification of the 100 richest dietary sources of polyphenols: an application of the phenol-explorer database. Eur J Clin Nutr. 2010;64(Suppl 3):S112\u201320.","journal-title":"Eur J Clin Nutr"},{"issue":"1 Suppl","key":"1354_CR60","doi-asserted-by":"publisher","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","volume":"81","author":"C Manach","year":"2005","unstructured":"Manach C, et al. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005;81(1 Suppl):230S\u201342.","journal-title":"Am J Clin Nutr"},{"issue":"18","key":"1354_CR61","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1080\/10408398.2020.1791794","volume":"61","author":"A Reis","year":"2021","unstructured":"Reis A, et al. Interactions of dietary polyphenols with epithelial lipids: advances from membrane and cell models in the study of polyphenol absorption, transport and delivery to the epithelium. Crit Rev Food Sci Nutr. 2021;61(18):3007\u201330.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1354_CR62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.anaerobe.2013.07.009","volume":"23","author":"SG Parkar","year":"2013","unstructured":"Parkar SG, Trower TM, Stevenson DE. Fecal microbial metabolism of polyphenols and its effects on human gut microbiota. Anaerobe. 2013;23:12\u20139.","journal-title":"Anaerobe"},{"issue":"4","key":"1354_CR63","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1080\/10408398.2020.1744512","volume":"61","author":"MLY Wan","year":"2021","unstructured":"Wan MLY, Co VA, El-Nezami H. Dietary polyphenol impact on gut health and microbiota. Crit Rev Food Sci Nutr. 2021;61(4):690\u2013711.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"1354_CR64","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1039\/C6FO00032K","volume":"7","author":"L Zhou","year":"2016","unstructured":"Zhou L, et al. In vitro extraction and fermentation of polyphenols from grape seeds (Vitis vinifera) by human intestinal microbiota. Food Funct. 2016;7(4):1959\u201367.","journal-title":"Food Funct"},{"issue":"1\u20132","key":"1354_CR65","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.mrfmmm.2005.04.022","volume":"591","author":"P Dolara","year":"2005","unstructured":"Dolara P, et al. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res. 2005;591(1\u20132):237\u201346.","journal-title":"Mutat Res"},{"issue":"6","key":"1354_CR66","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1021\/jf803638d","volume":"57","author":"M Larrosa","year":"2009","unstructured":"Larrosa M, et al. Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model. J Agric Food Chem. 2009;57(6):2211\u201320.","journal-title":"J Agric Food Chem"},{"issue":"6","key":"1354_CR67","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1039\/c3fo60630a","volume":"5","author":"Y Qiao","year":"2014","unstructured":"Qiao Y, et al. Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity. Food Funct. 2014;5(6):1241\u20139.","journal-title":"Food Funct"},{"issue":"1","key":"1354_CR68","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0308-8146(00)00126-6","volume":"71","author":"T Kabuki","year":"2000","unstructured":"Kabuki T, et al. Characterization of novel antimicrobial compounds from mango (Mangifera indica L.) kernel seeds. Food Chem. 2000;71(1):61\u20136.","journal-title":"Food Chem"},{"key":"1354_CR69","doi-asserted-by":"crossref","unstructured":"Wang K et al. Dietary propolis ameliorates dextran sulfate sodium-induced colitis and modulates the gut microbiota in rats fed a western diet. Nutrients. 2017;9(8).","DOI":"10.3390\/nu9080875"},{"issue":"4","key":"1354_CR70","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1017\/S0007114507853384","volume":"99","author":"X Tzounis","year":"2008","unstructured":"Tzounis X, et al. Flavanol monomer-induced changes to the human faecal microflora. Br J Nutr. 2008;99(4):782\u201392.","journal-title":"Br J Nutr"},{"issue":"3","key":"1354_CR71","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1574-6968.1987.tb02352.x","volume":"3","author":"H Englyst","year":"1987","unstructured":"Englyst H, Hay S, Macfarlane G. Polysaccharide breakdown by mixed populations of human faecal bacteria. FEMS Microbiol Ecol. 1987;3(3):163\u201371.","journal-title":"FEMS Microbiol Ecol"},{"issue":"9","key":"1354_CR72","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41579-022-00712-1","volume":"20","author":"JF Wardman","year":"2022","unstructured":"Wardman JF, et al. Carbohydrate-active enzymes (CAZymes) in the gut microbiome. Nat Rev Microbiol. 2022;20(9):542\u201356.","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"1354_CR73","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nrmicro3050","volume":"11","author":"A El Kaoutari","year":"2013","unstructured":"El Kaoutari A, et al. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nat Rev Microbiol. 2013;11(7):497\u2013504.","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"1354_CR74","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","volume":"82","author":"K Murota","year":"2018","unstructured":"Murota K, Nakamura Y, Uehara M. Flavonoid metabolism: the interaction of metabolites and gut microbiota. Biosci Biotechnol Biochem. 2018;82(4):600\u201310.","journal-title":"Biosci Biotechnol Biochem"},{"key":"1354_CR75","doi-asserted-by":"crossref","unstructured":"Singh S et al. Polycystic ovary syndrome: etiology, current management, and future therapeutics. J Clin Med. 2023;12(4).","DOI":"10.3390\/jcm12041454"},{"issue":"9","key":"1354_CR76","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1002\/ptr.6419","volume":"33","author":"A Durazzo","year":"2019","unstructured":"Durazzo A, et al. Polyphenols: a concise overview on the chemistry, occurrence, and human health. Phytother Res. 2019;33(9):2221\u201343.","journal-title":"Phytother Res"},{"issue":"2","key":"1354_CR77","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1039\/C8FO01997E","volume":"10","author":"CG Fraga","year":"2019","unstructured":"Fraga CG, et al. The effects of polyphenols and other bioactives on human health. Food Funct. 2019;10(2):514\u201328.","journal-title":"Food Funct"},{"issue":"1","key":"1354_CR78","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/jhn.12582","volume":"32","author":"EO Igwe","year":"2019","unstructured":"Igwe EO, et al. A systematic literature review of the effect of anthocyanins on gut microbiota populations. J Hum Nutr Diet. 2019;32(1):53\u201362.","journal-title":"J Hum Nutr Diet"},{"key":"1354_CR79","doi-asserted-by":"publisher","first-page":"114594","DOI":"10.1016\/j.jep.2021.114594","volume":"282","author":"F Moshfegh","year":"2022","unstructured":"Moshfegh F, et al. Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice. J Ethnopharmacol. 2022;282:114594.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"1354_CR80","doi-asserted-by":"publisher","first-page":"E965","DOI":"10.1152\/ajpendo.00560.2019","volume":"318","author":"A Morissette","year":"2020","unstructured":"Morissette A, et al. Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice. Am J Physiology-Endocrinology Metabolism. 2020;318(6):E965\u201380.","journal-title":"Am J Physiology-Endocrinology Metabolism"},{"issue":"24","key":"1354_CR81","doi-asserted-by":"publisher","first-page":"e2100152","DOI":"10.1002\/mnfr.202100152","volume":"65","author":"S Li","year":"2021","unstructured":"Li S, et al. Role of gut microbiota in the anti-colitic effects of anthocyanin-containing potatoes. Mol Nutr Food Res. 2021;65(24):e2100152.","journal-title":"Mol Nutr Food Res"},{"key":"1354_CR82","doi-asserted-by":"publisher","first-page":"109098","DOI":"10.1016\/j.foodres.2020.109098","volume":"132","author":"Y Wu","year":"2020","unstructured":"Wu Y, et al. In vitro gastrointestinal digestion and fecal fermentation reveal the effect of different encapsulation materials on the release, degradation and modulation of gut microbiota of blueberry anthocyanin extract. Food Res Int. 2020;132:109098.","journal-title":"Food Res Int"},{"key":"1354_CR83","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jnutbio.2017.08.017","volume":"51","author":"S Bibi","year":"2018","unstructured":"Bibi S, et al. Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis. J Nutr Biochem. 2018;51:40\u20136.","journal-title":"J Nutr Biochem"},{"issue":"17","key":"1354_CR84","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1007\/s00018-019-03122-4","volume":"76","author":"AK Yadav","year":"2019","unstructured":"Yadav AK, et al. Autophagy in hypoxic ovary. Cell Mol Life Sci. 2019;76(17):3311\u201322.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1354_CR85","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tem.2018.11.001","volume":"30","author":"VG Thackray","year":"2019","unstructured":"Thackray VG. Sex, microbes, and polycystic ovary syndrome. Trends Endocrinol Metab. 2019;30(1):54\u201365.","journal-title":"Trends Endocrinol Metab"},{"key":"1354_CR86","doi-asserted-by":"crossref","unstructured":"Choi S et al. Difference in the gut microbiome between ovariectomy-induced obesity and diet-induced obesity. 2017.","DOI":"10.4014\/jmb.1710.10001"},{"key":"1354_CR87","doi-asserted-by":"crossref","unstructured":"Cai ZY et al. Bioavailability of tea catechins and its improvement. Molecules. 2018;23(9).","DOI":"10.3390\/molecules23092346"},{"key":"1354_CR88","doi-asserted-by":"crossref","unstructured":"Reygaert WC. Green tea catechins: their use in treating and preventing infectious diseases BioMed research international, 2018. 2018.","DOI":"10.1155\/2018\/9105261"},{"issue":"19","key":"1354_CR89","doi-asserted-by":"publisher","first-page":"10053","DOI":"10.1128\/JVI.01473-15","volume":"89","author":"N Calland","year":"2015","unstructured":"Calland N, et al. Polyphenols inhibit hepatitis C virus entry by a new mechanism of action. J Virol. 2015;89(19):10053\u201363.","journal-title":"J Virol"},{"key":"1354_CR90","doi-asserted-by":"publisher","first-page":"905215","DOI":"10.1155\/2015\/905215","volume":"2015","author":"L Marin","year":"2015","unstructured":"Marin L, et al. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int. 2015;2015:905215.","journal-title":"Biomed Res Int"},{"issue":"1","key":"1354_CR91","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13020-020-00405-y","volume":"15","author":"G Hong","year":"2020","unstructured":"Hong G, et al. Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice. Chin Med. 2020;15(1):125.","journal-title":"Chin Med"},{"issue":"4","key":"1354_CR92","first-page":"1215","volume":"14","author":"H Ghafurniyan","year":"2015","unstructured":"Ghafurniyan H, et al. The effect of green tea extract on reproductive improvement in estradiol valerate-induced polycystic ovarian syndrome in rat. Iran J Pharm Res. 2015;14(4):1215\u201333.","journal-title":"Iran J Pharm Res"},{"issue":"2","key":"1354_CR93","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00404-019-05194-w","volume":"300","author":"M Hager","year":"2019","unstructured":"Hager M, et al. The impact of a standardized micronutrient supplementation on PCOS-typical parameters: a randomized controlled trial. Arch Gynecol Obstet. 2019;300(2):455\u201360.","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"1354_CR94","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3945\/an.117.016568","volume":"8","author":"JK Bird","year":"2017","unstructured":"Bird JK, et al. Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota. Adv Nutr. 2017;8(6):839\u201349.","journal-title":"Adv Nutr"},{"issue":"1","key":"1354_CR95","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/nyas.12875","volume":"1348","author":"I Ortega","year":"2015","unstructured":"Ortega I, Duleba AJ. Ovarian actions of resveratrol. Ann N Y Acad Sci. 2015;1348(1):86\u201396.","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"1354_CR96","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1039\/C7FO01300K","volume":"8","author":"A Rauf","year":"2017","unstructured":"Rauf A, et al. A comprehensive review of the health perspectives of resveratrol. Food Funct. 2017;8(12):4284\u2013305.","journal-title":"Food Funct"},{"issue":"19","key":"1354_CR97","doi-asserted-by":"publisher","first-page":"4554","DOI":"10.3390\/molecules25194554","volume":"25","author":"R Pasquariello","year":"2020","unstructured":"Pasquariello R, et al. The role of resveratrol in mammalian reproduction. Molecules. 2020;25(19):4554.","journal-title":"Molecules"},{"key":"1354_CR98","doi-asserted-by":"publisher","first-page":"911381","DOI":"10.3389\/fimmu.2022.911381","volume":"13","author":"J Wang","year":"2022","unstructured":"Wang J, et al. Resveratrol alleviating the ovarian function under oxidative stress by alternating microbiota related tryptophan-kynurenine pathway. Front Immunol. 2022;13:911381.","journal-title":"Front Immunol"},{"issue":"4","key":"1354_CR99","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/molehr\/gaq002","volume":"16","author":"DH Wong","year":"2010","unstructured":"Wong DH, et al. Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells. Mol Hum Reprod. 2010;16(4):251\u20139.","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"1354_CR100","doi-asserted-by":"publisher","first-page":"782","DOI":"10.7150\/thno.67167","volume":"12","author":"M Chen","year":"2022","unstructured":"Chen M, et al. Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication. Theranostics. 2022;12(2):782.","journal-title":"Theranostics"},{"issue":"6","key":"1354_CR101","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1016\/j.clnu.2021.02.004","volume":"40","author":"A Mansour","year":"2021","unstructured":"Mansour A, et al. Effect of resveratrol on menstrual cyclicity, hyperandrogenism and metabolic profile in women with PCOS. Clin Nutr. 2021;40(6):4106\u201312.","journal-title":"Clin Nutr"},{"issue":"24","key":"1354_CR102","doi-asserted-by":"publisher","first-page":"e2100457","DOI":"10.1002\/mnfr.202100457","volume":"65","author":"A Liang","year":"2021","unstructured":"Liang A, et al. Resveratrol improves follicular development of PCOS rats by regulating the glycolytic pathway. Mol Nutr Food Res. 2021;65(24):e2100457.","journal-title":"Mol Nutr Food Res"},{"key":"1354_CR103","doi-asserted-by":"publisher","first-page":"1019562","DOI":"10.3389\/fnut.2022.1019562","volume":"9","author":"A Liang","year":"2022","unstructured":"Liang A, et al. Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells. Front Nutr. 2022;9:1019562.","journal-title":"Front Nutr"},{"key":"1354_CR104","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1477-7827-10-14","volume":"10","author":"Y Morita","year":"2012","unstructured":"Morita Y, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reprod Biol Endocrinol. 2012;10:14.","journal-title":"Reprod Biol Endocrinol"},{"issue":"3\u20134","key":"1354_CR105","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.anireprosci.2013.06.013","volume":"140","author":"S Pavlov\u00e1","year":"2013","unstructured":"Pavlov\u00e1 S, et al. The involvement of SIRT1 and transcription factor NF-\u03baB (p50\/p65) in regulation of porcine ovarian cell function. Anim Reprod Sci. 2013;140(3\u20134):180\u20138.","journal-title":"Anim Reprod Sci"},{"key":"1354_CR106","doi-asserted-by":"crossref","unstructured":"Corrie L et al. Interplay of gut microbiota in polycystic ovarian syndrome: role of gut microbiota, mechanistic pathways and potential treatment strategies. Pharmaceuticals (Basel). 2023;16(2).","DOI":"10.3390\/ph16020197"},{"issue":"3","key":"1354_CR107","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1365-2265.2012.04400.x","volume":"78","author":"T Usui","year":"2013","unstructured":"Usui T, et al. Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status. Clin Endocrinol (Oxf). 2013;78(3):365\u201372.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1354_CR108","doi-asserted-by":"crossref","unstructured":"Messina M. Soy and health update: evaluation of the clinical and epidemiologic literature. Nutrients. 2016;8(12).","DOI":"10.3390\/nu8120754"},{"issue":"6","key":"1354_CR109","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/ajcn\/77.6.1459","volume":"77","author":"L Zubik","year":"2003","unstructured":"Zubik L, Meydani M. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am J Clin Nutr. 2003;77(6):1459\u201365.","journal-title":"Am J Clin Nutr"},{"issue":"18","key":"1354_CR110","doi-asserted-by":"publisher","first-page":"8800","DOI":"10.1039\/D1FO00684C","volume":"12","author":"M Luo","year":"2021","unstructured":"Luo M, et al. Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway. Food Funct. 2021;12(18):8800\u201311.","journal-title":"Food Funct"},{"key":"1354_CR111","doi-asserted-by":"crossref","unstructured":"Liyanage GSG et al. Effects of soy isoflavones, resistant starch and antibiotics on polycystic ovary syndrome (PCOS)-like features in letrozole-treated rats. Nutrients. 2021;13(11).","DOI":"10.3390\/nu13113759"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-024-01354-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T07:08:40Z","timestamp":1711523320000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-024-01354-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":111,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1354"],"URL":"https:\/\/doi.org\/10.1186\/s13048-024-01354-y","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"10 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}