{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:32:16Z","timestamp":1790011936909,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Jiangsu Province Innovation and Entrepreneurship Program","award":["JSSCRC2021569"],"award-info":[{"award-number":["JSSCRC2021569"]}]},{"name":"Wuxi \u201cTaihu Talent Team\u201d project","award":["Y20222023"],"award-info":[{"award-number":["Y20222023"]}]},{"name":"Jiangsu Province Medical Distinguished Expert"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The accurate prediction of pregnancy outcomes in in vitro fertilization (IVF) cycles is crucial. While several studies have been conducted on the predictive power of serum estradiol (E<jats:sub>2<\/jats:sub>) and \u03b2-hCG concentrations post-embryo transfer (ET) for pregnancy outcomes, there is debate on the predictive value of E<jats:sub>2<\/jats:sub>. The objective of this study was to investigate the predictive efficacy of combining serum E<jats:sub>2<\/jats:sub> and \u03b2-hCG levels on early reproductive outcomes 12 days after embryo transfer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 1521 patients with \u03b2-hCG positive values on day 12 following frozen-thawed embryo transfer (FET) with natural endometrial preparation cycles (NCs) were gathered in affiliated Women\u2019s Hospital of Jiangnan University. Using logistic regression, the relationship between pregnancy outcome and early serum E<jats:sub>2<\/jats:sub> and \u03b2-hCG concentrations was examined. The receiver-operating characteristic (ROC) analysis was used to assess the predictive accuracy of the serum E<jats:sub>2<\/jats:sub> and \u03b2-hCG concentrations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Notable distinctions were observed in the serum E<jats:sub>2<\/jats:sub> and \u03b2-hCG levels on the twelfth day following FET with NCs between the groups classified as clinical pregnancy group (CP Group) and biochemical pregnancy group (BP Group). In addition, the cutoff values for E<jats:sub>2<\/jats:sub> and \u03b2-hCG on day 12 following FET with NCs in cleavage embryo group (CE Group) were 129.25 pg\/mL and 156.60 mIU\/mL, respectively. The threshold values for E<jats:sub>2<\/jats:sub> and \u03b2-hCG for the blastocyst group (B Group) were 174.45 pg\/mL and 217.70 mIU\/mL. Serum E<jats:sub>2 day12<\/jats:sub> and \u03b2-hCG <jats:sub>day12<\/jats:sub> were found to be substantially linked with clinical pregnancy by logistic regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Serum E<jats:sub>2<\/jats:sub> and \u03b2-hCG concentrations were found to be significantly different between the CP Group and BP Group in infertility women underwent FET with NCs. Our retrospective cohort study\u2019s findings suggest that the combination of early E<jats:sub>2<\/jats:sub> and \u03b2-hCG levels on day 12 post-FET could be used as a predictive tool to evaluate the likelihood of both positive and negative pregnancy outcomes in FET with NCs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13048-024-01433-0","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T12:01:51Z","timestamp":1718971311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combined analysis of estradiol and \u03b2-hCG to predict the early pregnancy outcome of FET: a retrospective study"],"prefix":"10.1186","volume":"17","author":[{"given":"Man","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"1433_CR1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejogrb.2017.11.020","volume":"220","author":"C Puget","year":"2018","unstructured":"Puget C, Joueidi Y, Bauville E, Laviolle B, Bendavid C, Lavou\u00e9 V, et al. 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