{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:35:43Z","timestamp":1794202543962,"version":"4.8.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-024-01508-y","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T09:05:01Z","timestamp":1726131901000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Research progress of ferroptosis in female infertility"],"prefix":"10.1186","volume":"17","author":[{"given":"Fan","family":"peiyin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"yuxian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"jiali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"1508_CR1","unstructured":"Phillips K, Olanrewaju R A, Omole F. Infertility: evaluation and management [J]. Am Fam Physician. 2023;107(6):623\u201330."},{"key":"1508_CR2","doi-asserted-by":"crossref","unstructured":"Vander Borght M. Fertility and infertility: definition and epidemiology [J]. Clin Biochem. 2018;62:2\u201310.","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"1508_CR3","doi-asserted-by":"crossref","unstructured":"Li G, Lin Y, Zhang Y, et al. Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis [J]. Cell Death Discov. 2022;8(1):29.","DOI":"10.1038\/s41420-022-00821-z"},{"key":"1508_CR4","doi-asserted-by":"crossref","unstructured":"Stringer JM, Alesi L R, Winship A L, et al. Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life [J]. Hum Reprod Update. 2023;29(4):434\u201356.","DOI":"10.1093\/humupd\/dmad005"},{"key":"1508_CR5","doi-asserted-by":"crossref","unstructured":"Mowery N, T, Terzian W T H. Nelson A C. Acute lung injury [J]. Curr Probl Surg. 2020;57(5):100777.","DOI":"10.1016\/j.cpsurg.2020.100777"},{"key":"1508_CR6","doi-asserted-by":"crossref","unstructured":"Dolma S, Lessnick S L, Hahn W C, et al. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells [J]. Cancer Cell. 2003;3(3):285\u201396.","DOI":"10.1016\/S1535-6108(03)00050-3"},{"key":"1508_CR7","doi-asserted-by":"crossref","unstructured":"Liu M, Wu K, Wu Y. The emerging role of ferroptosis in female reproductive disorders [J]. Biomed Pharmacother. 2023;166:115415.","DOI":"10.1016\/j.biopha.2023.115415"},{"key":"1508_CR8","doi-asserted-by":"crossref","unstructured":"Andrews N C. Schmidt P J. Iron homeostasis [J]. Annu Rev Physiol. 2007;69:69\u201385.","DOI":"10.1146\/annurev.physiol.69.031905.164337"},{"key":"1508_CR9","doi-asserted-by":"crossref","unstructured":"Gao M, Monian P, Quadri N, et al. Glutaminolysis and transferrin regulate ferroptosis [J]. Mol Cell. 2015;59(2):298\u2013308.","DOI":"10.1016\/j.molcel.2015.06.011"},{"key":"1508_CR10","doi-asserted-by":"crossref","unstructured":"Kajarabille N, Latunde-Dada GO. Programmed cell-death by Ferroptosis: antioxidants as mitigators [J]. Int J Mol Sci, 2019, 20(19).","DOI":"10.3390\/ijms20194968"},{"key":"1508_CR11","doi-asserted-by":"crossref","unstructured":"Santana-Codina N, Del Rey M Q, Kapner K S, et al. NCOA4-Mediated ferritinophagy is a pancreatic Cancer dependency via maintenance of Iron Bioavailability for Iron-Sulfur Cluster proteins [J]. Cancer Discov. 2022;12(9):2180\u201397.","DOI":"10.1158\/2159-8290.CD-22-0043"},{"key":"1508_CR12","doi-asserted-by":"crossref","unstructured":"Lee S, Hwang N, Seok B G, et al. Autophagy mediates an amplification loop during ferroptosis [J]. Cell Death Dis. 2023;14(7):464.","DOI":"10.1038\/s41419-023-05978-8"},{"key":"1508_CR13","doi-asserted-by":"crossref","unstructured":"Dixon SJ, Lemberg K M, Lamprecht M R, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death [J]. Cell. 2012;149(5):1060\u201372.","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"1508_CR14","doi-asserted-by":"crossref","unstructured":"Gao M, YI J, Zhu J et al. Role of Mitochondria in ferroptosis [J]. Mol Cell, 2019, 73(2): 354\u2009\u2013\u200963.e3.","DOI":"10.1016\/j.molcel.2018.10.042"},{"key":"1508_CR15","doi-asserted-by":"crossref","unstructured":"Mao Kaganve, Qu G. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis [J]. Nat Chem Biol. 2017;13(1):81\u201390.","DOI":"10.1038\/nchembio.2238"},{"key":"1508_CR16","doi-asserted-by":"crossref","unstructured":"Matsushita M, Freigang S, Schneider C, et al. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection [J]. J Exp Med. 2015;212(4):555\u201368.","DOI":"10.1084\/jem.20140857"},{"key":"1508_CR17","doi-asserted-by":"crossref","unstructured":"Bayir H, Anthonymuthu T S, Tyurina Y Y, et al. Achieving life through death: Redox Biology of Lipid Peroxidation in ferroptosis [J]. Cell Chem Biol. 2020;27(4):387\u2013408.","DOI":"10.1016\/j.chembiol.2020.03.014"},{"key":"1508_CR18","doi-asserted-by":"crossref","unstructured":"Riegman M, Sagie L, Galed C, et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture [J]. Nat Cell Biol. 2020;22(9):1042\u20138.","DOI":"10.1038\/s41556-020-0565-1"},{"key":"1508_CR19","doi-asserted-by":"crossref","unstructured":"Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications [J]. Cell Res. 2021;31(2):107\u201325.","DOI":"10.1038\/s41422-020-00441-1"},{"key":"1508_CR20","doi-asserted-by":"crossref","unstructured":"Li Y, He Y, Cheng W, et al. Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility [J]. Cell Death Discov. 2023;9(1):306.","DOI":"10.1038\/s41420-023-01606-8"},{"key":"1508_CR21","doi-asserted-by":"crossref","unstructured":"Ni Z, Li Y, Song D, et al. Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity [J]. Cell Death Dis. 2022;13(7):579.","DOI":"10.1038\/s41419-022-05037-8"},{"key":"1508_CR22","doi-asserted-by":"crossref","unstructured":"Shen H H, Zhang T, Yang H L, et al. Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis [J]. Theranostics. 2021;11(7):3512\u201326.","DOI":"10.7150\/thno.55241"},{"key":"1508_CR23","doi-asserted-by":"crossref","unstructured":"Cacciottola L, Donnez J, Dolmans MM. Can endometriosis-related oxidative stress pave the way for New Treatment targets? [J]. Int J Mol Sci, 2021, 22(13).","DOI":"10.3390\/ijms22137138"},{"key":"1508_CR24","doi-asserted-by":"crossref","unstructured":"Li Y, Zeng X. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis [J]. Hum Reprod. 2021;36(4):951\u201364.","DOI":"10.1093\/humrep\/deaa363"},{"key":"1508_CR25","doi-asserted-by":"crossref","unstructured":"Woo JH, Choi Y S, Choi JH. Iron-storage protein ferritin is upregulated in endometriosis and Iron overload contributes to a migratory phenotype [J]. Biomedicines, 2020, 8(11).","DOI":"10.3390\/biomedicines8110454"},{"key":"1508_CR26","doi-asserted-by":"crossref","unstructured":"Sikora J, Smycz-Kubanska M, Mielczarek-Palacz A et al. Abnormal peritoneal regulation of chemokine activation-the role of IL-8 in pathogenesis of endometriosis [J]. Am J Reprod Immunol, 2017, 77(4).","DOI":"10.1111\/aji.12622"},{"key":"1508_CR27","doi-asserted-by":"crossref","unstructured":"Hsu C Y, Hsieh T H, Tsai C F, et al. miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis [J]. J Pathol. 2014;232(3):330\u201343.","DOI":"10.1002\/path.4295"},{"key":"1508_CR28","doi-asserted-by":"crossref","unstructured":"Gong T, Liu L, Jiang W, et al. DAMP-sensing receptors in sterile inflammation and inflammatory diseases [J]. Nat Rev Immunol. 2020;20(2):95\u2013112.","DOI":"10.1038\/s41577-019-0215-7"},{"key":"1508_CR29","doi-asserted-by":"crossref","unstructured":"Jang E J, Kim D H, Lee B, et al. Activation of proinflammatory signaling by 4-hydroxynonenal-src adducts in aged kidneys [J]. Oncotarget. 2016;7(32):50864\u201374.","DOI":"10.18632\/oncotarget.10854"},{"key":"1508_CR30","unstructured":"Defr\u00e8re S, Gonz\u00e1lez-Ramos R, Lousse JC, et al. Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis [J]. Histol Histopathol. 2011;26(8):1083\u201392."},{"key":"1508_CR31","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ramos R, Van Langendonckt A, Defr\u00e8re S, et al. Involvement of the nuclear factor-\u03baB pathway in the pathogenesis of endometriosis [J]. Fertil Steril. 2010;94(6):1985\u201394.","DOI":"10.1016\/j.fertnstert.2010.01.013"},{"key":"1508_CR32","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Mend\u00edvil C, Luengo E, Trigo-Alonso P, et al. Protective role of microglial HO-1 blockade in aging: implication of iron metabolism [J]. Redox Biol. 2021;38:101789.","DOI":"10.1016\/j.redox.2020.101789"},{"key":"1508_CR33","doi-asserted-by":"crossref","unstructured":"Chen X, Zhou Y, Wu D, et al. Iron overload compromises preimplantation mouse embryo development [J]. Reprod Toxicol. 2021;105:156\u201365.","DOI":"10.1016\/j.reprotox.2021.08.010"},{"key":"1508_CR34","doi-asserted-by":"crossref","unstructured":"Sanchez A M, Papaleo E, Corti L, et al. Iron availability is increased in individual human ovarian follicles in close proximity to an endometrioma compared with distal ones [J]. Hum Reprod. 2014;29(3):577\u201383.","DOI":"10.1093\/humrep\/det466"},{"key":"1508_CR35","doi-asserted-by":"crossref","unstructured":"Li A, Ni Z, Zhang J, et al. Transferrin Insufficiency and Iron overload in Follicular Fluid Contribute to Oocyte Dysmaturity in Infertile Women with Advanced endometriosis [J]. Front Endocrinol (Lausanne). 2020;11:391.","DOI":"10.3389\/fendo.2020.00391"},{"key":"1508_CR36","doi-asserted-by":"crossref","unstructured":"Teo C F, Wollaston-Hayden E E Wellsl. Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes [J]. Mol Cell Endocrinol. 2010;318(1\u20132):44\u201353.","DOI":"10.1016\/j.mce.2009.09.022"},{"key":"1508_CR37","doi-asserted-by":"crossref","unstructured":"Shah JS, Sabouni R, Cayton Vaught K C, et al. Biomechanics and mechanical signaling in the ovary: a systematic review [J]. J Assist Reprod Genet. 2018;35(7):1135\u201348.","DOI":"10.1007\/s10815-018-1180-y"},{"key":"1508_CR38","doi-asserted-by":"crossref","unstructured":"Beharier O, Kajiwara K. Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome [J]. Placenta. 2021;108:32\u20138.","DOI":"10.1016\/j.placenta.2021.03.007"},{"key":"1508_CR39","doi-asserted-by":"crossref","unstructured":"Ng S W, Norwitz S G, Norwitz E R. The impact of Iron overload and ferroptosis on Reproductive disorders in humans: implications for preeclampsia [J]. Int J Mol Sci, 2019, 20(13).","DOI":"10.3390\/ijms20133283"},{"key":"1508_CR40","doi-asserted-by":"crossref","unstructured":"Xie Y, Hou W, Song X, et al. Ferroptosis: process and function [J]. Cell Death Differ. 2016;23(3):369\u201379.","DOI":"10.1038\/cdd.2015.158"},{"key":"1508_CR41","doi-asserted-by":"crossref","unstructured":"Ko P J Magtanongl, Dixon SJ. Emerging roles for lipids in non-apoptotic cell death [J]. Cell Death Differ. 2016;23(7):1099\u2013109.","DOI":"10.1038\/cdd.2016.25"},{"key":"1508_CR42","doi-asserted-by":"crossref","unstructured":"Deng L, He S, Guo N, et al. Molecular mechanisms of ferroptosis and relevance to inflammation [J]. Inflamm Res. 2023;72(2):281\u201399.","DOI":"10.1007\/s00011-022-01672-1"},{"key":"1508_CR43","unstructured":"Lai YL, Zeng FL, Feng M, Chen ZY, Gao J, Deng GP. A study on the mechanism of Huayu Xiaozheng Granule in regulating the sensitivity of trophocytes to ferroptosis to treat tubal pregnancy [J]. China J Traditional Chin Med Pharm. 2022;37(08):4366\u201370."},{"key":"1508_CR44","doi-asserted-by":"crossref","unstructured":"Lai Y, Zeng F, Chen Z, et al. Shikonin could be used to treat Tubal pregnancy via enhancing ferroptosis sensitivity [J]. Drug Des Devel Ther. 2022;16:2083\u201399.","DOI":"10.2147\/DDDT.S364441"},{"key":"1508_CR45","doi-asserted-by":"crossref","unstructured":"Nash Z Daviesm. Premature ovarian insufficiency [J]. BMJ. 2024;384:e077469.","DOI":"10.1136\/bmj-2023-077469"},{"key":"1508_CR46","doi-asserted-by":"crossref","unstructured":"Rossetti R, Ferrari I. Genetics of primary ovarian insufficiency [J]. Clin Genet. 2017;91(2):183\u201398.","DOI":"10.1111\/cge.12921"},{"key":"1508_CR47","doi-asserted-by":"crossref","unstructured":"Goswami D, Conway G S. Premature ovarian failure [J]. Hum Reprod Update. 2005;11(4):391\u2013410.","DOI":"10.1093\/humupd\/dmi012"},{"key":"1508_CR48","doi-asserted-by":"crossref","unstructured":"Sullivan SD, Castrillon D H. Insights into primary ovarian insufficiency through genetically engineered mouse models [J]. Semin Reprod Med. 2011;29(4):283\u201398.","DOI":"10.1055\/s-0031-1280914"},{"key":"1508_CR49","doi-asserted-by":"crossref","unstructured":"Jin M, Yu Y, Huang H. An update on primary ovarian insufficiency [J]. Sci China Life Sci. 2012;55(8):677\u201386.","DOI":"10.1007\/s11427-012-4355-2"},{"key":"1508_CR50","doi-asserted-by":"crossref","unstructured":"Zhang J, Liu Y, Yao W, et al. Initiation of follicular atresia: gene networks during early atresia in pig ovaries [J]. Reproduction. 2018;156(1):23\u201333.","DOI":"10.1530\/REP-18-0058"},{"key":"1508_CR51","doi-asserted-by":"crossref","unstructured":"Zhao W P, Wang H W, Liu J, et al. Mitochondrial respiratory chain complex abnormal expressions and fusion disorder are involved in fluoride-induced mitochondrial dysfunction in ovarian granulosa cells [J]. Chemosphere. 2019;215:619\u201325.","DOI":"10.1016\/j.chemosphere.2018.10.043"},{"key":"1508_CR52","doi-asserted-by":"crossref","unstructured":"Wang JJ, Ge W, Zhai Q Y, et al. Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice [J]. PLoS Biol. 2020;18(12):e3001025.","DOI":"10.1371\/journal.pbio.3001025"},{"key":"1508_CR53","doi-asserted-by":"crossref","unstructured":"Wang F, Liu Y, Ni F, et al. BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency [J]. Nat Commun. 2022;13(1):5871.","DOI":"10.1038\/s41467-022-33323-8"},{"key":"1508_CR54","doi-asserted-by":"crossref","unstructured":"Chen H, Nie P, Li J, et al. Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction [J]. J Ovarian Res. 2024;17(1):107.","DOI":"10.1186\/s13048-024-01434-z"},{"key":"1508_CR55","doi-asserted-by":"crossref","unstructured":"Anandhan A, Dodson M. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8 [J]. Sci Adv. 2023;9(5):eade9585.","DOI":"10.1126\/sciadv.ade9585"},{"key":"1508_CR56","doi-asserted-by":"crossref","unstructured":"Zhou Y, Huang J. Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2\/GPX4 pathway [J]. J Ovarian Res. 2024;17(1):80.","DOI":"10.1186\/s13048-024-01403-6"},{"key":"1508_CR57","doi-asserted-by":"crossref","unstructured":"Geng Z, Nie X et al. Ling L,. Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota [J]. Oxid Med Cell Longev, 2022, 2022: 4362317.","DOI":"10.1155\/2022\/4362317"},{"key":"1508_CR58","doi-asserted-by":"crossref","unstructured":"Zhang J, Su T, Fan Y, et al. Spotlight on iron overload and ferroptosis: Research progress in female infertility [J]. Life Sci. 2024;340:122370.","DOI":"10.1016\/j.lfs.2023.122370"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01508-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-024-01508-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01508-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T09:07:28Z","timestamp":1726132048000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-024-01508-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1508"],"URL":"https:\/\/doi.org\/10.1186\/s13048-024-01508-y","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"183"}}