{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:41Z","timestamp":1790741981822,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Mechanism underlying the etiology of polycystic ovary syndrome (PCOS) is still debatable. Present study explores the link between iron-mediated ferroptosis and PCOS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methodology<\/jats:title>\n            <jats:p>Blood samples were collected from 150 PCOS females along with healthy controls. Expression analysis of FTH1, NCOA4, GPX4, HAMP, A2M and HP genes was estimated by RT-qPCR. Serum was used for estimation of lipid peroxidation, peroxidase enzyme, ferritin and total protein.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Relative expression of FTH1 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), HAMP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), GPX4, A2M, HP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was downregulated and NCOA4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was upregulated in PCOS group compared to control. A significant difference was observed in mRNA expression of selected genes when \u2264\u200930year age group PCOS was compared to &gt;\u200930year age PCOS group and their respective controls. Deregulation of gene expression was prominent in PCOS group with obese and overweight BMI compared to underweight and normal BMI group. Menstrual cycle length and marital status of PCOS females had no significant association with selected gene expression. Expression deregulation in targeted genes was observed in PCOS patients with complaints of either diabetes, high blood pressure or both. Increased level of lipid peroxidation, serum ferritin and total protein, while decreased peroxidase activity was observed in PCOS group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) compared to control.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The present study postulated the role of iron overload in trigger of ferroptosis following elevated lipid peroxidation and low peroxidase activity. Moreover, unveil the association of genes related to iron-regulating metabolism with etiology of underlying PCOS mechanism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1186\/s13048-024-01562-6","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T06:02:27Z","timestamp":1741413747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism"],"prefix":"10.1186","volume":"18","author":[{"given":"Nighat","family":"Hayat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3364-5510","authenticated-orcid":false,"given":"Zertashia","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayab","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasreen Rehmat","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehmina","family":"Mazhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"1562_CR1","doi-asserted-by":"publisher","first-page":"100060","DOI":"10.1016\/j.eurox.2019.100060","volume":"3","author":"N Ajmal","year":"2019","unstructured":"Ajmal N, Khan SZ, Shaikh R. Polycystic ovary syndrome (PCOS) and genetic predisposition: a review article. Eur J Obstet Gynecol Reprod Biol. 2019;3:100060. https:\/\/doi.org\/10.1016\/j.eurox.2019.100060.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"1562_CR2","doi-asserted-by":"publisher","first-page":"545","DOI":"10.29271\/jcpsp.2020.05.545","volume":"30","author":"A Azhar","year":"2020","unstructured":"Azhar A, Abid F, Rehman R. Polycystic ovary syndrome, subfertility and Vitamin D Deficiency. J Coll Physicians Surg Pak. 2020;30(5):545\u20136. https:\/\/doi.org\/10.29271\/jcpsp.2020.05.545.","journal-title":"J Coll Physicians Surg Pak"},{"key":"1562_CR3","doi-asserted-by":"publisher","first-page":"263349412091103","DOI":"10.1177\/263349412091103","volume":"14","author":"YV Louwers","year":"2020","unstructured":"Louwers YV, Laven JS. Characteristics of polycystic ovary syndrome throughout life. Ther Adv Reprod Health. 2020;14:2633494120911038. https:\/\/doi.org\/10.1177\/263349412091103.","journal-title":"Ther Adv Reprod Health"},{"issue":"7","key":"1562_CR4","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.3390\/ijms22073789","volume":"22","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R, Meczekalski B. Chronic low Grade inflammation in Pathogenesis of PCOS. Int J Mol Sci. 2021;22(7):3789. https:\/\/doi.org\/10.3390\/ijms22073789.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1562_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1210\/er.2015-1018","volume":"36","author":"DA Dumesic","year":"2015","unstructured":"Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015;36(5):487\u2013525. https:\/\/doi.org\/10.1210\/er.2015-1018.","journal-title":"Endocr Rev"},{"key":"1562_CR6","doi-asserted-by":"publisher","first-page":"141049","DOI":"10.1016\/j.scitotenv.2020.141049","volume":"745","author":"D Wang","year":"2020","unstructured":"Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y. Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice. Sci Total Environ. 2020;745:141049. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.141049.","journal-title":"Sci Total Environ"},{"issue":"7","key":"1562_CR7","doi-asserted-by":"publisher","first-page":"9563","DOI":"10.1096\/fj.202000605RR","volume":"34","author":"C Zhang","year":"2020","unstructured":"Zhang C, Hu J, Wang W, Sun Y, Sun K. HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS. FASEB J. 2020;34(7):9563\u201374. https:\/\/doi.org\/10.1096\/fj.202000605RR.","journal-title":"FASEB J"},{"issue":"5","key":"1562_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"D Tang","year":"2019","unstructured":"Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. Cell Res. 2019;29(5):347\u201364. https:\/\/doi.org\/10.1038\/s41422-019-0164-5.","journal-title":"Cell Res"},{"issue":"5","key":"1562_CR9","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060\u201372. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042.","journal-title":"Cell"},{"issue":"8","key":"1562_CR10","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","volume":"1861","author":"GO Latunde-Dada","year":"2017","unstructured":"Latunde-Dada GO, Ferroptosis. Role of lipid peroxidation, iron and ferritinophagy. Biochim Biophys Acta Gen Subj. 2017;1861(8):1893\u2013900. https:\/\/doi.org\/10.1016\/j.bbagen.2017.05.019.","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"8","key":"1562_CR11","doi-asserted-by":"publisher","first-page":"e23095","DOI":"10.1096\/fj.202300918R","volume":"37","author":"I Yanatori","year":"2023","unstructured":"Yanatori I, Nishina S, Kishi F, Hino K. Newly uncovered biochemical and functional aspects of ferritin. FASEB J. 2023;37(8):e23095. https:\/\/doi.org\/10.1096\/fj.202300918R.","journal-title":"FASEB J"},{"key":"1562_CR12","doi-asserted-by":"publisher","first-page":"710963","DOI":"10.3389\/fcvm.2021.710963","volume":"8","author":"H Hu","year":"2021","unstructured":"Hu H, Chen Y, Jing L, Zhai C, Shen L. The link between ferroptosis and cardiovascular diseases: a novel target for treatment. Front Cardiovasc Med. 2021;8:710963. https:\/\/doi.org\/10.3389\/fcvm.2021.710963.","journal-title":"Front Cardiovasc Med"},{"key":"1562_CR13","doi-asserted-by":"publisher","first-page":"108381","DOI":"10.1016\/j.reprotox.2023.108381","volume":"118","author":"X Li","year":"2023","unstructured":"Li X, Duan X, Tan D, Zhang B, Xu A, Qiu N, Chen Z. Iron deficiency and overload in men and woman of reproductive age, and pregnant women. Reprod Toxicol. 2023;118:108381. https:\/\/doi.org\/10.1016\/j.reprotox.2023.108381.","journal-title":"Reprod Toxicol"},{"issue":"13","key":"1562_CR14","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.3390\/ijms20133283","volume":"20","author":"SW Ng","year":"2019","unstructured":"Ng SW, Norwitz SG, Norwitz ER. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int J Mol Sci. 2019;20(13):3283. https:\/\/doi.org\/10.3390\/ijms20133283.","journal-title":"Int J Mol Sci"},{"key":"1562_CR15","doi-asserted-by":"publisher","unstructured":"Yang L, Tian S, Chen Y, Miao C, Zhao Y, Wang R, Zhang Q. Ferroptosis-related gene model to predict overall survival of ovarian carcinoma. J Oncol. 2021;16687391. https:\/\/doi.org\/10.1155\/2021\/6687391.","DOI":"10.1155\/2021\/6687391"},{"issue":"1","key":"1562_CR16","doi-asserted-by":"publisher","first-page":"BSR20212234","DOI":"10.1042\/BSR20212234","volume":"43","author":"M Mathew","year":"2023","unstructured":"Mathew M, Sivaprakasam S, Jennifer LP, Bhutia YD, Ganapathy V. Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues. Biosci Rep. 2023;43(1):BSR20212234. https:\/\/doi.org\/10.1042\/BSR20212234.","journal-title":"Biosci Rep"},{"key":"1562_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.12.105","volume":"196","author":"Y Wu","year":"2023","unstructured":"Wu Y, Yang R, Lan J, Wu Y, Huang J, Fan Q, You Y, Lin H, Jiao X, Chen H, Cao C, Zhang Q. Iron overload modulates follicular microenvironment via ROS\/HIF-1alpha\/FSHR signaling. Free Radic Biol Med. 2023;196:37\u201352. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.12.105.","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"1562_CR18","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1515\/hsz-2016-0336","volume":"398","author":"S Rockfield","year":"2017","unstructured":"Rockfield S, Raffel J, Mehta R, Rehman N, Nanjundan M. Iron overload and altered Iron Metabolism in Ovarian Cancer. Biol Chem. 2017;398(9):995\u20131007. https:\/\/doi.org\/10.1515\/hsz-2016-0336.","journal-title":"Biol Chem"},{"issue":"5","key":"1562_CR19","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/antiox9050405","volume":"9","author":"R Meli","year":"2020","unstructured":"Meli R, Monnolo A, Annunziata C, Pirozzi C, Ferrante MC. Oxidative stress and BPA toxicity: an antioxidant Approach for Male and Female Reproductive Dysfunction. Antioxid. 2020;9(5):405. https:\/\/doi.org\/10.3390\/antiox9050405.","journal-title":"Antioxid"},{"key":"1562_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","volume":"152","author":"F Ursini","year":"2020","unstructured":"Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic Biol Med. 2020;152:175\u201385. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.02.027.","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"1562_CR21","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/nu10091173","volume":"10","author":"N Ueda","year":"2018","unstructured":"Ueda N, Takasawa K. Impact of inflammation on Ferritin, Hepcidin and the management of Iron Deficiency Anemia in chronic kidney disease. Nutr. 2018;10(9):1173. https:\/\/doi.org\/10.3390\/nu10091173.","journal-title":"Nutr"},{"key":"1562_CR22","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.2174\/0929867324666170316120538","volume":"24","author":"N Ueda","year":"2017","unstructured":"Ueda N, Takasawa K. Role of hepcidin-25 in chronic kidney disease: Anemia and beyond. Curr Med Chem. 2017;24:1417\u201352. https:\/\/doi.org\/10.2174\/0929867324666170316120538.","journal-title":"Curr Med Chem"},{"issue":"11","key":"1562_CR23","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/cbin.10505","volume":"39","author":"A Miseta","year":"2015","unstructured":"Miseta A, Nagy J, Nagy T, Poor VS, Fekete Z, Sipos K. Hepcidin and its potential clinical utility. Cell Biol Int. 2015;39(11):1191\u2013202. https:\/\/doi.org\/10.1002\/cbin.10505.","journal-title":"Cell Biol Int"},{"issue":"4","key":"1562_CR24","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/jth.15647","volume":"20","author":"J Lagrange","year":"2022","unstructured":"Lagrange J, Lecompte T, Lacolley TP, Regnault V. Alpha-2-macroglobulin in hemostasis and thrombosis: an underestimated old double-edged sword. J Thromb Haemost. 2022;20(4):806\u201315. https:\/\/doi.org\/10.1111\/jth.15647.","journal-title":"J Thromb Haemost"},{"issue":"8","key":"1562_CR25","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1210\/jc.2010-0220","volume":"95","author":"M Insenser","year":"2010","unstructured":"Insenser M, Mart\u00ednez-Garc\u00eda MA, Montes R, San-Millan JL, Escobar-Morreale HF. Proteomic Analysis of Plasma in the polycystic ovary syndrome identifies novel markers involved in Iron Metabolism, Acute-Phase response, and inflammation. J Clin Endocrinol Metab. 2010;95(8):3863\u201370. https:\/\/doi.org\/10.1210\/jc.2010-0220.","journal-title":"J Clin Endocrinol Metab"},{"issue":"14","key":"1562_CR26","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","volume":"250","author":"I Carlberg","year":"1975","unstructured":"Carlberg I, Mannervik B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem. 1975;250(14):5475\u201380. https:\/\/doi.org\/10.1016\/S0021-9258(19)41206-4.","journal-title":"J Biol Chem"},{"key":"1562_CR27","doi-asserted-by":"publisher","first-page":"11425","DOI":"10.1007\/s11356-019-07422-x","volume":"10","author":"S Ahmad","year":"2020","unstructured":"Ahmad S, Arif B, Akram Z, Ahmed MW. Association of intronic polymorphisms (rs1549339, rs13402242) and mRNA expression variations in PSMD1 gene in arsenic-exposed workers. Environ Sci Pollut Res. 2020;10:11425\u201337. https:\/\/doi.org\/10.1007\/s11356-019-07422-x.","journal-title":"Environ Sci Pollut Res"},{"key":"1562_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12920-021-00962-7","volume":"14","author":"Y Yu","year":"2021","unstructured":"Yu Y, Tan P, Zhuang Z, Wang Z, Zhu L, Qiu R, Xu H. DIA proteomics analysis through serum profiles reveals the significant proteins as candidate biomarkers in women with PCOS. BMC Med Genomics. 2021;14:125. https:\/\/doi.org\/10.1186\/s12920-021-00962-7.","journal-title":"BMC Med Genomics"},{"key":"1562_CR29","doi-asserted-by":"publisher","first-page":"572384","DOI":"10.3389\/fendo.2020.572384","volume":"11","author":"J Yin","year":"2020","unstructured":"Yin J, Hong X, Ma J, Bu Y, Liu R. Serum Trace Elements in patients with polycystic ovary syndrome: a systematic review and Meta-analysis. Front Endocrinol (Lausanne). 2020;11:572384. https:\/\/doi.org\/10.3389\/fendo.2020.572384.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"1562_CR30","first-page":"210","volume":"12","author":"HB Rashidi","year":"2018","unstructured":"Rashidi HB, Shams S, Shariat M, Bagheri M, Mohebi M, Haghollahi F. The association of serum hepcidin levels and insulin resistance in PCOS patients: a case-control study. J Family Reprod Health. 2018;12(4):210\u20136.","journal-title":"J Family Reprod Health"},{"issue":"10","key":"1562_CR31","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1073\/pnas.0900453106","volume":"106","author":"I De Domenico","year":"2009","unstructured":"De Domenico I, Lo E, Ward DM, Kaplan J. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci. 2009;106(10):3800\u20135. https:\/\/doi.org\/10.1073\/pnas.0900453106.","journal-title":"Proc Natl Acad Sci"},{"issue":"35","key":"1562_CR32","doi-asserted-by":"publisher","first-page":"25450","DOI":"10.1074\/jbc.M113.471573","volume":"288","author":"ML Huang","year":"2013","unstructured":"Huang ML, Austin CJ, Sari MA, Rahmanto YS, Ponka P, Vyoral D, Richardson DR. Hepcidin bound to \u03b12-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels. J Biol Chem. 2013;288(35):25450\u201365. https:\/\/doi.org\/10.1074\/jbc.M113.471573.","journal-title":"J Biol Chem"},{"key":"1562_CR33","doi-asserted-by":"publisher","first-page":"100851","DOI":"10.1016\/j.mam.2020.100851","volume":"73","author":"A di-Masi","year":"2020","unstructured":"di-Masi A, De-Simone G, Ciaccio C, D\u2019Orso C, Coletta M, Ascenzi P. Haptoglobin: from hemoglobin scavenging to human health. Mol Aspects Med. 2020;73:100851. https:\/\/doi.org\/10.1016\/j.mam.2020.100851.","journal-title":"Mol Aspects Med"},{"issue":"7498","key":"1562_CR34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nat. 2014;509(7498):105\u20139. https:\/\/doi.org\/10.1038\/nature13148.","journal-title":"Nat"},{"key":"1562_CR35","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","volume":"17","author":"Y Tian","year":"2020","unstructured":"Tian Y, Lu J, Hao X, Li H 1, Zhang G, Liu X, Li X, Zhao C, Kuang W, Chen D, Zhu M. FTH1 inhibits ferroptosis through Ferritinophagy in the 6-OHDA model of Parkinson\u2019s Disease. Neurother. 2020;17:1796\u2013812. https:\/\/doi.org\/10.1007\/s13311-020-00929-z.","journal-title":"Neurother"},{"issue":"6","key":"1562_CR36","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","volume":"7","author":"Y Fang","year":"2021","unstructured":"Fang Y, Chen X, Tan Q, Zhou H, Xu J, Gu Q. Inhibiting ferroptosis through disrupting the NCOA4\u2013FTH1 Interaction: a new mechanism of action. ACS Cent Sci. 2021;7(6):980\u20139. https:\/\/doi.org\/10.1021\/acscentsci.0c01592.","journal-title":"ACS Cent Sci"},{"issue":"9","key":"1562_CR37","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1021\/acscentsci.0c01592","volume":"26","author":"M Gao","year":"2016","unstructured":"Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26(9):1021\u201332. https:\/\/doi.org\/10.1021\/acscentsci.0c01592.","journal-title":"Cell Res"},{"issue":"2","key":"1562_CR38","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41419-020-2334-2","volume":"11","author":"N Yamada","year":"2020","unstructured":"Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis. 2020;11(2):144. https:\/\/doi.org\/10.1038\/s41419-020-2334-2.","journal-title":"Cell Death Dis"},{"key":"1562_CR39","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","volume":"177","author":"I Alim","year":"2019","unstructured":"Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste.Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR. Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell. 2019;177:1262\u201379. https:\/\/doi.org\/10.1016\/j.cell.2019.03.032.","journal-title":"Cell"},{"key":"1562_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.03.015","volume":"217","author":"J Ma","year":"2024","unstructured":"Ma J, Chen S, Liu J, Liao Y, Li L, Wang CC, Song S, Feng R, Hu H, Quan S. Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy. Free Radic Biol Med. 2024;217:1\u201314. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.03.015.","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1562_CR41","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","volume":"35","author":"B Hassannia","year":"2019","unstructured":"Hassannia B, Vandenabeele P, Berghe TV. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35(6):830\u201349. https:\/\/doi.org\/10.1016\/j.ccell.2019.04.002.","journal-title":"Cancer Cell"},{"issue":"10","key":"1562_CR42","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","volume":"19","author":"Y Xie","year":"2023","unstructured":"Xie Y, Kang R, Klionsky DJ, Tang D. GPX4 in cell death, autophagy, and disease. Autophagy. 2023;19(10):2621\u201338. https:\/\/doi.org\/10.1080\/15548627.2023.2218764.","journal-title":"Autophagy"},{"issue":"4","key":"1562_CR43","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/hmg\/ddx424","volume":"27","author":"A Vinuela","year":"2018","unstructured":"Vinuela A, Brown AA, Buil A, Tsai P, Davies MN, Bell JT, Dermitzakis ET, Spector TD, Small KS. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort. Hum Mol Genet. 2018;27(4):732\u201341. https:\/\/doi.org\/10.1093\/hmg\/ddx424.","journal-title":"Hum Mol Genet"},{"issue":"5","key":"1562_CR44","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3390\/ijms20051146","volume":"20","author":"M Wlodarczyk","year":"2019","unstructured":"Wlodarczyk M, Nowicka G, Obesity. DNA damage, and development of obesity-related diseases. Int J Mol Sci. 2019;20(5):1146. https:\/\/doi.org\/10.3390\/ijms20051146.","journal-title":"Int J Mol Sci"},{"key":"1562_CR45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1385\/ENDO:30:1:45","volume":"30","author":"HJ Teede","year":"2006","unstructured":"Teede HJ, Hutchison S, Zoungas S, Meyer C. Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS. Endocrine. 2006;30:45\u201353. https:\/\/doi.org\/10.1385\/ENDO:30:1:45.","journal-title":"Endocrine"},{"key":"1562_CR46","doi-asserted-by":"publisher","unstructured":"Ozkan S, Y\u0131lmaz \u00d6\u00c7, Yavuz B. Increased masked hypertension prevalence in patients with polycystic ovary syndrome (PCOS). Clinical and Experimental Hypertension. 2020 16;42(8):681-4. https:\/\/doi.org\/10.1080\/10641963.2020.1772815","DOI":"10.1080\/10641963.2020.1772815"},{"issue":"12","key":"1562_CR47","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3390\/metabo11120869","volume":"11","author":"W Chen","year":"2021","unstructured":"Chen W, Pang Y. Metabolic syndrome and PCOS: Pathogenesis and the role of metabolites. Metabolites. 2021;11(12):869. https:\/\/doi.org\/10.3390\/metabo11120869.","journal-title":"Metabolites"},{"issue":"17","key":"1562_CR48","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.3390\/diagnostics13172814","volume":"13","author":"DM Rostami","year":"2023","unstructured":"Rostami DM, Rahmati M, Amanollahi SS, Ziaeefar P, Azizi F, Ramezani TF. The hidden link between polycystic ovary syndrome and kidney stones: finding from the Tehran lipid and glucose study (TLGS). Diagnostics. 2023;13(17):2814. https:\/\/doi.org\/10.3390\/diagnostics13172814.","journal-title":"Diagnostics"},{"key":"1562_CR49","doi-asserted-by":"publisher","unstructured":"Song Y, Ye W, Ye H, Xie T, Shen W, Zhou L. Serum testosterone acts as a prognostic indicator in polycystic ovary syndrome-associated kidney injury. Physiol Rep. 2019;16e14219. https:\/\/doi.org\/10.14814\/phy2.14219.","DOI":"10.14814\/phy2.14219"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01562-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-024-01562-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-024-01562-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T06:02:30Z","timestamp":1741413750000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-024-01562-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1562"],"URL":"https:\/\/doi.org\/10.1186\/s13048-024-01562-6","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"12 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of COMSATS University Islamabad (CUI\/Bio\/ERB\/2023\/29).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}