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Selenium-loaded chitosan nanoparticles (CS-SeNPs) have anti-inflammatory and antioxidant effects, indicating that they ameliorate Ag-NPs-induced ovarian toxicity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to assess how well CS-SeNPs counteract the damaging effects of Ag-NPs on the ovarian\u00a0tissue\u00a0of adult female albino rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty mature female albino rats were divided into four equal groups: for 60\u00a0days, Group I (control) was given 0.5\u00a0ml\/kg of distilled water; Group II was given Ag-NPs orally (100\u00a0mg\/kg); Group III was given Ag-NPs orally (100\u00a0mg\/kg\/d) plus CS-SeNPs (0.5\u00a0mg\/kg\/d); and Group IV was given only CS-SeNPs orally (0.5\u00a0mg\/kg\/d). All the ovarian tissues were\u00a0removed and\u00a0underwent immunohistochemical, histological, and biochemical analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ag-NPs-exposed rats revealed a marked reduction in reduced glutathione (GSH) and superoxide dismutase (SOD). Numerous histopathological alterations were found along with a significant increase in PCNA- and Caspase-3-immunoreactive cells. Most of these alterations were successfully ameliorated by CS-SeNPs, as indicated by marked increases in GSH and SOD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CS-SeNPs ameliorate the toxic effects of Ag-NPs on the ovarian\u00a0tissue\u00a0of adult female albino rats.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13048-024-01577-z","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T11:28:22Z","timestamp":1736249302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-4425","authenticated-orcid":false,"given":"Omnia E.","family":"Shalaby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-6424","authenticated-orcid":false,"given":"Yasmine H.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-4276","authenticated-orcid":false,"given":"Aya M.","family":"Mekkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7084-2604","authenticated-orcid":false,"given":"Mohamed Y.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-2464","authenticated-orcid":false,"given":"G. 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