{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:08:52Z","timestamp":1787497732096,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Beijing University of Chinese Medicine Key Discipline Construction Program Fund","award":["grant number 90010951310079"],"award-info":[{"award-number":["grant number 90010951310079"]}]},{"name":"The Third Affiliated Hospital of Beijing University of Chinese Medicine 2022 Institutional Cultivation Programs","award":["BZYSY-2022-PYMS-13"],"award-info":[{"award-number":["BZYSY-2022-PYMS-13"]}]},{"name":"Basic Research Program of Beijing University of Chinese Medicine","award":["2018-JYBZZ-JS138"],"award-info":[{"award-number":["2018-JYBZZ-JS138"]}]},{"name":"Beijing University of Chinese Medicine Vertical Development Fund for University-level Research","award":["2023-SFYZX-09"],"award-info":[{"award-number":["2023-SFYZX-09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01587-5","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:09:27Z","timestamp":1737004167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK\/PGC1- \u03b1\/Irisin pathway"],"prefix":"10.1186","volume":"18","author":[{"given":"Haijuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conglu","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"1587_CR1","doi-asserted-by":"publisher","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","volume":"2","author":"R Azziz","year":"2016","unstructured":"Azziz R, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"1587_CR2","doi-asserted-by":"publisher","first-page":"1361962","DOI":"10.3389\/fpubh.2024.1361962","volume":"12","author":"L Li","year":"2024","unstructured":"Li L, et al. Association between mild depressive states in polycystic ovary syndrome and an unhealthy lifestyle. Front Public Health. 2024;12(12):1361962.","journal-title":"Front Public Health"},{"key":"1587_CR3","doi-asserted-by":"publisher","unstructured":"Chen T et al. The relationship between polycystic ovary syndrome and insulin resistance from 1983 to 2022: A bibliometric analysis. Front Public Health. 2022;10:960965. https:\/\/doi.org\/10.3389\/fpubh.2022.960965.","DOI":"10.3389\/fpubh.2022.960965"},{"issue":"3","key":"1587_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4239\/wjd.v13.i3.129","volume":"13","author":"CA Amisi","year":"2022","unstructured":"Amisi CA. Markers of insulin resistance in polycystic ovary syndrome women: an update. World J Diabetes. 2022;13(3):129\u201349.","journal-title":"World J Diabetes"},{"issue":"3","key":"1587_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s12020-022-02981-5","volume":"75","author":"Y Luo","year":"2022","unstructured":"Luo Y, et al. Irisin: circulating levels in serum and its relation to gonadal axis. Endocrine. 2022;75(3):663\u201371.","journal-title":"Endocrine"},{"issue":"1","key":"1587_CR6","doi-asserted-by":"publisher","first-page":"10658","DOI":"10.1038\/s41598-024-61415-6","volume":"14","author":"J Lin","year":"2024","unstructured":"Lin J, et al. Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin\/AMPK activation. Sci Rep. 2024;14(1):10658.","journal-title":"Sci Rep"},{"key":"1587_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.peptides.2014.09.014","volume":"61","author":"S Aydin","year":"2014","unstructured":"Aydin S, et al. A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides. 2014;61:130\u20136.","journal-title":"Peptides"},{"issue":"5","key":"1587_CR8","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s40618-015-0403-7","volume":"39","author":"H Li","year":"2015","unstructured":"Li H, et al. Free androgen index and irisin in polycystic ovary syndrome. J Endocrinol Investig. 2015;39(5):549\u201356.","journal-title":"J Endocrinol Investig"},{"issue":"12","key":"1587_CR9","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s40618-018-0902-4","volume":"41","author":"L Zhang","year":"2018","unstructured":"Zhang L, et al. The association between circulating irisin levels and different phenotypes of polycystic ovary syndrome. J Endocrinol Investig. 2018;41(12):1401\u20137.","journal-title":"J Endocrinol Investig"},{"issue":"1","key":"1587_CR10","doi-asserted-by":"publisher","first-page":"6447","DOI":"10.1038\/s41598-019-42061-9","volume":"9","author":"CL Chang","year":"2019","unstructured":"Chang CL, et al. The serum level of irisin, but not asprosin, is abnormal in polycystic ovary syndrome patients. Sci Rep. 2019;9(1):6447.","journal-title":"Sci Rep"},{"issue":"7382","key":"1587_CR11","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","volume":"481","author":"P Bostr\u00f6m","year":"2012","unstructured":"Bostr\u00f6m P, et al. A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463\u20138.","journal-title":"Nature"},{"key":"1587_CR12","doi-asserted-by":"crossref","unstructured":"Yang Y et al. Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK\/PGC-1\u03b1 and PPAR\u03b1-mediated autophagy pathway. J Translational Med, 2024. 22(1).","DOI":"10.1186\/s12967-024-05060-7"},{"issue":"7","key":"1587_CR13","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","volume":"175","author":"H Kim","year":"2018","unstructured":"Kim H, et al. Irisin mediates effects on Bone and Fat via \u03b1V Integrin receptors. Cell. 2018;175(7):1756\u2013e176817.","journal-title":"Cell"},{"issue":"6270","key":"1587_CR14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1126\/science.aab4138","volume":"351","author":"EQ Toyama","year":"2016","unstructured":"Toyama EQ, et al. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016;351(6270):275\u201381.","journal-title":"Science"},{"issue":"2","key":"1587_CR15","doi-asserted-by":"publisher","first-page":"00524","DOI":"10.3389\/fendo.2019.00524","volume":"10","author":"LI Arhire","year":"2019","unstructured":"Arhire LI, Mihalache L, Covasa M. Irisin: a hope in understanding and managing obesity and metabolic syndrome. Front Endocrinol. 2019;10(2):00524.","journal-title":"Front Endocrinol"},{"issue":"1","key":"1587_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00404-016-4078-x","volume":"294","author":"S Eisenhardt","year":"2016","unstructured":"Eisenhardt S, Fleckenstein J. Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome. Arch Gynecol Obstet. 2016;294(1):193\u2013200.","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"1587_CR17","first-page":"1","volume":"45","author":"Q Wang","year":"2022","unstructured":"Wang Q. Ontology of Qi in Traditional Chinese Medicine based on China Philosophy and Modern Science. J Beijing Univ Chin Med. 2022;45(1):1\u201310.","journal-title":"J Beijing Univ Chin Med"},{"issue":"08","key":"1587_CR18","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1142\/S0192415X2050086X","volume":"48","author":"Y Huang","year":"2020","unstructured":"Huang Y, et al. Progress in Traditional Chinese Medicine for the treatment of Migraine. Am J Chin Med. 2020;48(08):1731\u201348.","journal-title":"Am J Chin Med"},{"issue":"07","key":"1587_CR19","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1142\/S0192415X16500737","volume":"44","author":"S Li","year":"2016","unstructured":"Li S, Xutian S. New Development in Traditional Chinese Medicine: symbolism-digit therapy as a special naturopathic treatment. Am J Chin Med. 2016;44(07):1311\u201323.","journal-title":"Am J Chin Med"},{"issue":"2","key":"1587_CR20","first-page":"23","volume":"42","author":"X Chen","year":"2024","unstructured":"Chen X, Wang X. Effect of Ziyin and Qianyang Method of Traditional Chinese Medicine on PI 3K\/Akt Signal Pathway, sex hormone and insulin related indexes in rats with polycystic ovary syndrome and insulin resistance. J Tradit Chin Med. 2024;42(2):23\u20138.","journal-title":"J Tradit Chin Med"},{"issue":"9","key":"1587_CR21","first-page":"10694","volume":"13","author":"C Shao","year":"2021","unstructured":"Shao C, Dong W, Zhang H. Application of Guijiaosan Shenque acupoint paste can improve the scores of obesity, endocrine and TCM symptoms in treating obese polycystic ovary syndrome. Am J Transl Res. 2021;13(9):10694\u2013702.","journal-title":"Am J Transl Res"},{"issue":"1","key":"1587_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41392-024-01756-w","volume":"9","author":"L Qian","year":"2024","unstructured":"Qian L, et al. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases. Signal Transduct Target Ther. 2024;9(1):50.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1587_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13048-023-01242-x","volume":"16","author":"Y Weng","year":"2023","unstructured":"Weng Y, et al. Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1\u03b1-TXNIP\/ROS-NLRP3 pathway in PCOS. J Ovarian Res. 2023;16(1):151.","journal-title":"J Ovarian Res"},{"issue":"12","key":"1587_CR24","doi-asserted-by":"publisher","first-page":"1030151","DOI":"10.3389\/fendo.2022.1030151","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X, et al. Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota. Front Endocrinol. 2022;13(12):1030151.","journal-title":"Front Endocrinol"},{"issue":"1","key":"1587_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13048-024-01422-3","volume":"17","author":"A Abdi","year":"2024","unstructured":"Abdi A, et al. The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway. J Ovarian Res. 2024;17(1):91.","journal-title":"J Ovarian Res"},{"issue":"1","key":"1587_CR26","doi-asserted-by":"publisher","first-page":"1070264","DOI":"10.3389\/fendo.2023.1070264","volume":"14","author":"Q Peng","year":"2023","unstructured":"Peng Q, et al. Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis. Front Endocrinol. 2023;14(1):1070264.","journal-title":"Front Endocrinol"},{"issue":"2","key":"1587_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"A Nair","year":"2016","unstructured":"Nair A, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27\u201331.","journal-title":"J Basic Clin Pharm"},{"issue":"1","key":"1587_CR28","first-page":"65","volume":"6","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE. Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fertility Res Pract. 2020;6(1):65.","journal-title":"Fertility Res Pract"},{"issue":"2","key":"1587_CR29","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/s00266-021-02618-4","volume":"46","author":"JS Lee","year":"2021","unstructured":"Lee JS, et al. Influence of irradiation on capsules of silicone implants covered with Acellular dermal matrix in mice. Aesthetic Plast Surg. 2021;46(2):937\u201346.","journal-title":"Aesthetic Plast Surg"},{"key":"1587_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.molimm.2024.04.015","volume":"172","author":"X Cheng","year":"2024","unstructured":"Cheng X, Li Y, Wang H. Activation of Wnt\/\u03b2-catenin signal induces DCs to differentiate into immune tolerant regDCs in septic mice. Mol Immunol. 2024;172:38\u201346.","journal-title":"Mol Immunol"},{"issue":"12","key":"1587_CR31","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1007\/s00125-022-05787-2","volume":"65","author":"MJ Davies","year":"2022","unstructured":"Davies MJ, et al. Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2022;65(12):1925\u201366.","journal-title":"Diabetologia"},{"issue":"30","key":"1587_CR32","doi-asserted-by":"publisher","first-page":"148524","DOI":"10.1016\/j.gene.2024.148524","volume":"921","author":"AA El Leithy","year":"2024","unstructured":"El Leithy AA, et al. Spirulina versus metformin for controlling some insulin signaling pathway genes in induced polycystic ovary syndrome rat model. Gene. 2024;921(30):148524.","journal-title":"Gene"},{"key":"1587_CR33","doi-asserted-by":"crossref","unstructured":"Li Q, et al. Metformin-induced autophagy and irisin improves INS\u20101 cell function and survival in high\u2010glucose environment via AMPK\/SIRT1\/PGC\u20101\u03b1 signal pathway. Volume 7. Food Science & Nutrition; 2019. pp. 1695\u2013703. 5.","DOI":"10.1002\/fsn3.1006"},{"issue":"4","key":"1587_CR34","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/cen.13805","volume":"89","author":"W Wang","year":"2018","unstructured":"Wang W, et al. Abnormal irisin level in serum and endometrium is associated with metabolic dysfunction in polycystic ovary syndrome patients. Clin Endocrinol. 2018;89(4):474\u201380.","journal-title":"Clin Endocrinol"},{"issue":"1","key":"1587_CR35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12905-022-01994-6","volume":"22","author":"X Yang","year":"2022","unstructured":"Yang X, et al. Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K\/AKT signaling. BMC Womens Health. 2022;22(1):412.","journal-title":"BMC Womens Health"},{"issue":"1","key":"1587_CR36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/09513590.2021.2003326","volume":"38","author":"JL Hern\u00e1ndez-Jim\u00e9nez","year":"2021","unstructured":"Hern\u00e1ndez-Jim\u00e9nez JL, et al. Polycystic ovarian syndrome: signs and feedback effects of hyperandrogenism and insulin resistance. Gynecol Endocrinol. 2021;38(1):2\u20139.","journal-title":"Gynecol Endocrinol"},{"issue":"7","key":"1587_CR37","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3109\/01443615.2016.1174200","volume":"36","author":"R Abali","year":"2016","unstructured":"Abali R, et al. Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome. J Obstet Gynaecol. 2016;36(7):897\u2013901.","journal-title":"J Obstet Gynaecol"},{"issue":"4","key":"1587_CR38","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/09513590.2017.1393065","volume":"34","author":"C Wang","year":"2017","unstructured":"Wang C, et al. Higher circulating irisin levels in patients with polycystic ovary syndrome:a meta-analysis. Gynecol Endocrinol. 2017;34(4):290\u20133.","journal-title":"Gynecol Endocrinol"},{"issue":"12","key":"1587_CR39","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1507\/endocrj.EJ16-0249","volume":"63","author":"Agnieszka","year":"2016","unstructured":"Agnieszka, Adamska, et al. Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome. Endocr J. 2016;63(12):1107\u201312.","journal-title":"Endocr J"},{"issue":"5","key":"1587_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejogrb.2024.03.034","volume":"297","author":"D Kuai","year":"2024","unstructured":"Kuai D, et al. Relationship between serum apelin, visfatin levels, and body composition in polycystic ovary syndrome patients. Eur J Obstet Gynecol Reproductive Biology. 2024;297(5):24\u20139.","journal-title":"Eur J Obstet Gynecol Reproductive Biology"},{"issue":"1","key":"1587_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40618-016-0523-8","volume":"40","author":"K Polak","year":"2016","unstructured":"Polak K, et al. New markers of insulin resistance in polycystic ovary syndrome. J Endocrinol Investig. 2016;40(1):1\u20138.","journal-title":"J Endocrinol Investig"},{"issue":"4","key":"1587_CR42","doi-asserted-by":"publisher","first-page":"e94235","DOI":"10.1371\/journal.pone.0094235","volume":"9","author":"B Yan","year":"2014","unstructured":"Yan B, et al. Association of serum irisin with metabolic syndrome in obese Chinese adults. PLoS ONE. 2014;9(4):e94235.","journal-title":"PLoS ONE"},{"issue":"12","key":"1587_CR43","doi-asserted-by":"publisher","first-page":"E2539","DOI":"10.1210\/jc.2014-1180","volume":"99","author":"CL Chang","year":"2014","unstructured":"Chang CL, et al. Circulating Irisin and glucose-dependent insulinotropic peptide are Associated with the development of polycystic ovary syndrome. J Clin Endocrinol Metabolism. 2014;99(12):E2539\u201348.","journal-title":"J Clin Endocrinol Metabolism"},{"issue":"2","key":"1587_CR44","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/eci.12196","volume":"44","author":"NM Al-Daghri","year":"2014","unstructured":"Al-Daghri NM, et al. Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects. Eur J Clin Invest. 2014;44(2):119\u201324.","journal-title":"Eur J Clin Invest"},{"issue":"0","key":"1587_CR45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1265\/ehpm.23-00146","volume":"28","author":"C Zuo","year":"2023","unstructured":"Zuo C, et al. Acute and chronic functional and traditional resistance training improve muscular fitness in young males via the AMPK\/PGC-1\u03b1\/irisin signaling pathway. Environ Health Prev Med. 2023;28(0):69\u201369.","journal-title":"Environ Health Prev Med"},{"issue":"1","key":"1587_CR46","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1186\/s12889-023-15730-8","volume":"23","author":"MS Butt","year":"2023","unstructured":"Butt MS, et al. Benefits of physical activity on reproductive health functions among polycystic ovarian syndrome women: a systematic review. BMC Public Health. 2023;23(1):882.","journal-title":"BMC Public Health"},{"issue":"3","key":"1587_CR47","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1748-1716.2010.02181.x","volume":"201","author":"LC Gormsen","year":"2011","unstructured":"Gormsen LC, et al. Time-course effects of physiological free fatty acid surges on insulin sensitivity in humans. Acta Physiol. 2011;201(3):349\u201356.","journal-title":"Acta Physiol"},{"issue":"12","key":"1587_CR48","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1210\/en.2006-0879","volume":"147","author":"KJ McInnes","year":"2006","unstructured":"McInnes KJ, et al. Regulation of Adenosine 5\u2032,Monophosphate-Activated Protein Kinase and Lipogenesis by Androgens contributes to visceral obesity in an estrogen-deficient state. Endocrinology. 2006;147(12):5907\u201313.","journal-title":"Endocrinology"},{"key":"1587_CR49","first-page":"46","volume":"34","author":"S Yosaee","year":"2020","unstructured":"Yosaee S, et al. Serum irisin levels in metabolically healthy versus metabolically unhealthy obesity: a case-control study. Med J Islam Repub Iran. 2020;34:46.","journal-title":"Med J Islam Repub Iran"},{"issue":"2","key":"1587_CR50","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.rbmo.2017.10.114","volume":"36","author":"X Cai","year":"2018","unstructured":"Cai X, et al. Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis. Reprod Biomed Online. 2018;36(2):172\u201380.","journal-title":"Reprod Biomed Online"},{"key":"1587_CR51","doi-asserted-by":"crossref","unstructured":"Li Y et al. Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3\/ERCC1\/MAPK axis. J Ovarian Res, 2023. 16(1).","DOI":"10.1186\/s13048-023-01200-7"},{"key":"1587_CR52","doi-asserted-by":"publisher","first-page":"962154","DOI":"10.3389\/fendo.2022.962154","volume":"13","author":"XL Jiang","year":"2022","unstructured":"Jiang XL, et al. Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome. Front Endocrinol (Lausanne). 2022;13:962154.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"1587_CR53","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11655-020-3219-z","volume":"27","author":"S Xiang","year":"2020","unstructured":"Xiang S, et al. Effect of Electro-acupuncture on expression of IRS-1\/PI3K\/GLUT4 pathway in ovarian granulosa cells of infertile patients with polycystic ovary syndrome-insulin resistance of phlegm-dampness syndrome. Chin J Integr Med. 2020;27(5):330\u20135.","journal-title":"Chin J Integr Med"},{"issue":"5","key":"1587_CR54","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1530\/EJE-19-0505","volume":"181","author":"R Fl\u00e1via","year":"2019","unstructured":"Fl\u00e1via R. Brown adipose tissue activity is reduced in women with polycystic ovary syndrome. Eur J Endocrinol. 2019;181(5):473\u201380.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1587_CR55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/cen.13913","volume":"90","author":"S Shorakae","year":"2019","unstructured":"Shorakae S, et al. Brown adipose tissue thermogenesis in polycystic ovary syndrome. Clin Endocrinol. 2019;90(3):425\u201332.","journal-title":"Clin Endocrinol"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01587-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01587-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01587-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:00:54Z","timestamp":1737007254000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01587-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1587"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01587-5","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"11 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental procedures were agreed and approved by the Laboratory Animal Ethics Sub-committee of the Academic Committee of Beijing University of Chinese Medicine (BUCM) (No.: BUCM-2023030104-1105).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}