{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:15:06Z","timestamp":1792800906895,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University","award":["QNCXTD2023017"],"award-info":[{"award-number":["QNCXTD2023017"]}],"id":[{"id":"https:\/\/ror.org\/056swr059","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110900"],"award-info":[{"award-number":["2019YFA0110900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"key international (regional) cooperative research projects of China","award":["81820108016"],"award-info":[{"award-number":["81820108016"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31970800"],"award-info":[{"award-number":["31970800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01596-4","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T07:49:42Z","timestamp":1737359382000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model"],"prefix":"10.1186","volume":"18","author":[{"given":"Zhenye","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"6","key":"1596_CR1","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2003-032046","volume":"89","author":"R Azziz","year":"2004","unstructured":"Azziz R, et al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"1596_CR2","doi-asserted-by":"publisher","first-page":"e11010","DOI":"10.1016\/j.heliyon.2022.e11010","volume":"8","author":"AM Rababa'h","year":"2022","unstructured":"Rababa\u2019h AM, Matani BR, Yehya A. An update of polycystic ovary syndrome: causes and therapeutics options. Heliyon. 2022;8(10):e11010.","journal-title":"Heliyon"},{"issue":"4","key":"1596_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/humupd\/dmn015","volume":"14","author":"S Franks","year":"2008","unstructured":"Franks S, Stark J, Hardy K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update. 2008;14(4):367\u201378.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"1596_CR4","doi-asserted-by":"publisher","first-page":"e116","DOI":"10.1097\/j.pbj.0000000000000116","volume":"6","author":"A Cunha","year":"2021","unstructured":"Cunha A, P\u00f3voa AM. Infertility management in women with polycystic ovary syndrome: a review. Porto Biomed J. 2021;6(1):e116.","journal-title":"Porto Biomed J"},{"issue":"11","key":"1596_CR5","doi-asserted-by":"publisher","first-page":"765","DOI":"10.6061\/clinics\/2015(11)09","volume":"70","author":"AS Melo","year":"2015","unstructured":"Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics (Sao Paulo). 2015;70(11):765\u20139.","journal-title":"Clinics (Sao Paulo)"},{"issue":"3","key":"1596_CR6","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/humupd\/dms059","volume":"19","author":"M Murri","year":"2013","unstructured":"Murri M, et al. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update. 2013;19(3):268\u201388.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"1596_CR7","doi-asserted-by":"publisher","first-page":"e0151960","DOI":"10.1371\/journal.pone.0151960","volume":"11","author":"VM Victor","year":"2016","unstructured":"Victor VM, et al. Insulin resistance in pcos patients enhances oxidative stress and leukocyte adhesion: role of myeloperoxidase. PLoS ONE. 2016;11(3):e0151960.","journal-title":"PLoS ONE"},{"issue":"7","key":"1596_CR8","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.3390\/ijms22073789","volume":"22","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, et al. Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci. 2021;22(7):3789.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1596_CR9","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.3390\/ijms22052734","volume":"22","author":"S Aboeldalyl","year":"2021","unstructured":"Aboeldalyl S, et al. The role of chronic inflammation in polycystic ovarian syndrome-a systematic review and meta-analysis. Int J Mol Sci. 2021;22(5):2734.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1596_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/00006254-198202000-00001","volume":"37","author":"PE Hughesdon","year":"1982","unstructured":"Hughesdon PE. Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called \u201chyperthecosis.\u201d Obstet Gynecol Surv. 1982;37(2):59\u201377.","journal-title":"Obstet Gynecol Surv"},{"issue":"24","key":"1596_CR11","doi-asserted-by":"publisher","first-page":"eabn4564","DOI":"10.1126\/sciadv.abn4564","volume":"8","author":"T Umehara","year":"2022","unstructured":"Umehara T, et al. Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary. Sci Adv. 2022;8(24):eabn4564.","journal-title":"Sci Adv"},{"issue":"35","key":"1596_CR12","doi-asserted-by":"publisher","first-page":"eabq1475","DOI":"10.1126\/sciadv.abq1475","volume":"8","author":"DA Landry","year":"2022","unstructured":"Landry DA, et al. Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci Adv. 2022;8(35):eabq1475.","journal-title":"Sci Adv"},{"issue":"3","key":"1596_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/REP-16-0129","volume":"152","author":"SM Briley","year":"2016","unstructured":"Briley SM, et al. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction. 2016;152(3):245\u201360.","journal-title":"Reproduction"},{"issue":"3","key":"1596_CR14","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1530\/REP-18-0583","volume":"158","author":"AP Snider","year":"2019","unstructured":"Snider AP, Wood JR. Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction. 2019;158(3):R79-r90.","journal-title":"Reproduction"},{"issue":"1","key":"1596_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","volume":"9","author":"Y Zong","year":"2024","unstructured":"Zong Y, et al. Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther. 2024;9(1):124.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"1596_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/cdd.2014.150","volume":"22","author":"G Filomeni","year":"2015","unstructured":"Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015;22(3):377\u201388.","journal-title":"Cell Death Differ"},{"issue":"1","key":"1596_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"W Chen","year":"2023","unstructured":"Chen W, Zhao H, Li Y. Mitochondrial dynamics in health and disease: mechanisms and potential targets. Signal Transduct Target Ther. 2023;8(1):333.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1596_CR18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12943-023-01744-8","volume":"22","author":"Z Yuan","year":"2023","unstructured":"Yuan Z, et al. Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments. Mol Cancer. 2023;22(1):48.","journal-title":"Mol Cancer"},{"key":"1596_CR19","doi-asserted-by":"publisher","first-page":"684592","DOI":"10.1155\/2012\/684592","volume":"2012","author":"ML Taddei","year":"2012","unstructured":"Taddei ML, et al. Mitochondrial oxidative stress due to complex I dysfunction promotes fibroblast activation and melanoma cell invasiveness. J Signal Transduct. 2012;2012:684592.","journal-title":"J Signal Transduct"},{"issue":"17","key":"1596_CR20","doi-asserted-by":"publisher","first-page":"13123","DOI":"10.3390\/ijms241713123","volume":"24","author":"KM Siemers","year":"2023","unstructured":"Siemers KM, Klein AK, Baack ML. Mitochondrial dysfunction in PCOS: insights into reproductive organ pathophysiology. Int J Mol Sci. 2023;24(17):13123.","journal-title":"Int J Mol Sci"},{"key":"1596_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.05.010","volume":"187","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, et al. Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3. Free Radic Biol Med. 2022;187:1\u201316.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"1596_CR22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/biolre\/ioab078","volume":"105","author":"Y Wang","year":"2021","unstructured":"Wang Y, et al. NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome\u2021. Biol Reprod. 2021;105(2):371\u201380.","journal-title":"Biol Reprod"},{"issue":"1","key":"1596_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","volume":"22","author":"C Cant\u00f3","year":"2015","unstructured":"Cant\u00f3 C, Menzies KJ, Auwerx J. NAD(+) metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. Cell Metab. 2015;22(1):31\u201353.","journal-title":"Cell Metab"},{"key":"1596_CR24","doi-asserted-by":"publisher","first-page":"101195","DOI":"10.1016\/j.molmet.2021.101195","volume":"49","author":"S Amjad","year":"2021","unstructured":"Amjad S, et al. Role of NAD(+) in regulating cellular and metabolic signaling pathways. Mol Metab. 2021;49:101195.","journal-title":"Mol Metab"},{"issue":"6","key":"1596_CR25","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","volume":"23","author":"J Camacho-Pereira","year":"2016","unstructured":"Camacho-Pereira J, et al. CD38 dictates age-related nad decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab. 2016;23(6):1127\u201339.","journal-title":"Cell Metab"},{"key":"1596_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.05.003","volume":"156","author":"Q Yang","year":"2020","unstructured":"Yang Q, et al. Increasing ovarian NAD(+) levels improve mitochondrial functions and reverse ovarian aging. Free Radic Biol Med. 2020;156:1\u201310.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"1596_CR27","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.3390\/ijms24032959","volume":"24","author":"B Polj\u0161ak","year":"2023","unstructured":"Polj\u0161ak B, et al. The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases: strategies for NAD+ modulation. Int J Mol Sci. 2023;24(3):2959.","journal-title":"Int J Mol Sci"},{"key":"1596_CR28","doi-asserted-by":"publisher","first-page":"101886","DOI":"10.1016\/j.redox.2021.101886","volume":"41","author":"T Li","year":"2021","unstructured":"Li T, et al. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. Redox Biol. 2021;41:101886.","journal-title":"Redox Biol"},{"issue":"1","key":"1596_CR29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13048-024-01445-w","volume":"17","author":"X Teng","year":"2024","unstructured":"Teng X, Wang Z, Wang X. Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model. J Ovarian Res. 2024;17(1):121.","journal-title":"J Ovarian Res"},{"key":"1596_CR30","doi-asserted-by":"publisher","first-page":"9782373","DOI":"10.1155\/2019\/9782373","volume":"2019","author":"Q Xie","year":"2019","unstructured":"Xie Q, et al. Mesenchymal stem cells alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by inhibiting inflammation in mice. Stem Cells Int. 2019;2019:9782373.","journal-title":"Stem Cells Int"},{"issue":"5","key":"1596_CR31","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1210\/clinem\/dgaa960","volume":"106","author":"EBM Nascimento","year":"2021","unstructured":"Nascimento EBM, et al. Nicotinamide riboside enhances in vitro beta-adrenergic brown adipose tissue activity in humans. J Clin Endocrinol Metab. 2021;106(5):1437\u201347.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1596_CR32","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","volume":"15","author":"C Cant\u00f3","year":"2012","unstructured":"Cant\u00f3 C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012;15(6):838\u201347.","journal-title":"Cell Metab"},{"issue":"9","key":"1596_CR33","doi-asserted-by":"publisher","first-page":"e13904","DOI":"10.1111\/acel.13904","volume":"22","author":"Q Yang","year":"2023","unstructured":"Yang Q, et al. Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging. Aging Cell. 2023;22(9):e13904.","journal-title":"Aging Cell"},{"issue":"12","key":"1596_CR34","doi-asserted-by":"publisher","first-page":"e628","DOI":"10.1002\/ctm2.628","volume":"11","author":"Q Yang","year":"2021","unstructured":"Yang Q, et al. NAD(+) repletion attenuates obesity-induced oocyte mitochondrial dysfunction and offspring metabolic abnormalities via a SIRT3-dependent pathway. Clin Transl Med. 2021;11(12):e628.","journal-title":"Clin Transl Med"},{"key":"1596_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40738-020-00074-3","volume":"6","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE. Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fertil Res Pract. 2020;6:5.","journal-title":"Fertil Res Pract"},{"issue":"18","key":"1596_CR36","doi-asserted-by":"publisher","first-page":"14126","DOI":"10.3390\/ijms241814126","volume":"24","author":"N Zeber-Lubecka","year":"2023","unstructured":"Zeber-Lubecka N, Ciebiera M, Hennig EE. Polycystic ovary syndrome and oxidative stress-from bench to bedside. Int J Mol Sci. 2023;24(18):14126.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1596_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20081386","volume":"417","author":"MP Murphy","year":"2009","unstructured":"Murphy MP. How mitochondria produce reactive oxygen species. Biochem J. 2009;417(1):1\u201313.","journal-title":"Biochem J"},{"issue":"21","key":"1596_CR38","first-page":"2003","volume":"8","author":"C Guo","year":"2013","unstructured":"Guo C, et al. Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 2013;8(21):2003\u201314.","journal-title":"Neural Regen Res"},{"issue":"5","key":"1596_CR39","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","volume":"1863","author":"JS Bhatti","year":"2017","unstructured":"Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis. 2017;1863(5):1066\u201377.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"44","key":"1596_CR40","doi-asserted-by":"publisher","first-page":"E6823","DOI":"10.1073\/pnas.1612047113","volume":"113","author":"AT Perkins","year":"2016","unstructured":"Perkins AT, et al. Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors. Proc Natl Acad Sci U S A. 2016;113(44):E6823-e6830.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1596_CR41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.4161\/cc.6.5.3934","volume":"6","author":"V D'Angiolella","year":"2007","unstructured":"D\u2019Angiolella V, Santarpia C, Grieco D. Oxidative stress overrides the spindle checkpoint. Cell Cycle. 2007;6(5):576\u20139.","journal-title":"Cell Cycle"},{"issue":"1","key":"1596_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12958-022-00972-9","volume":"20","author":"Y Wan","year":"2022","unstructured":"Wan Y, et al. IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency. Reprod Biol Endocrinol. 2022;20(1):101.","journal-title":"Reprod Biol Endocrinol"},{"issue":"2","key":"1596_CR43","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S1472-6483(10)60866-8","volume":"12","author":"S Munn\u00e9","year":"2006","unstructured":"Munn\u00e9 S. Chromosome abnormalities and their relationship to morphology and development of human embryos. Reprod Biomed Online. 2006;12(2):234\u201353.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"1596_CR44","doi-asserted-by":"publisher","first-page":"10824","DOI":"10.1038\/s41598-017-11252-7","volume":"7","author":"N Takahashi","year":"2017","unstructured":"Takahashi N, et al. Activation of endoplasmic reticulum stress in granulosa cells from patients with polycystic ovary syndrome contributes to ovarian fibrosis. Sci Rep. 2017;7(1):10824.","journal-title":"Sci Rep"},{"issue":"9588","key":"1596_CR45","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","volume":"370","author":"RJ Norman","year":"2007","unstructured":"Norman RJ, et al. Polycystic ovary syndrome. Lancet. 2007;370(9588):685\u201397.","journal-title":"Lancet"},{"issue":"9","key":"1596_CR46","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.3390\/biomedicines11092560","volume":"11","author":"T Ruskovska","year":"2023","unstructured":"Ruskovska T, Bernlohr DA. The role of NAD(+) in metabolic regulation of adipose tissue: implications for obesity-induced insulin resistance. Biomedicines. 2023;11(9):2560.","journal-title":"Biomedicines"},{"issue":"1","key":"1596_CR47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12935-022-02664-1","volume":"22","author":"Q Xu","year":"2022","unstructured":"Xu Q, et al. Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment. Cancer Cell Int. 2022;22(1):242.","journal-title":"Cancer Cell Int"},{"issue":"4","key":"1596_CR48","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","volume":"30","author":"S Lautrup","year":"2019","unstructured":"Lautrup S, et al. NAD(+) in brain aging and neurodegenerative disorders. Cell Metab. 2019;30(4):630\u201355.","journal-title":"Cell Metab"},{"issue":"2","key":"1596_CR49","first-page":"125","volume":"53","author":"J Swierczy\u0144ski","year":"2001","unstructured":"Swierczy\u0144ski J, et al. Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding. Pol J Pharmacol. 2001;53(2):125\u201330.","journal-title":"Pol J Pharmacol"},{"key":"1596_CR50","doi-asserted-by":"publisher","first-page":"101583","DOI":"10.1016\/j.molmet.2022.101583","volume":"65","author":"A Aflatounian","year":"2022","unstructured":"Aflatounian A, et al. Declining muscle NAD(+) in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation. Mol Metab. 2022;65:101583.","journal-title":"Mol Metab"},{"key":"1596_CR51","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cophys.2018.03.011","volume":"3","author":"MA Walker","year":"2018","unstructured":"Walker MA, Tian R. NAD(H) in mitochondrial energy transduction: implications for health and disease. Curr Opin Physiol. 2018;3:101\u20139.","journal-title":"Curr Opin Physiol"},{"issue":"9","key":"1596_CR52","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.tem.2012.06.005","volume":"23","author":"LR Stein","year":"2012","unstructured":"Stein LR, Imai S. The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab. 2012;23(9):420\u20138.","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"1596_CR53","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12979-023-00398-w","volume":"20","author":"J Liang","year":"2023","unstructured":"Liang J, et al. Impact of NAD+ metabolism on ovarian aging. Immun Ageing. 2023;20(1):70.","journal-title":"Immun Ageing"},{"issue":"1","key":"1596_CR54","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/s42003-020-01514-y","volume":"3","author":"X Yuan","year":"2020","unstructured":"Yuan X, et al. NAD(+)\/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro. Commun Biol. 2020;3(1):774.","journal-title":"Commun Biol"},{"issue":"7","key":"1596_CR55","doi-asserted-by":"publisher","first-page":"100116","DOI":"10.1016\/j.crmeth.2021.100116","volume":"1","author":"Q Hu","year":"2021","unstructured":"Hu Q, et al. Genetically encoded biosensors for evaluating NAD(+)\/NADH ratio in cytosolic and mitochondrial compartments. Cell Rep Methods. 2021;1(7):100116.","journal-title":"Cell Rep Methods"},{"issue":"2","key":"1596_CR56","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.arr.2003.05.001","volume":"3","author":"AG Schwartz","year":"2004","unstructured":"Schwartz AG, Pashko LL. Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004;3(2):171\u201387.","journal-title":"Ageing Res Rev"},{"issue":"7","key":"1596_CR57","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3390\/metabo12070630","volume":"12","author":"C Canto","year":"2022","unstructured":"Canto C. NAD(+) precursors: a questionable redundancy. Metabolites. 2022;12(7):630.","journal-title":"Metabolites"},{"issue":"8","key":"1596_CR58","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1210\/js.2019-00078","volume":"3","author":"SF Witchel","year":"2019","unstructured":"Witchel SF, Oberfield SE, Pe\u00f1a AS. Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls. J Endocr Soc. 2019;3(8):1545\u201373.","journal-title":"J Endocr Soc"},{"issue":"4","key":"1596_CR59","doi-asserted-by":"publisher","first-page":"100812","DOI":"10.1016\/j.repbio.2023.100812","volume":"23","author":"D Danfeng","year":"2023","unstructured":"Danfeng D, et al. Oocyte quality is impaired in a hyperandrogenic PCOS mouse model by increased Foxo1 expression. Reprod Biol. 2023;23(4):100812.","journal-title":"Reprod Biol"},{"issue":"6","key":"1596_CR60","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/humupd\/dmw025","volume":"22","author":"AH Balen","year":"2016","unstructured":"Balen AH, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687\u2013708.","journal-title":"Hum Reprod Update"},{"key":"1596_CR61","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mito.2020.02.006","volume":"52","author":"P Shukla","year":"2020","unstructured":"Shukla P, Mukherjee S. Mitochondrial dysfunction: an emerging link in the pathophysiology of polycystic ovary syndrome. Mitochondrion. 2020;52:24\u201339.","journal-title":"Mitochondrion"},{"issue":"30","key":"1596_CR62","doi-asserted-by":"publisher","first-page":"12319","DOI":"10.1073\/pnas.1018793108","volume":"108","author":"K Selesniemi","year":"2011","unstructured":"Selesniemi K, et al. Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc Natl Acad Sci U S A. 2011;108(30):12319\u201324.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1596_CR63","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/sj.cr.7310095","volume":"16","author":"X Zhang","year":"2006","unstructured":"Zhang X, et al. Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles. Cell Res. 2006;16(10):841\u201350.","journal-title":"Cell Res"},{"issue":"2","key":"1596_CR64","doi-asserted-by":"publisher","first-page":"187","DOI":"10.4103\/0974-1208.101020","volume":"5","author":"S Rajani","year":"2012","unstructured":"Rajani S, et al. Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. J Hum Reprod Sci. 2012;5(2):187\u201393.","journal-title":"J Hum Reprod Sci"},{"issue":"1","key":"1596_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1179\/1351000212Y.0000000001","volume":"17","author":"H Massudi","year":"2012","unstructured":"Massudi H, et al. NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Rep. 2012;17(1):28\u201346.","journal-title":"Redox Rep"},{"issue":"7835","key":"1596_CR66","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","volume":"587","author":"NC Henderson","year":"2020","unstructured":"Henderson NC, Rieder F, Wynn TA. Fibrosis: from mechanisms to medicines. Nature. 2020;587(7835):555\u201366.","journal-title":"Nature"},{"issue":"1","key":"1596_CR67","doi-asserted-by":"publisher","first-page":"9","DOI":"10.18632\/aging.101370","volume":"10","author":"T Umehara","year":"2018","unstructured":"Umehara T, Richards JS, Shimada M. The stromal fibrosis in aging ovary. Aging (Albany NY). 2018;10(1):9\u201310.","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"1596_CR68","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13048-017-0375-7","volume":"11","author":"D Wang","year":"2018","unstructured":"Wang D, et al. DHEA-induced ovarian hyperfibrosis is mediated by TGF-\u03b2 signaling pathway. J Ovarian Res. 2018;11(1):6.","journal-title":"J Ovarian Res"},{"issue":"5","key":"1596_CR69","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/jcb.24748","volume":"115","author":"XZ Huang","year":"2014","unstructured":"Huang XZ, et al. Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-\u03b2\/Smad3 pathway. J Cell Biochem. 2014;115(5):996\u20131005.","journal-title":"J Cell Biochem"},{"issue":"5","key":"1596_CR70","doi-asserted-by":"publisher","first-page":"7084","DOI":"10.18632\/aging.202564","volume":"13","author":"J Zhou","year":"2021","unstructured":"Zhou J, et al. Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-\u03b21\/Smads signaling pathway in vivo. Aging (Albany NY). 2021;13(5):7084\u201395.","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"1596_CR71","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12020-022-03262-x","volume":"80","author":"X Pang","year":"2023","unstructured":"Pang X, et al. SIRT3 ameliorates polycystic ovary syndrome through FOXO1\/PGC-1\u03b1 signaling pathway. Endocrine. 2023;80(1):201\u201311.","journal-title":"Endocrine"},{"issue":"1","key":"1596_CR72","doi-asserted-by":"publisher","first-page":"5781","DOI":"10.1038\/s41467-023-41529-7","volume":"14","author":"T Huang","year":"2023","unstructured":"Huang T, et al. Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis. Nat Commun. 2023;14(1):5781.","journal-title":"Nat Commun"},{"key":"1596_CR73","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41420-020-00316-9","volume":"6","author":"X Li","year":"2020","unstructured":"Li X, et al. Mitochondrial dysfunction in fibrotic diseases. Cell Death Discov. 2020;6:80.","journal-title":"Cell Death Discov"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01596-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01596-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01596-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T07:49:49Z","timestamp":1737359389000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01596-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1596"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01596-4","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"19 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The current study received ethical approval, and all animal experiments were conducted in compliance with the regulations and guidelines of the ethics committee of the First Affiliated Hospital of Zhengzhou University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}